Abstract: Cytogenetic analysis still remains the gold standard method for prenatal diagnosis of trisomy 21 (Down syndrome, DS). Nevertheless, the conventional cytogenetic analysis needs live cultured cells and is too time-consuming for clinical application. In contrast, molecular methods such as FISH, QF-PCR, MLPA and quantitative Real-time PCR are rapid assays with results available in 24h. In the present study, we have successfully used a novel MGB TaqMan probe-based real time PCR assay for rapid diagnosis of trisomy 21 status in Down syndrome samples. We have also compared the results of this molecular method with corresponding results obtained by the cytogenetic analysis. Blood samples obtained from DS patients (n=25) and normal controls (n=20) were tested by quantitative Real-time PCR in parallel to standard G-banding analysis. Genomic DNA was extracted from peripheral blood lymphocytes. A high precision TaqMan probe quantitative Real-time PCR assay was developed to determine the gene dosage of DSCAM (target gene on 21q22.2) relative to PMP22 (reference gene on 17p11.2). The DSCAM/PMP22 ratio was calculated according to the formula; ratio=2 -ΔΔCT. The quantitative Real-time PCR was able to distinguish between trisomy 21 samples and normal controls with the gene ratios of 1.49±0.13 and 1.03±0.04 respectively (p value
Abstract: In this paper a new fast simplification method is
presented. Such method realizes Karnough map with large
number of variables. In order to accelerate the operation of the
proposed method, a new approach for fast detection of group
of ones is presented. Such approach implemented in the
frequency domain. The search operation relies on performing
cross correlation in the frequency domain rather than time one.
It is proved mathematically and practically that the number of
computation steps required for the presented method is less
than that needed by conventional cross correlation. Simulation
results using MATLAB confirm the theoretical computations.
Furthermore, a powerful solution for realization of complex
functions is given. The simplified functions are implemented
by using a new desigen for neural networks. Neural networks
are used because they are fault tolerance and as a result they
can recognize signals even with noise or distortion. This is
very useful for logic functions used in data and computer
communications. Moreover, the implemented functions are
realized with minimum amount of components. This is done
by using modular neural nets (MNNs) that divide the input
space into several homogenous regions. Such approach is
applied to implement XOR function, 16 logic functions on one
bit level, and 2-bit digital multiplier. Compared to previous
non- modular designs, a clear reduction in the order of
computations and hardware requirements is achieved.
Abstract: Neural networks are well known for their ability to
model non linear functions, but as statistical methods usually does,
they use a no parametric approach thus, a priori knowledge is not
obvious to be taken into account no more than the a posteriori
knowledge. In order to deal with these problematics, an original way
to encode the knowledge inside the architecture is proposed. This
method is applied to the problem of the evapotranspiration inside
karstic aquifer which is a problem of huge utility in order to deal
with water resource.
Abstract: In this study, any possible differences between mathematics beliefs and anxiety of prospective elementary mathematics teachers have been investigated according to their gender. In this purpose, 1st, 2nd, 3rd and 4th grade students from a Government University in Turkey were selected as a sample. Mathematics Teaching Anxiety Scale (MATAS) and Beliefs About Mathematics Survey (BAMS) has been used as data collection tools. As a result of the study, it has been observed that prospective male teachers have more instrumentalist approach in learning mathematics than females according to their mathematical beliefs. On the other hand, females have more mathematics teaching anxiety than males especially, for subject knowledge in mathematics and selfconfidence.
Abstract: Morphogenesis is the process that underpins the selforganised development and regeneration of biological systems. The ability to mimick morphogenesis in artificial systems has great potential for many engineering applications, including production of biological tissue, design of robust electronic systems and the co-ordination of parallel computing. Previous attempts to mimick these complex dynamics within artificial systems have relied upon the use of evolutionary algorithms that have limited their size and complexity. This paper will present some insight into the underlying dynamics of morphogenesis, then show how to, without the assistance of evolutionary algorithms, design cellular architectures that converge to complex patterns.
Abstract: This work presents a new approach of securing a
wireless network. The configuration is focused on securing &
Protecting wireless network traffic for a small network such as a
home or dorm room. The security Mechanism provided both
authentication, allowing only known authorized users access to the
wireless network, and encryption, preventing anyone from reading
the wireless traffic. The mentioned solution utilizes the open source
free S/WAN software which implements the Internet Protocol
Security –IPSEC. In addition to wireless components, wireless NIC
in PC and wireless access point needs a machine running Linux to act
as security gateway. While the current configuration assumes that the
wireless PC clients are running Linux, Windows XP/VISTA/7 based
machines equipped with VPN software which will allow to interface
with this configuration.
Abstract: A dynamic of Bertrand duopoly game is analyzed, where players use different production methods and choose their prices with bounded rationality. The equilibriums of the corresponding discrete dynamical systems are investigated. The stability conditions of Nash equilibrium under a local adjustment process are studied. The stability conditions of Nash equilibrium under a local adjustment process are studied. The stability of Nash equilibrium, as some parameters of the model are varied, gives rise to complex dynamics such as cycles of higher order and chaos. On this basis, we discover that an increase of adjustment speed of bounded rational player can make Bertrand market sink into the chaotic state. Finally, the complex dynamics, bifurcations and chaos are displayed by numerical simulation.
Abstract: Medical image segmentation based on image smoothing followed by edge detection assumes a great degree of importance in the field of Image Processing. In this regard, this paper proposes a novel algorithm for medical image segmentation based on vigorous smoothening by identifying the type of noise and edge diction ideology which seems to be a boom in medical image diagnosis. The main objective of this algorithm is to consider a particular medical image as input and make the preprocessing to remove the noise content by employing suitable filter after identifying the type of noise and finally carrying out edge detection for image segmentation. The algorithm consists of three parts. First, identifying the type of noise present in the medical image as additive, multiplicative or impulsive by analysis of local histograms and denoising it by employing Median, Gaussian or Frost filter. Second, edge detection of the filtered medical image is carried out using Canny edge detection technique. And third part is about the segmentation of edge detected medical image by the method of Normalized Cut Eigen Vectors. The method is validated through experiments on real images. The proposed algorithm has been simulated on MATLAB platform. The results obtained by the simulation shows that the proposed algorithm is very effective which can deal with low quality or marginal vague images which has high spatial redundancy, low contrast and biggish noise, and has a potential of certain practical use of medical image diagnosis.
Abstract: This paper investigates the problem of spreading
sequence and receiver code synchronization techniques for satellite
based CDMA communications systems. The performance of CDMA
system depends on the autocorrelation and cross-correlation
properties of the used spreading sequences. In this paper we propose
the uses of chaotic Lu system to generate binary sequences for
spreading codes in a direct sequence spread CDMA system. To
minimize multiple access interference (MAI) we propose the use of
genetic algorithm for optimum selection of chaotic spreading
sequences. To solve the problem of transmitter-receiver
synchronization, we use the passivity controls. The concept of
semipassivity is defined to find simple conditions which ensure
boundedness of the solutions of coupled Lu systems. Numerical
results are presented to show the effectiveness of the proposed
approach.
Abstract: Consider a mass production of HDD arms where
hundreds of CNC machines are used to manufacturer the HDD arms.
According to an overwhelming number of machines and models of
arm, construction of separate control chart for monitoring each HDD
arm model by each machine is not feasible. This research proposed a
strategy to optimize the SPC management on shop floor. The
procedure started from identifying the clusters of the machine with
similar manufacturing performance using clustering technique. The
three way control chart ( I - MR - R ) is then applied to each
clustered group of machine. This proposed research has
advantageous to the manufacturer in terms of not only better
performance of the SPC but also the quality management paradigm.
Abstract: Estimation of runoff water quality parameters is required to determine appropriate water quality management options. Various models are used to estimate runoff water quality parameters. However, most models provide event-based estimates of water quality parameters for specific sites. The work presented in this paper describes the development of a model that continuously simulates the accumulation and wash-off of water quality pollutants in a catchment. The model allows estimation of pollutants build-up during dry periods and pollutants wash-off during storm events. The model was developed by integrating two individual models; rainfall-runoff model, and catchment water quality model. The rainfall-runoff model is based on the time-area runoff estimation method. The model allows users to estimate the time of concentration using a range of established methods. The model also allows estimation of the continuing runoff losses using any of the available estimation methods (i.e., constant, linearly varying or exponentially varying). Pollutants build-up in a catchment was represented by one of three pre-defined functions; power, exponential, or saturation. Similarly, pollutants wash-off was represented by one of three different functions; power, rating-curve, or exponential. The developed runoff water quality model was set-up to simulate the build-up and wash-off of total suspended solids (TSS), total phosphorus (TP) and total nitrogen (TN). The application of the model was demonstrated using available runoff and TSS field data from road and roof surfaces in the Gold Coast, Australia. The model provided excellent representation of the field data demonstrating the simplicity yet effectiveness of the proposed model.
Abstract: Mouse L929 fibroblastic cell line, which is widely
used in many experiment aspects, was tested for their differentiation
potency in osteogenic differentiation and adipogenic differentiation.
Human dermal fibroblasts, which their differentiation potency are
still be in confliction, also be taken in the experiment. The
differentiations were conducted by using the inducing medium
ingredients which is generally used to induce differentiation of stem
cells. By the inducing media used, L929 mouse fibroblasts
successfully underwent osteogenic differentiation and adipogenic
differentiation while human dermal fibroblasts underwent only
osteogenic differentiation but not for adipogenic differentiation.
Human dermal fibroblasts are hard to be differentiated in adipogenic
lineage and need specific proper condition for induction.
Abstract: Decision tree algorithms have very important place at
classification model of data mining. In literature, algorithms use
entropy concept or gini index to form the tree. The shape of the
classes and their closeness to each other some of the factors that
affect the performance of the algorithm. In this paper we introduce a
new decision tree algorithm which employs data (attribute) folding
method and variation of the class variables over the branches to be
created. A comparative performance analysis has been held between
the proposed algorithm and C4.5.
Abstract: In this work we present an efficient approach for face
recognition in the infrared spectrum. In the proposed approach
physiological features are extracted from thermal images in order to
build a unique thermal faceprint. Then, a distance transform is used
to get an invariant representation for face recognition. The obtained
physiological features are related to the distribution of blood vessels
under the face skin. This blood network is unique to each individual
and can be used in infrared face recognition. The obtained results are
promising and show the effectiveness of the proposed scheme.
Abstract: In this study, a fuzzy integrated logical forecasting method (FILF) is extended for multi-variate systems by using a vector autoregressive model. Fuzzy time series forecasting (FTSF) method was recently introduced by Song and Chissom [1]-[2] after that Chen improved the FTSF method. Rather than the existing literature, the proposed model is not only compared with the previous FTS models, but also with the conventional time series methods such as the classical vector autoregressive model. The cluster optimization is based on the C-means clustering method. An empirical study is performed for the prediction of the chartering rates of a group of dry bulk cargo ships. The root mean squared error (RMSE) metric is used for the comparing of results of methods and the proposed method has superiority than both traditional FTS methods and also the classical time series methods.
Abstract: This paper investigates the effects of knowledge-based acceleration feedback control integrated with Automatic Generation Control (AGC) to enhance the quality of frequency control of governing system. The Intelligent Acceleration Feedback Controller (IAFC) is proposed to counter the over and under frequency occurrences due to major load change in power system network. Therefore, generator tripping and load shedding operations can be reduced. Meanwhile, the integration of IAFC with AGC, a well known Load-Frequency Control (LFC) is essential to ensure the system frequency is restored to the nominal value. Computer simulations of frequency response of governing system are used to optimize the parameters of IAFC. As a result, there is substantial improvement on the LFC of governing system that employing the proposed control strategy.
Abstract: Today, design requirements are extending more and
more from electronic (analogue and digital) to multidiscipline design.
These current needs imply implementation of methodologies to make
the CAD product reliable in order to improve time to market, study
costs, reusability and reliability of the design process.
This paper proposes a high level design approach applied for the
characterization and the optimization of Switched-Current Sigma-
Delta Modulators. It uses the new hardware description language
VHDL-AMS to help the designers to optimize the characteristics of
the modulator at a high level with a considerably reduced CPU time
before passing to a transistor level characterization.
Abstract: In this paper we have numerically analyzed terahertzrange
wavelength conversion using nondegenerate four wave mixing
(NDFWM) in a SOA integrated DFB laser (experiments reported
both in MIT electronics and Fujitsu research laboratories). For
analyzing semiconductor optical amplifier (SOA), we use finitedifference
beam propagation method (FDBPM) based on modified
nonlinear SchrÖdinger equation and for distributed feedback (DFB)
laser we use coupled wave approach. We investigated wavelength
conversion up to 4THz probe-pump detuning with conversion
efficiency -5dB in 1THz probe-pump detuning for a SOA integrated
quantum-well
Abstract: One of the most important power quality issues is voltage flicker. Nowadays this issue also impacts the power system all over the world. The fact of the matter is that the more and the larger capacity of wind generator has been installed. Under unstable wind power situation, the variation of output current and voltage have caused trouble to voltage flicker. Hence, the major purpose of this study is to analyze the impact of wind generator on voltage flicker of power system. First of all, digital simulation and analysis are carried out based on wind generator operating under various system short circuit capacity, impedance angle, loading, and power factor of load. The simulation results have been confirmed by field measurements.
Abstract: An approach for experimental measurement of the
dynamic characteristics of linear electromagnet actuators is
presented. It uses accelerometer sensor to register the armature
acceleration. The velocity and displacement of the moving parts can
be obtained by integration of the acceleration results. The armature
movement of permanent magnet linear actuator is acquired using this
technique. The results are analyzed and the performance of the
supposed approach is compared with the most commonly used
experimental setup where the displacement of the armature vs. time
is measured instead of its acceleration.