Abstract: This article demonstrated development of
controlled release system of an NSAID drug, Diclofenac
sodium employing different ratios of Ethyl cellulose.
Diclofenac sodium and ethyl cellulose in different proportions
were processed by microencapsulation based on phase
separation technique to formulate microcapsules. The
prepared microcapsules were then compressed into tablets to
obtain controlled release oral formulations. In-vitro evaluation
was performed by dissolution test of each preparation was
conducted in 900 ml of phosphate buffer solution of pH 7.2
maintained at 37 ± 0.5 °C and stirred at 50 rpm. At predetermined
time intervals (0, 0.5, 1.0, 1.5, 2, 3, 4, 6, 8, 10, 12,
16, 20 and 24 hrs). The drug concentration in the collected
samples was determined by UV spectrophotometer at 276 nm.
The physical characteristics of diclofenac sodium
microcapsules were according to accepted range. These were
off-white, free flowing and spherical in shape. The release
profile of diclofenac sodium from microcapsules was found to
be directly proportional to the proportion of ethylcellulose and
coat thickness. The in-vitro release pattern showed that with
ratio of 1:1 and 1:2 (drug: polymer), the percentage release of
drug at first hour was 16.91 and 11.52 %, respectively as
compared to 1:3 which is only 6.87 % with in this time. The
release mechanism followed higuchi model for its release
pattern. Tablet Formulation (F2) of present study was found
comparable in release profile the marketed brand Phlogin-SR,
microcapsules showed an extended release beyond 24 h.
Further, a good correlation was found between drug release
and proportion of ethylcellulose in the microcapsules.
Microencapsulation based on coacervation found as good
technique to control release of diclofenac sodium for making
the controlled release formulations.
Abstract: Problem-based learning (PBL) is one of the student
centered approaches and has been considered by a number of higher
educational institutions in many parts of the world as a method of
delivery. This paper presents a creative thinking approach for
implementing Problem-based Learning in Mechanics of Structure
within a Malaysian Polytechnics environment. In the learning
process, students learn how to analyze the problem given among the
students and sharing classroom knowledge into practice. Further,
through this course-s emphasis on problem-based learning, students
acquire creative thinking skills and professional skills as they tackle
complex, interdisciplinary and real-situation problems. Once the
creative ideas are generated, there are useful additional techniques
for tender ideas that will grow into a productive concept or solution.
The combination of creative skills and technical abilities will enable
the students to be ready to “hit-the-ground-running" and produce in
industry when they graduate.
Abstract: Solar power plants(SPPs) have shown a lot of good outcomes
in providing a various functions depending on industrial expectations by
deploying ad-hoc networking with helps of light loaded and battery powered
sensor nodes. In particular, it is strongly requested to develop an algorithm to
deriver the sensing data from the end node of solar power plants to the sink node
on time. In this paper, based on the above observation we have proposed an
IEEE802.15.4 based self routing scheme for solar power plants. The proposed
beacon based priority routing Algorithm (BPRA) scheme utilizes beacon
periods in sending message with embedding the high priority data and thus
provides high quality of service(QoS) in the given criteria. The performance
measures are the packet Throughput, delivery, latency, total energy
consumption. Simulation results under TinyOS Simulator(TOSSIM) have
shown the proposed scheme outcome the conventional Ad hoc On-Demand
Distance Vector(AODV) Routing in solar power plants.
Abstract: Requirements management is critical to software
delivery success and project lifecycle. Requirements management
and their traceability provide assistance for many software
engineering activities like impact analysis, coverage analysis,
requirements validation and regression testing. In addition
requirements traceability is the recognized component of many
software process improvement initiatives. Requirements traceability
also helps to control and manage evolution of a software system.
This paper aims to provide an evaluation of current requirements
management and traceability tools. Management and test managers
require an appropriate tool for the software under test. We hope,
evaluation identified here will help to select the efficient and
effective tool.
Abstract: Mobile ad hoc network is a collection of mobile
nodes communicating through wireless channels without any existing
network infrastructure or centralized administration. Because of the
limited transmission range of wireless network interfaces, multiple
"hops" may be needed to exchange data across the network. In order
to facilitate communication within the network, a routing protocol is
used to discover routes between nodes. The primary goal of such an
ad hoc network routing protocol is correct and efficient route
establishment between a pair of nodes so that messages may be
delivered in a timely manner. Route construction should be done
with a minimum of overhead and bandwidth consumption. This paper
examines two routing protocols for mobile ad hoc networks– the
Destination Sequenced Distance Vector (DSDV), the table- driven
protocol and the Ad hoc On- Demand Distance Vector routing
(AODV), an On –Demand protocol and evaluates both protocols
based on packet delivery fraction, normalized routing load, average
delay and throughput while varying number of nodes, speed and
pause time.
Abstract: Two optimized strategies were successfully established
to develop biomolecule-based magnetic nanoassemblies.
Streptavidin-coated and amine-coated magnetic nanoparticles were
chosen as model scaffolds onto which double-stranded DNA and
human immunoglobulin G were specifically conjugated in succession,
using biotin-streptavidin interaction or covalent cross-linkers. The
success of this study opens the prospect of developing selective and
sensitive nanoparticle-based structures for diagnostics or drug
delivery.
Abstract: Due to the rise of aging population, effective utilization
of healthcare resources has become an important issue. With the
advance of ICT technology, the application of tele-healthcare service
has received more attention than ever. The main purpose of this
research is to investigate how to conduct innovative design for
tele-healthcare service based on user-s perspectives. First, the
healthcare service blueprint was used to describe the processes
of tele-healthcare service delivery, and then construct PZB service
quality gap model based on the literature and practitioners-
interviews. Next, TRIZ theory is applied to implement service
innovation. We found the proposed service innovation procedures can
effectively improve the quality of service design.
Abstract: Nowadays pharmaceutical care departments located in
hospitals are amongst the important pillars of the healthcare system.
The aim of this study was to evaluate quality of hospital drugstores
affiliated with Kermanshah University of Medical Sciences.
In this cross-sectional study a validated questionnaire was used.
The questionnaire was filled in by the one of the researchers in all
seventeen hospital drugstores located in the teaching and nonteaching
hospitals affiliated with Kermanshah University of Medical
Sciences. The results shows that in observed hospitals,24% of
pharmacy environments, 25% of pharmacy store and storage
conditions, 49% of storage procedure, 25% of ordering drugs and
supplies, 73% of receiving supplies (proper procedure are fallowed
for receiving supplies), 35% of receiving supplies (prompt action
taken if deterioration of drugs received is suspected), 23.35% of
drugs delivery to patients and finally 0% of stock cards are used for
proper inventory control have full compliance with standards.
Abstract: Development of a Robust Supply Chain for Dynamic
Operating Environment as we move further into the twenty first
century, organisations are under increasing pressure to deliver a high
product variation at a reasonable cost without compromise in quality.
In a number of cases this will take the form of a customised or high
variety low volume manufacturing system that requires prudent
management of resources, among a number of functions, to achieve
competitive advantage. Purchasing and Supply Chain management is
one of such function and due to the substantial interaction with
external elements needs to be strategically managed. This requires a
number of primary and supporting tools that will enable the
appropriate decisions to be made rapidly. This capability is
especially vital in a dynamic environment as it provides a pivotal role
in increasing the profit margin of the product. The management of
this function can be challenging by itself and even more for Small
and Medium Enterprises (SMEs) due to the limited resources and
expertise available at their disposal.
This paper discusses the development of tools and concepts
towards effectively managing the purchasing and supply chain
function. The developed tools and concepts will provide a cost
effective way of managing this function within SMEs. The paper
further shows the use of these tools within Contechs, a manufacturer
of luxury boat interiors, and the associated benefits achieved as a
result of this implementation. Finally a generic framework towards
use in such environments is presented.
Abstract: Customer-supplier collaboration enables firms to
achieve greater success than acting independently. Nevertheless, not
many firms have fully utilized the potential of collaboration. This
paper presents organizational and human related success factors for
collaboration in manufacturing supply chains in casting industry. Our
research approach was a case study including multiple cases. Data
was gathered by interviews and group discussions in two different
research projects. In the first research project we studied seven firms
and in the second five. It was found that the success factors are
interrelated, in other words, organizational and human factors
together enable success but not any of them alone. Some of the found
success factors are a culture of following agreements, and a speed of
informing the partner about changes affecting to the product or the
delivery chain.
Abstract: A solar powered air heating system using one ended evacuated tubes is experimentally investigated. A solar air heater containing forty evacuated tubes is used for heating purpose. The collector surface area is about 4.44 m2. The length and outer diameters of the outer glass tube and absorber tube are 1500, 47 and 37 mm, respectively. In this experimental setup, we have a header (heat exchanger) of square shape (190 mm x 190 mm). The length of header is 1500 mm. The header consists of a hollow pipe in the center whose diameter is 60 mm through which the air is made to flow. The experimental setup contains approximately 108 liters of water. Water is working as heat collecting medium which collects the solar heat falling on the tubes. This heat is delivered to the air flowing through the header pipe. This heat flow is due to natural convection and conduction. The outlet air temperature depends upon several factors along with air flow rate and solar radiation intensity. The study has been done for both up-flow and down-flow of air in header in similar weather conditions, at different flow rates. In the present investigations the study has been made to find the effect of intensity of solar radiations and flow rate of air on the out let temperature of the air with time and which flow is more efficient. The obtained results show that the system is highly effective for the heating in this region. Moreover, it has been observed that system is highly efficient for the particular flow rate of air. It was also observed that downflow configuration is more effective than up-flow condition at all flow rates due to lesser losses in down-flow. The results show that temperature differences of upper head and lower head, both of water and surface of pipes on the respective ends is lower in down-flow.
Abstract: Nowadays, the importance of energy saving is clearance to everyone. By attention to increasing price of fuels and also the problems of environment pollutions, there are the most efforts for using fuels littler and more optimum in everywhere. This essay studies optimizing of gas consumption in gas-burner space heaters. In oven of each gas-burner space heaters there is two snags to prevent the hot air (the result of combustion of natural gas) to go out of oven of the gas-burner space heaters directly without delivering its heat to the space of favorite environment like a room. These snags cause a excess circulating that helps hot air deliver its heat to the space of favorite environment. It means the exhaust air temperature will be decreased then when there are no snags. This is the aim of this essay to use maximum potential energy of the natural gas to make heat. In this study, by the help of a finite volume software (FLUENT) consumption of the gas-burner space heaters is simulated and optimized. At the end of this writing, by comparing the results of software and experimental results, it will be proved the authenticity of this method.
Abstract: Does a communication modality matter in delivering e-learning information? With the recent growth of broadcasting systems, media technologies and e-learning contents, various systems with different communication modalities have been introduced. In accordance with these trends, this study examines the effects of the information delivery modality on psychology of students. Findings from an experiment indicated that the delivering information which includes a video modality elicited higher degrees of credibility, quality, representativeness of content, and perceived suitability for delivering information than those of auditory information. However, there is no difference between content liking and attitude. The Implications of the findings and the limitations are discussed.
Abstract: A learning content management system (LCMS) is an
environment to support web-based learning content development.
Primary function of the system is to manage the learning process as
well as to generate content customized to meet a unique requirement
of each learner. Among the available supporting tools offered by
several vendors, we propose to enhance the LCMS functionality to
individualize the presented content with the induction ability. Our
induction technique is based on rough set theory. The induced rules
are intended to be the supportive knowledge for guiding the content
flow planning. They can also be used as decision rules to help
content developers on managing content delivered to individual
learner.
Abstract: This study examined the toxicological effects and
safety of polypeptide k isolated from the seeds of Momordica
charantia in laboratory rats. 30 male Sprague Dawley rats (12 weeks
old, bodyweight 180-200 g) were randomly divided into 3 groups
(1000 mg/kg, 500 mg and 0 mg/kg). Rats were acclimatized to
laboratory conditions for 7 days and at day 8 rats were dosed orally
with polypeptide k (in 2% DMSO/normal saline) and the controls
received the dosed vehicle only. Rats were then observed for 72
hours before sacrificed. Rats were anaesthetized by pentobarbital
(50 mg/kg ip) and 2-3.0 mL of blood was taken by cardiac puncture
and rats were scarified by anaesthetic overdose. Immediately, organs
(heart, lungs, liver, kidneys) were weigh and taken for histology.
Organ sections were then evaluated by a histopathologist. Serum
samples were assayed for liver functions (ALT and γ-GT) and kidney
functions (BUN and creatinine). All rats showed normal behavior
after the dosing and no statistical changes were observed in all blood
parameters and organ weight. Histological examinations revealed
normal organ structures. In conclusion, dosing of rats up to 1000
mg/kg did not have any effects on the rat behavior, liver or kidney
functions nor histology of the selected organs.
Abstract: This paper provides new ways to explore the old
problem of failure of information systems development in an
organisation. Based on the theory of cognitive dissonance,
information systems (IS) failure is defined as a gap between what the
users expect from an information system and how well these
expectations are met by the perceived performance of the delivered
system. Bridging the expectation-perception gap requires that IS
professionals make a radical change from being the proprietor of
information systems and products to being service providers. In order
to deliver systems and services that IS users perceive as valuable, IS
people must become expert in determining and assessing users-
expectations and perceptions. It is also suggested that the IS
community, in general, has given relatively little attention to the
front-end process of requirements specification for IS development.
There is a simplistic belief that requirements are obtainable from
users, they are then translatable into a formal specification. The
process of information needs analysis is problematic and worthy of
investigation.
Abstract: This study was conducted to examine the effects of ketum extract on development of Chrysomya rufifacies and to analyze the presence of mitragynine in the larvae samples. 110 newly emerged first instar larvae of C. rufifacies were introduced on ketum extract-mixed cow liver at doses of 0, 20, 40 and 60g. Blowfly development rate was determined with 12 hour intervals and
mitragynine in larvae was extracted and quantitated. C. rufifacies in control group took about 192 hours to complete their development from first instar larvae to adult blowfly; meanwhile blowfly form from the highest dose of ketum was 264 hours. Mitragynine was detected in all groups of treatment, except for control. In conclusion, the presence of mitragynine in C. rufifacies is affected in delaying development rates of the blowfly for up to 62 hours or 3 days. Chemical analysis of mitragynine from larvae samples showed that this alkaloid present in all specimens analyzed.
Abstract: Supply network management adopts a systematic
and integrative approach to managing the operations and
relationships of various parties in a supply network. The objective
of the manufactures in their supply network is to reduce inventory
costs and increase customer satisfaction levels. One way of doing
that is to synchronize delivery performance. A supply network can
be described by nodes representing the companies and the links
(relationships) between these nodes. Uncertainty in delivery time
depends on type of network relationship between suppliers. The
problem is to understand how the individual uncertainties influence
the total uncertainty of the network and identify those parts of the
network, which has the highest potential for improving the total
delivery time uncertainty.
Abstract: The aim of this paper is to propose a dynamic integrated approach, based on modularity concept and on the business ecosystem approach, that exploit different eBusiness services for SMEs under an open business network platform. The adoption of this approach enables firms to collaborate locally for delivering the best product/service to the customers as well as globally by accessing international markets, interrelate directly with the customers, create relationships and collaborate with worldwide actors. The paper will be structured as following: We will start by offering an overview of the state of the art of eBusiness platforms among SME of food and tourism firms and then we discuss the main drawbacks that characterize them. The digital business ecosystem approach and the modularity concept will be described as the theoretical ground in which our proposed integrated model is rooted. Finally, the proposed model along with a discussion of the main value creation potentialities it might create for SMEs will be presented.
Abstract: Currently, most of distance learning courses can only
deliver standard material to students. Students receive course content
passively which leads to the neglect of the goal of education – “to suit
the teaching to the ability of students". Providing appropriate course
content according to students- ability is the main goal of this paper.
Except offering a series of conventional learning services, abundant
information available, and instant message delivery, a complete online
learning environment should be able to distinguish between students-
ability and provide learning courses that best suit their ability.
However, if a distance learning site contains well-designed course
content and design but fails to provide adaptive courses, students will
gradually loss their interests and confidence in learning and result in
ineffective learning or discontinued learning. In this paper, an
intelligent tutoring system is proposed and it consists of several
modules working cooperatively in order to build an adaptive learning
environment for distance education. The operation of the system is
based on the result of Self-Organizing Map (SOM) to divide students
into different groups according to their learning ability and learning
interests and then provide them with suitable course content.
Accordingly, the problem of information overload and internet traffic
problem can be solved because the amount of traffic accessing the
same content is reduced.