Abstract: Clinically, chickens showed progressively developed
clinical signs represented by sever cyanosis of the comb and wattles
with hemorrhage at the shanks, depression, and ruffling feathers with
loss of appetite and high daily mortalities. The ducks showed severe
neurological signs as torticollus, seizures and inability to stand with
mild signs of diarrhea and depression. Grossly, chickens showed
hemorrhages and congestion in most of the organs particularly lung,
liver, spleen, trachea and kidney. The examined ducks showed
multiple petechial hemorrhages, multifocal hemorrhagic necrosis in
the pancreas, pulmonary edema, congestion and hemorrhage in
meninges and congestion in the skeletal muscles. Histopathology
revealed severe congestion and hemorrhages in most of the organs
particularly lung, liver and kidney. Microscopic erosive tracheitis,
sever pulmonary congestion and perivascular oedema and lymphogranulocytic
pneumonia were constant. The liver showed hepatocyts
necrosis and lympho-granulocytic infiltration. The kidney showed
renal tubular necrosis and diffuse congestion. Multifocal, neuronal
necrosis, hemorrhages, multifocal glial nodules, lympho- histiocytic
perivascular cuffing, and occasional neuronophagia were observed in
the cerebrum. Other organs showed moderate changes.
Abstract: Advances in clinical medical imaging have brought about the routine production of vast numbers of medical images that need to be analyzed. As a result an enormous amount of computer vision research effort has been targeted at achieving automated medical image analysis. Computed Tomography (CT) is highly accurate for diagnosing liver tumors. This study aimed to evaluate the potential role of the wavelet and the neural network in the differential diagnosis of liver tumors in CT images. The tumors considered in this study are hepatocellular carcinoma, cholangio carcinoma, hemangeoma and hepatoadenoma. Each suspicious tumor region was automatically extracted from the CT abdominal images and the textural information obtained was used to train the Probabilistic Neural Network (PNN) to classify the tumors. Results obtained were evaluated with the help of radiologists. The system differentiates the tumor with relatively high accuracy and is therefore clinically useful.
Abstract: The purpose of this study was to understand the main
sources of copper (Cu) accumulation in target organs of tilapia
(Oreochromis mossambicus) and to investigate how the organism
mediate the process of Cu accumulation under prolonged conditions.
By measuring both dietary and waterborne Cu accumulation and total
concentrations in tilapia with biokinetic modeling approach, we were
able to clarify the biokinetic coping mechanisms for the long term Cu
accumulation. This study showed that water and food are both the
major source of Cu for the muscle and liver of tilapia. This implied
that control the Cu concentration in these two routes will be correlated
to the Cu bioavailability for tilapia. We found that exposure duration
and level of waterborne Cu drove the Cu accumulation in tilapia. The
ability for Cu biouptake and depuration in organs of tilapia were
actively mediated under prolonged exposure conditions. Generally,
the uptake rate, depuration rate and net bioaccumulation ability in all
selected organs decreased with the increasing level of waterborne Cu
and extension of exposure duration.Muscle tissues accounted for over
50%of the total accumulated Cu and played a key role in buffering the
Cu burden in the initial period of exposure, alternatively, the liver
acted a more important role in the storage of Cu with the extension of
exposures. We concluded that assumption of the constant biokinetic
rates could lead to incorrect predictions with overestimating the
long-term Cu accumulation in ecotoxicological risk assessments.
Abstract: Students in high education are presented with new terms and concepts in nearly every lecture they attend. Many of them prefer Web-based self-tests for evaluation of their concepts understanding since they can use those tests independently of tutors- working hours and thus avoid the necessity of being in a particular place at a particular time. There is a large number of multiple-choice tests in almost every subject designed to contribute to higher level learning or discover misconceptions. Every single test provides immediate feedback to a student about the outcome of that test. In some cases a supporting system displays an overall score in case a test is taken several times by a student. What we still find missing is how to secure delivering of personalized feedback to a user while taking into consideration the user-s progress. The present work is motivated to throw some light on that question.
Abstract: This paper proposes a new decision making structure
to determine the appropriate product delivery strategy for different products in a manufacturing system among make-to-stock, make-toorder,
and hybrid strategy. Given product delivery strategies for all products in the manufacturing system, the position of the Order
Penetrating Point (OPP) can be located regarding the delivery strategies among which location of OPP in hybrid strategy is a
cumbersome task. In this regard, we employ analytic network process, because there are varieties of interrelated driving factors
involved in choosing the right location. Moreover, the proposed structure is augmented with fuzzy sets theory in order to cope with
the uncertainty of judgments. Finally, applicability of the proposed structure is proven in practice through a real industrial case company.
The numerical results demonstrate the efficiency of the proposed decision making structure in order partitioning and OPP location.
Abstract: Internet is without any doubt the fastest and effective mean of communication making it possible to reach a great number of people in the world. It draws its base from exchange points. Indeed exchange points are used to inter-connect various Internet suppliers and operators in order to allow them to exchange traffic and it is with these interconnections that Internet made its great strides. They thus make it possible to limit the traffic delivered via the operators of transits. This limitation allows a significant improvement of the quality of service, a reduction in the latency time just as a reduction of the cost of connection for the final subscriber. Through this article we will show how the installation of an IXP allows an improvement and a diversification of the services just as a reduction of the Internet connection costs.
Abstract: Purpose: Planning and dosimetry of different VMAT algorithms (SmartArc, Ergo++, Autobeam) is compared with IMRT for Head and Neck Cancer patients. Modelling was performed to rule out the causes of discrepancies between planned and delivered dose. Methods: Five HNC patients previously treated with IMRT were re-planned with SmartArc (SA), Ergo++ and Autobeam. Plans were compared with each other and against IMRT and evaluated using DVHs for PTVs and OARs, delivery time, monitor units (MU) and dosimetric accuracy. Modelling of control point (CP) spacing, Leaf-end Separation and MLC/Aperture shape was performed to rule out causes of discrepancies between planned and delivered doses. Additionally estimated arc delivery times, overall plan generation times and effect of CP spacing and number of arcs on plan generation times were recorded. Results: Single arc SmartArc plans (SA4d) were generally better than IMRT and double arc plans (SA2Arcs) in terms of homogeneity and target coverage. Double arc plans seemed to have a positive role in achieving improved Conformity Index (CI) and better sparing of some Organs at Risk (OARs) compared to Step and Shoot IMRT (ss-IMRT) and SA4d. Overall Ergo++ plans achieved best CI for both PTVs. Dosimetric validation of all VMAT plans without modelling was found to be lower than ss-IMRT. Total MUs required for delivery were on average 19%, 30%, 10.6% and 6.5% lower than ss-IMRT for SA4d, SA2d (Single arc with 20 Gantry Spacing), SA2Arcs and Autobeam plans respectively. Autobeam was most efficient in terms of actual treatment delivery times whereas Ergo++ plans took longest to deliver. Conclusion: Overall SA single arc plans on average achieved best target coverage and homogeneity for both PTVs. SA2Arc plans showed improved CI and some OARs sparing. Very good dosimetric results were achieved with modelling. Ergo++ plans achieved best CI. Autobeam resulted in fastest treatment delivery times.
Abstract: The aims of this paper are to study the efficacy of
chitosan nanoparticles in stimulating specific antibody against
A/H1N1 influenza antigen in mice. Chitosan nanoparticles (CSN)
were characterized by TEM. The results showed that the average size
of CSN was from 80nm to 106nm. The efficacy of A/H1N1 influenza
vaccine loaded on the surface of CSN showed that loading efficiency
of A/H1N1 influenza antigen on CSN was from 93.75 to 100%. Safe
property of the vaccine were tested. In 10 days post vaccination,
group of CSN 30 kDa and 300 kDa loaded A/H1N1 influenza antigen
were the rate of immune response on mice to be 100% (9/9) higher
than Al(OH)3 and other adjuvant. 100% mice in the experiment of all
groups had immune response in 20 days post vaccination. The results
also showed that HI titer of the group using CSN 300 kDa as an
adjuvant increased significantly up to 3971 HIU, over three-fold
higher than the Al(OH)3 adjuvant, chitosan (CS), and one hundredfold
than the A/H1N1 antigen only. Stability of the vaccine
formulation was investigated.
Abstract: PCMs have always been viewed as a suitable
candidate for off peak thermal storage, particularly for refrigeration
systems, due to the high latent energy densities of these materials.
However, due to the need to have them encapsulated within a
container this density is reduced. Furthermore, PCMs have a low
thermal conductivity which reduces the useful amount of energy
which can be stored. To consider these factors, the true energy
storage density of a PCM system was proposed and optimised for
PCMs encapsulated in slabs. Using a validated numerical model of
the system, a parametric study was undertaken to investigate the
impact of the slab thickness, gap between slabs and the mass flow
rate. The study showed that, when optimised, a PCM system can
deliver a true energy storage density between 53% and 83% of the
latent energy density of the PCM.
Abstract: Image data holds a large amount of different context
information. However, as of today, these resources remain largely
untouched. It is thus the aim of this paper to present a basic technical
framework which allows for a quick and easy exploitation of context
information from image data especially by non-expert users.
Furthermore, the proposed framework is discussed in detail
concerning important social and ethical issues which demand special
requirements in system design. Finally, a first sensor prototype is
presented which meets the identified requirements. Additionally,
necessary implications for the software and hardware design of the
system are discussed, rendering a sensor system which could be
regarded as a good, acceptable and justifiable technical and thereby
enabling the extraction of context information from image data.
Abstract: The present paper presents a finite element model and
analysis for the interaction between a piezoresistive tactile sensor and
biological tissues. The tactile sensor is proposed for use in minimally
invasive surgery to deliver tactile information of biological tissues to
surgeons. The proposed sensor measures the relative hardness of soft
contact objects as well as the contact force. Silicone rubbers were
used as the phantom of biological tissues. Finite element analysis of
the silicone rubbers and the mechanical structure of the sensor were
performed using COMSOL Multiphysics (v3.4) environment. The
simulation results verify the capability of the sensor to be used to
differentiate between different kinds of silicone rubber materials.
Abstract: This paper employs a new approach to regulate the
blood glucose level of type I diabetic patient under an intensive
insulin treatment. The closed-loop control scheme incorporates
expert knowledge about treatment by using reinforcement learning
theory to maintain the normoglycemic average of 80 mg/dl and the
normal condition for free plasma insulin concentration in severe
initial state. The insulin delivery rate is obtained off-line by using Qlearning
algorithm, without requiring an explicit model of the
environment dynamics. The implementation of the insulin delivery
rate, therefore, requires simple function evaluation and minimal
online computations. Controller performance is assessed in terms of
its ability to reject the effect of meal disturbance and to overcome the
variability in the glucose-insulin dynamics from patient to patient.
Computer simulations are used to evaluate the effectiveness of the
proposed technique and to show its superiority in controlling
hyperglycemia over other existing algorithms
Abstract: Network layer multicast, i.e. IP multicast, even after
many years of research, development and standardization, is not
deployed in large scale due to both technical (e.g. upgrading of
routers) and political (e.g. policy making and negotiation) issues.
Researchers looked for alternatives and proposed application/overlay
multicast where multicast functions are handled by end hosts, not
network layer routers. Member hosts wishing to receive multicast
data form a multicast delivery tree. The intermediate hosts in the tree
act as routers also, i.e. they forward data to the lower hosts in the
tree. Unlike IP multicast, where a router cannot leave the tree until all
members below it leave, in overlay multicast any member can leave
the tree at any time thus disjoining the tree and disrupting the data
dissemination. All the disrupted hosts have to rejoin the tree. This
characteristic of the overlay multicast causes multicast tree unstable,
data loss and rejoin overhead. In this paper, we propose that each node
sets its leaving time from the tree and sends join request to a number
of nodes in the tree. The nodes in the tree will reject the request if
their leaving time is earlier than the requesting node otherwise they
will accept the request. The node can join at one of the accepting
nodes. This makes the tree more stable as the nodes will join the tree
according to their leaving time, earliest leaving time node being at the
leaf of the tree. Some intermediate nodes may not follow their leaving
time and leave earlier than their leaving time thus disrupting the tree.
For this, we propose a proactive recovery mechanism so that disrupted
nodes can rejoin the tree at predetermined nodes immediately. We
have shown by simulation that there is less overhead when joining
the multicast tree and the recovery time of the disrupted nodes is
much less than the previous works. Keywords
Abstract: The objective of the present study was to evaluate the
potential of hollow microneedles for enhancing the transdermal
delivery of Bovine Serum Albumin (MW~66,000 Da)-Fluorescein
Isothiocyanate (BSA-FITC) conjugate, a hydrophilic large molecular
compound. Moreover, the effect of different formulations was
evaluated. The series of binary mixtures composed of propylene
glycol (PG) and pH 7.4 phosphate buffer solution (PBS) was
prepared and used as a medium for BSA-FITC. The results showed
that there was no permeation of BSA-FITC solution across the
neonatal porcine skin without using hollow microneedles, whereas
the cumulative amount of BSA-FITC released at 8 h through the
neonatal porcine skin was about 60-70% when using hollow
microneedles. Furthermore, the results demonstrated that the higher
volume of PG in binary mixtures injected, the lower cumulative
amount of BSA-FITC released and release rate of BSA-FITC from
skin. These release profiles of BSA-FITC in binary mixtures were
expressed by Fick-s law of diffusion. These results suggest the
utilization of hollow microneedle to enhance transdermal delivery of
protein and provide useful information for designing an effective
hollow microneedle system.
Abstract: We propose that Virtual Learning Environments (VLEs) should be designed by taking into account the characteristics, the special needs and the specific operating rules of the academic institutions in which they are employed. In this context, we describe a VLE module that extends the support of the organization and delivery of course material by including administration activities related to the various stages of teaching. These include the co-ordination, collaboration and monitoring of the course material development process and institution-specific course material delivery modes. Our specialized module, which enhances VLE capabilities by Helping Educators and Learners through a Laboratory Assistance System, is willing to assist the Greek tertiary technological sector, which includes Technological Educational Institutes (T.E.I.).
Abstract: This paper presents a mathematical model and a
methodology to analyze the losses in transmission expansion
planning (TEP) under uncertainty in demand. The methodology is
based on discrete particle swarm optimization (DPSO). DPSO is a
useful and powerful stochastic evolutionary algorithm to solve the
large-scale, discrete and nonlinear optimization problems like TEP.
The effectiveness of the proposed idea is tested on an actual
transmission network of the Azerbaijan regional electric company,
Iran. The simulation results show that considering the losses even for
transmission expansion planning of a network with low load growth
is caused that operational costs decreases considerably and the
network satisfies the requirement of delivering electric power more
reliable to load centers.
Abstract: The notion of Next Generation Network (NGN) is
based on the Network Convergence concept which refers to
integration of services (such as IT and communication services) over
IP layer. As the most popular implementation of Service Oriented
Architecture (SOA), Web Services technology is known to be the
base for service integration. In this paper, we present a platform to
deliver communication services as web services. We also implement
a sample service to show the simplicity of making composite web
and communication services using this platform. A Service Logic
Execution Environment (SLEE) is used to implement the
communication services. The proposed architecture is in agreement
with Service Oriented Architecture (SOA) and also can be integrated
to an Enterprise Service Bus to make a base for NGN Service
Delivery Platform (SDP).
Abstract: Internet computer games turn to be more and more
attractive within the context of technology enhanced learning.
Educational games as quizzes and quests have gained significant
success in appealing and motivating learners to study in a different
way and provoke steadily increasing interest in new methods of
application. Board games are specific group of games where figures
are manipulated in competitive play mode with race conditions on a
surface according predefined rules. The article represents a new,
formalized model of traditional quizzes, puzzles and quests shown as
multimedia board games which facilitates the construction process of
such games. Authors provide different examples of quizzes and their
models in order to demonstrate the model is quite general and does
support not only quizzes, mazes and quests but also any set of
teaching activities. The execution process of such models is
explained and, as well, how they can be useful for creation and
delivery of adaptive e-learning courseware.
Abstract: Delivering course material via a virtual environment
is beneficial to today-s students because it offers the interactivity,
real-time interaction and social presence that students of all ages
have come to accept in our gaming rich community. It is essential
that the Net Generation also known as Generation Why, have
exposure to learning communities that encompass interactivity to
form social and educational connections. As student and professor
become interconnected through collaboration and interaction in a
virtual learning space, relationships develop and students begin to
take on an individual identity. With this in mind the research project
was developed to investigate the use of virtual environments on
student satisfaction and the effectiveness of course delivery.
Furthermore, the project was designed to integrate both interactive
(real-time) classes conducted in the Virtual Reality (VR)
environment while also creating archived VR sessions for student use
in retaining and reviewing course content.
Abstract: This paper explores gender related barriers to interagency collaboration in statutory children safeguard partnerships against a theoretical framework that considers individuals, professions and organisations interacting as part of a complex adaptive system. We argue that gender-framed obstacles to effective communication between culturally discrepant agencies can ultimately impact on the effectiveness of policy delivery,. We focused our research on three partnership structures in Sefton Metropolitan Borough in order to observe how interactions occur, whether the agencies involved perceive their occupational environment as being gender affected and whether they believe this can hinder effective collaboration with other biased organisations. Our principal empirical findings indicate that there is a general awareness amongst professionals of the role that gender plays in each of the agencies reviewed, that gender may well constitute a barrier to effective communication, but there is a sense in which there is little scope for change in the short term. We aim to signal here, however, the need to change against the risk of service failure.