Abstract: The main aim is to perform mutational analysis of CTLA4 gene Exon 1 in SLE patients. A total of 61 SLE patients fulfilling “American College of Rheumatology (ACR) criteria" and 61 controls were enrolled in this study. The region of CTLA4 gene exon 1 was amplified by using Step-down PCR technique. Extracted DNA of band 354 bp was sequenced to analyze mutations in the exon-1 of CTLA-4 gene. Further, protein sequences were identified from nucleotide sequences of CTLA4 Exon 1 by using Expasy software and through Blast P software it was found that CTLA4 protein sequences of Pakistani SLE patients were similar to that of Chinese SLE population. No variations were found after patients sequences were compared with that of the control sequence. Furthermore it was found that CTLA4 protein sequences of Pakistani SLE patients were similar to that of Chinese SLE population. Thus CTLA4 gene may not be responsible for an autoimmune disease SLE.
Abstract: This paper shows that some properties of the decision
rules in the literature do not hold by presenting a counterexample. We
give sufficient and necessary conditions under which these properties
are valid. These results will be helpful when one tries to choose the
right decision rules in the research of rough set theory.
Abstract: The purpose of semantic web research is to transform
the Web from a linked document repository into a distributed knowledge base and application platform, thus allowing the vast range of available information and services to be more efficiently
exploited. As a first step in this transformation, languages such as
OWL have been developed. Although fully realizing the Semantic Web still seems some way off, OWL has already been very
successful and has rapidly become a defacto standard for ontology
development in fields as diverse as geography, geology, astronomy,
agriculture, defence and the life sciences. The aim of this paper is to classify key concepts of Semantic Web as well as introducing a new
practical approach which uses these concepts to outperform Word Wide Web.
Abstract: Hidden Markov Model (HMM) is a stochastic method
which has been used in various signal processing and character
recognition. This study proposes to use HMM to recognize Javanese
characters from a number of different handwritings, whereby HMM
is used to optimize the number of state and feature extraction. An
85.7 % accuracy is obtained as the best result in 16-stated vertical
model using pure HMM. This initial result is satisfactory for
prompting further research.
Abstract: Automated discovery of hierarchical structures in
large data sets has been an active research area in the recent past.
This paper focuses on the issue of mining generalized rules with crisp
hierarchical structure using Genetic Programming (GP) approach to
knowledge discovery. The post-processing scheme presented in this
work uses flat rules as initial individuals of GP and discovers
hierarchical structure. Suitable genetic operators are proposed for the
suggested encoding. Based on the Subsumption Matrix(SM), an
appropriate fitness function is suggested. Finally, Hierarchical
Production Rules (HPRs) are generated from the discovered
hierarchy. Experimental results are presented to demonstrate the
performance of the proposed algorithm.
Abstract: As a tool for human spatial cognition and thinking, the map has been playing an important role. Maps are perhaps as fundamental to society as language and the written word. Economic and social development requires extensive and in-depth understanding of their own living environment, from the scope of the overall global to urban housing. This has brought unprecedented opportunities and challenges for traditional cartography . This paper first proposed the concept of scaleless-map and its basic characteristics, through the analysis of the existing multi-scale representation techniques. Then some strategies are presented for automated mapping compilation. Taking into account the demand of automated map compilation, detailed proposed the software - WJ workstation must have four technical features, which are generalization operators, symbol primitives, dynamically annotation and mapping process template. This paper provides a more systematic new idea and solution to improve the intelligence and automation of the scaleless cartography.
Abstract: This article is devoted to the analysis of results of
sociological researches carried out by authors directed on studying of
opinion of representatives of small, medium and big business on
formation of the Customs Union, Common Free Market Zone with
participation of Kazakhstan, Russia and Belarus.
It-s forecasted that companies, their branches will interpenetrate
with registration and moving their businesses to regions with more
beneficial conditions. They say that in Kazakhstan there are more
profitable geo-strategic operating environment for business and lower
taxes. Russia using this opportunity will create new conditions for
expansion into other countries of Central Asia and China. Opinions
of participants of questionnaire and expert poll different in estimation
of value of these two integration mechanisms since market segments
on the one hand extend, but also on the other hand - loss of exclusive
influence in certain fields of activity.
Abstract: Digital news with a variety topics is abundant on the
internet. The problem is to classify news based on its appropriate
category to facilitate user to find relevant news rapidly. Classifier
engine is used to split any news automatically into the respective
category. This research employs Support Vector Machine (SVM) to
classify Indonesian news. SVM is a robust method to classify
binary classes. The core processing of SVM is in the formation of an
optimum separating plane to separate the different classes. For
multiclass problem, a mechanism called one against one is used to
combine the binary classification result. Documents were taken
from the Indonesian digital news site, www.kompas.com. The
experiment showed a promising result with the accuracy rate of 85%.
This system is feasible to be implemented on Indonesian news
classification.
Abstract: The objective of this research is to explore the role of actors at the local level in managing the Pre-hospital Emergency Medical Service (EMS) system in Thailand. The research method was done through documentary research, individual interviews, and one forum conducted in each province. This paper uses the case of three provinces located in three regions in Thailand including; Ubon Ratchathani (North-eastern region), Lampang (Northern Region), and Songkhla (Southern Region). The result shows that, recently, the role of the local government in being the service provider for their local people is increasingly concerned. In identifying the key success factors towards the EMS system, it includes; (i) the local executives- vision and influence that the decisions made by them, for both PAO (Provincial Administration Organisation (PAO) and TAO (Tambon Administration Organisation), is vital to address the overall challenges in EMS development, (ii) the administrative system through reforming their working style create the flexibility in running the EMS task, (iii) the network-based management among different agencies at the local level leads to the better EMS practices, and (iv) the development in human resource is very vital in delivering the effective services.
Abstract: The goals of the present research are to estimate Six Sigma implementation in Latvian commercial banks and to identify the perceived benefits of its implementation. To achieve the goals, the authors used sequential explanatory method. To obtain empirical data, the authors have developed the questionnaire and adapted it for the employees of Latvian commercial banks. The questions are related to Six Sigma implementation and its perceived benefits. The questionnaire mainly consists of closed questions, the evaluation of which is based on 5 point Likert scale. The obtained empirical data has shown that of the two hypotheses put forward in the present research – Hypothesis 1 – has to be rejected, while Hypothesis 2 has been partially confirmed. The authors have also faced some research limitations related to the fact that the participants in the questionnaire belong to different rank of the organization hierarchy.
Abstract: Evaluation of educational portals is an important
subject area that needs more attention from researchers. A university
that has an educational portal which is difficult to use and interact by
teachers or students or management staff can reduce the position and
reputation of the university. Therefore, it is important to have the
ability to make an evaluation of the quality of e-services the
university provide to improve them over time.
The present study evaluates the usability of the Information
Technology Faculty portal at University of Benghazi. Two evaluation
methods were used: a questionnaire-based method and an online
automated tool-based method. The first method was used to measure
the portal's external attributes of usability (Information, Content and
Organization of the portal, Navigation, Links and Accessibility,
Aesthetic and Visual Appeal, Performance and Effectiveness and
educational purpose) from users' perspectives, while the second
method was used to measure the portal's internal attributes of
usability (number and size of HTML files, number and size of images,
load time, HTML check errors, browsers compatibility problems,
number of bad and broken links), which cannot be perceived by the
users. The study showed that some of the usability aspects have been
found at the acceptable level of performance and quality, and some
others have been found otherwise. In general, it was concluded that
the usability of IT faculty educational portal generally acceptable.
Recommendations and suggestions to improve the weakness and
quality of the portal usability are presented in this study.
Abstract: The method of modeling is the key technology for
digital mockup (DMU). Based upon the developing for mechanical
product DMU, the theory, method and approach for virtual
environment (VE) and virtual object (VO) were studied. This paper
has expounded the design goal and architecture of DMU system,
analyzed the method of DMU application, and researched the general
process of physics modeling and behavior modeling.
Abstract: The purpose of this research was to demonstrate
prevalence of post-exposure preventive measures (PEP) after needlestick
injuries and its relationship with locus of control beliefs in a
sample of medical students. In this cross-sectional study, 300 medical
students with history of having experienced needle stick injuries
(NSI) for at least once filled in a questionnaire to determine if they
perceived themselves to be responsible and effective in preventing
blood born infections after NSI. About 38% of students did not seek
any professional consult or PEP after NSI due to lack of enough time
or access, anxiety about tests results, belief in uselessness of followup
and not being able to change destiny. These 114 students were not
different from others regarding their scores on NSI specific scale of
locus of health control. Thus, the potentiality of NSI locus of control
beliefs in predicting PEP was not seen in this study.
Abstract: The study of proteomics reached unexpected levels of
interest, as a direct consequence of its discovered influence over
some complex biological phenomena, such as problematic diseases
like cancer. This paper presents a new technique that allows for an
accurate analysis of the human interactome network. It is basically
a two-step analysis process that involves, at first, the detection of
each protein-s absolute importance through the betweenness centrality
computation. Then, the second step determines the functionallyrelated
communities of proteins. For this purpose, we use a community
detection technique that is based on the edge betweenness
calculation. The new technique was thoroughly tested on real biological
data and the results prove some interesting properties of those proteins that are involved in the carcinogenesis process. Apart from its
experimental usefulness, the novel technique is also computationally
effective in terms of execution times. Based on the analysis- results, some topological features of cancer mutated proteins are presented
and a possible optimization solution for cancer drugs design is suggested.
Abstract: This paper is concerned with the role strategic
management plays in higher education and the methods it entails.
Using the University of West Bohemia and the Czech Republic as
examples, the paper describes the methods used in furthering
strategic objectives within institutions and their different parts
(faculties, institutes). The nature of the demands faced by the
university dictates the need for a strategic framework which defines
the basic objectives and parameters of tertiary education and research
in a local, regional and national context. Sharing strategies with a
wider range of actors (universities, cities, regions, the practical
sphere) is key to laying the foundations for more efficient
cooperation.
Abstract: Computerized lip reading has been one of the most
actively researched areas of computer vision in recent past because
of its crime fighting potential and invariance to acoustic environment.
However, several factors like fast speech, bad pronunciation,
poor illumination, movement of face, moustaches and beards make
lip reading difficult. In present work, we propose a solution for
automatic lip contour tracking and recognizing letters of English
language spoken by speakers using the information available from
lip movements. Level set method is used for tracking lip contour
using a contour velocity model and a feature vector of lip movements
is then obtained. Character recognition is performed using modified
k nearest neighbor algorithm which assigns more weight to nearer
neighbors. The proposed system has been found to have accuracy
of 73.3% for character recognition with speaker lip movements as
the only input and without using any speech recognition system in
parallel. The approach used in this work is found to significantly
solve the purpose of lip reading when size of database is small.
Abstract: Despite the fact that Arabic language is currently one
of the most common languages worldwide, there has been only a
little research on Arabic speech recognition relative to other
languages such as English and Japanese. Generally, digital speech
processing and voice recognition algorithms are of special
importance for designing efficient, accurate, as well as fast automatic
speech recognition systems. However, the speech recognition process
carried out in this paper is divided into three stages as follows: firstly,
the signal is preprocessed to reduce noise effects. After that, the
signal is digitized and hearingized. Consequently, the voice activity
regions are segmented using voice activity detection (VAD)
algorithm. Secondly, features are extracted from the speech signal
using Mel-frequency cepstral coefficients (MFCC) algorithm.
Moreover, delta and acceleration (delta-delta) coefficients have been
added for the reason of improving the recognition accuracy. Finally,
each test word-s features are compared to the training database using
dynamic time warping (DTW) algorithm. Utilizing the best set up
made for all affected parameters to the aforementioned techniques,
the proposed system achieved a recognition rate of about 98.5%
which outperformed other HMM and ANN-based approaches
available in the literature.
Abstract: Setting up of rural telecentres, popularly referred to as
Common Service Centres (CSCs), are considered one of the initial
forerunners of rural e-Governance initiatives under the Government
of India-s National e-Governance Plan (NeGP). CSCs are
implemented on public-private partnership (PPP) – where State
governments play a major role in facilitating the establishment of
CSCs and investments are made by private companies referred to as
Service Centre Agencies (SCAs). CSC implementation is expected to
help in improving public service delivery in a transparent and
efficient manner. However, there is very little research undertaken to
study the actual impact of CSC implementation at the grassroots
level. This paper addresses the gap by identifying the circumstances,
concerns and expectations from the point-of-view of citizens and
examining the finer aspects of social processes in the context of rural
e-Governance.
Abstract: Built environments have a large impact on environmental sustainability and if it is not considered properly can negatively affect our planet. The application of transformable intelligent building systems that automatically respond to environmental conditions is one of the best ways that can intelligently assist us to create sustainable environment. The significance of this issue is evident as energy crisis and environmental changes has made the sustainability the main concerns in many societies. The aim of this research is to review and evaluate the importance and influence of transformable intelligent structure on the creation of sustainable architecture. Intelligent systems in current buildings provide convenience through automatically responding to changes in environmental conditions, reducing energy dissipation and increase of the lifecycle of buildings. This paper by analyzing significant intelligent building systems will evaluate the potentials of transformable intelligent systems in the creation of sustainable architecture and environment.
Abstract: There are two common types of operational research techniques, optimisation and metaheuristic methods. The latter may be defined as a sequential process that intelligently performs the exploration and exploitation adopted by natural intelligence and strong inspiration to form several iterative searches. An aim is to effectively determine near optimal solutions in a solution space. In this work, a type of metaheuristics called Ant Colonies Optimisation, ACO, inspired by a foraging behaviour of ants was adapted to find optimal solutions of eight non-linear continuous mathematical models. Under a consideration of a solution space in a specified region on each model, sub-solutions may contain global or multiple local optimum. Moreover, the algorithm has several common parameters; number of ants, moves, and iterations, which act as the algorithm-s driver. A series of computational experiments for initialising parameters were conducted through methods of Rigid Simplex, RS, and Modified Simplex, MSM. Experimental results were analysed in terms of the best so far solutions, mean and standard deviation. Finally, they stated a recommendation of proper level settings of ACO parameters for all eight functions. These parameter settings can be applied as a guideline for future uses of ACO. This is to promote an ease of use of ACO in real industrial processes. It was found that the results obtained from MSM were pretty similar to those gained from RS. However, if these results with noise standard deviations of 1 and 3 are compared, MSM will reach optimal solutions more efficiently than RS, in terms of speed of convergence.