Abstract: We have developed an energy based approach for identifying the binding sites and important residues for binding in protein-protein complexes. We found that the residues and residuepairs with charged and aromatic side chains are important for binding. These residues influence to form cation-¤Ç, electrostatic and aromatic interactions. Our observation has been verified with the experimental binding specificity of protein-protein complexes and found good agreement with experiments. The analysis on surrounding hydrophobicity reveals that the binding residues are less hydrophobic than non-binding sites, which suggests that the hydrophobic core are important for folding and stability whereas the surface seeking residues play a critical role in binding. Further, the propensity of residues in the binding sites of receptors and ligands, number of medium and long-range contacts, and influence of neighboring residues will be discussed.
Abstract: The incessant discomfort for Voluntary Counselling and Testing (VCT) exhibited by students in some tertiary institutions in Kano State, Nigeria is capable of causing Psychological Resistance as well as jeopardizing the purpose of HIV intervention. This study investigated the Prevalence of Psychological Resistance to VCT of HIV/AIDS among students of tertiary institutions in the state. Two null hypotheses were postulated and tested. Cross- Sectional Survey Design was employed in which 1512 sample was selected from a student population of 104,841 following Stratified Random Sampling technique. A self-developed 20-item scale whose reliability coefficient is 0.83 was used for data collection. Data analyzed via Chi-square and t-test reveals a prevalence of 38% with males (Mean=0.34; SD=0.475) constituting 60% and females (Mean=0.45; SD=0.498) 40%. Also, the calculated chi-square and ttest were not significant at 0.05 as such the null hypotheses were upheld. Recommendation offered suggests the use of reinforcement and social support for students who patronize HIV/AIDS counselling.
Abstract: The bioassay-guided isolation and purification of an
ethyl acetate extract of Aspergillus terreus MC751 led to the
characterization of butyrolactone I as an antidiabetic and antioxidant.
The antidiabetic activity of butyrolactone I was evaluated by α-
glucosidase and α-amylase inhibition assays. Butyrolactone I
demonstrated significant concentration-dependent, mixed-type
inhibitory activity against yeast α-glucosidase with an IC50 of 54μM.
However, the compound exhibited less activity against rat intestinal
α-glucosidase and α-amylase. This is the first report on α-glucosidase
inhibitory activity of butyrolactone I. The antioxidative activity of
butyrolactone I was evaluated based on scavenging effects on 1,1-
diphenyl-2-picrylhydrazyl (DPPH) (IC50 =51 μM) and hydrogen
peroxide (IC50= 141 μM) radicals as well as a reducing power assay.
The results suggest that butyrolactone I is a promising antidiabetic as
well as antioxidant and should be considered for clinical trials.
Abstract: With constraints on data availability and for study of power system stability it is adequate to model the synchronous generator with field circuit and one equivalent damper on q-axis known as the model 1.1. This paper presents a systematic procedure for modelling and simulation of a single-machine infinite-bus power system installed with a thyristor controlled series compensator (TCSC) where the synchronous generator is represented by model 1.1, so that impact of TCSC on power system stability can be more reasonably evaluated. The model of the example power system is developed using MATLAB/SIMULINK which can be can be used for teaching the power system stability phenomena, and also for research works especially to develop generator controllers using advanced technologies. Further, the parameters of the TCSC controller are optimized using genetic algorithm. The non-linear simulation results are presented to validate the effectiveness of the proposed approach.
Abstract: During the last few decades in the academic field, the
debate has increased on the effects of social geography on the
opportunities of socioeconomic integration. On one hand, it has been
discussed how the contents of the urban structure and social
geography affect not only the way people interact, but also their
chances of social and economic integration. On the other hand, it has
also been discussed how the urban structure is also constrained and
transformed by the action of social actors. Without questioning the
powerful influence of structural factors, related to the logic of the
production system, labor markets, education and training, the
research has shown the role played by place of residence in shaping
individual outcomes such as unemployment. In the context of this
debate the importance of territory of residence with respect to the
problem of unemployment has been highlighted.
Although statistics of unemployment have already demonstrated
the unequal incidence of the phenomenon in social groups, the issue
of uneven territorial impact on the phenomenon at intra-urban level
remains relatively unknown.
The purpose of this article is to show and to interpret the spatial
patterns of unemployment in the city of Porto using GIS (Geographic
Information System - GIS) technology. Under this analysis the
overlap of the spatial patterns of unemployment with the spatial
distribution of social housing, allows the discussion of the
relationship that occurs between these patterns and the reasons that
might explain the relative immutability of socioeconomic problems in
some neighborhoods.
Abstract: The batch nature limits the standard kernel principal component analysis (KPCA) methods in numerous applications, especially for dynamic or large-scale data. In this paper, an efficient adaptive approach is presented for online extraction of the kernel principal components (KPC). The contribution of this paper may be divided into two parts. First, kernel covariance matrix is correctly updated to adapt to the changing characteristics of data. Second, KPC are recursively formulated to overcome the batch nature of standard KPCA.This formulation is derived from the recursive eigen-decomposition of kernel covariance matrix and indicates the KPC variation caused by the new data. The proposed method not only alleviates sub-optimality of the KPCA method for non-stationary data, but also maintains constant update speed and memory usage as the data-size increases. Experiments for simulation data and real applications demonstrate that our approach yields improvements in terms of both computational speed and approximation accuracy.
Abstract: Collateralized Debt Obligations are not as widely used
nowadays as they were before 2007 Subprime crisis. Nonetheless
there remains an enthralling challenge to optimize cash flows
associated with synthetic CDOs. A Gaussian-based model is used
here in which default correlation and unconditional probabilities of
default are highlighted. Then numerous simulations are performed
based on this model for different scenarios in order to evaluate the
associated cash flows given a specific number of defaults at different
periods of time. Cash flows are not solely calculated on a single
bought or sold tranche but rather on a combination of bought and
sold tranches. With some assumptions, the simplex algorithm gives
a way to find the maximum cash flow according to correlation of
defaults and maturities. The used Gaussian model is not realistic in
crisis situations. Besides present system does not handle buying or
selling a portion of a tranche but only the whole tranche. However the
work provides the investor with relevant elements on how to know
what and when to buy and sell.
Abstract: Semiconductor detector arrays are widely used in
high-temperature plasma diagnostics. They have a fast response,
which allows observation of many processes and instabilities in
tokamaks. In this paper, there are reviewed several diagnostics based
on semiconductor arrays as cameras, AXUV photodiodes (referred
often as fast “bolometers") and detectors of both soft X-rays and
visible light installed on the COMPASS tokamak recently. Fresh
results from both spring and summer campaigns in 2012 are
introduced. Examples of the utilization of the detectors are shown on
the plasma shape determination, fast calculation of the radiation
center, two-dimensional plasma radiation tomography in different
spectral ranges, observation of impurity inflow, and also on
investigation of MHD activity in the COMPASS tokamak discharges.
Abstract: Purpose: Planning and dosimetry of different VMAT algorithms (SmartArc, Ergo++, Autobeam) is compared with IMRT for Head and Neck Cancer patients. Modelling was performed to rule out the causes of discrepancies between planned and delivered dose. Methods: Five HNC patients previously treated with IMRT were re-planned with SmartArc (SA), Ergo++ and Autobeam. Plans were compared with each other and against IMRT and evaluated using DVHs for PTVs and OARs, delivery time, monitor units (MU) and dosimetric accuracy. Modelling of control point (CP) spacing, Leaf-end Separation and MLC/Aperture shape was performed to rule out causes of discrepancies between planned and delivered doses. Additionally estimated arc delivery times, overall plan generation times and effect of CP spacing and number of arcs on plan generation times were recorded. Results: Single arc SmartArc plans (SA4d) were generally better than IMRT and double arc plans (SA2Arcs) in terms of homogeneity and target coverage. Double arc plans seemed to have a positive role in achieving improved Conformity Index (CI) and better sparing of some Organs at Risk (OARs) compared to Step and Shoot IMRT (ss-IMRT) and SA4d. Overall Ergo++ plans achieved best CI for both PTVs. Dosimetric validation of all VMAT plans without modelling was found to be lower than ss-IMRT. Total MUs required for delivery were on average 19%, 30%, 10.6% and 6.5% lower than ss-IMRT for SA4d, SA2d (Single arc with 20 Gantry Spacing), SA2Arcs and Autobeam plans respectively. Autobeam was most efficient in terms of actual treatment delivery times whereas Ergo++ plans took longest to deliver. Conclusion: Overall SA single arc plans on average achieved best target coverage and homogeneity for both PTVs. SA2Arc plans showed improved CI and some OARs sparing. Very good dosimetric results were achieved with modelling. Ergo++ plans achieved best CI. Autobeam resulted in fastest treatment delivery times.
Abstract: Based on a global kinetics of direct dimethyl ether (DME) synthesis process from syngas, a steady-state one-dimensional mathematical model for the bubble column slurry reactor (BCSR) has been established. It was built on the assumption of plug flow of gas phase, sedimentation-dispersion model of catalyst grains and isothermal chamber regardless of reaction heats and rates for the design of an industrial scale bubble column slurry reactor. The simulation results indicate that higher pressure and lower temperature were favorable to the increase of CO conversion, DME selectivity, products yield and the height of slurry bed, which has a coincidence with the characteristic of DME synthesis reaction system, and that the height of slurry bed is lessen with the increasing of operation temperature in the range of 220-260℃. CO conversion, the optimal operation conditions in BCSR were proposed.
Abstract: The major objective of this study is to understand the
potential of a newly fabricated equipment to study the thermal
properties of nonwoven textile fabrics treated with aerogel at subzero
temperatures. Thermal conductivity was calculated by using the
empirical relation Fourier’s law, The relationship between the
thermal conductivity and thermal resistance of the samples were
studied at various environmental temperatures (which was set in the
clima temperature system between +25oC to -25oC). The newly
fabricated equipment was found to be a suitable for measuring at
subzero temperatures. This field of measurements is being developed
and will be the subject of further research which will be more suitable
for measurement of the various thermal characteristics.
Abstract: This paper proposes a new approach to perform the
problem of real-time face detection. The proposed method combines
primitive Haar-Like feature and variance value to construct a new
feature, so-called Variance based Haar-Like feature. Face in image
can be represented with a small quantity of features using this
new feature. We used SVM instead of AdaBoost for training and
classification. We made a database containing 5,000 face samples
and 10,000 non-face samples extracted from real images for learning
purposed. The 5,000 face samples contain many images which have
many differences of light conditions. And experiments showed that
face detection system using Variance based Haar-Like feature and
SVM can be much more efficient than face detection system using
primitive Haar-Like feature and AdaBoost. We tested our method on
two Face databases and one Non-Face database. We have obtained
96.17% of correct detection rate on YaleB face database, which is
higher 4.21% than that of using primitive Haar-Like feature and
AdaBoost.
Abstract: In this paper, a new hybrid of genetic algorithm (GA)
and simulated annealing (SA), referred to as GSA, is presented. In
this algorithm, SA is incorporated into GA to escape from local
optima. The concept of hierarchical parallel GA is employed to
parallelize GSA for the optimization of multimodal functions. In
addition, multi-niche crowding is used to maintain the diversity in
the population of the parallel GSA (PGSA). The performance of the
proposed algorithms is evaluated against a standard set of multimodal
benchmark functions. The multi-niche crowding PGSA and normal
PGSA show some remarkable improvement in comparison with the
conventional parallel genetic algorithm and the breeder genetic
algorithm (BGA).
Abstract: To date, theoretical studies concerning the Carbon
Fiber Reinforced Polymer (CFRP) strengthening of RC beams with
openings have been rather limited. In addition, various numerical
analyses presented so far have effectively simulated the behaviour of
solid beam strengthened by FRP material. In this paper, a two
dimensional nonlinear finite element analysis is presented to validate
against the laboratory test results of six RC beams. All beams had the
same rectangular cross-section geometry and were loaded under four
point bending. The crack pattern results of the finite element model
show good agreement with the crack pattern of the experimental
beams. The load midspan deflection curves of the finite element
models exhibited a stiffer result compared to the experimental beams.
The possible reason may be due to the perfect bond assumption used
between the concrete and steel reinforcement.
Abstract: The huge development of new technologies and the
apparition of open communication system more and more
sophisticated create a new challenge to protect digital content from
piracy. Digital watermarking is a recent research axis and a new
technique suggested as a solution to these problems. This technique
consists in inserting identification information (watermark) into
digital data (audio, video, image, databases...) in an invisible and
indelible manner and in such a way not to degrade original medium-s
quality. Moreover, we must be able to correctly extract the
watermark despite the deterioration of the watermarked medium (i.e
attacks). In this paper we propose a system for watermarking satellite
images. We chose to embed the watermark into frequency domain,
precisely the discrete wavelet transform (DWT). We applied our
algorithm on satellite images of Tunisian center. The experiments
show satisfying results. In addition, our algorithm showed an
important resistance facing different attacks, notably the compression
(JEPG, JPEG2000), the filtering, the histogram-s manipulation and
geometric distortions such as rotation, cropping, scaling.
Abstract: The subcellular organelles called oil bodies (OBs) are lipid-filled quasi-spherical droplets produced from the endoplasmic reticulum (ER) and then released into the cytoplasm during seed development. It is believed that an OB grows by coalescence with other OBs and that its stability depends on the composition of oleosins, major proteins inserted in the hemi membrane that covers OBs. In this study, we measured the OB-volume distribution from different genotypes of A. thaliana after 7, 8, 9, 10 and 11 days of seed development. In order to test the hypothesis of OBs dynamics, we developed a simple mathematical model using non-linear differential equations inspired from the theory of coagulation. The model describes the evolution of OB-volume distribution during the first steps of seed development by taking into consideration the production of OBs, the increase of triacylglycerol volume to be stored, and the growth by coalescence of OBs. Fitted parameters values show an increase in the OB production and coalescence rates in A. thaliana oleosin mutants compared to wild type.
Abstract: In literatures, many researches proposed various
methods to reduce PAPR (Peak to Average Power Ratio). Among
those, DSI (Dummy Sequence Insertion) is one of the most attractive
methods for WiMAX systems because it does not require side
information transmitted along with user data. However, the
conventional DSI methods find dummy sequence by performing an
iterative procedure until achieving PAPR under a desired threshold.
This causes a significant delay on finding dummy sequence and also
effects to the overall performances in WiMAX systems. In this paper,
the new method based on DSI is proposed by finding dummy
sequence without the need of iterative procedure. The fast DSI
method can reduce PAPR without either delays or required side
information. The simulation results confirm that the proposed method
is able to carry out PAPR performances as similar to the other
methods without any delays. In addition, the simulations of WiMAX
system with adaptive modulations are also investigated to realize the
use of proposed methods on various fading schemes. The results
suggest the WiMAX designers to modify a new Signal to Noise Ratio
(SNR) criteria for adaptation.
Abstract: The aims of this paper are to study the efficacy of
chitosan nanoparticles in stimulating specific antibody against
A/H1N1 influenza antigen in mice. Chitosan nanoparticles (CSN)
were characterized by TEM. The results showed that the average size
of CSN was from 80nm to 106nm. The efficacy of A/H1N1 influenza
vaccine loaded on the surface of CSN showed that loading efficiency
of A/H1N1 influenza antigen on CSN was from 93.75 to 100%. Safe
property of the vaccine were tested. In 10 days post vaccination,
group of CSN 30 kDa and 300 kDa loaded A/H1N1 influenza antigen
were the rate of immune response on mice to be 100% (9/9) higher
than Al(OH)3 and other adjuvant. 100% mice in the experiment of all
groups had immune response in 20 days post vaccination. The results
also showed that HI titer of the group using CSN 300 kDa as an
adjuvant increased significantly up to 3971 HIU, over three-fold
higher than the Al(OH)3 adjuvant, chitosan (CS), and one hundredfold
than the A/H1N1 antigen only. Stability of the vaccine
formulation was investigated.
Abstract: In distributed resource allocation a set of agents must assign their resources to a set of tasks. This problem arises in many real-world domains such as distributed sensor networks, disaster rescue, hospital scheduling and others. Despite the variety of approaches proposed for distributed resource allocation, a systematic formalization of the problem, explaining the different sources of difficulties, and a formal explanation of the strengths and limitations of key approaches is missing. We take a step towards this goal by using a formalization of distributed resource allocation that represents both dynamic and distributed aspects of the problem. In this paper we present a new idea for target tracking in sensor networks and compare it with previous approaches. The central contribution of the paper is a generalized mapping from distributed resource allocation to DDCSP. This mapping is proven to correctly perform resource allocation problems of specific difficulty. This theoretical result is verified in practice by a simulation on a realworld distributed sensor network.
Abstract: This research investigates the factors that influence moral judgments when dealing with ethical dilemmas in the organizational context. It also investigates the antecedents of individual ethical ideology (idealism and relativism). A mixed method study, which combines qualitative (field study) and quantitative (survey) approaches, was used in this study. An initial model was developed first, which was then fine-tuned based on field studies. Data were collected from managers in Malaysian large organizations. The results of this study reveal that in-group collectivism culture, power distance culture, parental values, and religiosity were significant as antecedents of ethical ideology. However, direct effects of these variables on moral judgment were not significant. Furthermore, the results of this study confirm the significant effects of ethical ideology on moral judgment. This study provides valuable insight into evaluating the validity of existing theory as proposed in the literature and offers significant practical implications.