Abstract: This study presents a mathematical modeling approach to the planning of HIV therapies on an individual basis. The model replicates clinical data from typical-progressors to AIDS for all stages of the disease with good agreement. Clinical data from rapid-progressors and long-term non-progressors is also matched by estimation of immune system parameters only. The ability of the model to reproduce these phenomena validates the formulation, a fact which is exploited in the investigation of effective therapies. The therapy investigation suggests that, unlike continuous therapy, structured treatment interruptions (STIs) are able to control the increase in both the drug-sensitive and drug-resistant virus population and, hence, prevent the ultimate progression from HIV to AIDS. The optimization results further suggest that even patients characterised by the same progression type can respond very differently to the same treatment and that the latter should be designed on a case-by-case basis. Such a methodology is presented here.
Abstract: This study examined the effects of eight weeks of
whole-body vibration training (WBVT) on vertical and decuple jump
performance in handball athletes. Sixteen collegiate Level I handball
athletes volunteered for this study. They were divided equally as
control group and experimental group (EG). During the period of the
study, all athletes underwent the same handball specific training, but
the EG received additional WBVT (amplitude: 2 mm, frequency: 20 -
40 Hz) three time per week for eight consecutive weeks. The vertical
jump performance was evaluated according to the maximum height of
squat jump (SJ) and countermovement jump (CMJ). Single factor
ANCOVA was used to examine the differences in each parameter
between the groups after training with the pretest values as a covariate.
The statistic significance was set at p < .05. After 8 weeks WBVT, the
EG had significantly improved the maximal height of SJ (40.92 ± 2.96
cm vs. 48.40 ± 4.70 cm, F = 5.14, p < .05) and the maximal height
CMJ (47.25 ± 7.48 cm vs. 52.20 ± 6.25 cm, F = 5.31, p < .05). 8 weeks
of additional WBVT could improve the vertical and decuple jump
performance in handball athletes. Enhanced motor unit
synchronization and firing rates, facilitated muscular contraction
stretch-shortening cycle, and improved lower extremity
neuromuscular coordination could account for these enhancements.
Abstract: The removal of hydrogen sulphide is required for reasons of health, odour problems, safety and corrosivity problems. The means of removing hydrogen sulphide mainly depend on its concentration and kind of medium to be purified. The paper deals with a method of hydrogen sulphide removal from the air by its catalytic oxidation to elemental sulphur with the use of Fe-EDTA complex. The possibility of obtaining fibrous filtering materials able to remove small concentrations of H2S from the air were described. The base of these materials is fibrous ion exchanger with Fe(III)- EDTA complex immobilized on their functional groups. The complex of trivalent iron converts hydrogen sulphide to elemental sulphur. Bivalent iron formed in the reaction is oxidized by the atmospheric oxygen, so complex of trivalent iron is continuously regenerated and the overall process can be accounted as pseudocatalytic. In the present paper properties of several fibrous catalysts based on ion exchangers with different chemical nature (weak acid,weak base and strong base) were described. It was shown that the main parameters affecting the process of catalytic oxidation are:concentration of hydrogen sulphide in the air, relative humidity of the purified air, the process time and the content of Fe-EDTA complex in the fibres. The data presented show that the filtering layers with anion exchange package are much more active in the catalytic processes of hydrogen sulphide removal than cation exchanger and inert materials. In the addition to the nature of the fibres relative air humidity is a critical factor determining efficiency of the material in the air purification from H2S. It was proved that the most promising carrier of the Fe-EDTA catalyst for hydrogen sulphide oxidation are Fiban A-6 and Fiban AK-22 fibres.
Abstract: In this paper, a PSO-based approach is proposed to
derive a digital controller for redesigned digital systems having an interval plant based on resemblance of the extremal gain/phase
margins. By combining the interval plant and a controller as an interval system, extremal GM/PM associated with the loop transfer function
can be obtained. The design problem is then formulated as an optimization problem of an aggregated error function revealing the deviation on the extremal GM/PM between the redesigned digital
system and its continuous counterpart, and subsequently optimized by
a proposed PSO to obtain an optimal set of parameters for the digital controller. Computer simulations have shown that frequency
responses of the redesigned digital system having an interval plant bare a better resemblance to its continuous-time counter part by the incorporation of a PSO-derived digital controller in comparison to those obtained using existing open-loop discretization methods.
Abstract: Increasing energy absorption is a significant parameter
in vehicle design. Absorbing more energy results in decreasing
occupant damage. Limitation of the deflection in a side impact results
in decreased energy absorption (SEA) and increased peak load (PL).
Hence a high crash force jeopardizes passenger safety and vehicle
integrity. The aims of this paper are to determine suitable dimensions
and material of a square beam subjected to side impact, in order to
maximize SEA and minimize PL. To achieve this novel goal, the
geometric parameters of a square beam are optimized using the
response surface method (RSM).multi-objective optimization is
performed, and the optimum design for different response features is
obtained.
Abstract: Power Spectral Density (PSD) of quasi-stationary processes can be efficiently estimated using the short time Fourier series (STFT). In this paper, an algorithm has been proposed that computes the PSD of quasi-stationary process efficiently using offline autoregressive model order estimation algorithm, recursive parameter estimation technique and modified sliding window discrete Fourier Transform algorithm. The main difference in this algorithm and STFT is that the sliding window (SW) and window for spectral estimation (WSA) are separately defined. WSA is updated and its PSD is computed only when change in statistics is detected in the SW. The computational complexity of the proposed algorithm is found to be lesser than that for standard STFT technique.
Abstract: The purpose of the study is to determine the primary mathematics student teachers- views related to use instructional technology tools in course of the learning process and to reveal how the sample presentations towards different mathematical concepts affect their views. This is a qualitative study involving twelve mathematics students from a public university. The data gathered from two semi-structural interviews. The first one was realized in the beginning of the study. After that the representations prepared by the researchers were showed to the participants. These representations contain animations, Geometer-s Sketchpad activities, video-clips, spreadsheets, and power-point presentations. The last interview was realized at the end of these representations. The data from the interviews and content analyses were transcribed and read and reread to explore the major themes. Findings revealed that the views of the students changed in this process and they believed that the instructional technology tools should be used in their classroom.
Abstract: NFκB is a transcription factor regulating many
function of the vessel wall. In the normal condition , NFκB is
revealed diffuse cytoplasmic expressionsuggesting that the system is
inactive. The presence of activation NFκB provide a potential
pathway for the rapid transcriptional of a variety of genes encoding
cytokines, growth factors, adhesion molecules and procoagulatory
factors. It is likely to play an important role in chronic inflamatory
disease involved atherosclerosis. There are many stimuli with the
potential to active NFκB, including hyperlipidemia. We used 24 mice
which was divided in 6 groups. The HFD given by et libitum
procedure during 2, 4, and 6 months. The parameters in this study
were the amount of NFKB activation ,H2O2 as ROS and VCAM-1 as
a product of NFKB activation. H2O2 colorimetryc assay performed
directly using Anti Rat H2O2 ELISA Kit. The NFKB and VCAM-1
detection obtained from aorta mice, measured by ELISA kit and
imunohistochemistry. There was a significant difference activation of
H2O2, NFKB and VCAM-1 level at induce HFD after 2, 4 and 6
months. It suggest that HFD induce ROS formation and increase the
activation of NFKB as one of atherosclerosis marker that caused by
hyperlipidemia as classical atheroschlerosis risk factor.
Abstract: This study was conducted to evaluate factors
regulating groundwater quality in an area with agriculture as main
use. Under this study twelve groundwater samples have been
collected from Padra taluka, Dabhoi taluka and Savli taluka of
Vadodara district. Groundwater samples were chemically analyzed
for major physicochemical parameter in order to understand the
different geochemical processes affecting the groundwater quality.
The analytical results shows higher concentration of total dissolved
solids (16.67%), electrical conductivity (25%) and magnesium
(8.33%) for pre monsoon and total dissolved solids (16.67%),
electrical conductivity (33.3%) and magnesium (8.33%) for post
monsoon which indicates signs of deterioration as per WHO and BIS
standards. On the other hand, 50% groundwater sample is unsuitable
for irrigation purposes based on irrigation quality parameters. The
study revealed that application of fertilizer for agricultural
contributing the higher concentration of ions in aquifer of Vadodara
district.
Abstract: The wide increase and diffusion on telecommunication
technologies have caused a huge spread of electromagnetic sources
in most European Countries. Since the public is continuously being
exposed to electromagnetic radiation the possible health effects have
become the focus of population concerns. As a result, electromagnetic
field monitoring stations which control field strength in commercial
frequency bands are being placed on the flat roof of many buildings.
However there is no guidance on where to place them. This paper
presents an analysis of frequency, polarization and angles of incidence
of a plane wave which impinges on a flat roof security wall and its
dependence on electromagnetic field strength meters placement.
Abstract: Dual phase steels (DPS)s have a microstructure
consisting of a hard second phase called Martensite in the soft Ferrite
matrix. In recent years, there has been interest in dual-phase steels,
because the application of these materials has made significant usage;
particularly in the automotive sector Composite microstructure of
(DPS)s exhibit interesting characteristic mechanical properties such
as continuous yielding, low yield stress to tensile strength
ratios(YS/UTS), and relatively high formability; which offer
advantages compared with conventional high strength low alloy
steels(HSLAS). The research dealt with the characterization of
damage in (DPS)s. In this study by review the mechanisms of failure
due to volume fraction of martensite second phase; a new method is
introduced to identifying the mechanisms of failure in the various
phases of these types of steels. In this method the acoustic emission
(AE) technique was used to detect damage progression. These failure
mechanisms consist of Ferrite-Martensite interface decohesion and/or
martensite phase fracture. For this aim, dual phase steels with
different volume fraction of martensite second phase has provided by
various heat treatment methods on a low carbon steel (0.1% C), and
then AE monitoring is used during tensile test of these DPSs. From
AE measurements and an energy ratio curve elaborated from the
value of AE energy (it was obtained as the ratio between the strain
energy to the acoustic energy), that allows detecting important
events, corresponding to the sudden drops. These AE signals events
associated with various failure mechanisms are classified for ferrite
and (DPS)s with various amount of Vm and different martensite
morphology. It is found that AE energy increase with increasing Vm.
This increasing of AE energy is because of more contribution of
martensite fracture in the failure of samples with higher Vm. Final
results show a good relationship between the AE signals and the
mechanisms of failure.
Abstract: Injection forging is a Nett-shape manufacturing
process in which one or two punches move axially causing a radial
flow into a die cavity in a form which is prescribed by the exitgeometry,
such as pulley, flanges, gears and splines on a shaft. This
paper presents an experimental and numerical study of the injection
forging of splines in terms of load requirement and material flow.
Three dimensional finite element analyses are used to investigate the
effect of some important parameters in this process. The experiment
has been carried out using solid commercial lead billets with two
different billet diameters and four different dies.
Abstract: The purpose of this work is measurement of the
system presampling MTF of a variable resolution x-ray (VRX) CT
scanner. In this paper, we used the parameters of an actual VRX CT
scanner for simulation and study of effect of different focal spot sizes
on system presampling MTF by Monte Carlo method (GATE
simulation software). Focal spot size of 0.6 mm limited the spatial
resolution of the system to 5.5 cy/mm at incident angles of below 17º
for cell#1. By focal spot size of 0.3 mm the spatial resolution
increased up to 11 cy/mm and the limiting effect of focal spot size
appeared at incident angles of below 9º. The focal spot size of 0.3
mm could improve the spatial resolution to some extent but because
of magnification non-uniformity, there is a 10 cy/mm difference
between spatial resolution of cell#1 and cell#256. The focal spot size
of 0.1 mm acted as an ideal point source for this system. The spatial
resolution increased to more than 35 cy/mm and at all incident angles
the spatial resolution was a function of incident angle. By the way
focal spot size of 0.1 mm minimized the effect of magnification nonuniformity.
Abstract: The dental composites are preferably used as filling
materials due to their esthetic appearances. Nevertheless one of the
major problems, during the application of the dental composites, is
shape change named as “polymerisation shrinkage" affecting clinical
success of the dental restoration while photo-polymerisation.
Polymerisation shrinkage of composites arises basically from the
formation of a polymer due to the monomer transformation which
composes of an organic matrix phase. It was sought, throughout this
study, to detect and evaluate the structural polymerisation shrinkage
of prepared dental composites in order to optimize the effects of
various fillers included in hydroxyapatite (HA)-reinforced dental
composites and hence to find a means to modify the properties of
these dental composites prepared with defined parameters. As a
result, the shrinkage values of the experimental dental composites
were decreased by increasing the filler content of composites and the
composition of different fillers used had effect on the shrinkage of
the prepared composite systems.
Abstract: For the efficient and safe use of the cable-stayed
bridge, a design based on the detailed local analysis of the cable anchor
system is required. Also, a theoretical design process for the anchor
system should be prepared and reviewed. Generally, the size of the
fixing pipe in the anchor system is decided according to the
specifications prepared by cable-manufacturing companies, and
accordingly, there is difficulty determining the initial inner diameters
of the fixing pipes. As such, there is no choice but to use the products
with the existing sizes. In this study, the existing design process of the
fixing pipe, is a type of guide pipe anchor in the cable anchor system,
is reviewed, a formula determining the thickness of the fixing pipe is
proposed, and the convenience and validity of the suggested equation
is compared with the results of the existing designs to verify its
convenience and validity.
Abstract: Nowadays, butyl acetate, a pineapple flavor has been applied widely in food, beverage, cosmetic and pharmaceutical industries. In this study, Butyl acetate, a flavor ester was successfully synthesized via green synthesis of enzymatic reaction route. Commercial immobilized lipase from Rhizomucor miehei (Lipozyme RMIM) was used as biocatalyst in the esterification reaction between acetic acid and butanol. Various reaction parameters such as reaction time (RT), temperature (T) and amount of enzyme (E) were chosen to optimize the reaction synthesis in solvent-free system. The optimum condition to produce butyl acetate was at reaction time (RT), 18 hours; temperature (T), 37°C and amount of enzyme, 25 % (w/w of total substrate). Analysis of yield showed that at optimum condition, >78 % of butyl acetate was produced. The product was confirmed as butyl acetate from FTIR analysis whereby the presence of an ester group was observed at wavenumber of 1742 cm-1.
Abstract: The new technology of fuzzy neural networks for identification of parameters for mathematical models of geofields is proposed and checked. The effectiveness of that soft computing technology is demonstrated, especially in the early stage of modeling, when the information is uncertain and limited.
Abstract: Water leakage is a serious problem in the maintenance of a waterworks facility. Monitoring the water flow rate is one way to locate leakage. However, conventional flowmeters such as the wet-type flowmeter and the clamp-on type ultrasonic flowmeter require additional construction for their installation and are therefore quite expensive. This paper proposes a novel estimation system for the flow rate in a water pipeline, which employs a vibration sensor. This assembly can be attached to any water pipeline without the need for additional high-cost construction. The vibration sensor is designed based on a condenser microphone. This sensor detects vibration caused by water flowing through a pipeline. It is possible to estimate the water flow rate by measuring the amplitude of the output signal from the vibration sensor. We confirmed the validity of the proposed sensing system experimentally.
Abstract: The modeling of inelastic behavior of plastic materials requires measurements providing information on material response to different multiaxial loading conditions. Different triaxiality conditions and values of Lode parameters have to be
covered for complex description of the material plastic behavior.
Samples geometries providing material plastic behavoiur over the range of interest are proposed with the use of FEM analysis. Round samples with 3 different notches and smooth surface are used
together with butterfly type of samples tested at angle ranging for 0 to
90°. Identification of ductile damage parameters is carried out on
the basis of obtained experimental data for austenitic stainless steel.
The obtained material plastic damage parameters are subsequently applied to FEM simulation of notched CT normally samples used for
fracture mechanics testing and results from the simulation are
compared with real tests.
Abstract: In order to alleviate the mental and physical problems
of persons with disabilities, animal-assisted therapy (AAT) is one of
the possible modalities that employs the merit of the human-animal
interaction. Nevertheless, to achieve the purpose of AAT for persons
with severe disabilities (e.g. spinal cord injury, stroke, and
amyotrophic lateral sclerosis), real-time animal language
interpretation is desirable. Since canine behaviors can be visually
notable from its tail, this paper proposes the automatic real-time
interpretation of canine tail language for human-canine interaction in
the case of persons with severe disabilities. Canine tail language is
captured via two 3-axis accelerometers. Directions and frequencies
are selected as our features of interests. The novel fuzzy rules based
on Gaussian-Trapezoidal model and center of gravity (COG)-based
defuzzification method are proposed in order to interpret the features
into four canine emotional behaviors, i.e., agitate, happy, scare and
neutral as well as its blended emotional behaviors. The emotional
behavior model is performed in the simulated dog and has also been
evaluated in the real dog with the perfect recognition rate.