Abstract: In molecular biology, microarray technology is widely and successfully utilized to efficiently measure gene activity. If working with less studied organisms, methods to design custom-made microarray probes are available. One design criterion is to select probes with minimal melting temperature variances thus ensuring similar hybridization properties. If the microarray application focuses on the investigation of metabolic pathways, it is not necessary to cover the whole genome. It is more efficient to cover each metabolic pathway with a limited number of genes. Firstly, an approach is presented which minimizes the overall melting temperature variance of selected probes for all genes of interest. Secondly, the approach is extended to include the additional constraints of covering all pathways with a limited number of genes while minimizing the overall variance. The new optimization problem is solved by a bottom-up programming approach which reduces the complexity to make it computationally feasible. The new method is exemplary applied for the selection of microarray probes in order to cover all fungal secondary metabolite gene clusters for Aspergillus terreus.
Abstract: This study was set to determine the antimicrobial
activities of brine salting, chlorinated solution, and oil frying
treatments on enteric bacteria and fungi in Rastrineobola argentea
fish from fish landing beaches within L. Victoria basin of western
Kenya. Statistical differences in effectiveness of the different
treatment methods was determined by single factor ANOVA, and
paired two-tail t-Test was performed to compare the differences in
moisture contents before and after storage. Oil fried fish recorded the
lowest microbial loads, sodium chloride at 10% concentration was
the second most effective and chlorinated solution even at 150ppm
was the least effective against the bacteria and fungi in fish. Moisture
contents of the control and treated fish were significantly lower after
storage. These results show that oil frying of fish should be adopted
for processing and preserving Rastrineobola argentea which is the
most abundant and affordable fish species from Lake Victoria.
Abstract: The limit load carrying capacity of functionally
graded materials (FGM) circular plates subjected to an arbitrary
rotationally symmetric loading has been computed. It is provided that
the plate material behaves rigid perfectly plastic and obeys either the
Square or the Tresca yield criterion. To this end the upper and lower
bound principles of limit analysis are employed to determine the
exact value for the limiting load. The correctness of the result are
verified and finally limiting loads for two examples namely; through
radius and through thickness FGM circular plates with simply
supported edges are calculated, respectively and moreover, the values
of critical loading factor are determined.
Abstract: Remarkable changes, like the progress in the ability to understand others' minds, can be identified in several socio-cognitive dimensions between age four and seven. Recently, the parenting attitudes have been considerate as one of the potential extrinsic modifiers of these important developmental aspects. The aim of present study is to explore the relationship among authoritarian parenting attitudes and individual differences in Theory of Mind performance. The study included ninety-two Costarrican preschoolers. Six False-belief tasks, an Advanced Theory of Mind test and the Parenting Attitudes Inventory were used. The results demonstrate that participants with high and low Authoritarian Parenting Received differ in their performance on First and Second Order False-belief tasks, but not in Advanced Theory of Mind tasks. Theoretical considerations about possible explanations regarding these results are discussed and methodological limitations are considered to shed light over future directions.
Abstract: This paper aims at a new challenge of customer
satisfaction on mobile customer relationship management. In this
paper presents a conceptualization of mCRM on its unique
characteristics of customer satisfaction. Also, this paper develops an
empirical framework in conception of customer satisfaction in
mCRM. A single-case study is applied as the methodology. In order to
gain an overall view of the empirical case, this paper accesses to
invisible and important information of company in this investigation.
Interview is the key data source form the main informants of the
company through which the issues are identified and the proposed
framework is built. It supports the development of customer
satisfaction in mCRM; links this theoretical framework into practice;
and provides the direction for future research. Therefore, this paper is
very useful for the industries as it helps them to understand how
customer satisfaction changes the mCRM structure and increase the
business competitive advantage. Finally, this paper provides a
contribution in practice by linking a theoretical framework in
conception of customer satisfaction in mCRM for companies to a
practical real case.
Abstract: In this paper, a novel associative memory model will be proposed and applied to memory retrievals based on the conventional continuous time model. The conventional model presents memory capacity is very low and retrieval process easily converges to an equilibrium state which is very different from the stored patterns. Genetic Algorithms is well-known with the capability of global optimal search escaping local optimum on progress to reach a global optimum. Based on the well-known idea of Genetic Algorithms, this work proposes a heuristic rule to make a mutation when the state of the network is trapped in a spurious memory. The proposal heuristic associative memory show the stored capacity does not depend on the number of stored patterns and the retrieval ability is up to ~ 1.
Abstract: The paper discusses a 3D numerical solution of the inverse boundary problem for a continuous casting process of alloy. The main goal of the analysis presented within the paper was to estimate heat fluxes along the external surface of the ingot. The verified information on these fluxes was crucial for a good design of a mould, effective cooling system and generally the whole caster. In the study an enthalpy-porosity technique implemented in Fluent package was used for modeling the solidification process. In this method, the phase change interface was determined on the basis of the liquid fraction approach. In inverse procedure the sensitivity analysis was applied for retrieving boundary conditions. A comparison of the measured and retrieved values showed a high accuracy of the computations. Additionally, the influence of the accuracy of measurements on the estimated heat fluxes was also investigated.
Abstract: The present study is aim to prepare and evaluate the selfnanoemulsifying drug delivery (SNEDDS) system of a poorly water soluble drug valsartan in order to achieve a better dissolution rate which would further help in enhancing oral bioavailability. The present research work describes a SNEDDS of valsartan using labrafil M 1944 CS, Tween 80 and Transcutol HP. The pseudoternary phase diagrams with presence and absence of drug were plotted to check for the emulsification range and also to evaluate the effect of valsartan on the emulsification behavior of the phases. The mixtures consisting of oil (labrafil M 1944 CS) with surfactant (tween 80), co-surfactant (Transcutol HP) were found to be optimum formulations. Prepared formulations were evaluated for its particle size distribution, nanoemulsifying properties, robustness to dilution, self emulsication time, turbidity measurement, drug content and invitro dissolution. The optimized formulations are further evaluated for heating cooling cycle, centrifugation studies, freeze thaw cycling, particle size distribution and zeta potential were carried out to confirm the stability of the formed SNEDDS formulations. The prepared formulation revealed t a significant improvement in terms of the drug solubility as compared with marketed tablet and pure drug.
Abstract: The phase diagrams and compositions of coexisting
phases have been determined for aqueous two-phase systems
containing poly(propylene glycol) with average molecular weight of
425 and sodium citrate at various pH of 3.93, 4.44, 4.6, 4.97, 5.1,
8.22. The effect of pH on the salting-out effect of poly (propylene
glycol) by sodium citrate has been studied. It was found that, an
increasing in pH caused the expansion of two-phase region.
Increasing pH also increases the concentration of PPG in the PPGrich
phase, while the salt-rich phase will be somewhat mole diluted.
Abstract: An unsupervised classification algorithm is derived
by modeling observed data as a mixture of several mutually
exclusive classes that are each described by linear combinations of
independent non-Gaussian densities. The algorithm estimates the
data density in each class by using parametric nonlinear functions
that fit to the non-Gaussian structure of the data. This improves
classification accuracy compared with standard Gaussian mixture
models. When applied to textures, the algorithm can learn basis
functions for images that capture the statistically significant structure
intrinsic in the images. We apply this technique to the problem of
unsupervised texture classification and segmentation.
Abstract: In this paper, we present a new method for
incorporating global shift invariance in support vector machines.
Unlike other approaches which incorporate a feature extraction stage,
we first scale the image and then classify it by using the modified
support vector machines classifier. Shift invariance is achieved by
replacing dot products between patterns used by the SVM classifier
with the maximum cross-correlation value between them. Unlike the
normal approach, in which the patterns are treated as vectors, in our
approach the patterns are treated as matrices (or images). Crosscorrelation
is computed by using computationally efficient
techniques such as the fast Fourier transform. The method has been
tested on the ORL face database. The tests indicate that this method
can improve the recognition rate of an SVM classifier.
Abstract: In order to enhance the usability of the human computer interface (HCI) on the touchscreen, this study explored the optimal tactile depth and effect of visual cues on the user-s tendency to touch the touchscreen icons. The experimental program was designed on the touchscreen in this study. Results indicated that the ratio of the icon size to the tactile depth was 1:0.106. There were significant effects of experienced users and novices on the tactile feedback depth (p < 0.01). In addition, the results proved that the visual cues provided a feedback that helped to guide the user-s touch icons accurately and increased the capture efficiency for a tactile recognition field. This tactile recognition field was 18.6 mm in length. There was consistency between the experienced users and novices under the visual cue effects. Finally, the study developed an applied design with touch feedback for touchscreen icons.
Abstract: The real representation of the quaternionic matrix is
definited and studied. The relations between the positive (semi)define
quaternionic matrix and its real representation matrix are presented.
By means of the real representation, the relation between the positive
(semi)definite solutions of quaternionic matrix equations and those of
corresponding real matrix equations is established.
Abstract: A fuzzy classifier using multiple ellipsoids approximating decision regions for classification is to be designed in this paper. An algorithm called Gustafson-Kessel algorithm (GKA) with an adaptive distance norm based on covariance matrices of prototype data points is adopted to learn the ellipsoids. GKA is able toadapt the distance norm to the underlying distribution of the prototypedata points except that the sizes of ellipsoids need to be determined a priori. To overcome GKA's inability to determine appropriate size ofellipsoid, the genetic algorithm (GA) is applied to learn the size ofellipsoid. With GA combined with GKA, it will be shown in this paper that the proposed method outperforms the benchmark algorithms as well as algorithms in the field.
Abstract: This paper introduces application of multi degree of freedom fuzzy(MDOFF) controller in permanent magnet (PM)drive system. The drive system model is developed for FO control. Simulation of the system is carried out to predict the performance at NL and under load,. The results indicate that application of MDOFF controller is effective for sensorless PM drive system.
Abstract: The elimination of ranitidine (a pharmaceutical
compound) has been carried out in the presence of UV-C radiation.
After some preliminary experiments, it has been experienced the no
influence of the gas nature (air or oxygen) bubbled in photolytic
experiments. From simple photolysis experiments the quantum yield
of this compound has been determined. Two photolytic
approximation has been used, the linear source emission in parallel
planes and the point source emission in spherical planes. The
quantum yield obtained was in the proximity of 0.05 mol Einstein-1
regardless of the method used. Addition of free radical promoters
(hydrogen peroxide) increases the ranitidine removal rate while the
use of photocatalysts (TiO2) negatively affects the process.
Abstract: In this work the opportunity of construction of the
qualifiers for face-recognition systems based on conjugation criteria
is investigated. The linkage between the bipartite conjugation, the
conjugation with a subspace and the conjugation with the null-space
is shown. The unified solving rule is investigated. It makes the
decision on the rating of face to a class considering the linkage
between conjugation values. The described recognition method can
be successfully applied to the distributed systems of video control
and video observation.
Abstract: Tumour suppressors are key participants in the
prevention of cancer. Regulation of their expression through
miRNAs is important for comprehensive translation inhibition of
tumour suppressors and elucidation of carcinogenesis mechanisms.
We studies the possibility of 1521 miRNAs to bind with 873 mRNAs
of human tumour suppressors using RNAHybrid 2.1 and ERNAhybrid
programmes. Only 978 miRNAs were found to be
translational regulators of 812 mRNAs, and 61 mRNAs did not have
any miRNA binding sites. Additionally, 45.9% of all miRNA binding
sites were located in coding sequences (CDSs), 33.8% were located
in 3' untranslated region (UTR), and 20.3% were located in the
5'UTR. MiRNAs binding with more than 50 target mRNAs and
mRNAs binding with several miRNAs were selected. Hsa-miR-5096
had 15 perfectly complementary binding sites with mRNAs of 14
tumour suppressors. These newly indentified miRNA binding sites
can be used in the development of medicines (anti-sense therapies)
for cancer treatment.
Abstract: In this study, the dispersed model is used to predict
gas phase concentration, liquid drop concentration. The venturi
scrubber efficiency is calculated by gas phase concentration. The
modified model has been validated with available experimental data
of Johnstone, Field and Tasler for a range of throat gas velocities,
liquid to gas ratios and particle diameters and is used to study the
effect of some design parameters on collection efficiency.
Abstract: This article investigates a contribution of synthesized visual speech. Synthesis of visual speech expressed by a computer consists in an animation in particular movements of lips. Visual speech is also necessary part of the non-manual component of a sign language. Appropriate methodology is proposed to determine the quality and the accuracy of synthesized visual speech. Proposed methodology is inspected on Czech speech. Hence, this article presents a procedure of recording of speech data in order to set a synthesis system as well as to evaluate synthesized speech. Furthermore, one option of the evaluation process is elaborated in the form of a perceptual test. This test procedure is verified on the measured data with two settings of the synthesis system. The results of the perceptual test are presented as a statistically significant increase of intelligibility evoked by real and synthesized visual speech. Now, the aim is to show one part of evaluation process which leads to more comprehensive evaluation of the sign speech synthesis system.