Abstract: Alpfa-fetoprotein and its fragments may be an important vehicle for targeted delivery of radionuclides to the tumor. We investigated the effect of conditions on the labeling of biologically active synthetic peptide based on the (F-afp) with technetium-99m. The influence of the nature of the buffer solution, pH, concentration of reductant, concentration of the peptide and the reaction temperature on the yield of labeling was examined. As a result, the following optimal conditions for labeling of (F-afp) are found: pH 8.5 (phosphate and bicarbonate buffers) and pH from 1.7 to 7.0 (citrate buffer). The reaction proceeds with sufficient yield at room temperature for 30 min at the concentration of SnCl2 and (Fafp) (F-afp) is to be less than 10 mkg/ml and 25 mkg/ml, respectively. Investigations of the test drug accumulation in the tumor cells of human breast cancer were carried out. Results can be assumed that the in vivo study of the (F-afp) in experimental tumor lesions will show concentrations sufficient for imaging these lesions by SPECT.
Abstract: We investigate efficient spreading codes for transmitter based techniques of code division multiple access (CDMA) systems. The channel is considered to be known at the transmitter which is usual in a time division duplex (TDD) system where the channel is assumed to be the same on uplink and downlink. For such a TDD/CDMA system, both bitwise and blockwise multiuser transmission schemes are taken up where complexity is transferred to the transmitter side so that the receiver has minimum complexity. Different spreading codes are considered at the transmitter to spread the signal efficiently over the entire spectrum. The bit error rate (BER) curves portray the efficiency of the codes in presence of multiple access interference (MAI) as well as inter symbol interference (ISI).
Abstract: The prospective analysis is presented as an important tool to identify the most relevant opportunities and needs in research and development from planned interventions in innovation systems. This study chose Phyllanthus niruri, known as "stone break" to describe the knowledge about the specie, by using biotechnological forecasting through the software Vantage Point. It can be seen a considerable increase in studies on Phyllanthus niruri in recent years and that there are patents about this plant since twenty-five years ago. India was the country that most carried out research on the specie, showing interest, mainly in studies of hepatoprotection, antioxidant and anti-cancer activities. Brazil is in the second place, with special interest for anti-tumor studies. Given the identification of the Brazilian groups that exploit the species it is possible to mediate partnerships and cooperation aiming to help on the implementing of the Program of Herbal medicines (phytotherapics) in Brazil.
Abstract: Data clustering is an important data exploration technique
with many applications in data mining. We present an enhanced
version of the well known single link clustering algorithm. We will
refer to this algorithm as DCBOR. The proposed algorithm alleviates
the chain effect by removing the outliers from the given dataset.
So this algorithm provides outlier detection and data clustering
simultaneously. This algorithm does not need to update the distance
matrix, since the algorithm depends on merging the most k-nearest
objects in one step and the cluster continues grow as long as possible
under specified condition. So the algorithm consists of two phases;
at the first phase, it removes the outliers from the input dataset. At
the second phase, it performs the clustering process. This algorithm
discovers clusters of different shapes, sizes, densities and requires
only one input parameter; this parameter represents a threshold for
outlier points. The value of the input parameter is ranging from 0 to
1. The algorithm supports the user in determining an appropriate
value for it. We have tested this algorithm on different datasets
contain outlier and connecting clusters by chain of density points,
and the algorithm discovers the correct clusters. The results of
our experiments demonstrate the effectiveness and the efficiency of
DCBOR.
Abstract: CTMA-bentonite and BTEA-Bentonite prepared by Na-bentonite cation exchanged with cetyltrimethylammonium(CTMA) and benzyltriethylammonium (BTEA). Products were characterized by XRD and IR techniques.The d001 spacing value of CTMA-bentonite and BTEA-bentonite are 7.54Å and 3.50Å larger than that of Na-bentonite at 100% cation exchange capacity, respectively. The IR spectrum showed that the intensities of OH stretching and bending vibrations of the two organoclays decreased greatly comparing to untreated Na-bentonite. Batch experiments were carried out at 303 K, 318 K and 333 K to obtain the sorption isotherms of Crystal violet onto the two organoclays. The results show that the sorption isothermal data could be well described by Freundlich model. The dynamical data for the two organoclays fit well with pseudo-second-order kinetic model. The adsorption capacity of CTMA-bentonite was found higher than that of BTEA-Bentonite. Thermodynamic parameters such as changes in the free energy (ΔG°), the enthalpy (ΔH°) and the entropy (ΔS°) were also evaluated. The overall adsorption process of Crystal violet onto the two organoclays were spontaneous, endothermic physisorption. The CTMA-bentonite and BTEA-Bentonite could be employed as low-cost alternatives to activated carbon in wastewater treatment for the removal of color which comes from textile dyes.
Abstract: This paper presents a study of the Taguchi design
application to optimize surface quality in damper inserted end milling
operation. Maintaining good surface quality usually involves
additional manufacturing cost or loss of productivity. The Taguchi
design is an efficient and effective experimental method in which a
response variable can be optimized, given various factors, using
fewer resources than a factorial design. This Study included spindle
speed, feed rate, and depth of cut as control factors, usage of different
tools in the same specification, which introduced tool condition and
dimensional variability. An orthogonal array of L9(3^4)was used;
ANOVA analyses were carried out to identify the significant factors
affecting surface roughness, and the optimal cutting combination was
determined by seeking the best surface roughness (response) and
signal-to-noise ratio. Finally, confirmation tests verified that the
Taguchi design was successful in optimizing milling parameters for
surface roughness.
Abstract: Shadoo protein (Sho) was described in 2003 as the newest member of Prion protein superfamily [1]. Sho has similar structural motifs like prion protein (PrP) that is known for its central role in transmissible spongiform enchephalopathies. Although a great number of functions have been proposed, the exact physiological function of PrP is not known yet. Investigation of the function and localization of Sho may help us to understand the function of the Prion protein superfamily. Analyzing the subcellular localization of YFP-tagged forms of Sho, we detected the protein in the plasma membrane and in the nucleus of various cell lines. To reveal the localization of the endogenous protein we generated antibodies against Shadoo as well as employed commercially available anti-Shadoo antibodies: i) EG62 anti-mouse Shadoo antibody generated by Eurogentec Ltd.; ii) S-12 anti-human Shadoo antibody by Santa Cruz Biotechnology Inc.; iii) R-12 anti-mouse Shadoo antibody by Santa Cruz Biotechnology Inc.; iv) SPRN antibody against human Shadoo by Abgent Inc. We carried out immunocytochemistry on non-transfected HeLa, Zpl 2-1, Zw 3-5, GT1-1, GT1-7 and SHSY5Y cells as well as on YFP-Sho, Sho-YFP, and YFP-GPI transfected HeLa cells. Their specificity (in antibody-peptide competition assay) and co-localization (with the YFP signal) were assessed.
Abstract: This research was to evaluate a technical feasibility of
making single-layer experimental particleboard panels from bamboo
waste (Dendrocalamus asper Backer) by converting bamboo into
strips, which are used to make laminated bamboo furniture. Variable
factors were density (600, 700 and 800 kg/m3) and temperature of
condition (25, 40 and 55 °C). The experimental panels were tested for
their physical and mechanical properties including modulus of
elasticity (MOE), modulus of rupture (MOR), internal bonding
strength (IB), screw holding strength (SH) and thickness swelling
values according to the procedures defined by Japanese Industrial
Standard (JIS). The test result of mechanical properties showed that
the MOR, MOE and IB values were not in the set criteria, except the
MOR values at the density of 700 kg/m3 at 25 °C and at the density
of 800 kg/m3 at 25 and 40 °C, the IB values at the density of 600
kg/m3, at 40 °C, and at the density of 800 kg/m3 at 55 °C. The SH
values had the test result according to the set standard, except with
the density of 600 kg/m3, at 40 and 55 °C. Conclusively, a valuable
renewable biomass, bamboo waste could be used to manufacture
boards.
Abstract: Scalability poses a severe threat to the existing
DRAM technology. The capacitors that are used for storing and
sensing charge in DRAM are generally not scaled beyond 42nm.
This is because; the capacitors must be sufficiently large for reliable
sensing and charge storage mechanism. This leaves DRAM memory
scaling in jeopardy, as charge sensing and storage mechanisms
become extremely difficult. In this paper we provide an overview of
the potential and the possibilities of using Phase Change Memory
(PCM) as an alternative for the existing DRAM technology. The
main challenges that we encounter in using PCM are, the limited
endurance, high access latencies, and higher dynamic energy
consumption than that of the conventional DRAM. We then provide
an overview of various methods, which can be employed to
overcome these drawbacks. Hybrid memories involving both PCM
and DRAM can be used, to achieve good tradeoffs in access latency
and storage density. We conclude by presenting, the results of these
methods that makes PCM a potential replacement for the current
DRAM technology.
Abstract: The study investigated the practices of organisations in Gulf Cooperation Council (GCC) countries with regards to G2C egovernment maturity. It reveals that e-government G2C initiatives in the surveyed countries in particular, and arguably around the world in general, are progressing slowly because of the lack of a trusted and secure medium to authenticate the identities of online users. The authors conclude that national ID schemes will play a major role in helping governments reap the benefits of e-government if the three advanced technologies of smart card, biometrics and public key infrastructure (PKI) are utilised to provide a reliable and trusted authentication medium for e-government services.
Abstract: This paper deals with wireless relay communication
systems in which multiple sources transmit information to the
destination node by the help of multiple relays. We consider a
signal forwarding technique based on the minimum mean-square
error (MMSE) approach with multiple antennas for each relay. A
source-relay-destination joint design strategy is proposed with power
constraints at the destination and the source nodes. Simulation results
confirm that the proposed joint design method improves the average
MSE performance compared with that of conventional MMSE relaying
schemes.
Abstract: Fine-grained data replication over the Internet allows duplication of frequently accessed data objects, as opposed to entire sites, to certain locations so as to improve the performance of largescale content distribution systems. In a distributed system, agents representing their sites try to maximize their own benefit since they are driven by different goals such as to minimize their communication costs, latency, etc. In this paper, we will use game theoretical techniques and in particular auctions to identify a bidding mechanism that encapsulates the selfishness of the agents, while having a controlling hand over them. In essence, the proposed game theory based mechanism is the study of what happens when independent agents act selfishly and how to control them to maximize the overall performance. A bidding mechanism asks how one can design systems so that agents- selfish behavior results in the desired system-wide goals. Experimental results reveal that this mechanism provides excellent solution quality, while maintaining fast execution time. The comparisons are recorded against some well known techniques such as greedy, branch and bound, game theoretical auctions and genetic algorithms.
Abstract: A minimal complexity version of component mode
synthesis is presented that requires simplified computer
programming, but still provides adequate accuracy for modeling
lower eigenproperties of large structures and their transient
responses. The novelty is that a structural separation into components
is done along a plane/surface that exhibits rigid-like behavior, thus
only normal modes of each component is sufficient to use, without
computing any constraint, attachment, or residual-attachment modes.
The approach requires only such input information as a few (lower)
natural frequencies and corresponding undamped normal modes of
each component. A novel technique is shown for formulation of
equations of motion, where a double transformation to generalized
coordinates is employed and formulation of nonproportional damping
matrix in generalized coordinates is shown.
Abstract: In the present article, a new method has been developed to enhance the application of equipment monitoring, which in turn results in improving condition-based maintenance economic impact in an automobile parts manufacturing factory. This study also describes how an effective software with a simple database can be utilized to achieve cost-effective improvements in maintenance performance. The most important results of this project are indicated here: 1. 63% reduction in direct and indirect maintenance costs. 2. Creating a proper database to analyse failures. 3. Creating a method to control system performance and develop it to similar systems. 4. Designing a software to analyse database and consequently create technical knowledge to face unusual condition of the system. Moreover, the results of this study have shown that the concept and philosophy of maintenance has not been understood in most Iranian industries. Thus, more investment is strongly required to improve maintenance conditions.
Abstract: The main aim is to perform mutational analysis of CTLA4 gene Exon 1 in SLE patients. A total of 61 SLE patients fulfilling “American College of Rheumatology (ACR) criteria" and 61 controls were enrolled in this study. The region of CTLA4 gene exon 1 was amplified by using Step-down PCR technique. Extracted DNA of band 354 bp was sequenced to analyze mutations in the exon-1 of CTLA-4 gene. Further, protein sequences were identified from nucleotide sequences of CTLA4 Exon 1 by using Expasy software and through Blast P software it was found that CTLA4 protein sequences of Pakistani SLE patients were similar to that of Chinese SLE population. No variations were found after patients sequences were compared with that of the control sequence. Furthermore it was found that CTLA4 protein sequences of Pakistani SLE patients were similar to that of Chinese SLE population. Thus CTLA4 gene may not be responsible for an autoimmune disease SLE.
Abstract: A techno-economic evaluation for efficient use of
energy in a large scale industrial plant of methanol is carried out.
This assessment is based on integration of a gas turbine with an
existing plant of methanol in which the outlet gas products of
exothermic reactor is expanded to power generation. Also, it is
decided that methanol production rate is constant through addition of
power generation system to the existing methanol plant. Having
incorporated a gas turbine with the existing plant, the economic
results showed total investment of MUSD 16.9, energy saving of 3.6
MUSD/yr with payback period of approximately 4.7 years.
Abstract: In this paper a mixed method by combining an evolutionary and a conventional technique is proposed for reduction of Single Input Single Output (SISO) continuous systems into Reduced Order Model (ROM). In the conventional technique, the mixed advantages of Mihailov stability criterion and continued Fraction Expansions (CFE) technique is employed where the reduced denominator polynomial is derived using Mihailov stability criterion and the numerator is obtained by matching the quotients of the Cauer second form of Continued fraction expansions. Then, retaining the numerator polynomial, the denominator polynomial is recalculated by an evolutionary technique. In the evolutionary method, the recently proposed Differential Evolution (DE) optimization technique is employed. DE method is based on the minimization of the Integral Squared Error (ISE) between the transient responses of original higher order model and the reduced order model pertaining to a unit step input. The proposed method is illustrated through a numerical example and compared with ROM where both numerator and denominator polynomials are obtained by conventional method to show its superiority.
Abstract: Nanoemulsions are a class of emulsions with a droplet
size in the range of 50–500 nm and have attracted a great deal of
attention in recent years because it is unique characteristics. The
physicochemical properties of nanoemulsion suggests that it can be
successfully used to recover the residual oil which is trapped in the
fine pore of reservoir rock by capillary forces after primary and
secondary recovery. Oil-in-water nanoemulsion which can be formed
by high-energy emulsification techniques using specific surfactants
can reduce oil-water interfacial tension (IFT) by 3-4 orders of
magnitude. The present work is aimed on characterization of oil-inwater
nanoemulsion in terms of its phase behavior, morphological
studies; interfacial energy; ability to reduce the interfacial tension and
understanding the mechanisms of mobilization and displacement of
entrapped oil blobs by lowering interfacial tension both at the
macroscopic and microscopic level. In order to investigate the
efficiency of oil-water nanoemulsion in enhanced oil recovery
(EOR), experiments were performed to characterize the emulsion in
terms of their physicochemical properties and size distribution of the
dispersed oil droplet in water phase. Synthetic mineral oil and a series
of surfactants were used to prepare oil-in-water emulsions.
Characterization of emulsion shows that it follows pseudo-plastic
behaviour and drop size of dispersed oil phase follows lognormal
distribution. Flooding experiments were also carried out in a
sandpack system to evaluate the effectiveness of the nanoemulsion as
displacing fluid for enhanced oil recovery. Substantial additional
recoveries (more than 25% of original oil in place) over conventional
water flooding were obtained in the present investigation.
Abstract: The aim of this paper is to study in depth some
methodological aspects of social interventation, focusing on desirable
passage from social maternage method to peer advocacy method. For
this purpose, we intend analyze social and organizative components,
that affect operator-s professional action and that are part of his
psychological environment, besides the physical and social one. In
fact, operator-s interventation should not be limited to a pure supply
of techniques, nor to take shape as improvised action, but “full of
good purposes".
Abstract: In this paper, an algorithm for detecting and attenuating
puff noises frequently generated under the mobile environment is
proposed. As a baseline system, puff detection system is designed
based on Gaussian Mixture Model (GMM), and 39th Mel Frequency
Cepstral Coefficient (MFCC) is extracted as feature parameters. To
improve the detection performance, effective acoustic features for puff
detection are proposed. In addition, detected puff intervals are
attenuated by high-pass filtering. The speech recognition rate was
measured for evaluation and confusion matrix and ROC curve are used
to confirm the validity of the proposed system.