Abstract: P16/INK4A is tumor suppressor protein that plays a critical role in cell cycle regulation. Loss of P16 protein expression has been implicated in pathogenesis of many cancers, including lymphoma. Therefore, we sought to investigate if loss of P16 protein expression is associated with lymphoma and/or any specific lymphoma subtypes (Hodgkin-s lymphoma (HL) and nonHodgkin-s lymphoma (NHL)). Fifty-five lymphoma cases consisted of 30 cases of HL and 25 cases of NHL, with an age range of 3 to 78 years, were examined for loss of P16 by immunohistochemical technique using a specific antibody reacting against P16. In total, P16 loss was seen in 33% of all lymphoma cases. P16 loss was identified in 47.7% of HL cases. In contrast, only 16% of NHL showed loss of P16. Loss of P16 was seen in 67% of HL patients with 50 years of age or older, whereas P16 loss was found in only 42% of HL patients with less than 50 years of age. P16 loss in HL is somewhat higher in male (55%) than in female (30%). In subtypes of HL, P16 loss was found exclusively in all cases of lymphocyte depletion, lymphocyte predominance and unclassified cases, whereas P16 loss was seen in 39% of mixed cellularity and 29% of nodular sclerosis cases. In low grade NHL patients, P16 loss was seen in approximately one-third of cases, whereas no or very rare of P16 loss was found in intermediate and high grade cases. P16 loss did not show any correlation with age or gender of NHL patients. In conclusion, the high rate of P16 loss seen in our study suggests that loss of P16 expression plays a critical role in the pathogenesis of lymphoma, particularly with HL.
Abstract: Work-life balance has been acknowledged and
promoted for the sake of employee retention. It is essential for a
manager to realize the human resources situation within a company to
help employees work happily and perform at their best. This paper
suggests knowledge management and critical thinking are useful to
motivate employees to think about their work-life balance. A
qualitative case study is presented, which aimed to discover the
meaning of work-life balance-s meaning from the perspective of Thai
knowledge workers and how it affects their decision-making towards
work resignation. Results found three types of work-life balance
dimensions; a work- life balance including a workplace and a private
life setting, an organizational working life balance only, and a worklife
balance only in a private life setting. These aspects all influenced
the decision-making of the employees. Factors within a theme of an
organizational work-life balance were involved with systematic
administration, fair treatment, employee recognition, challenging
assignments to gain working experience, assignment engagement,
teamwork, relationship with superiors, and working environment,
while factors concerning private life settings were about personal
demands such as an increasing their salary or starting their own
business.
Abstract: The purpose of this study is to derive optimal shapes of
a body located in viscous flows by the finite element method using the
acoustic velocity and the four-step explicit scheme. The formulation
is based on an optimal control theory in which a performance function
of the fluid force is introduced. The performance function should be
minimized satisfying the state equation. This problem can be transformed
into the minimization problem without constraint conditions
by using the adjoint equation with adjoint variables corresponding to
the state equation. The performance function is defined by the drag
and lift forces acting on the body. The weighted gradient method
is applied as a minimization technique, the Galerkin finite element
method is used as a spatial discretization and the four-step explicit
scheme is used as a temporal discretization to solve the state equation
and the adjoint equation. As the interpolation, the orthogonal basis
bubble function for velocity and the linear function for pressure
are employed. In case that the orthogonal basis bubble function is
used, the mass matrix can be diagonalized without any artificial
centralization. The shape optimization is performed by the presented
method.
Abstract: The aim of this study was to examine the dynamics of functional composition of a non flooded Amazonian forest in response to drought stress in terms of diameter growth, recruitment and mortality. The survey was carried out in the continuous forest of the Biological dynamics of forest fragments project 90 km outside the city of Manaus, state of Amazonas Brazil. All stems >10 cm dbh where identified to species level and monitored in 18 one hectare permanent sample plots from 1981 to 2004.For statistical analysis all species where aggregated in three ecological guilds. Two distinct drought events occurred in 1983 and 1997. Results showed that more early successional species performed better than later successional ones. Response was significant for both events but for the 1997 event this was more pronounced possibly because of the fact that the event was in the middle of the dry rather than the wet period as was the 1983 one.
Abstract: School experiences, family bonding and self-concept
had always been a crucial factor in influencing all aspects of a
student-s development. The purpose of this study is to develop and to
validate a priori model of self-concept among students. The study
was tested empirically using Structural Equation Modeling (SEM)
and Confirmatory Factor Analysis (CFA) to validate the structural
model. To address these concerns, 1167 students were randomly
selected and utilized the Cognitive Psycho-Social University of
Malaya instrument (2009).Resulted demonstrated there is indirect
effect from family bonding to self-concept through school
experiences among secondary school students as a mediator. Besides
school experiences, there is a direct effect from family bonding to
self-concept and family bonding to school experiences among
students.
Abstract: In this article the influence of higher frequency effects
in addition to a special damper design on the electrical behavior of a
synchronous generator main exciter machine is investigated. On the
one hand these machines are often highly stressed by harmonics from
the bridge rectifier thus facing additional eddy current losses. On the
other hand the switching may cause the excitation of dangerous
voltage peaks in resonant circuits formed by the diodes of the
rectifier and the commutation reactance of the machine. Therefore
modern rotating exciters are treated like synchronous generators
usually modeled with a second order equivalent circuit. Hence the
well known Standstill Frequency Response Test (SSFR) method is
applied to a test machine in order to determine parameters for the
simulation. With these results it is clearly shown that higher
frequencies have a strong impact on the conventional equivalent
circuit model. Because of increasing field displacement effects in the
stranded armature winding the sub-transient reactance is even smaller
than the armature leakage at high frequencies. As a matter of fact this
prevents the algorithm to find an equivalent scheme. This issue is
finally solved using Laplace transfer functions fully describing the
transient behavior at the model ports.
Abstract: The purposes of this research were to study the citizen
participation in preventing illegal drugs in one of a poor and small
community of Bangkok, Thailand and to compare the level of
participation and concern of illegal drugs problem by using
demographic variables. This paper drew upon data collected from a
local citizens survey conducted in Bangkok, Thailand during summer
of 2012. A total of 200 respondents were elicited as data input for,
and one way ANOVA test. The findings revealed that the overall
citizen participation was in the level of medium. The mean score
showed that benefit from the program was ranked as the highest and
the decision to participate was ranked as second while the follow-up
of the program was ranked as the lowest.
In terms of the difference in demographic such as gender, age,
level of education, income, and year of residency, the hypothesis
testing’s result disclosed that there were no difference in their level
of participation. However, difference in occupation showed a
difference in their level of participation and concern which was
significant at the 0.05 confidence level.
Abstract: Cosmic showers, from their places of origin in space,
after entering earth generate secondary particles called Extensive Air
Shower (EAS). Detection and analysis of EAS and similar High
Energy Particle Showers involve a plethora of experimental setups
with certain constraints for which soft-computational tools like
Artificial Neural Network (ANN)s can be adopted. The optimality
of ANN classifiers can be enhanced further by the use of Multiple
Classifier System (MCS) and certain data - dimension reduction
techniques. This work describes the performance of certain data
dimension reduction techniques like Principal Component Analysis
(PCA), Independent Component Analysis (ICA) and Self Organizing
Map (SOM) approximators for application with an MCS formed
using Multi Layer Perceptron (MLP), Recurrent Neural Network
(RNN) and Probabilistic Neural Network (PNN). The data inputs are
obtained from an array of detectors placed in a circular arrangement
resembling a practical detector grid which have a higher dimension
and greater correlation among themselves. The PCA, ICA and SOM
blocks reduce the correlation and generate a form suitable for real
time practical applications for prediction of primary energy and
location of EAS from density values captured using detectors in a
circular grid.
Abstract: Nowadays, ontologies are the only widely accepted paradigm for the management of sharable and reusable knowledge in a way that allows its automatic interpretation. They are collaboratively created across the Web and used to index, search and annotate documents. The vast majority of the ontology based approaches, however, focus on indexing texts at document level. Recently, with the advances in ontological engineering, it became clear that information indexing can largely benefit from the use of general purpose ontologies which aid the indexing of documents at word level. This paper presents a concept indexing algorithm, which adds ontology information to words and phrases and allows full text to be searched, browsed and analyzed at different levels of abstraction. This algorithm uses a general purpose ontology, OntoRo, and an ontologically tagged corpus, OntoCorp, both developed for the purpose of this research. OntoRo and OntoCorp are used in a two-stage supervised machine learning process aimed at generating ontology tagging rules. The first experimental tests show a tagging accuracy of 78.91% which is encouraging in terms of the further improvement of the algorithm.
Abstract: In this paper, we present a maintenance model of a
two-unit series system with economic dependence. Unit#1 which is
considered to be more expensive and more important, is subject to
condition monitoring (CM) at equidistant, discrete time epochs and
unit#2, which is not subject to CM has a general lifetime distribution.
The multivariate observation vectors obtained through condition
monitoring carry partial information about the hidden state of unit#1,
which can be in a healthy or a warning state while operating. Only the
failure state is assumed to be observable for both units. The objective
is to find an optimal opportunistic maintenance policy minimizing
the long-run expected average cost per unit time. The problem
is formulated and solved in the partially observable semi-Markov
decision process framework. An effective computational algorithm
for finding the optimal policy and the minimum average cost is
developed, illustrated by a numerical example.
Abstract: Mobile ad-hoc networks (MANETs) are a form of
wireless networks which do not require a base station for providing
network connectivity. Mobile ad-hoc networks have many
characteristics which distinguish them from other wireless networks
which make routing in such networks a challenging task. Cluster
based routing is one of the routing schemes for MANETs in which
various clusters of mobile nodes are formed with each cluster having
its own clusterhead which is responsible for routing among clusters.
In this paper we have proposed and implemented a distributed
weighted clustering algorithm for MANETs. This approach is based
on combined weight metric that takes into account several system
parameters like the node degree, transmission range, energy and
mobility of the nodes. We have evaluated the performance of
proposed scheme through simulation in various network situations.
Simulation results show that proposed scheme outperforms the
original distributed weighted clustering algorithm (DWCA).
Abstract: This paper presents the doping profile measurement
and characterization technique for the pocket implanted nano scale
n-MOSFET. Scanning capacitance microscopy and atomic force
microscopy have been used to image the extent of lateral dopant
diffusion in MOS structures. The data are capacitance vs. voltage
measurements made on a nano scale device. The technique is nondestructive
when imaging uncleaved samples. Experimental data from
the published literature are presented here on actual, cleaved device
structures which clearly indicate the two-dimensional dopant profile
in terms of a spatially varying modulated capacitance signal. Firstorder
deconvolution indicates the technique has much promise for
the quantitative characterization of lateral dopant profiles. The pocket
profile is modeled assuming the linear pocket profiles at the source
and drain edges. From the model, the effective doping concentration
is found to use in modeling and simulation results of the various
parameters of the pocket implanted nano scale n-MOSFET. The
potential of the technique to characterize important device related
phenomena on a local scale is also discussed.
Abstract: This paper presents a new technique for detection of
human faces within color images. The approach relies on image
segmentation based on skin color, features extracted from the two-dimensional
discrete cosine transform (DCT), and self-organizing
maps (SOM). After candidate skin regions are extracted, feature
vectors are constructed using DCT coefficients computed from those
regions. A supervised SOM training session is used to cluster feature
vectors into groups, and to assign “face" or “non-face" labels to those
clusters. Evaluation was performed using a new image database of
286 images, containing 1027 faces. After training, our detection
technique achieved a detection rate of 77.94% during subsequent
tests, with a false positive rate of 5.14%. To our knowledge, the
proposed technique is the first to combine DCT-based feature
extraction with a SOM for detecting human faces within color
images. It is also one of a few attempts to combine a feature-invariant
approach, such as color-based skin segmentation, together with
appearance-based face detection. The main advantage of the new
technique is its low computational requirements, in terms of both
processing speed and memory utilization.
Abstract: This is a comprehensive large-sample study of Australian earnings management. Using a sample of 4,844 firm-year observations across nine Australia industries from 2000 to 2006, we find substantial corporate earnings management activity across several Australian industries. We document strong evidence of size and return on assets being primary determinants of earnings management in Australia. The effects of size and return on assets are also found to be dominant in both income-increasing and incomedecreasing earnings manipulation. We also document that that periphery sector firms are more likely to involve larger magnitude of earnings management than firms in the core sector.
Abstract: This paper presents a new adaptive DMC controller
that improves the controller performance in case of plant-model
mismatch. The new controller monitors the plant measured output,
compares it with the model output and calculates weights applied to
the controller move. Simulations show that the new controller can
help improve control performance and avoid instability in case of
severe model mismatches.
Abstract: We demonstrate the synthesis of intermediary views
within a sequence of color encoded, materials discriminating, X-ray
images that exhibit animated depth in a visual display. During the
image acquisition process, the requirement for a linear X-ray detector
array is replaced by synthetic image. Scale Invariant Feature
Transform, SIFT, in combination with material segmented morphing
is employed to produce synthetic imagery. A quantitative analysis of
the feature matching performance of the SIFT is presented along with
a comparative study of the synthetic imagery. We show that the total
number of matches produced by SIFT reduces as the angular
separation between the generating views increases. This effect is
accompanied by an increase in the total number of synthetic pixel
errors. The trends observed are obtained from 15 different luggage
items. This programme of research is in collaboration with the UK
Home Office and the US Dept. of Homeland Security.
Abstract: In this report we present a rule-based approach to
detect anomalous telephone calls. The method described here uses
subscriber usage CDR (call detail record) data sampled over two
observation periods: study period and test period. The study period
contains call records of customers- non-anomalous behaviour.
Customers are first grouped according to their similar usage
behaviour (like, average number of local calls per week, etc). For
customers in each group, we develop a probabilistic model to describe
their usage. Next, we use maximum likelihood estimation (MLE) to
estimate the parameters of the calling behaviour. Then we determine
thresholds by calculating acceptable change within a group. MLE is
used on the data in the test period to estimate the parameters of the
calling behaviour. These parameters are compared against thresholds.
Any deviation beyond the threshold is used to raise an alarm. This
method has the advantage of identifying local anomalies as compared
to techniques which identify global anomalies. The method is tested
for 90 days of study data and 10 days of test data of telecom
customers. For medium to large deviations in the data in test window,
the method is able to identify 90% of anomalous usage with less than
1% false alarm rate.
Abstract: Atherosclerosis was identified as a chronic inflammatory process resulting from interactions between plasma lipoproteins, cellular components (monocyte, macrophages, T lymphocytes, endothelial cells and smooth muscle cells) and the extracellular matrix of the arterial wall. Several types of genes were known to express during formation of atherosclerosis. This study is carried out to identify unknown differentially expressed gene (DEG) in atherogenesis. Rabbit’s aorta tissues were stained by H&E for histomorphology. GeneFishing™ PCR analysis was performed from total RNA extracted from the aorta tissues. The DNA fragment from DEG was cloned, sequenced and validated by Real-time PCR. Histomorphology showed intimal thickening in the aorta. DEG detected from ACP-41 was identified as cathepsin B gene and showed upregulation at week-8 and week-12 of atherogenesis. Therefore, ACP-based GeneFishing™ PCR facilitated identification of cathepsin B gene which was differentially expressed during development of atherosclerosis.
Abstract: This research aimed to modify pineapple leaf paper
(PALP) for using as wet media in the evaporation cooling system by
improving wet mechanical property (tensile strength) without
compromising water absorption property. Polyamideamineepichorohydrin
resin (PAE) and carboxymethylcellulose (CMC)
were used to strengthen the paper, and the PAE and CMC ratio of
80:20 showed the optimum wet and dry tensile index values, which
were higher than those of the commercial cooling pad (CCP).
Compared with CCP, PALP itself and all the PAE/CMC modified
PALP possessed better water absorption. The PAE/CMC modified
PALP had potential to become a new type of wet media.
Abstract: Human genome is not only the evolutionary
summation of all advantageous events, but also houses lesions of
deleterious foot prints. A single gene mutation sometimes may
express multiple consequences in numerous tissues and a linear
relationship of the genotype and the phenotype may often be obscure.
ß Thalassemia minor, a transfusion independent mild anaemia,
coupled with environment among other factors may articulate into
phenotypic pleotropy with Hypocholesterolemia, Vitamin D
deficiency, Tissue hypoxia, Hyper-parathyroidism and Psychological
alterations. Occurrence of Pancreatic insufficiency, resultant
steatorrhoea, Vitamin-D (25-OH) deficiency (13.86 ngm/ml) with
Hypocholesterolemia (85mg/dl) in a 30 years old male ß Thal-minor
patient (Hemoglobin 11mg/dl with Fetal Hemoglobin 2.10%, Hb A2
4.60% and Hb Adult 84.80% and altered Hemogram) with increased
Para thyroid hormone (62 pg/ml) & moderate Serum Ca+2
(9.5mg/ml) indicate towards a cascade of phenotypic pleotropy
where the ß Thalassemia mutation ,be it in the 5’ cap site of the
mRNA , differential splicing etc in heterozygous state is effecting
several metabolic pathways. Compensatory extramedulary
hematopoiesis may not coped up well with the stressful life style of
the young individual and increased erythropoietic stress with high
demand for cholesterol for RBC membrane synthesis may have
resulted in Hypocholesterolemia.Oxidative stress and tissue hypoxia
may have caused the pancreatic insufficiency, leading to Vitamin D
deficiency. This may in turn have caused the secondary
hyperparathyroidism to sustain serum Calcium level. Irritability and
stress intolerance of the patient was a cumulative effect of the vicious
cycle of metabolic compromises. From these findings we propose
that the metabolic deficiencies in the ß Thalassemia mutations may
be considered as the phenotypic display of the pleotropy to explain
the genetic epidemiology.
According to the recommendations from the NIH Workshop on
Gene-Environment Interplay in Common Complex Diseases: Forging
an Integrative Model, study design of observations should be
informed by gene-environment hypotheses and results of a study
(genetic diseases) should be published to inform future hypotheses.
Variety of approaches is needed to capture data on all possible
aspects, each of which is likely to contribute to the etiology of
disease. Speakers also agreed that there is a need for development of
new statistical methods and measurement tools to appraise
information that may be missed out by conventional method where
large sample size is needed to segregate considerable effect.
A meta analytic cohort study in future may bring about significant
insight on to the title comment.