Abstract: Tuberculosis (TB) is a bacterial infectious disease caused by the obligate human pathogen, Mycobacterium tuberculosis. Multidrug-resistant tuberculosis (MDR-TB) is a global reality that threatens tuberculosis control. Resistance to antibiotic Rifampicin, occurs in 95% of cases through nucleotide substitutions in an 81-bp core region of the rpoB i.e; beta subunit of DNA dependant RNA polymerase. In this paper, we studied the Rifampicin-rpoB receptor interactions In silico. First, homology modeling was performed to obtain the three dimensional structure of Mycobacterium rpoB. Sixty analogs of Rifampicin were prepared using Marvin sketch software. Both original Rifampicin and the analogs were docked with rpoB and energy values were obtained. Out of sixty analogs, 43 analogs had lesser energy values than conventional Rifampicin and hence are predicted to have greater binding affinity to rpoB. Thus, this study offers a route for the development of Rifampicin analogs against multi drug resistant Mycobacterium rpoB.
Abstract: This paper applies the homotopy analysis method method to a nonlinear differential-difference equation arising in nanotechnology. Continuum hypothesis on nanoscales is invalid, and a differential-difference model is considered as an alternative approach to describing discontinued problems. Comparison of the approximate solution with the exact one reveals that the method is very effective.
Abstract: In this article, a simulation method called the Homotopy Perturbation Method (HPM) is employed in the steady flow of a Walter's B' fluid in a vertical channel with porous wall. We employed Homotopy Perturbation Method to derive solution of a nonlinear form of equation obtained from exerting similarity transforming to the ordinary differential equation gained from continuity and momentum equations of this kind of flow. The results obtained from the Homotopy Perturbation Method are then compared with those from the Runge–Kutta method in order to verify the accuracy of the proposed method. The results show that the Homotopy Perturbation Method can achieve good results in predicting the solution of such problems. Ultimately we use this solution to obtain the other terms of velocities and physical discussion about it.
Abstract: In the present research, the titanium-catalyzed
ethylene dimerization and more specifically, the concomitant byproducts
and polymer formation have been studied in the presence of 2,5-dimethoxytetrahydrofuran as an electron donor compound in the
combination with triethylaluminium (TEA) as activator. Then, we
added ethylene chlorobromide as a new efficient promoter to the
relevant catalyst system. Finally, the behavior of novel homogeneous
[Titanium tetrabutoxide (Ti(OC4H9)4)/2,5-dimethoxytetrahydrofuran/
TEA/ethylene chlorobromide] was investigated in the various
operating conditions for the optimum production of 1-butene. In the
optimum conditions, a very high ethylene conversion (almost 90.77
%), a relative high selectivity to 1-butene (79.00 %), yield of reaction equal to 71.70 % and a significant productivity (turnover frequency
equal to 1370 h-1) were achieved.
Abstract: Combining classifiers is a useful method for solving
complex problems in machine learning. The ECOC (Error Correcting
Output Codes) method has been widely used for designing combining
classifiers with an emphasis on the diversity of classifiers. In this
paper, in contrast to the standard ECOC approach in which individual
classifiers are chosen homogeneously, classifiers are selected
according to the complexity of the corresponding binary problem. We
use SATIMAGE database (containing 6 classes) for our experiments.
The recognition error rate in our proposed method is %10.37 which
indicates a considerable improvement in comparison with the
conventional ECOC and stack generalization methods.
Abstract: The purpose of this paper is to explore the role of
cognitive decision effort in recommendation system, combined with
indicators "information quality" and "service quality" from IS success
model to exam the awareness of the user for the "recommended system
performance". A total of 411 internet user answered a questionnaire
assessing their attention of use and satisfaction of recommendation
system in internet book store. Quantitative result indicates following
research results. First, information quality of recommended system
has obvious influence in consumer shopping decision-making process,
and the attitude to use the system. Second, in the process of consumer's
shopping decision-making, the recommendation system has no
significant influence for consumers to pay lower cognitive
decision-making effort. Third, e-commerce platform provides
recommendations and information is necessary, but the quality of
information on user needs must be considered, or they will be other
competitors offer homogeneous services replaced.
Abstract: Among the many promising nanomaterials with antifungal properties, metal nanoparticles (silver nanoparticles) stand out due to their high chemical activity. Therefore, the aim of this study was to evaluate the effect of silver nanoparticles (AgNPs) against Phomopsis sp. AgNPs were synthesized by silver nitrate reduction with sodium citrate and stabilized with ammonia. The synthesized AgNPs have further been characterized by UV/Visible spectroscopy, Biophysical techniques like Dynamic light scattering (DLS) and Scanning Electron Microscopy (SEM). The average diameter of the prepared silver colloidal nanoparticles was about 52 nm. Absolute inhibitions (100%) were observed on treated with a 270 and 540 µg ml-1 concentration of AgNPs. The results from the study of the AgNPs antifungal effect are significant and suggest that the synthesized silver nanoparticles may have an advantage compared with conventional fungicides.
Abstract: An accurate procedure to determine free vibrations of
beams and plates is presented.
The natural frequencies are exact solutions of governing vibration
equations witch load to a nonlinear homogeny system.
The bilinear and linear structures considered simulate a bridge.
The dynamic behavior of this one is analyzed by using the theory of
the orthotropic plate simply supported on two sides and free on the
two others. The plate can be excited by a convoy of constant or
harmonic loads. The determination of the dynamic response of the
structures considered requires knowledge of the free frequencies and
the shape modes of vibrations. Our work is in this context. Indeed,
we are interested to develop a self-consistent calculation of the Eigen
frequencies.
The formulation is based on the determination of the solution of
the differential equations of vibrations. The boundary conditions
corresponding to the shape modes permit to lead to a homogeneous
system. Determination of the noncommonplace solutions of this
system led to a nonlinear problem in Eigen frequencies.
We thus, develop a computer code for the determination of the
eigenvalues. It is based on a method of bisection with interpolation
whose precision reaches 10 -12. Moreover, to determine the
corresponding modes, the calculation algorithm that we develop uses
the method of Gauss with a partial optimization of the "pivots"
combined with an inverse power procedure. The Eigen frequencies
of a plate simply supported along two opposite sides while
considering the two other free sides are thus analyzed. The results
could be generalized with the case of a beam by regarding it as a
plate with low width.
We give, in this paper, some examples of treated cases. The
comparison with results presented in the literature is completely
satisfactory.
Abstract: Rice husk is a lignocellulosic source that can be
converted to ethanol. Three hundreds grams of rice husk was mixed
with 1 L of 0.18 N sulfuric acid solutions then was heated in an
autoclave. The reaction was expected to be at constant temperature
(isothermal), but before that temperature was achieved, reaction has
occurred. The first liquid sample was taken at temperature of 140 0C
and repeated every 5 minute interval. So the data obtained are in the
regions of non-isothermal and isothermal. It was observed that the
degradation has significant effects on the ethanol production. The
kinetic constants can be expressed by Arrhenius equation with the
frequency factors for hydrolysis and sugar degradation of 1.58 x 105
1/min and 2.29 x 108 L/mole/min, respectively, while the activation
energies are 64,350 J/mole and 76,571 J/mole. The highest ethanol
concentration from fermentation is 1.13% v/v, attained at 220 0C.
Abstract: In this paper, we investigate the problem of the existence, uniqueness and global asymptotic stability of the equilibrium point for a class of neural networks, the neutral system has mixed time delays and parameter uncertainties. Under the assumption that the activation functions are globally Lipschitz continuous, we drive a new criterion for the robust stability of a class of neural networks with time delays by utilizing the Lyapunov stability theorems and the Homomorphic mapping theorem. Numerical examples are given to illustrate the effectiveness and the advantage of the proposed main results.
Abstract: Data Envelopment Analysis (DEA) is one of the most
widely used technique for evaluating the relative efficiency of a set
of homogeneous decision making units. Traditionally, it assumes that
input and output variables are known in advance, ignoring the critical
issue of data uncertainty. In this paper, we deal with the problem
of efficiency evaluation under uncertain conditions by adopting the
general framework of the stochastic programming. We assume that
output parameters are represented by discretely distributed random
variables and we propose two different models defined according to a
neutral and risk-averse perspective. The models have been validated
by considering a real case study concerning the evaluation of the
technical efficiency of a sample of individual firms operating in
the Italian leather manufacturing industry. Our findings show the
validity of the proposed approach as ex-ante evaluation technique
by providing the decision maker with useful insights depending on
his risk aversion degree.
Abstract: The paper presents an analytical solution for dispersion
of a solute in the peristaltic motion of a couple stress fluid
through a porous medium with slip condition in the presence of both
homogeneous and heterogeneous chemical reactions. The average
effective dispersion coefficient has been found using Taylor-s limiting
condition and long wavelength approximation. The effects of various
relevant parameters on the average coefficient of dispersion have been
studied. The average effective dispersion coefficient tends to increase
with permeability parameter but tends to decrease with homogeneous
chemical reaction rate parameter, couple stress parameter, slip parameter
and heterogeneous reaction rate parameter.
Abstract: An important step in three-dimensional reconstruction
and computer vision is camera calibration, whose objective is to
estimate the intrinsic and extrinsic parameters of each camera. In this
paper, two linear methods based on the different planes are given. In
both methods, the general plane is used to replace the calibration
object with very good precision. In the first method, after controlling
the camera to undergo five times- translation movements and taking
pictures of the orthogonal planes, a set of linear constraints of the
camera intrinsic parameters is then derived by means of homography
matrix. The second method is to get all camera parameters by taking
only one picture of a given radius circle. experiments on simulated
data and real images,indicate that our method is reasonable and is a
good supplement to camera calibration.
Abstract: A method based on the power series solution is proposed to solve the natural frequency of flapping vibration for the rotating inclined Euler beam with constant angular velocity. The vibration of the rotating beam is measured from the position of the corresponding steady state axial deformation. In this paper the governing equations for linear vibration of a rotating Euler beam are derived by the d'Alembert principle, the virtual work principle and the consistent linearization of the fully geometrically nonlinear beam theory in a rotating coordinate system. The governing equation for flapping vibration of the rotating inclined Euler beam is linear ordinary differential equation with variable coefficients and is solved by a power series with four independent coefficients. Substituting the power series solution into the corresponding boundary conditions at two end nodes of the rotating beam, a set of homogeneous equations can be obtained. The natural frequencies may be determined by solving the homogeneous equations using the bisection method. Numerical examples are studied to investigate the effect of inclination angle on the natural frequency of flapping vibration for rotating inclined Euler beams with different angular velocity and slenderness ratio.
Abstract: The stability test problem for homogeneous large-scale perturbed bilinear time-delay systems subjected to constrained inputs is considered in this paper. Both nonlinear uncertainties and interval systems are discussed. By utilizing the Lyapunove equation approach associated with linear algebraic techniques, several delay-independent criteria are presented to guarantee the robust stability of the overall systems. The main feature of the presented results is that although the Lyapunov stability theorem is used, they do not involve any Lyapunov equation which may be unsolvable. Furthermore, it is seen the proposed schemes can be applied to solve the stability analysis problem of large-scale time-delay systems.
Abstract: In this study, a high accuracy protein-protein interaction
prediction method is developed. The importance of the proposed
method is that it only uses sequence information of proteins while
predicting interaction. The method extracts phylogenetic profiles of
proteins by using their sequence information. Combining the phylogenetic
profiles of two proteins by checking existence of homologs
in different species and fitting this combined profile into a statistical
model, it is possible to make predictions about the interaction status
of two proteins.
For this purpose, we apply a collection of pattern recognition
techniques on the dataset of combined phylogenetic profiles of protein
pairs. Support Vector Machines, Feature Extraction using ReliefF,
Naive Bayes Classification, K-Nearest Neighborhood Classification,
Decision Trees, and Random Forest Classification are the methods
we applied for finding the classification method that best predicts
the interaction status of protein pairs. Random Forest Classification
outperformed all other methods with a prediction accuracy of 76.93%
Abstract: Many electronic voting systems, classified mainly as homomorphic cryptography based, mix-net based and blind signature based, appear after the eighties when zero knowledge proofs were introduced. The common ground for all these three systems is that none of them works without real time cryptologic calculations that should be held on a server. As far as known, the agent-based approach has not been used in a secure electronic voting system. In this study, an agent-based electronic voting schema, which does not contain real time calculations on the server side, is proposed. Conventional cryptologic methods are used in the proposed schema and some of the requirements of an electronic voting system are constructed within the schema. The schema seems quite secure if the used cryptologic methods and agents are secure. In this paper, proposed schema will be explained and compared with already known electronic voting systems.
Abstract: TiO2 nanoparticles were synthesized by hydrothermal
method at 180°C from TiOSO4 aqueous solution with1m/l
concentration. The obtained products were coated with silica by
means of a seeded polymerization technique for a coating time of
1440 minutes to obtain well defined TiO2@SiO2 core-shell structure.
The uncoated and coated nanoparticles were characterized by using
X-Ray diffraction technique (XRD), Fourier Transform Infrared
Spectroscopy (FT-IR) to study their physico-chemical properties.
Evidence from XRD and FTIR results show that SiO2 is
homogenously coated on the surface of titania particles. FTIR spectra
show that there exists an interaction between TiO2 and SiO2 and
results in the formation of Ti-O-Si chemical bonds at the interface of
TiO2 particles and SiO2 coating layer. The non linear optical limiting
properties of TiO2 and TiO2@SiO2 nanoparticles dispersed in
ethylene glycol were studied at 532nm using 5ns Nd:YAG laser
pulses. Three-photon absorption is responsible for optical limiting
characteristics in these nanoparticles and it is seen that the optical
nonlinearity is enhanced in core-shell structures when compared with
single counterparts. This effective three-photon type absorption at
this wavelength, is of potential application in fabricating optical
limiting devices.
Abstract: Metal cutting is a severe plastic deformation process
involving large strains, high strain rates, and high temperatures.
Conventional analysis of the chip formation process is based on bulk
material deformation disregarding the inhomogeneous nature of the
material microstructure. A series of orthogonal cutting tests of AISI
1045 and 1144 steel were conducted which yielded similar process
characteristics and chip formations. With similar shear angles and cut
chip thicknesses, shear strains for both chips were found to range
from 2.0 up to 2.8. The manganese-sulfide (MnS) precipitate in the
1144 steel has a very distinct and uniform shape which allows for
comparison before and after chip formation. From close observations
of MnS precipitates in the cut chips it is shown that the conventional
approach underestimates plastic strains in metal cutting.
Experimental findings revealed local shear strains around a value of
6. These findings and their implications are presented and discussed.
Abstract: We proposed the use of a Toda-Rayleigh ring as a
central pattern generator (CPG) for controlling hexapodal robots. We
show that the ring composed of six Toda-Rayleigh units coupled to
the limb actuators reproduces the most common hexapodal gaits. We
provide an electrical circuit implementation of the CPG and test our
theoretical results obtaining fixed gaits. Then we propose a method
of incorporation of the actuator (motor) dynamics in the CPG. With
this approach we close the loop CPG – environment – CPG, thus
obtaining a decentralized model for the leg control that does not
require higher level intervention to the CPG during locomotion in
a nonhomogeneous environments. The gaits generated by the novel
CPG are not fixed, but adapt to the current robot bahvior.