Abstract: Severe acute respiratory syndrome (SARS) is a respiratory disease in humans which is caused by the SARS coronavirus. The treatment of coronavirus-associated SARS has been evolving and so far there is no consensus on an optimal regimen. The mainstream therapeutic interventions for SARS involve broad-spectrum antibiotics and supportive care, as well as antiviral agents and immunomodulatory therapy. The Protein- Ligand interaction plays a significant role in structural based drug designing. In the present work we have taken the receptor Angiotensin converting enzyme 2 and identified the drugs that are commonly used against SARS. They are Lopinavir, Ritonavir, Ribavirin, and Oseltamivir. The receptor Angiotensin converting enzyme 2 (ACE-2) was docked with above said drugs and the energy value obtained are as follows, Lopinavir (-292.3), Ritonavir (-325.6), Oseltamivir (- 229.1), Ribavirin (-208.8). Depending on the least energy value we have chosen the best two drugs out of the four conventional drugs. We tried to improve the binding efficiency and steric compatibility of the two drugs namely Ritonavir and Lopinavir. Several modifications were made to the probable functional groups (phenylic, ketonic groups in case of Ritonavir and carboxylic groups in case of Lopinavir respectively) which were interacting with the receptor molecule. Analogs were prepared by Marvin Sketch software and were docked using HEX docking software. Lopinavir analog 8 and Ritonavir analog 11 were detected with significant energy values and are probable lead molecule. It infers that some of the modified drugs are better than the original drugs. Further work can be carried out to improve the steric compatibility of the drug based upon the work done above for a more energy efficient binding of the drugs to the receptor.
Abstract: The development of wireless communication technologies has changed our living style in global level. After the international success of mobile telephony standards, the location and time independent voice connection has become a default method in daily telecommunications. As for today, highly advanced multimedia messaging plays a key role in value added service handling. Along with evolving data services, the need for more complex applications can be seen, including the mobile usage of broadcast technologies. Here performance of a system design for terrestrial multimedia content is examined with emphasis on mobile reception. This review paper has accommodated the understanding of physical layer role and the flavour of terrestrial channel effects on the terrestrial multimedia transmission using OFDM keeping DVB-H as benchmark standard.
Abstract: In this paper, we introduce an mobile agent framework
with proactive load balancing for ambient intelligence (AmI) environments.
One of the main obstacles of AmI is the scalability in
which the openness of AmI environment introduces dynamic resource
requirements on agencies. To mediate this scalability problem, our
framework proposes a load balancing module to proactively analyze
the resource consumption of network bandwidth and preferred agencies
to suggest the optimal communication method to its user. The
framework generally formulates an AmI environment that consists
of three main components: (1) mobile devices, (2) hosts or agencies,
and (3) directory service center (DSC). A preliminary implementation
was conducted with NetLogo and the experimental results show that
the proposed approach provides enhanced system performance by
minimizing the network utilization to provide users with responsive
services.
Abstract: This paper presents a sensor-based motion planning algorithm for 3-DOF car-like robots with a nonholonomic constraint. Similar to the classic Bug family algorithms, the proposed algorithm enables the car-like robot to navigate in a completely unknown environment using only the range sensor information. The car-like robot uses the local range sensor view to determine the local path so that it moves towards the goal. To guarantee that the robot can approach the goal, the two modes of motion are repeated, termed motion-to-goal and wall-following. The motion-to-goal behavior lets the robot directly move toward the goal, and the wall-following behavior makes the robot circumnavigate the obstacle boundary until it meets the leaving condition. For each behavior, the nonholonomic motion for the car-like robot is planned in terms of the instantaneous turning radius. The proposed algorithm is implemented to the real robot and the experimental results show the performance of proposed algorithm.
Abstract: This paper presents a cold flow simulation study of a small gas turbine combustor performed using laboratory scale test rig. The main objective of this investigation is to obtain physical insight of the main vortex, responsible for the efficient mixing of fuel and air. Such models are necessary for predictions and optimization of real gas turbine combustors. Air swirler can control the combustor performance by assisting in the fuel-air mixing process and by producing recirculation region which can act as flame holders and influences residence time. Thus, proper selection of a swirler is needed to enhance combustor performance and to reduce NOx emissions. Three different axial air swirlers were used based on their vane angles i.e., 30°, 45°, and 60°. Three-dimensional, viscous, turbulent, isothermal flow characteristics of the combustor model operating at room temperature were simulated via Reynolds- Averaged Navier-Stokes (RANS) code. The model geometry has been created using solid model, and the meshing has been done using GAMBIT preprocessing package. Finally, the solution and analysis were carried out in a FLUENT solver. This serves to demonstrate the capability of the code for design and analysis of real combustor. The effects of swirlers and mass flow rate were examined. Details of the complex flow structure such as vortices and recirculation zones were obtained by the simulation model. The computational model predicts a major recirculation zone in the central region immediately downstream of the fuel nozzle and a second recirculation zone in the upstream corner of the combustion chamber. It is also shown that swirler angles changes have significant effects on the combustor flowfield as well as pressure losses.
Abstract: A bond graph model of an electrical transformer
including the nonlinear saturation is presented. A nonlinear observer for the transformer based on multivariable circle
criterion in the physical domain is proposed. In order to show the saturation and hysteresis effects on the electrical transformer,
simulation results are obtained. Finally, the paper describes that convergence of the estimates to the true states is achieved.
Abstract: Textile structures are engineered and fabricated to
meet worldwide structural applications. Nevertheless, research
varying textile structure on natural fibre as composite reinforcement
was found to be very limited. Most of the research is focusing on
short fibre and random discontinuous orientation of the reinforcement
structure. Realizing that natural fibre (NF) composite had been
widely developed to be used as synthetic fibre composite
replacement, this research attempted to examine the influence of
woven and cross-ply laminated structure towards its mechanical
performances. Laminated natural fibre composites were developed
using hand lay-up and vacuum bagging technique. Impact and
flexural strength were investigated as a function of fibre type (coir
and kenaf) and reinforcement structure (imbalanced plain woven,
0°/90° cross-ply and +45°/-45° cross-ply). Multi-level full factorial
design of experiment (DOE) and analysis of variance (ANOVA) was
employed to impart data as to how fibre type and reinforcement
structure parameters affect the mechanical properties of the
composites. This systematic experimentation has led to determination
of significant factors that predominant influences the impact and
flexural properties of the textile composites. It was proven that both
fibre type and reinforcement structure demonstrated significant
difference results. Overall results indicated that coir composite and
woven structure exhibited better impact and flexural strength. Yet,
cross-ply composite structure demonstrated better fracture resistance.
Abstract: In this article, we discuss project-based learning in the context of a wheel garden as an instructional tool in science and mathematics education. A wheel garden provides multiple opportunities to teach across the curriculum, to integrate disciplines, and to promote community involvement. Grounded in the theoretical framework of constructivism, the wheel garden provides a multidisciplined educational tool that provides a hands-on, non-traditional arena for learning. We will examine some of the cultural, art, science, and mathematics connections made with this project.
Abstract: The image segmentation method described in this
paper has been developed as a pre-processing stage to be used in
methodologies and tools for video/image indexing and retrieval by
content. This method solves the problem of whole objects extraction
from background and it produces images of single complete objects
from videos or photos. The extracted images are used for calculating
the object visual features necessary for both indexing and retrieval
processes.
The segmentation algorithm is based on the cooperation among an
optical flow evaluation method, edge detection and region growing
procedures. The optical flow estimator belongs to the class of
differential methods. It permits to detect motions ranging from a
fraction of a pixel to a few pixels per frame, achieving good results in
presence of noise without the need of a filtering pre-processing stage
and includes a specialised model for moving object detection.
The first task of the presented method exploits the cues from
motion analysis for moving areas detection. Objects and background
are then refined using respectively edge detection and seeded region
growing procedures. All the tasks are iteratively performed until
objects and background are completely resolved.
The method has been applied to a variety of indoor and outdoor
scenes where objects of different type and shape are represented on
variously textured background.
Abstract: The occurrence and removal of trace organic
contaminants in the aquatic environment has become a focus of
environmental concern. For the selective removal of carbamazepine
from loaded waters molecularly imprinted polymers (MIPs) were
synthesized with carbamazepine as template. Parameters varied were
the type of monomer, crosslinker, and porogen, the ratio of starting
materials, and the synthesis temperature. Best results were obtained
with a template to crosslinker ratio of 1:20, toluene as porogen, and
methacrylic acid (MAA) as monomer. MIPs were then capable to
recover carbamazepine by 93% from a 10-5 M landfill leachate
solution containing also caffeine and salicylic acid. By comparison,
carbamazepine recoveries of 75% were achieved using a nonimprinted
polymer (NIP) synthesized under the same conditions, but
without template. In landfill leachate containing solutions
carbamazepine was adsorbed by 93-96% compared with an uptake of
73% by activated carbon. The best solvent for desorption was
acetonitrile, with which the amount of solvent necessary and dilution
with water was tested. Selected MIPs were tested for their reusability
and showed good results for at least five cycles. Adsorption
isotherms were prepared with carbamazepine solutions in the
concentration range of 0.01 M to 5*10-6 M. The heterogeneity index
showed a more homogenous binding site distribution.
Abstract: Fine alignment of main ship power plants mechanisms
and shaft lines provides long-term and failure-free performance of
propulsion system while fast and high-quality installation of
mechanisms and shaft lines decreases common labor intensity. For
checking shaft line allowed stress and setting its alignment it is
required to perform calculations considering various stages of life
cycle. In 2012 JSC SSTC developed special software complex
“Shaftline” for calculation of alignment of having its own I/O
interface and display of shaft line 3D model. Alignment of shaft line
as per bearing loads is rather labor-intensive procedure. In order to
decrease its duration, JSC SSTC developed automated alignment
system from ship power plants mechanisms. System operation
principle is based on automatic simulation of design load on bearings.
Initial data for shaft line alignment can be exported to automated
alignment system from PC “Shaft line”.
Abstract: This paper addresses the fundamental requirements for
starting an online business. It covers the process of ideation,
conceptualization, formulation, and implementation of new venture
ideas on the Web. Using Facebook as an illustrative example, we learn
how to turn an idea into a successful electronic business and to execute
a business plan with IT skills, management expertise, a good
entrepreneurial attitude, and an understanding of Internet culture. The
personality traits and characteristics of a successful e-commerce
entrepreneur are discussed with reference to Facebook-s founder,
Mark Zuckerberg. Facebook is a social and e-commerce success. It
provides a trusted environment of which participants can conduct
business with social experience. People are able to discuss products
before, during the after the sale within the Facebook environment. The
paper also highlights the challenges and opportunities for e-commerce
entrepreneurial startups to go public and of entering the China market.
Abstract: This paper considers the robust exponential stability issues for a class of uncertain switched neutral system which delays switched according to the switching rule. The system under consideration includes both stable and unstable subsystems. The uncertainties considered in this paper are norm bounded, and possibly time varying. Based on multiple Lyapunov functional approach and dwell-time technique, the time-dependent switching rule is designed depend on the so-called average dwell time of stable subsystems as well as the ratio of the total activation time of stable subsystems and unstable subsystems. It is shown that by suitably controlling the switching between the stable and unstable modes, the robust stabilization of the switched uncertain neutral systems can be achieved. Two simulation examples are given to demonstrate the effectiveness of the proposed method.
Abstract: one of the significant factors for improving the
accuracy of Land Surface Temperature (LST) retrieval is the correct
understanding of the directional anisotropy for thermal radiance. In
this paper, the multiple scattering effect between heterogeneous
non-isothermal surfaces is described rigorously according to the
concept of configuration factor, based on which a directional thermal
radiance model is built, and the directional radiant character for urban
canopy is analyzed. The model is applied to a simple urban canopy
with row structure to simulate the change of Directional Brightness
Temperature (DBT). The results show that the DBT is aggrandized
because of the multiple scattering effects, whereas the change range of
DBT is smoothed. The temperature difference, spatial distribution,
emissivity of the components can all lead to the change of DBT. The
“hot spot" phenomenon occurs when the proportion of high
temperature component in the vision field came to a head. On the other
hand, the “cool spot" phenomena occur when low temperature
proportion came to the head. The “spot" effect disappears only when
the proportion of every component keeps invariability. The model
built in this paper can be used for the study of directional effect on
emissivity, the LST retrieval over urban areas and the adjacency effect
of thermal remote sensing pixels.
Abstract: In this study, an inland metropolitan area, Gwangju, in Korea was selected to assess the amplification potential of earthquake motion and provide the information for regional seismic countermeasure. A geographic information system-based expert system was implemented for reliably predicting the spatial geotechnical layers in the entire region of interesting by building a geo-knowledge database. Particularly, the database consists of the existing boring data gathered from the prior geotechnical projects and the surface geo-knowledge data acquired from the site visit. For practical application of the geo-knowledge database to estimate the earthquake hazard potential related to site amplification effects at the study area, seismic zoning maps on geotechnical parameters, such as the bedrock depth and the site period, were created within GIS framework. In addition, seismic zonation of site classification was also performed to determine the site amplification coefficients for seismic design at any site in the study area. KeywordsEarthquake hazard, geo-knowledge, geographic information system, seismic zonation, site period.
Abstract: In recent years, new product development became more and more competitive and globalized, and the designing phase is critical for the product success. The concept of modularity can provide the necessary foundation for organizations to design products that can respond rapidly to market needs. The paper describes data structures and algorithms of intelligent Web-based system for modular design taking into account modules compatibility relationship and given design requirements. The system intelligence is realized by developed algorithms for choice of modules reflecting all system restrictions and requirements. The proposed data structure and algorithms are illustrated by case study of personal computer configuration. The applicability of the proposed approach is tested through a prototype of Web-based system.
Abstract: The design of a landing gear is one of the fundamental aspects of aircraft design. The need for a light weight, high strength, and stiffness characteristics coupled with techno economic feasibility are a key to the acceptability of any landing gear construction. In this paper, an approach for analyzing two different designed landing gears for an unmanned aircraft vehicle (UAV) using advanced CAE techniques will be applied. Different landing conditions have been considered for both models. The maximum principle stresses for each model along with the factor of safety are calculated for every loading condition. A conclusion is drawing about better geometry.
Abstract: This paper deals with modeling and parameter
identification of nonlinear systems described by Hammerstein model
having Piecewise nonlinear characteristics such as Dead-zone
nonlinearity characteristic. The simultaneous use of both an easy
decomposition technique and the triangular basis functions leads to a
particular form of Hammerstein model. The approximation by using
Triangular basis functions for the description of the static nonlinear
block conducts to a linear regressor model, so that least squares
techniques can be used for the parameter estimation. Singular Values
Decomposition (SVD) technique has been applied to separate the
coupled parameters. The proposed approach has been efficiently
tested on academic examples of simulation.
Abstract: Stipples are desired for pattern fillings and
transparency effects. In contrast, some graphics standards, including
OpenGL ES 1.1 and 2.0, omitted this feature. We represent details of
providing line stipples and polygon stipples, through combining
texture mapping and alpha blending functions. We start from the
OpenGL-specified stipple-related API functions. The details of
mathematical transformations are explained to get the correct texture
coordinates. Then, the overall algorithm is represented, and its
implementation results are followed. We accomplished both of line
and polygon stipples, and verified its result with conformance test
routines.
Abstract: This paper explores the sense of place in the Vredefort Dome World Heritage site, South Africa, as an essential input for the formulation of spatial planning proposals for the area. Intangible aspects such as personal and symbolic meanings of sites are currently not integrated in spatial planning in South Africa. This may have a detrimental effect on local inhabitants who have a long history with the site and built up a strong place identity. Involving local inhabitants at an early stage of the planning process and incorporating their attitudes and opinions in future intervention in the area, may also contribute to the acceptance of the legitimacy of future policy. An interdisciplinary and mixed-method research approach was followed in this study in order to identify possible ways to anchor spatial planning proposals in the identity of the place. In essence, the qualitative study revealed that inhabitants reflect a deep and personal relationship with and within the area, which contributes significantly to their sense of emotional security and selfidentity. Results include a strong conservation-orientated attitude with regard to the natural rural character of the site, especially in the inner core.