Abstract: Yeast cells live in a constantly changing environment that requires the continuous adaptation of their genomic program in order to sustain their homeostasis, survive and proliferate. Due to the advancement of high throughput technologies, there is currently a large amount of data such as gene expression, gene deletion and protein-protein interactions for S. Cerevisiae under various environmental conditions. Mining these datasets requires efficient computational methods capable of integrating different types of data, identifying inter-relations between different components and inferring functional groups or 'modules' that shape intracellular processes. This study uses computational methods to delineate some of the mechanisms used by yeast cells to respond to environmental changes. The GRAM algorithm is first used to integrate gene expression data and ChIP-chip data in order to find modules of coexpressed and co-regulated genes as well as the transcription factors (TFs) that regulate these modules. Since transcription factors are themselves transcriptionally regulated, a three-layer regulatory cascade consisting of the TF-regulators, the TFs and the regulated modules is subsequently considered. This three-layer cascade is then modeled quantitatively using artificial neural networks (ANNs) where the input layer corresponds to the expression of the up-stream transcription factors (TF-regulators) and the output layer corresponds to the expression of genes within each module. This work shows that (a) the expression of at least 33 genes over time and for different stress conditions is well predicted by the expression of the top layer transcription factors, including cases in which the effect of up-stream regulators is shifted in time and (b) identifies at least 6 novel regulatory interactions that were not previously associated with stress-induced changes in gene expression. These findings suggest that the combination of gene expression and protein-DNA interaction data with artificial neural networks can successfully model biological pathways and capture quantitative dependencies between distant regulators and downstream genes.
Abstract: The aim of this study is to find out and analyze the
role of gender and age on the perceptions of students to the distant
online program offered by Vocational High School in Sakarya
University. The research is based on a questionnaire as a mean of
data collection method to find out the role of age and gender on the
student-s perceptions toward online education, and the study
progressed through finding relationships between the variables used
in the data collection instrument. The findings of the analysis
revealed that although the students registered to the online program
by will, they preferred the traditional face-to-face education due to
the difficulty of the nonverbal communication, their incompetence of
using the technology required, and their belief in traditional face-toface
learning more than online education.
Regarding gender, the results showed that the female students
have a better perception of the online education as opposed to the
male students. Regarding age, the results showed that the older the
students are the more is their preference towards attending face-toface
classes.
Abstract: A new OTA-based logarithmic-control variable gain
current amplifier (LCCA) is presented. It consists of two Operational
Transconductance Amplifier (OTA) and two PMOS transistors
biased in weak inversion region. The circuit operates from 0.6V DC
power supply and consumes 0.6 μW. The linear-dB controllable
output range is 43 dB with maximum error less than 0.5dB. The
functionality of the proposed design was confirmed using HSPICE in
0.35μm CMOS process technology.
Abstract: The 2008 Candlelight Protests of Korea was very
significant to portray the political environment among the South
Korean youth. Many challenges and new advanced technologies have
driven the youth community to be engaged in the political arena that
has shifted them from traditional Korean youth to a very greater
community. Due to historical perspective with the people of North
Korea, the young generation has embraced different view of ethnic
nationalism. This study examines the youth involvement in politics in
line with their level of acceptance the practice of democracy. The
increase usage of new media has shown great results in the survey
results whereby the youth used as a platform to gain political
information and brought higher degree of their sociopolitical interests
among them. Furthermore, the rise of nationalism and patriotism will
be discussed in this paper to the dynamism of the political approaches
used by the Korea government
Abstract: Breast skin-line estimation and breast segmentation is an important pre-process in mammogram image processing and computer-aided diagnosis of breast cancer. Limiting the area to be processed into a specific target region in an image would increase the accuracy and efficiency of processing algorithms. In this paper we are presenting a new algorithm for estimating skin-line and breast segmentation using fast marching algorithm. Fast marching is a partial-differential equation based numerical technique to track evolution of interfaces. We have introduced some modifications to the traditional fast marching method, specifically to improve the accuracy of skin-line estimation and breast tissue segmentation. Proposed modifications ensure that the evolving front stops near the desired boundary. We have evaluated the performance of the algorithm by using 100 mammogram images taken from mini-MIAS database. The results obtained from the experimental evaluation indicate that this algorithm explains 98.6% of the ground truth breast region and accuracy of the segmentation is 99.1%. Also this algorithm is capable of partially-extracting nipple when it is available in the profile.
Abstract: In blended learning environments, the Internet can be combined with other technologies. The aim of this research was to design, introduce and validate a model to support synchronous and asynchronous activities by managing content domains in an Adaptive Hypermedia System (AHS). The application is based on information recovery techniques, clustering algorithms and adaptation rules to adjust the user's model to contents and objects of study. This system was applied to blended learning in higher education. The research strategy used was the case study method. Empirical studies were carried out on courses at two universities to validate the model. The results of this research show that the model had a positive effect on the learning process. The students indicated that the synchronous and asynchronous scenario is a good option, as it involves a combination of work with the lecturer and the AHS. In addition, they gave positive ratings to the system and stated that the contents were adapted to each user profile.
Abstract: Knowledge bases are basic components of expert
systems or intelligent computational programs. Knowledge bases
provide knowledge, events that serve deduction activity,
computation and control. Therefore, researching and developing of
models for knowledge representation play an important role in
computer science, especially in Artificial Intelligence Science and
intelligent educational software. In this paper, the extensive
deduction computational model is proposed to design knowledge
bases whose attributes are able to be real values or functional values.
The system can also solve problems based on knowledge bases.
Moreover, the models and algorithms are applied to produce the
educational software for solving alternating current problems or
solving set of equations automatically.
Abstract: This paper reports on an effort to address the issue of
inequality in girls- and women-s access to science, engineering and
technology (SET) education and careers through raising awareness on
SET among secondary school girls in South Africa. Girls participated
in hands-on high-tech rapid prototyping environment of a fabrication
laboratory that was aimed at stimulating creativity and innovation as
part of a Fab Kids initiative. The Fab Kids intervention is about
creating a SET pipeline as part of the Young Engineers and Scientists
of Africa Initiative.The methodology was based on a real world
situation and a hands-on approach. In the process, participants
acquired a number of skills including computer-aided design,
research skills, communication skills, teamwork skills, technical
drawing skills, writing skills and problem-solving skills. Exposure to
technology enhanced the girls- confidence in being able to handle
technology-related tasks.
Abstract: Quantitative trait loci (QTL) experiments have yielded
important biological and biochemical information necessary for
understanding the relationship between genetic markers and
quantitative traits. For many years, most QTL algorithms only
allowed one observation per genotype. Recently, there has been an
increasing demand for QTL algorithms that can accommodate more
than one observation per genotypic distribution. The Bayesian
hierarchical model is very flexible and can easily incorporate this
information into the model. Herein a methodology is presented that
uses a Bayesian hierarchical model to capture the complexity of the
data. Furthermore, the Markov chain Monte Carlo model composition
(MC3) algorithm is used to search and identify important markers. An
extensive simulation study illustrates that the method captures the
true QTL, even under nonnormal noise and up to 6 QTL.
Abstract: The overall objective of this research is a strain
improvement technology for efficient pectinase production. A novel
cells cultivation technology by immobilization of fungal cells has
been studied in long time continuous fermentations. Immobilization
was achieved by using of new material for absorption of stores of
immobilized cultures which was for the first time used for
immobilization of microorganisms. Effects of various conditions of
nitrogen and carbon nutrition on the biosynthesis of pectolytic
enzymes in Aspergillus awamori 1-8 strain were studied. Proposed
cultivation technology along with optimization of media components
for pectinase overproduction led to increased pectinase productivity
in Aspergillus awamori 1-8 from 7 to 8 times. Proposed technology
can be applied successfully for production of major industrial
enzymes such as α-amylase, protease, collagenase etc.
Abstract: Expression data analysis is based mostly on the
statistical approaches that are indispensable for the study of
biological systems. Large amounts of multidimensional data resulting
from the high-throughput technologies are not completely served by
biostatistical techniques and are usually complemented with visual,
knowledge discovery and other computational tools. In many cases,
in biological systems we only speculate on the processes that are
causing the changes, and it is the visual explorative analysis of data
during which a hypothesis is formed. We would like to show the
usability of multidimensional visualization tools and promote their
use in life sciences. We survey and show some of the
multidimensional visualization tools in the process of data
exploration, such as parallel coordinates and radviz and we extend
them by combining them with the self-organizing map algorithm. We
use a time course data set of transitional cell carcinoma of the bladder
in our examples. Analysis of data with these tools has the potential to
uncover additional relationships and non-trivial structures.
Abstract: Biometric measures of one kind or another have been
used to identify people since ancient times, with handwritten
signatures, facial features, and fingerprints being the traditional
methods. Of late, Systems have been built that automate the task of
recognition, using these methods and newer ones, such as hand
geometry, voiceprints and iris patterns. These systems have different
strengths and weaknesses. This work is a two-section composition. In
the starting section, we present an analytical and comparative study
of common biometric techniques. The performance of each of them
has been viewed and then tabularized as a result. The latter section
involves the actual implementation of the techniques under
consideration that has been done using a state of the art tool called,
MATLAB. This tool aids to effectively portray the corresponding
results and effects.
Abstract: There are many sources trough which the soil get
enriched and contaminated with REEs. The determination of REEs in
environmental samples has been limited because of the lack of
sensitive analytical techniques. Soil samples were collected from
four sites including open cast coal mine, natural coal burning, coal
washery and control in the coal field located in Dhanbad, India.
Total concentrations of rare earth elements (REEs) were determined
using the inductively coupled plasma atomic absorption spectrometry
in order to assess enrichment status in the coal field. Results showed
that the mean concentrations of La, Pr, Eu, Tb, Ho, and Tm in open
cast mine and natural coal burning sites were elevated compared to
the reference concentrations, while Ce, Nd, Sm, and Gd were
elevated in coal washery site. When compared to reference soil,
heavy REEs (HREEs) were enriched in open cast mines and natural
coal burning affected soils, however, the HREEs were depleted in the
coal washery sites. But, the Chondrite-normalization diagram showed
significant enrichment for light REEs (LREEs) in all the soils. High
concentration of Pr, Eu, Tb, Ho, Tm, and Lu in coal mining and coal
burning sites may pose human health risks. Factor analysis showed
that distribution and relative abundance of REEs of the coal washery
site is comparable with the control. Eventually washing or cleaning
of coal could significantly decrease the emission of REEs from coal
into the environment.
Abstract: The ability of information systems to operate in conjunction with each other encompassing communication protocols, hardware, software, application, and data compatibility layers. There has been considerable work in industry on the development of component interoperability models, such as CORBA, (D)COM and JavaBeans. These models are intended to reduce the complexity of software development and to facilitate reuse of off-the-shelf components. The focus of these models is syntactic interface specification, component packaging, inter-component communications, and bindings to a runtime environment. What these models lack is a consideration of architectural concerns – specifying systems of communicating components, explicitly representing loci of component interaction, and exploiting architectural styles that provide well-understood global design solutions. The development of complex business applications is now focused on an assembly of components available on a local area network or on the net. These components must be localized and identified in terms of available services and communication protocol before any request. The first part of the article introduces the base concepts of components and middleware while the following sections describe the different up-todate models of communication and interaction and the last section shows how different models can communicate among themselves.
Abstract: This paper presents anti-synchronization of chaos
between two different chaotic systems using active control method.
The proposed technique is applied to achieve chaos antisynchronization
for the Lü and Rössler dynamical systems.
Numerical simulations are implemented to verify the results.
Abstract: Calibration estimation is a method of adjusting the
original design weights to improve the survey estimates by using
auxiliary information such as the known population total (or mean)
of the auxiliary variables. A calibration estimator uses calibrated
weights that are determined to minimize a given distance measure to
the original design weights while satisfying a set of constraints
related to the auxiliary information. In this paper, we propose a new
multivariate calibration estimator for the population mean in the
stratified sampling design, which incorporates information available
for more than one auxiliary variable. The problem of determining the
optimum calibrated weights is formulated as a Mathematical
Programming Problem (MPP) that is solved using the Lagrange
multiplier technique.
Abstract: In this paper, we present the information life cycle, and analyze the importance of managing the corporate application portfolio across this life cycle. The approach presented here does not correspond just to the extension of the traditional information system development life cycle. This approach is based in the generic life cycle employed in other contexts like manufacturing or marketing. In this paper it is proposed a model of an information system life cycle, supported in the assumption that a system has a limited life. But, this limited life may be extended. This model is also applied in several cases; being reported here two examples of the framework application in a construction enterprise, and in a manufacturing enterprise.
Abstract: The purpose of present paper was to investigate
perceptions of Korean secondary school students about social issues
related to biological sciences. Twenty issues were selected based on
topics of articles in the newspaper from 2005 to 2010. The issues were
categorized into biotechnology, health-disease and environment
domains. Subjects were 541 high school students (male 253 and
female 288). On the survey, students were asked to answer on 5-point
Lickert scales how they thought of the effect of biological phenomena
or events related to biological issues on the individual life and the
society. They perceived that the biological issues would be more
effectible on the society than on the individual life. Female students
had a little more perceptions than males.
Abstract: In recent years image watermarking has become an
important research area in data security, confidentiality and image
integrity. Many watermarking techniques were proposed for medical
images. However, medical images, unlike most of images, require
extreme care when embedding additional data within them because
the additional information must not affect the image quality and
readability. Also the medical records, electronic or not, are linked to
the medical secrecy, for that reason, the records must be confidential.
To fulfill those requirements, this paper presents a lossless
watermarking scheme for DICOM images. The proposed a fragile
scheme combines two reversible techniques based on difference
expansion for patient's data hiding and protecting the region of
interest (ROI) with tamper detection and recovery capability.
Patient's data are embedded into ROI, while recovery data are
embedded into region of non-interest (RONI). The experimental
results show that the original image can be exactly extracted from the
watermarked one in case of no tampering. In case of tampered ROI,
tampered area can be localized and recovered with a high quality
version of the original area.
Abstract: Case based reasoning (CBR) methodology presents a foundation for a new technology of building intelligent computeraided diagnoses systems. This Technology directly addresses the problems found in the traditional Artificial Intelligence (AI) techniques, e.g. the problems of knowledge acquisition, remembering, robust and maintenance. This paper discusses the CBR methodology, the research issues and technical aspects of implementing intelligent medical diagnoses systems. Successful applications in cancer and heart diseases developed by Medical Informatics Research Group at Ain Shams University are also discussed.