Abstract: To ensure targeting of apoferritin nanocarrier with
encapsulated doxorubicin drug, we used a peptide linker based on a
protein G with N-terminus affinity towards Fc region of antibodies.
To connect the peptide to the surface of apoferritin, the C-terminus of
peptide was made of cysteine with affinity to gold. The surface of
apoferritin with encapsulated doxorubicin (APODOX) was coated
either with gold nanoparticles (APODOX-Nano) or gold(III) chloride
hydrate reduced with sodium borohydride (APODOX-HAu). The
reduction with sodium borohydride caused a loss of doxorubicin
fluorescent properties and probably accompanied with the loss of its
biological activity. Fluorescent properties of APODOX-Nano were
similar to the unmodified APODOX; therefore it was more suited for
the intended use. To evaluate the specificity of apoferritin modified
with antibodies, ELISA-like method was used with the surface of
microtitration plate wells coated by the antigen (goat anti-human IgG
antibodies). To these wells, the nanocarrier was applied. APODOX
without the modification showed 5× lower affinity to the antigen than
APODOX-Nano modified gold and targeting antibodies (human IgG
antibodies).
Abstract: Current research is targeting new molecular
mechanisms that underlie non-alcoholic fatty liver disease (NAFLD)
and associated metabolic disorders like non-alcoholic steatohepatitis
(NASH). Forty New Zealand White rabbits have been used and fed a
high protein (HP) and energy diet based on grains and containing
11.76 MJ/kg. Boron added to 3 experimental groups’ drinking waters
(30 mg boron/L) as boron compounds. Biochemical analysis
including boron levels, and nuclear magnetic resonance (NMR) based
metabolomics evaluation, and mRNA expression of peroxisome
proliferator-activated receptor (PPAR) family was performed. LDLcholesterol
concentrations alone were decreased in all the
experimental groups. Boron levels in serum and feces were increased.
Content of acetate was in about 2x higher for anhydrous borax group,
at least 3x higher for boric acid group. PPARα mRNA expression
was significantly decreased in boric acid group. Anhydrous borax
attenuated mRNA levels of PPARγ, which was further suppressed by
boric acid. Boron supplementation decreased the degenerative
alterations in hepatocytes. Except borax group other boron groups did
not have a pronounced change in tubular epithels of kidney. In
conclusion, high protein and energy diet leads hepatocytes’
degenerative changes which can be prevented by boron
supplementation. Boric acid seems to be more effective in this
situation.
Abstract: The popularity of quality management system models
continues to grow despite the transitional crisis in 2008. Their
development is associated with demands of the new requirements for
entrepreneurs, such as risk analysis projects and more emphasis on
supervision of outsourced processes. In parallel, it is appropriate to
focus attention on the selection of companies aspiring to a quality
management system. This is particularly important in the automotive
supplier industry, where requirements transferred to the levels in the
supply chain should be clear, transparent and fairly satisfied. The
author has carried out a series of researches aimed at finding the
factors that allow for the effective implementation of the quality
management system in automotive companies. The research was
focused on four groups of companies: 1) manufacturing (parts and
assemblies for the purpose of sale or for vehicle manufacturers), 2)
service (repair and maintenance of the car) 3) services for the
transport of goods or people, 4) commercial (auto parts and vehicles).
The identified determinants were divided into two types of criteria:
internal and external, as well as hard and soft. The article presents the
hard – technical factors that an automotive company must meet in
order to achieve the goal of the quality management system
implementation.
Abstract: This paper discusses the forensic investigation of a
fatality-involved catastrophic structure collapse and the special
challenges faced when tasked with directing such an effort. While
this paper discusses the investigation’s findings and the outcome of
the event; this paper’s primary focus is on the challenges faced
directing a forensic investigation that requires coordinating with
governmental oversight while also having to accommodate multiple
parties’ investigative teams. In particular the challenges discussed
within this paper included maintaining on-site safety and operations
while accommodating outside investigator’s interests. In addition this
paper discusses unique challenges that one may face such as what to
do about unethical conduct of interested party’s investigative teams,
“off the record” sharing of information, and clandestinely transmitted
evidence.
Abstract: This paper pioneers Care Robot Impact Assessment
(CRIA), a methodology used to identify, analyze, mitigate and
eliminate the risks posed by the insertion of non-medical personal
care robots (PCR) in medical care facilities. Its precedent instruments
[Privacy and Surveillance Impact Assessment (PIA and SIA)] fall
behind in coping with robots. Indeed, personal care robots change
dramatically how care is delivered. The paper presents a specific
risk-sector methodology, identifies which robots are under its scope
and presents some of the challenges introduced by these robots.
Abstract: Paranoid ideation is a common thought process that
constitutes a defense against perceived social threats. The current
study aimed at the characterization of paranoid ideation in youths and
to explore the possible predictors involved in the development of
paranoid ideations. Paranoid ideation, shame, submission, early
childhood memories and current depressive, anxious and stress
symptomatology were assessed in a sample of 1516 Portuguese
youths. Higher frequencies of paranoid ideation were observed,
particularly in females and youths from lower socioeconomic status.
The main predictors identified relates to submissive behaviors and
adverse childhood experiences, and especially to shame feelings. The
current study emphasizes that the these predictors are similar to
findings in adults and clinical populations, and future implications to
research and clinical practice aiming at paranoid ideations are
discussed, as well as the pertinence of the study of mediating factors
that allow a wider understanding of this thought process in younger
populations and the prevention of psychopathology in adulthood.
Abstract: For the music composer Myriam Marbe the musical
time and memory represent 2 (complementary) phenomena with
conclusive impact on the settlement of new musical ontologies.
Summarizing the most important achievements of the contemporary
techniques of composition, her vision on the microform presented in
The Concert for Daniel Kientzy, saxophone and orchestra transcends
the linear and unidirectional time in favour of a flexible, multivectorial
speech with spiral developments, where the sound substance
is auto(re)generated by analogy with the fundamental processes of
the memory. The conceptual model is of an archetypal essence, the
music composer being concerned with identifying the mechanisms of
the creation process, especially of those specific to the collective
creation (of oral tradition). Hence the spontaneity of expression,
improvisation tint, free rhythm, micro-interval intonation, coloristictimbral
universe dominated by multiphonics and unique sound
effects, hence the atmosphere of ritual, however purged by the
primary connotations and reprojected into a wonderful spectacular
space. The Concert is a work of artistic maturity and enforces respect,
among others, by the timbral diversity of the three species of
saxophone required by the music composer (baritone, sopranino and
alt), in Part III Daniel Kientzy shows the performance of playing two
saxophones concomitantly. The score of the music composer Myriam
Marbe contains a deeply spiritualized music, full or archetypal
symbols, a music whose drama suggests a real cinematographic
movement.
Abstract: We present a gas-liquid microfluidic system as a
reactor to obtain magnetite nanoparticles with an excellent degree of
control regarding their crystalline phase, shape and size. Several
types of microflow approaches were selected to prevent nanomaterial
aggregation and to promote homogenous size distribution. The
selected reactor consists of a mixer stage aided by ultrasound waves
and a reaction stage using a N2-liquid segmented flow to prevent
magnetite oxidation to non-magnetic phases. A milli-fluidic reactor
was developed to increase the production rate where a magnetite
throughput close to 450 mg/h in a continuous fashion was obtained.
Abstract: The paper presents a novel screening method to
indicate congenital heart diseases (CHD), which otherwise could
remain undetected because of their low level. Therefore, not
belonging to the high-risk population, the pregnancies are not subject
to the regular fetal monitoring with ultrasound echocardiography.
Based on the fact that CHD is a morphological defect of the heart
causing turbulent blood flow, the turbulence appears as a murmur,
which can be detected by fetal phonocardiography (fPCG). The
proposed method applies measurements on the maternal abdomen
and from the recorded sound signal a sophisticated processing
determines the fetal heart murmur. The paper describes the problems
and the additional advantages of the fPCG method including the
possibility of measurements at home and its combination with the
prescribed regular cardiotocographic (CTG) monitoring. The
proposed screening process implemented on a telemedicine system
provides an enhanced safety against hidden cardiac diseases.
Abstract: Five palm oil ether monoesters utilized as novel
biodiesels were synthesized and structurally identified in the paper.
The investigation was made on the effect of ether species on
physicochemical properties of the palm oil ether monoesters. The
results showed that density, kinematic viscosity, smoke point, and
solidifying point increase linearly with their –CH2 group number in
certain relationships. Cetane number is enhanced whereas heat value
decreases linearly with –CH2 group number. In addition, the
influencing regularities of the volumetric content of the palm oil ether
monoesters on the fuel properties were also studied when the ether
monoesters are used as diesel fuel additives.
Abstract: Toddy sediment (TS) was cultured in a PDA medium
to determine initial yeast load, and also it was undergone sun, shade,
solar, dehumidified cold air (DCA) and hot air oven (at 400, 500 and
60oC) drying with a view to preserve viability of yeast. Thereafter,
this study was conducted according to two factor factorial design in
order to determine best preservation method. Therein the dried TS
from the best drying method was taken and divided into two portions.
One portion was mixed with 3: 7 ratio of TS: rice flour and the
mixture was divided in to two again. While one portion was kept
under in house condition the other was in a refrigerator. Same
procedure was followed to the rest portion of TS too but it was at the
same ratio of corn flour. All treatments were vacuum packed in triple
laminate pouches and the best preservation method was determined
in terms of leavening index (LI). The TS obtained from the best
preservation method was used to make foods (bread and hopper) and
organoleptic properties of it were evaluated against same of ordinary
foods using sensory panel with a five point hedonic scale.
Results revealed that yeast load or fresh TS was 58×106 CFU/g.
The best drying method in preserving viability of yeast was DCA
because LI of this treatment (96%) is higher than that of other three
treatments. Organoleptic properties of foods prepared from best
preservation method are as same as ordinary foods according to Duo
trio test.
Abstract: New design of three dimensional (3D) flywheel system
based on gimbal and gyro mechanics is proposed. The 3D flywheel
device utilizes the rotational motion of three spherical shells and the
conservation of angular momentum to achieve planar locomotion.
Actuators mounted to the ring-shape frames are installed within the
system to drive the spherical shells to rotate, for the purpose of steering
and stabilization. Similar to the design of 2D flywheel system, it is
expected that the spherical shells may function like a “flyball” to store
and supply mechanical energy; additionally, in comparison with
typical single-wheel and spherical robots, the 3D flywheel can be used
for developing omnidirectional robotic systems with better mobility.
The Lagrangian method is applied to derive the equation of motion of
the 3D flywheel system, and simulation studies are presented to verify
the proposed design.
Abstract: Pneumatic reactors have been widely employed in various sectors of the chemical industry, especially where are required high heat and mass transfer rates. This study aimed to obtain correlations that allow the prediction of gas hold-up (Ԑ) and volumetric oxygen transfer coefficient (kLa), and compare these values, for three models of pneumatic reactors on two scales utilizing Newtonian fluids. Values of kLa were obtained using the dynamic pressure-step method, while e was used for a new proposed measure. Comparing the three models of reactors studied, it was observed that the mass transfer was superior to draft-tube airlift, reaching e of 0.173 and kLa of 0.00904s-1. All correlations showed good fit to the experimental data (R2≥94%), and comparisons with correlations from the literature demonstrate the need for further similar studies due to shortage of data available, mainly for airlift reactors and high viscosity fluids.
Abstract: Potassium borates, which are widely used in welding
and metal refining industry, as a lubricating oil additive, cement
additive, fiberglass additive and insulation compound, are one of the
important groups of borate minerals. In this study the production of a
potassium borate mineral via hydrothermal method is aimed. The
potassium source of potassium nitrate (KNO3) was used along with a
sodium source of sodium hydroxide (NaOH) and boron source of
boric acid (H3BO3). The constant parameters of reaction temperature
and reaction time were determined as 80°C and 1 h, respectively. The
molar ratios of 1:1:3 (as KNO3:NaOH:H3BO3), 1:1:4, 1:1:5, 1:1:6
and 1:1:7 were used. Following the synthesis the identifications of
the produced products were conducted by X-Ray Diffraction (XRD),
Fourier Transform Infrared Spectroscopy (FT-IR) and Raman
Spectroscopy. The results of the experiments and analysis showed in
the ratio of 1:1:6, the Santite mineral with powder diffraction file
number (pdf no.) of 01-072-1688, which is known as potassium
pentaborate (KB5O8·4H2O) was synthesized as best.
Abstract: This paper examines the system protection for cyber-physical
systems (CPS). CPS are particularly characterized by their
networking system components. This means they are able to adapt to
the needs of their users and its environment. With this ability, CPS
have new, specific requirements on the protection against anti-counterfeiting,
know-how loss and manipulation. They increase the
requirements on system protection because piracy attacks can be
more diverse, for example because of an increasing number of
interfaces or through the networking abilities. The new requirements
were identified and in a next step matched with existing protective
measures. Due to the found gap the development of new protection
measures has to be forced to close this gap. Moreover a comparison
of the effectiveness between selected measures was realized and the
first results are presented in this paper.
Abstract: This paper presents a method of evaluating the effect
of aggregate angularity on hot mix asphalt (HMA) properties and its
relationship to the Permanent Deformation resistance. The research
concluded that aggregate particle angularity had a significant effect
on the Permanent Deformation performance, and also that with an
increase in coarse aggregate angularity there was an increase in the
resistance of mixes to Permanent Deformation. A comparison
between the measured data and predictive data of permanent
deformation predictive models showed the limits of existing
prediction models. The numerical analysis described the permanent
deformation zones and concluded that angularity has an effect of the
onset of these zones. Prediction of permanent deformation help road
agencies and by extension economists and engineers determine the
best approach for maintenance, rehabilitation, and new construction
works of the road infrastructure.
Abstract: In a practical power system, the power plants are not
located at the same distance from the center of loads and their fuel
costs are different. Also, under normal operating conditions, the
generation capacity is more than the total load demand and losses.
Thus, there are many options for scheduling generation. In an
interconnected power system, the objective is to find the real and
reactive power scheduling of each power plant in such a way as to
minimize the operating cost. This means that the generator’s real and
reactive powers are allowed to vary within certain limits so as to meet
a particular load demand with minimum fuel cost. This is called
optimal power flow problem. In this paper, Economic Load Dispatch
(ELD) of real power generation is considered. Economic Load
Dispatch (ELD) is the scheduling of generators to minimize total
operating cost of generator units subjected to equality constraint of
power balance within the minimum and maximum operating limits of
the generating units. In this paper, genetic algorithms are considered.
ELD solutions are found by solving the conventional load flow
equations while at the same time minimizing the fuel costs.
Abstract: This paper addresses the design of hospital Intensive
Care Unit windows for the achievement of visual comfort and energy
savings. The aim was to identify the window size and shading system
configurations that could fulfill daylighting adequacy, avoid glare
and reduce energy consumption. The study focused on addressing the
effect of utilizing different shading systems in association with a
range of Window-to-Wall Ratios (WWR) in different orientations
under the desert clear-sky of Cairo, Egypt.
The results of this study demonstrated that solar penetration is a
critical concern affecting the design of ICU windows in desert
locations, as in Cairo, Egypt. Use of shading systems was found to be
essential in providing acceptable daylight performance and energy
saving. Careful positioning of the ICU window towards a proper
orientation can dramatically improve performance. It was observed
that ICU windows facing the north direction enjoyed the widest range
of successful window configuration possibilities at different WWRs.
ICU windows facing south enjoyed a reasonable number of
configuration options as well. By contrast, the ICU windows facing
the east orientation had a very limited number of options that provide
acceptable performance. These require additional local shading
measures at certain times due to glare incidence. Moreover, use of
horizontal sun breakers and solar screens to protect the ICU windows
proved to be more successful than the other alternatives in a wide
range of Window to Wall Ratios. By contrast, the use of light shelves
and vertical shading devices seemed questionable.
Abstract: Electrodeposition is a simple and economic technique
for precision coating of different shaped substrates with pure metal,
alloy or composite films. Dc electrodeposition was used to produce
Cr, Co-Cr and Co-Cr/TiO2 nano-composite coatings from Cr(III)
based electrolytes onto 316L SS substrates. The effects of TiO2 nanoparticles
concentration on co-deposition of these particles along with
Cr content and microhardness of the coatings were investigated.
Morphology of the Cr, Co-Cr and Co-Cr/TiO2 coatings besides their
tribological behavior were studied. The results showed that increment
of TiO2 nanoparticles concentration from 0 to 30 g L-1 in the bath
increased their co-deposition and Cr content of the coatings from 0 to
3.5 wt.% and from 23.7 to 31.2 wt.%, respectively. Microhardness of
Cr coating was about 920 Hv which was higher than Co-Cr and even
Co-Cr/TiO2 films. Microhardness of Co-Cr and Co-Cr/TiO2 coatings
were improved by increasing their Cr and TiO2 content. All the
coatings had nodular morphology and contained microcracks.
Nodules sizes and the number of microcracks in the alloy and
composite coatings were lower than the Cr film. Wear results
revealed that the Co-Cr/TiO2 coating had the lowest wear loss
between all the samples, while the Cr film had the worst wear
resistance.
Abstract: The comprehensive CFD models have been used to
represent and study the heterogeneous combustion of biomass. In the
present work, the operation of a global flue gas circuit in the sugarcane
bagasse combustion, from wind boxes below primary air grate
supply, passing by bagasse insertion in swirl burners and boiler
furnace, to boiler bank outlet is simulated. It uses five different
meshes representing each part of this system located in sequence:
wind boxes and grate, boiler furnace, swirl burners, superheaters and
boiler bank. The model considers turbulence using standard k-ε,
combustion using EDM, radiation heat transfer using DTM with 16
ray directions and bagasse particle tracking represented by Schiller-
Naumann model. The results showed good agreement with expected
behavior found in literature and equipment design. The more detailed
results view in separated parts of flue gas system allows observing
some flow behaviors that cannot be represented by usual
simplifications like bagasse supply under homogeneous axial and
rotational vectors and others that can be represented using new
considerations like the representation of 26 thousand grate orifices by
144 rectangular inlets.