Abstract: For the treatment of acute and chronic lung diseases it is preferred to deliver medicaments by inhalation. The drug is delivered directly to tracheobronchial tree. This way allows the given medicament to get directly into the place of action and it makes rapid onset of action and maximum efficiency. The transport of aerosol particles in the particular part of the lung is influenced by their size, anatomy of the lungs, breathing pattern and airway resistance. This article deals with calculation of airway resistance in the lung model of Horsfield. It solves the problem of determination of the pressure losses in bifurcation and thus defines the pressure drop at a given location in the bronchial tree. The obtained data will be used as boundary conditions for transport of aerosol particles in a central part of bronchial tree realized by Computational Fluid Dynamics (CFD) approach. The results obtained from CFD simulation will allow us to provide information on the required particle size and optimal inhalation technique for particle transport into particular part of the lung.
Abstract: Ocimum americanum L (Lamiaceae) is an annual herb
that is native to tropical Africa. The in vitro and in vivo antioxidant
activity of its aqueous extract was carefully investigated by assessing
the DPPH radical scavenging activity, ABTS radical scavenging
activity and hydrogen peroxide radical scavenging activity. The
reducing power, total phenol, total flavonoids and flavonols content
of the extract were also evaluated. The data obtained revealed that the
extract is rich in polyphenolic compounds and scavenged the radicals
in a concentration dependent manner. This was done in comparison
with the standard antioxidants such as BHT and Vitamin C. Also, the
induction of oxidative damage with paracetamol (2000 mg/kg)
resulted in the elevation of lipid peroxides and significant (P < 0.05)
decrease in activities of superoxide dismutase, glutathione
peroxidase, glutathione reductase and catalase in the liver and kidney
of rats. However, the pretreatment of rats with aqueous extract of O.
americanum leaves (200 and 400 mg/kg) and silymarin (100 mg/kg)
caused a significant (P < 0.05) reduction in the values of lipid
peroxides and restored the levels of antioxidant parameters in these
organs. These findings suggest that the leaves of O. americanum have
potent antioxidant properties which may be responsible for its
acclaimed folkloric uses.
Abstract: The emerging Cognitive Radio is combo of both the
technologies i.e. Radio dynamics and software technology. It involve
wireless system with efficient coding, designing, and making them
artificial intelligent to take the decision according to the surrounding
environment and adopt themselves accordingly, so as to deliver the
best QoS. This is the breakthrough from fixed hardware and fixed
utilization of the spectrum. This software-defined approach of
research is centralized at user-definition and application driven
model, various software method are used for the optimization of the
wireless communication. This paper focused on the Spectrum
allocation technique using genetic algorithm GA to evolve radio,
represented by chromosomes. The chromosomes gene represents the
adjustable parameters in given radio and by using GA, evolving over
the generations, the optimized set of parameters are evolved, as per
the requirement of user and availability of the spectrum, in our
prototype the gene consist of 6 different parameters, and the best set
of parameters are evolved according to the application need and
availability of the spectrum holes and thus maintaining best QoS for
user, simultaneously maintaining licensed user rights. The analyzing
tool Matlab is used for the performance of the prototype.
Abstract: In medical imaging, segmentation of different areas of
human body like bones, organs, tissues, etc. is an important issue.
Image segmentation allows isolating the object of interest for further
processing that can lead for example to 3D model reconstruction of
whole organs. Difficulty of this procedure varies from trivial for
bones to quite difficult for organs like liver. The liver is being
considered as one of the most difficult human body organ to segment.
It is mainly for its complexity, shape versatility and proximity of
other organs and tissues. Due to this facts usually substantial user
effort has to be applied to obtain satisfactory results of the image
segmentation. Process of image segmentation then deteriorates from
automatic or semi-automatic to fairly manual one. In this paper,
overview of selected available software applications that can handle
semi-automatic image segmentation with further 3D volume
reconstruction of human liver is presented. The applications are being
evaluated based on the segmentation results of several consecutive
DICOM images covering the abdominal area of the human body.
Abstract: In Brazil, neonatal mortality rate is considered
incompatible with the country development conditions, and has been
a Public Health concern. Reduction in infant mortality rates has also
been part of the Millennium Development Goals, a commitment
made by countries, members of the Organization of United Nations
(OUN), including Brazil. Fetal mortality rate is considered a highly
sensitive indicator of health care quality. Suitable actions, such as
good quality and access to health services may contribute positively
towards reduction in these fetal and neonatal rates. With appropriate
antenatal follow-up and health care during gestation and delivery,
some death causes could be reduced or even prevented by means of
early diagnosis and intervention, as well as changes in risk factors
and interventions. Objectives: To study the quality of maternal and
infant health care based on fetal and neonatal mortality, as well as the
possible actions to prevent those deaths in Botucatu (Brazil).
Methods: Classification of prevention according to the International
Classification of Diseases and the modified Wigglesworth´s
classification. In order to evaluate adequacy, indicators of quality of
antenatal and delivery care were established by the authors. Results:
Considering fetal deaths, 56.7% of them occurred before delivery,
which reveals possible shortcomings in antenatal care, and 38.2% of
them were a result of intra- labor changes, which could be prevented
or reduced by adequate obstetric management. These findings were
different from those in the group of early neonatal deaths which were
also studied. Adequacy of health services showed that antenatal and
childbirth care was appropriate for 24% and 33.3% of pregnant
women, respectively, which corroborates the results of prevention.
These results revealed that shortcomings in obstetric and antenatal
care could be the causes of deaths in the study. Early and late
neonatal deaths have similar characteristics: 76% could be prevented
or reduced mainly by adequate newborn care (52.9%) and adequate
health care for gestational women (11.7%). When adequacy of care
was evaluated, childbirth and newborn care was adequate in 25.8%
and antenatal care was adequate in 16.1%. In conclusion, direct
relationship was found between adequacy and quality of care
rendered to pregnant women and newborns, and fetal and infant
mortality. Moreover, our findings highlight that deaths could be
prevented by an adequate obstetric and neonatal management.
Abstract: Leukaemia is a blood cancer disease that contributes
to the increment of mortality rate in Malaysia each year. There are
two main categories for leukaemia, which are acute and chronic
leukaemia. The production and development of acute leukaemia cells
occurs rapidly and uncontrollable. Therefore, if the identification of
acute leukaemia cells could be done fast and effectively, proper
treatment and medicine could be delivered. Due to the requirement of
prompt and accurate diagnosis of leukaemia, the current study has
proposed unsupervised pixel segmentation based on clustering
algorithm in order to obtain a fully segmented abnormal white blood
cell (blast) in acute leukaemia image. In order to obtain the
segmented blast, the current study proposed three clustering
algorithms which are k-means, fuzzy c-means and moving k-means
algorithms have been applied on the saturation component image.
Then, median filter and seeded region growing area extraction
algorithms have been applied, to smooth the region of segmented
blast and to remove the large unwanted regions from the image,
respectively. Comparisons among the three clustering algorithms are
made in order to measure the performance of each clustering
algorithm on segmenting the blast area. Based on the good sensitivity
value that has been obtained, the results indicate that moving kmeans
clustering algorithm has successfully produced the fully
segmented blast region in acute leukaemia image. Hence, indicating
that the resultant images could be helpful to haematologists for
further analysis of acute leukaemia.
Abstract: Risperidone (RISP) is an antipsychotic agent and has
low water solubility and nontargeted delivery results in numerous
side effects. Hence, an attempt was made to develop SLNs hydrogel
for intranasal delivery of RISP to achieve maximum bioavailability
and reduction of side effects. RISP loaded SLNs composed of 1.65%
(w/v) lipid mass were produced by high shear homogenization (HSH)
coupled ultrasound (US) method using glycerylmonostearate (GMS)
or Imwitor 900K (solid lipid). The particles were loaded with 0.2%
(w/v) of the RISP & surface-tailored with a 2.02% (w/v) non-ionic
surfactant Tween® 80. Optimization was done using 32 factorial
design using Design Expert® software. The prepared SLNs
dispersion incorporated into Polycarbophil AA1 hydrogel (0.5%
w/v). The final gel formulation was evaluated for entrapment
efficiency, particle size, rheological properties, X ray diffraction, in
vitro diffusion, ex vivo permeation using sheep nasal mucosa and
histopathological studies for nasocilliary toxicity. The entrapment
efficiency of optimized SLNs was found to be 76 ± 2%,
polydispersity index
Abstract: Liver disorders are one of the major problems of the
world. Despite its frequent occurrence, high morbidity and high
mortality, its medical management is currently inadequate. This study
was designed to evaluate the hepatoprotective effect of saponin
extract of the root of Garcinia kola on the integrity of the liver of
paracetamol induced wistar albino rats. Twenty five (25) male adult
wistar albino rats were divided into five (5) groups. Group I was the
Control group that received distilled water only, group II was the
negative control that received 2 g/kg of paracetamol on the 13th day,
and group III, IV and V were pre-treated with 100, 200 and
400mg/kg of the saponin extract before inducing the liver damage on
the 13th day with 2 g/kg of paracetamol. Twenty four (24) h after
administration, the rats were sacrificed and blood samples were
collected. The serum Alanine Transaminase (ALT), Aspartate
Transaminase (AST), Alkaline Phosphatase (ALP) activities,
Bilirubin and conjugated bilirubin, glucose and protein
concentrations were evaluated. The liver was fixed immediately in
Formalin and was processed and stained in Haematoxylin and Eosin
(H&E). Administration of saponin extract from the root of Garcinia
kola significantly decreased paracetamol induced elevated enzymes
in the test group. Also histological observations showed that saponin
extract of the root of Garcinia kola exhibited a significant liver
protection against the toxicant as evident by the cells trying to return
to normal. Saponin extract from the root of Garcinia kola indicated a
protection of structural integrity of the hepatocytic cell membrane
and regeneration of the damaged liver.
Abstract: A feeding experiment was conducted to determine the
optimum dietary protein and lipid levels for juvenile fancy carp. Eight
experimental diets were formulated to contain four protein levels (200,
300, 400 and 500 g kg-1) with two lipid levels (70 and 140 g kg-1).
Triplicate groups of fish (initial weight, 12.1±0.2 g fish-1) were
hand-fed the diets to apparent satiation for 8 weeks. Fish growth
performance, feed utilization and feed intake were significantly
(P0.05). Weight gain and feed efficiency ratio tended to
increase as dietary protein level increased up to 400 and 500 g kg-1,
respectively. Daily feed intake of fish decreased with increasing
dietary protein level and that of fish fed diet contained 500 g kg-1
protein was significantly lower than other fish groups. The protein
efficiency ratio of fish fed 400 and 500 g kg-1 protein was lower than
that of fish fed 200 and 300 g kg-1 protein. Moisture, crude protein and
crude lipid contents of muscle and liver were significantly affected by
dietary protein, but not by dietary lipid level (P>0.05). The increase in
dietary lipid level resulted in an increase in linoleic acid in liver and
muscle paralleled with a decrease in n-3 highly unsaturated fatty acids
content in muscle of fish. In considering these results, it was concluded
that the diet containing 400 g kg-1 protein with 70 g kg-1 lipid level is
optimal for growth and efficient feed utilization of juvenile fancy carp.
Abstract: Nowadays, the successful implementation of ICTs is
vital for almost any kind of organization. Good governance and ICT
management are essential for delivering value, managing
technological risks, managing resources and performance
measurement. In addition, outsourcing is a strategic IT service
solution which complements IT services provided internally in
organizations. This paper proposes the measurement tools of a new
holistic maturity model based on standards ISO/IEC 20000 and
ISO/IEC 38500, and the frameworks and best practices of ITIL and
COBIT, with a specific focus on IT outsourcing. These measurement
tools allow independent validation and practical application in the
field of higher education, using a questionnaire, metrics tables, and
continuous improvement plan tables as part of the measurement
process. Guidelines and standards are proposed in the model for
facilitating adaptation to universities and achieving excellence in the
outsourcing of IT services.
Abstract: The purpose of this study was to reduce patient
waiting times, improve system throughput and improve resources
utilization in radiology department. A discrete event simulation
model was developed using Arena simulation software to investigate
different alternatives to improve the overall system delivery based on
adding resource scenarios due to the linkage between patient waiting
times and resource availability. The study revealed that there is no
addition investment need to procure additional scanner but hospital
management deploy managerial tactics to enhance machine
utilization and reduce the long waiting time in the department.
Abstract: Liposome plays an important role in medical and
pharmaceutical science as e.g. nano scale drug carriers. Liposomes
are vesicles of varying size consisting of a spherical lipid bilayer and
an aqueous inner compartment. Magnet-driven liposome used for the
targeted delivery of drugs to organs and tissues. These liposome
preparations contain encapsulated drug components and finely
dispersed magnetic particles.
Liposomes are vesicles of varying size consisting of a spherical
lipid bilayer and an aqueous inner compartment that are generated in
vitro. These are useful in terms of biocompatibility, biodegradability,
and low toxicity, and can control biodistribution by changing the size,
lipid composition, and physical characteristics. Furthermore,
liposomes can entrap both hydrophobic and hydrophilic drugs and are
able to continuously release the entrapped substrate, thus being useful
drug carriers. Magnetic liposomes (MLs) are phospholipid vesicles
that encapsulate magneticor paramagnetic nanoparticles. They are
applied as contrast agents for magnetic resonance imaging (MRI).
The biological synthesis of nanoparticles using plant extracts plays
an important role in the field of nanotechnology. Green-synthesized
magnetite nanoparticles-protein hybrid has been produced by treating
Iron (III) / Iron (II) chloride with the leaf extract of Datura inoxia.
The phytochemicals present in the leaf extracts act as a reducing as
well stabilizing agents preventing agglomeration, which include
flavonoids, phenolic compounds, cardiac glycosides, proteins and
sugars.
The magnetite nanoparticles-protein hybrid has been trapped
inside the aqueous core of the liposome prepared by reversed phase
evaporation (REV) method using oleic and linoleic acid which has
been shown to be driven under magnetic field confirming the
formation magnetic liposome (ML). Chemical characterization of
stealth magnetic liposome has been performed by breaking the
liposome and release of magnetic nanoparticles. The presence iron
has been confirmed by colour complex formation with KSCN and
UV-Vis study using spectrophotometer Cary 60, Agilent.
This magnet driven liposome using nanoparticles-protein hybrid
can be a smart vesicles for the targeted drug delivery.
Abstract: In this paper, we present a robust algorithm to recognize extracted text from grocery product images captured by mobile phone cameras. Recognition of such text is challenging since text in grocery product images varies in its size, orientation,
style, illumination, and can suffer from perspective distortion.
Pre-processing is performed to make the characters scale and
rotation invariant. Since text degradations can not be appropriately
defined using well-known geometric transformations such
as translation, rotation, affine transformation and shearing, we
use the whole character black pixels as our feature vector.
Classification is performed with minimum distance classifier
using the maximum likelihood criterion, which delivers very
promising Character Recognition Rate (CRR) of 89%. We
achieve considerably higher Word Recognition Rate (WRR) of
99% when using lower level linguistic knowledge about product
words during the recognition process.
Abstract: The focal aspire of e-Government (eGovt) is to offer
citizen-centered service delivery. Accordingly, the citizenry
consumes services from multiple government agencies through
national portal. Thus, eGovt is an enterprise with the primary
business motive of transparent, efficient and effective public services
to its citizenry and its logical structure is the eGovernment Enterprise
Architecture (eGEA). Since eGovt is IT oriented multifaceted
service-centric system, EA doesn’t do much on an automated
enterprise other than the business artifacts. Service-Oriented
Architecture (SOA) manifestation led some governments to pertain
this in their eGovts, but it limits the source of business artifacts. The
concurrent use of EA and SOA in eGovt executes interoperability and
integration and leads to Service-Oriented e-Government Enterprise
(SOeGE). Consequently, agile eGovt system becomes a reality. As an
IT perspective eGovt comprises of centralized public service artifacts
with the existing application logics belong to various departments at
central, state and local level. The eGovt is renovating to SOeGE by
apply the Service-Orientation (SO) principles in the entire system.
This paper explores IT perspective of SOeGE in India which
encompasses the public service models and illustrated with a case
study the Passport service of India.
Abstract: Cloud computing has provided the impetus for change
in the demand, sourcing, and consumption of IT-enabled services.
The technology developed from an emerging trend towards a ‘musthave’.
Many organizations harnessed on the quick-wins of cloud
computing within the last five years but nowadays reach a plateau
when it comes to sustainable savings and performance. This study
aims to investigate what is needed from an organizational perspective
to make cloud computing a sustainable success. The study was
carried out in Germany among senior IT professionals, both in
management and delivery positions. Our research shows that IT
executives must be prepared to realign their IT workforce to sustain
the advantage of cloud computing for today and the near future.
While new roles will undoubtedly emerge, roles alone cannot ensure
the success of cloud deployments. What is needed is a change in the
IT workforce’s business behaviour, or put more simply, the ways in
which the IT personnel works. It gives clear guidance on which
dimensions of an employees’ working behaviour need to be adapted.
The practical implications are drawn from a series of semi-structured
interviews, resulting in a high-level workforce enablement plan.
Lastly, it elaborates on tools and gives clear guidance on which
pitfalls might arise along the proposed workforce enablement
process.
Abstract: Logistics distributors face the issue of having to
provide increasing service levels while being forced to reduce costs at
the same time. Same-day delivery, quick order processing and rapidly
growing ranges of articles are only some of the prevailing challenges.
One key aspect of the performance of an intra-logistics system is how
often and in which amplitude congestions and dysfunctions affect the
processing operations. By gaining knowledge of the so called
‘performance availability’ of such a system during the planning stage,
oversizing and wasting can be reduced whereas planning
transparency is increased. State of the art for the determination of this
KPI is simulation studies. However, their structure and therefore their
results may vary unforeseeably. This article proposes a concept for
the establishment of ‘certified’ and hence reliable and comparable
simulation models.
Abstract: This paper aims to represent the commercial activity
of a city taking as source data the social network Foursquare. The
city of Murcia is selected as case study, and the location-based
social network Foursquare is the main source of information. After
carrying out a reorganisation of the user-generated data extracted
from Foursquare, it is possible to graphically display on a map the
various city spaces and venues especially those related to commercial,
food and entertainment sector businesses. The obtained visualisation
provides information about activity patterns in the city of Murcia
according to the people‘s interests and preferences and, moreover,
interesting facts about certain characteristics of the town itself.
Abstract: In oases, the surface water resources are becoming
increasingly scarce and groundwater resources, which generally have
a poor quality due to the high levels of salinity, are often
overexploited. Water saving have therefore become imperative for
better oases sustainability. If drip irrigation is currently recommended
in Morocco for saving water and valuing, its use in the sub-desert
areas does not keep water safe from high evaporation rates. An
alternative to this system would be the use of subsurface drip
irrigation. This technique is defined as an application of water under
the soil surface through drippers, which deliver water at rates
generally similar to surface drip irrigation. As subsurface drip
irrigation is a recently introduced in Morocco, a better understanding
of the infiltration process around a buried source, in local conditions,
and its impact on plant growth is necessarily required. This study
aims to contribute to improving the water use efficiency by testing
the performance of subsurface irrigation system, especially in areas
where water is a limited source. The objectives of this research are
performance evaluation in arid conditions of the subsurface drip
irrigation system for young date palms compared to the surface drip.
In this context, an experimental test is installed at a farmer’s field in
the area of Erfoud (Errachidia Province, southeastern Morocco),
using the subsurface drip irrigation system in comparison with the
classic drip system for young date palms. Flow measurement to
calculate the uniformity of the application of water was done through
two methods: a flow measurement of drippers above the surface and
another one underground. The latter method has also helped us to
estimate losses through evaporation for both irrigation techniques. In
order to compare the effect of two irrigation modes, plants were
identified for each type of irrigation to monitor certain agronomic
parameters (cumulative numbers of palms and roots development).
Experimentation referred to a distribution uniformity of about 88%;
considered acceptable for subsurface drip irrigation while it is around
80% for the surface drip irrigation. The results also show an increase
in root development and in the number of palm, as well as a
substantial water savings due to lower evaporation losses compared
to the classic drip irrigation.
The results of this study showed that subsurface drip irrigation is
an efficient technique, which allows sustainable irrigation in arid
areas.
Abstract: In today’s highly competitive, dynamic and
technology driven business circumstances, marketers are under
steady pressure to deliver the best. Organizations are continuously
improving and upgrading themselves to meet customer expectations
and demands. Technology has not only changed the way in which
business is done in modern times but has also transformed the way to
reach out to target audience. Marketers have identified most recent
media options to communicate and convince potential customers.
Numerous scholars have studied the research domain of advertising
and have tried to recognize different measures of advertisement
effectiveness in context of various media. The objective of this paper
is to critically review accessible literature on advertisement
effectiveness in context of varied advertising media, recognize major
gaps in the literature and identify future research prospects on the
basis of critical analysis of literature.
Abstract: In a highly competitive environment, it becomes more
important to shorten the whole business process while delivering or
even enhancing the business value to the customers and suppliers.
Although the workflow management systems receive much attention
for its capacity to practically support the business process enactment,
the effective workflow modeling method remain still challenging and
the high degree of process complexity makes it more difficult to gain
the short lead time. This paper presents a workflow structuring method
in a holistic way that can reduce the process complexity using
activity-needs and formal concept analysis, which eventually enhances
the key performance such as quality, delivery, and cost in business
process.