Abstract: Various nanomaterials can be used as a drug delivery
vehicles in nanomedicine, called nanocarriers. They can either be
organic or inorganic, synthetic or natural-based. Although synthetic
nanocarriers are easier to produce, they can often be toxic for the
organism and thus not suitable for use in treatment. From naturalbased
nanocarriers, the most commonly used are protein cages or
viral capsids. In this work, virus bacteriophage λ was used for
delivery of different cytotoxic drugs (cisplatin, carboplatin,
oxaliplatin and doxorubicin). Large quantities of phage λ were
obtained from phage λ-producing strain of E. coli cultivated in
medium with 0.2% maltose. After killing of E. coli with chloroform
and its removal by centrifugation, the phage was concentrated by
ultracentrifugation at 130 000×g and 4°C for 3 h. The encapsulation
of the drugs was performed by infusion method and four different
concentrations of the drugs were encapsulated (200; 100; 50; 25
μg·mL-1). Free drug molecules were removed by filtration. The
encapsulation was verified using the absorbance for doxorubicin and
atomic absorption spectrometry for platinum cytostatics. The amount
of encapsulated drug linearly increased with the increasing
concentration of applied drug with the determination coefficient
R2=0.989 for doxorubicin; R2=0.967 for cisplatin; R2=0.989 for
carboplatin and R2=0.996 for oxaliplatin. The overall encapsulation
efficiency was calculated as 50% for doxorubicin; 8% for cisplatin;
6% for carboplatin and 10% for oxaliplatin.
Abstract: The practical efficient approach is suggested for
estimation of the seismoacoustic sources energy in C-OTDR
monitoring systems. This approach is represents the sequential plan
for confidence estimation both the seismoacoustic sources energy, as
well the absorption coefficient of the soil. The sequential plan
delivers the non-asymptotic guaranteed accuracy of obtained
estimates in the form of non-asymptotic confidence regions with
prescribed sizes. These confidence regions are valid for a finite
sample size when the distributions of the observations are unknown.
Thus, suggested estimates are non-asymptotic and nonparametric,
and also these estimates guarantee the prescribed estimation accuracy
in form of prior prescribed size of confidence regions, and prescribed
confidence coefficient value.
Abstract: High Performance Liquid Chromatography (HPLC)
method was developed and validated for simultaneous estimation of
6-Gingerol(6G) and 6-Shogaol(6S) in joint pain relief gel containing
ginger extract. The chromatographic separation was achieved by
using C18 column, 150 x 4.6mm i.d., 5μ Luna, mobile phase
containing acetonitrile and water (gradient elution). The flow rate
was 1.0 ml/min and the absorbance was monitored at 282 nm. The
proposed method was validated in terms of the analytical parameters
such as specificity, accuracy, precision, linearity, range, limit of
detection (LOD), limit of quantification (LOQ), and determined
based on the International Conference on Harmonization (ICH)
guidelines. The linearity ranges of 6G and 6S were obtained over 20-
60 and 6-18 μg/ml respectively. Good linearity was observed over the
above-mentioned range with linear regression equation Y= 11016x-
23778 for 6G and Y = 19276x-19604 for 6S (x is concentration of
analytes in μg/ml and Y is peak area). The value of correlation
coefficient was found to be 0.9994 for both markers. The limit of
detection (LOD) and limit of quantification (LOQ) for 6G were
0.8567 and 2.8555 μg/ml and for 6S were 0.3672 and 1.2238 μg/ml
respectively. The recovery range for 6G and 6S were found to be
91.57 to 102.36 % and 84.73 to 92.85 % for all three spiked levels.
The RSD values from repeated extractions for 6G and 6S were 3.43
and 3.09% respectively. The validation of developed method on
precision, accuracy, specificity, linearity, and range were also
performed with well-accepted results.
Abstract: A solar receiver is designed for operation under
extremely uneven heat flux distribution, cyclic weather, and cloud
transient cycle conditions, which can include large thermal stress and
even receiver failure. In this study, the effect of different oil velocity
on convection coefficient factor and impact of wind velocity on local
Nusselt number by Finite Volume Method will be analyzed. This
study is organized to give an overview of the numerical modeling
using a MATLAB software, as an accurate, time efficient and
economical way of analyzing the heat transfer trends over stationary
receiver tube for different Reynolds number. The results reveal when
oil velocity is below 0.33m/s, the value of convection coefficient is
negligible at low temperature. The numerical graphs indicate that
when oil velocity increases up to 1.2 m/s, heat convection coefficient
increases significantly. In fact, a reduction in oil velocity causes a
reduction in heat conduction through the glass envelope. In addition,
the different local Nusselt number is reduced when the wind blows
toward the concave side of the collector and it has a significant effect
on heat losses reduction through the glass envelope.
Abstract: Magnetic Resonance Imaging (MRI) is one of the
most important medical imaging modality. Subjective assessment of
the image quality is regarded as the gold standard to evaluate MR
images. In this study, a database of 210 MR images which contains
ten reference images and 200 distorted images is presented. The
reference images were distorted with four types of distortions: Rician
Noise, Gaussian White Noise, Gaussian Blur and DCT compression.
The 210 images were assessed by ten subjects. The subjective scores
were presented in Difference Mean Opinion Score (DMOS). The
DMOS values were compared with four FR-IQA metrics. We have
used Pearson Linear Coefficient (PLCC) and Spearman Rank Order
Correlation Coefficient (SROCC) to validate the DMOS values. The
high correlation values of PLCC and SROCC shows that the DMOS
values are close to the objective FR-IQA metrics.
Abstract: Large-scale machine tools for the manufacturing of
large work pieces, e.g. blades, casings or gears for wind turbines,
feature pose-dependent dynamic behavior. Small structural damping
coefficients lead to long decay times for structural vibrations that
have negative impacts on the production process. Typically, these
vibrations are handled by increasing the stiffness of the structure by
adding mass. This is counterproductive to the needs of sustainable
manufacturing as it leads to higher resource consumption both in
material and in energy. Recent research activities have led to higher
resource efficiency by radical mass reduction that is based on controlintegrated
active vibration avoidance and damping methods. These
control methods depend on information describing the dynamic
behavior of the controlled machine tools in order to tune the
avoidance or reduction method parameters according to the current
state of the machine. This paper presents the appearance, consequences and challenges
of the pose-dependent dynamic behavior of lightweight large-scale
machine tool structures in production. It starts with the theoretical
introduction of the challenges of lightweight machine tool structures
resulting from reduced stiffness. The statement of the pose-dependent
dynamic behavior is corroborated by the results of the experimental
modal analysis of a lightweight test structure. Afterwards, the
consequences of the pose-dependent dynamic behavior of lightweight
machine tool structures for the use of active control and vibration
reduction methods are explained. Based on the state of the art of
pose-dependent dynamic machine tool models and the modal
investigation of an FE-model of the lightweight test structure, the
criteria for a pose-dependent model for use in vibration reduction are
derived. The description of the approach for a general posedependent
model of the dynamic behavior of large lightweight
machine tools that provides the necessary input to the aforementioned
vibration avoidance and reduction methods to properly tackle
machine vibrations is the outlook of the paper.
Abstract: Polycyclic Aromatic Hydrocarbons (PAHs) are
formed mainly because of incomplete combustion of organic
materials during industrial, domestic activities or natural occurrence.
Their toxicity and contamination of terrestrial and aquatic ecosystem
have been established. However, with limited validity index, previous
research has focused on PAHs isomer pair ratios of variable
physicochemical properties in source identification. The objective of
this investigation was to determine the empirical validity of Pearson
Correlation Coefficient (PCC) and Cluster Analysis (CA) in PAHs
source identification along soil samples of different land uses.
Therefore, 16 PAHs grouped, as Endocrine Disruption Substances
(EDSs) were determined in 10 sample stations in top and sub soils
seasonally. PAHs was determined the use of Varian 300 gas
chromatograph interfaced with flame ionization detector. Instruments
and reagents used are of standard and chromatographic grades
respectively. PCC and CA results showed that the classification of
PAHs along pyrolitic and petrogenic organics used in source
signature is about the predominance PAHs in environmental matrix.
Therefore, the distribution of PAHs in the studied stations revealed
the presence of trace quantities of the vast majority of the sixteen
PAHs, which may ultimately inhabit the actual source signature
authentication. Therefore, factors to be considered when evaluating
possible sources of PAHs could be; type and extent of bacterial
metabolism, transformation products/substrates, and environmental
factors such as salinity, pH, oxygen concentration, nutrients, light
intensity, temperature, co-substrates, and environmental medium are
hereby recommended as factors to be considered when evaluating
possible sources of PAHs.
Abstract: The purpose of the study was to examine lifelong
education for teachers as a tool for achieving effective teaching and
learning. Lifelong education enhances social inclusion, personal
development, citizenship, employability, teaching and learning,
community and the nation. It is imperative that the teacher needs to
update his knowledge regularly to be able to perform optimally, since
he has a major position in the inculcation of desirable elements in
students, and the challenges of lifelong education were also
discussed. Descriptive survey design was adopted for the study. A
simple random sampling technique was used to select 80 teachers as
sample from a population of 105 senior secondary school teachers in
Makurdi Local Government Area of Benue State. A 20-item self
designed questionnaire subjected to expert validation and reliability
was used to collect data. The reliability Alpha coefficient of 0.87 was
established using Cronbach’s Alpha technique, mean scores and
standard deviation were used to answer the 2 research questions
while chi-square was used to analyse data for the 2 null hypotheses,
which states that lifelong education for teachers is not a significant
tool for achieving effective teaching and lifelong education for
teachers does not significantly impact on effective learning. The
findings of the study revealed that, lifelong education for teachers can
be used as a tool for achieving effective teaching and learning, and
the study recommended among others that government, organizations
and individuals should in collaboration put lifelong education
programmes for teachers on the priority list. The paper concluded
that the strategic position of lifelong education for teachers towards
enhanced teaching, learning and the production of quality manpower
in the society makes it imperative for all hands to be on “deck” to
support the programme financially and otherwise.
Abstract: The objective of the paper is a numerical study of heat
transfer between perforated metal plates and the surrounding air
flows. Different perforation structures can nowadays be found in
various industrial products. Besides improving the mechanical
properties, the perforations can intensify the heat transfer as well. The
heat transfer coefficient depends on a wide range of parameters such
as type of perforation, size, shape, flow properties of the surrounding
air etc. The paper was focused on three different perforation
structures which have been investigated from the point of the view of
the production in the previous studies. To determine the heat
coefficients and the Nusselt numbers, the numerical simulation
approach was adopted. The calculations were performed using the
OpenFOAM software. The three-dimensional, unstable, turbulent and
incompressible air flow around the perforated surface metal plate was
considered.
Abstract: Pure nickel coatings have been successfully
electrodeposited on copper substrates by the pulse plating technique.
The influence of current density, duty cycle and pulse frequency on
the surface morphology, crystal orientation, and microhardness was
determined. It was found that the crystallite size of the deposit
increases with increasing current density and duty cycle. The crystal
orientation progressively changed from a random texture at 1 A/dm2
to (200) texture at 10 A/dm2. Increasing pulse frequency resulted in
increased texture coefficient and peak intensity of (111) reflection.
An increase in duty cycle resulted in considerable increase in texture
coefficient and peak intensity of (311) reflection. Coatings obtained
at high current densities and duty cycle present a mixed morphology
of small and large grains. Maximum microhardness of 193 Hv was
achieved at 4 A/dm2, 10 Hz and duty cycle of 50%. Nickel coatings
with (200) texture are ductile while (111) texture improves the
microhardness of the coatings.
Abstract: Lateral torsional buckling is a global buckling mode
which should be considered in design of slender structural members
under flexure about their strong axis. It is possible to compute the
load which causes lateral torsional buckling of a beam by finite
element analysis, however, closed form equations are needed in
engineering practice for calculation ease which can be obtained by
using energy method. In lateral torsional buckling applications of
energy method, a proper function for the critical lateral torsional
buckling mode should be chosen which can be thought as the
variation of twisting angle along the buckled beam. Accuracy of the
results depends on how close is the chosen function to the exact
mode. Since critical lateral torsional buckling mode of the cantilever
I-beams varies due to material properties, section properties and
loading case, the hardest step is to determine a proper mode function
in application of energy method. This paper presents an approximate function for critical lateral
torsional buckling mode of doubly symmetric cantilever I-beams.
Coefficient matrices are calculated for concentrated load at free end,
uniformly distributed load and constant moment along the beam
cases. Critical lateral torsional buckling modes obtained by presented
function and exact solutions are compared. It is found that the modes
obtained by presented function coincide with differential equation
solutions for considered loading cases.
Abstract: Presently various computational techniques are used
in modeling and analyzing environmental engineering data. In the
present study, an intra-comparison of polynomial and radial basis
kernel functions based on Support Vector Regression and, in turn, an
inter-comparison with Multi Linear Regression has been attempted in
modeling mass transfer capacity of vertical (θ = 90O) and inclined (θ
multiple plunging jets (varying from 1 to 16 numbers). The data set
used in this study consists of four input parameters with a total of
eighty eight cases, forty four each for vertical and inclined multiple
plunging jets. For testing, tenfold cross validation was used.
Correlation coefficient values of 0.971 and 0.981 along with
corresponding root mean square error values of 0.0025 and 0.0020
were achieved by using polynomial and radial basis kernel functions
based Support Vector Regression respectively. An intra-comparison
suggests improved performance by radial basis function in
comparison to polynomial kernel based Support Vector Regression.
Further, an inter-comparison with Multi Linear Regression
(correlation coefficient = 0.973 and root mean square error = 0.0024)
reveals that radial basis kernel functions based Support Vector
Regression performs better in modeling and estimating mass transfer
by multiple plunging jets.
Abstract: Adequate and reliable estimates of aquifer parameters
are of utmost importance for proper management of vital
groundwater resources. At present scenario, the ground water is
polluted because of industrial waste disposed over the land and the
contaminants are transported in the aquifer from one area to another
area, which is depending on the characteristics of the aquifer and
contaminants. To know the contaminant transport, the accurate
estimation of aquifer properties is highly needed. Conventionally,
these properties are estimated through pumping tests carried out on
water wells. The occurrence and movement of ground water in the
aquifer are characteristically defined by the aquifer parameters. The
pumping (aquifer) test is the standard technique for estimating
various hydraulic properties of aquifer systems, viz., transmissivity
(T), hydraulic conductivity (K), storage coefficient (S) etc., for which
the graphical method is widely used. The study area for conducting
pumping test is Pydibheemavaram Industrial area near the coastal
belt of Srikulam, AP, India. The main objective of the present work is
to estimate the aquifer properties for developing contaminant
transport model for the study area.
Abstract: Exact solution of an unsteady MHD flow of elasticoviscous
fluid through a porous media in a tube of elliptic cross
section under the influence of magnetic field and constant pressure
gradient has been obtained in this paper. Initially, the flow is
generated by a constant pressure gradient. After attaining the steady
state, the pressure gradient is suddenly withdrawn and the resulting
fluid motion in a tube of elliptical cross section by taking into
account of the porosity factor and magnetic parameter of the
bounding surface is investigated. The problem is solved in two-stages
the first stage is a steady motion in tube under the influence of a
constant pressure gradient, the second stage concern with an unsteady
motion. The problem is solved employing separation of variables
technique. The results are expressed in terms of a non-dimensional
porosity parameter, magnetic parameter and elastico-viscosity
parameter, which depends on the Non-Newtonian coefficient. The
flow parameters are found to be identical with that of Newtonian case
as elastic-viscosity parameter, magnetic parameter tends to zero, and
porosity tends to infinity. The numerical results were simulated in
MATLAB software to analyze the effect of Elastico-viscous
parameter, porosity parameter, and magnetic parameter on velocity
profile. Boundary conditions were satisfied. It is seen that the effect
of elastico-viscosity parameter, porosity parameter and magnetic
parameter of the bounding surface has significant effect on the
velocity parameter.
Abstract: In this paper, the results of Kano from one dimensional
cosine and sine series are extended to two dimensional cosine and sine
series. To extend these results, some classes of coefficient sequences
such as class of semi convexity and class R are extended from
one dimension to two dimensions. Further, the function f(x, y) is
two dimensional Fourier Cosine and Sine series or equivalently it
represents an integrable function or not, has been studied. Moreover,
some results are obtained which are generalization of Moricz’s
results.
Abstract: This study, tries to suggest a design method based on
displacement using finite difference numerical modeling in
reinforcing soil retaining wall with steel strip. In this case, dynamic
loading characteristics such as duration, frequency, peak ground
acceleration, geometrical characteristics of reinforced soil structure
and type of the site are considered to correct the pseudo static method
and finally introduce the pseudo static coefficient as a function of
seismic performance level and peak ground acceleration. For this
purpose, the influence of dynamic loading characteristics,
reinforcement length, height of reinforced system and type of the site
are investigated on seismic behavior of reinforcing soil retaining wall
with steel strip. Numerical results illustrate that the seismic response
of this type of wall is highly dependent to cumulative absolute
velocity, maximum acceleration, and height and reinforcement length
so that the reinforcement length can be introduced as the main factor
in shape of failure. Considering the loading parameters, geometric parameters of the
wall and type of the site showed that the used method in this study
leads to efficient designs in comparison with other methods, which
are usually based on limit-equilibrium concept. The outputs show the
over-estimation of equilibrium design methods in comparison with
proposed displacement based methods here.
Abstract: The need to save time and cost of soil testing at the
planning stage of road work has necessitated developing predictive
models. This study proposes a model for predicting the dry density of
lateritic soils stabilized with corn cob ash (CCA) and blended cement
- CCA. Lateritic soil was first stabilized with CCA at 1.5, 3.0, 4.5 and
6% of the weight of soil and then stabilized with the same
proportions as replacement for cement. Dry density, specific gravity,
maximum degree of saturation and moisture content were determined
for each stabilized soil specimen, following standard procedure.
Polynomial equations containing alpha and beta parameters for CCA
and blended CCA-cement were developed. Experimental values were
correlated with the values predicted from the Matlab curve fitting
tool, and the Solver function of Microsoft Excel 2010. The correlation
coefficient (R2) of 0.86 was obtained indicating that the model could
be accepted in predicting the maximum dry density of CCA stabilized
soils to facilitate quick decision making in roadworks.
Abstract: This article presents the main results of a numerical
investigation on the uncertainty of dynamic response of structures
with statistically correlated random damping Gamma distributed. A
computational method based on a Linear Statistical Model (LSM) is
implemented to predict second order statistics for the response of a
typical industrial building structure. The significance of random
damping with correlated parameters and its implications on the
sensitivity of structural peak response in the neighborhood of a
resonant frequency are discussed in light of considerable ranges of
damping uncertainties and correlation coefficients. The results are
compared to those generated using Monte Carlo simulation
techniques. The numerical results obtained show the importance of
damping uncertainty and statistical correlation of damping
coefficients when obtaining accurate probabilistic estimates of
dynamic response of structures. Furthermore, the effectiveness of the
LSM model to efficiently predict uncertainty propagation for
structural dynamic problems with correlated damping parameters is
demonstrated.
Abstract: Rice Husk (RH) is the major byproduct in the
processing of paddy rice. The management of this waste has become
a big challenge to some of the rice producers, some of these wastes
are left in open dumps while some are burn in the open space, and
these two actions have been contributing to environmental pollution.
This study evaluates an alternative waste management of this
agricultural product for use as a civil engineering material. The RH
was burn in a controlled environment to form Rice Husk Ash (RHA).
The RHA was mix with lateritic clay at 0, 2, 4, 6, 8, and 10%
proportion by weight. Chemical test was conducted on the open burn
and controlled burn RHA with the lateritic clay. Physical test such as
particle size distribution, Atterberg limits test, and density test were
carried out on the mix material. The chemical composition obtained
for the RHA showed that the total percentage compositions of Fe2O3,
SiO2 and Al2O3 were found to be above 70% (class “F” pozzolan)
which qualifies it as a very good pozzolan. The coefficient of
uniformity (Cu) was 8 and coefficient of curvature (Cc) was 2 for the
soil sample. The Plasticity Index (PI) for the 0, 2, 4, 6, 8. 10% was
21.0, 18.8, 16.7, 14.4, 12.4 and 10.7 respectively. The work
concluded that RHA can be effectively used in hydraulic barriers and
as a stabilizing agent in soil stabilization.
Abstract: This article presents an alternative collapse capacity
intensity measure in the three elements form which is influenced by
the spectral ordinates at periods longer than that of the first mode
period at near and far source sites. A parameter, denoted by β, is
defined by which the spectral ordinate effects, up to the effective
period (2T1), on the intensity measure are taken into account. The
methodology permits to meet the hazard-levelled target extreme
event in the probabilistic and deterministic forms. A MATLAB code
is developed involving OpenSees to calculate the collapse capacities
of the 8 archetype RC structures having 2 to 20 stories for regression
process. The incremental dynamic analysis (IDA) method is used to
calculate the structure’s collapse values accounting for the element
stiffness and strength deterioration. The general near field set
presented by FEMA is used in a series of performing nonlinear
analyses. 8 linear relationships are developed for the 8structutres
leading to the correlation coefficient up to 0.93. A collapse capacity
near field prediction equation is developed taking into account the
results of regression processes obtained from the 8 structures. The
proposed prediction equation is validated against a set of actual near
field records leading to a good agreement. Implementation of the
proposed equation to the four archetype RC structures demonstrated
different collapse capacities at near field site compared to those of
FEMA. The reasons of differences are believed to be due to
accounting for the spectral shape effects.