Abstract: It has been established that microRNAs (miRNAs) play
an important role in gene expression by post-transcriptional regulation
of messengerRNAs (mRNAs). However, the precise relationships
between microRNAs and their target genes in sense of numbers,
types and biological relevance remain largely unclear. Dissecting the
miRNA-target relationships will render more insights for miRNA
targets identification and validation therefore promote the understanding
of miRNA function. In miRBase, miRanda is the key
algorithm used for target prediction for Zebrafish. This algorithm
is high-throughput but brings lots of false positives (noise). Since
validation of a large scale of targets through laboratory experiments
is very time consuming, several computational methods for miRNA
targets validation should be developed. In this paper, we present an
integrative method to investigate several aspects of the relationships
between miRNAs and their targets with the final purpose of extracting
high confident targets from miRanda predicted targets pool. This is
achieved by using the techniques ranging from statistical tests to
clustering and association rules. Our research focuses on Zebrafish.
It was found that validated targets do not necessarily associate with
the highest sequence matching. Besides, for some miRNA families,
the frequency of their predicted targets is significantly higher in the
genomic region nearby their own physical location. Finally, in a case
study of dre-miR-10 and dre-miR-196, it was found that the predicted
target genes hoxd13a, hoxd11a, hoxd10a and hoxc4a of dre-miR-
10 while hoxa9a, hoxc8a and hoxa13a of dre-miR-196 have similar
characteristics as validated target genes and therefore represent high
confidence target candidates.
Abstract: A new code synchronization algorithm is proposed in
this paper for the secondary cell-search stage in wideband CDMA
systems. Rather than using the Cyclically Permutable (CP) code in the
Secondary Synchronization Channel (S-SCH) to simultaneously
determine the frame boundary and scrambling code group, the new
synchronization algorithm implements the same function with less
system complexity and less Mean Acquisition Time (MAT). The
Secondary Synchronization Code (SSC) is redesigned by splitting into
two sub-sequences. We treat the information of scrambling code group
as data bits and use simple time diversity BCH coding for further
reliability. It avoids involved and time-costly Reed-Solomon (RS)
code computations and comparisons. Analysis and simulation results
show that the Synchronization Error Rate (SER) yielded by the new
algorithm in Rayleigh fading channels is close to that of the
conventional algorithm in the standard. This new synchronization
algorithm reduces system complexities, shortens the average
cell-search time and can be implemented in the slot-based cell-search
pipeline. By taking antenna diversity and pipelining correlation
processes, the new algorithm also shows its flexible application in
multiple antenna systems.
Abstract: In the multi objective optimization, in the case when generated set of Pareto optimal solutions is large, occurs the problem to select of the best solution from this set. In this paper, is suggested a method to order of Pareto set. Ordering the Pareto optimal set carried out in conformity with the introduced distance function between each solution and selected reference point, where the reference point may be adjusted to represent the preferences of a decision making agent. Preference information about objective weights from a decision maker may be expressed imprecisely. The developed elicitation procedure provides an opportunity to obtain surrogate numerical weights for the objectives, and thus, to manage impreciseness of preference. The proposed method is a scalable to many objectives and can be used independently or as complementary to the various visualization techniques in the multidimensional case.
Abstract: The Internet has become an indispensable part of our lives. Witnessing recent web-based mass collaboration, e.g. Wikipedia, people are questioning whether the Internet has made fundamental changes to the society or whether it is merely a hyperbolic fad. It has long been assumed that collective action for a certain goal yields the problem of free-riding, due to its non-exclusive and non-rival characteristics. Then, thanks to recent technological advances, the on-line space experienced the following changes that enabled it to produce public goods: 1) decrease in the cost of production or coordination 2) externality from networked structure 3) production function which integrates both self-interest and altruism. However, this research doubts the homogeneity of on-line mass collaboration and argues that a more sophisticated and systematical approach is required. The alternative that we suggest is to connect the characteristics of the goal to the motivation. Despite various approaches, previous literature fails to recognize that motivation can be structurally restricted by the characteristic of the goal. First we draw a typology of on-line mass collaboration with 'the extent of expected beneficiary' and 'the existence of externality', and then we examine each combination of motivation using Benkler-s framework. Finally, we explore and connect such typology with its possible dominant participating motivation.
Abstract: In this paper, we present a system for content-based
retrieval of large database of classified satellite images, based on
user's relevance feedback (RF).Through our proposed system, we
divide each satellite image scene into small subimages, which stored
in the database. The modified radial basis functions neural network
has important role in clustering the subimages of database according
to the Euclidean distance between the query feature vector and the
other subimages feature vectors. The advantage of using RF
technique in such queries is demonstrated by analyzing the database
retrieval results.
Abstract: This paper presents a new sufficient condition for the
existence, uniqueness and global asymptotic stability of the equilibrium point for Cohen-Grossberg neural networks with multiple time delays. The results establish a relationship between the network parameters
of the neural system independently of the delay parameters. The results are also compared with the previously reported results in
the literature.
Abstract: Let G be a graph of order n, and let k 2 and m 0 be two integers. Let h : E(G) [0, 1] be a function. If e∋x h(e) = k holds for each x V (G), then we call G[Fh] a fractional k-factor of G with indicator function h where Fh = {e E(G) : h(e) > 0}. A graph G is called a fractional (k,m)-deleted graph if there exists a fractional k-factor G[Fh] of G with indicator function h such that h(e) = 0 for any e E(H), where H is any subgraph of G with m edges. In this paper, it is proved that G is a fractional (k,m)-deleted graph if (G) k + m + m k+1 , n 4k2 + 2k − 6 + (4k 2 +6k−2)m−2 k−1 and max{dG(x), dG(y)} n 2 for any vertices x and y of G with dG(x, y) = 2. Furthermore, it is shown that the result in this paper is best possible in some sense.
Abstract: Stability of functionally graded beams with piezoelectric layers subjected to axial compressive load that is simply supported at both ends is studied in this paper. The displacement field of beam is assumed based on first order shear deformation beam theory. Applying the Hamilton's principle, the governing equation is established. The influences of applied voltage, dimensionless geometrical parameter, functionally graded index and piezoelectric thickness on the critical buckling load of beam are presented. To investigate the accuracy of the present analysis, a compression study is carried out with a known data.
Abstract: The tree structured approach of non-uniform filterbank
(NUFB) is normally used in perfect reconstruction (PR). The PR is
not always feasible due to certain limitations, i.e, constraints in
selecting design parameters, design complexity and some times
output is severely affected by aliasing error if necessary and
sufficient conditions of PR is not satisfied perfectly. Therefore, there
has been generalized interest of researchers to go for near perfect
reconstruction (NPR). In this proposed work, an optimized tree
structure technique is used for the design of NPR non-uniform
filterbank. Window functions of Blackman family are used to design
the prototype FIR filter. A single variable linear optimization is used
to minimize the amplitude distortion. The main feature of the
proposed design is its simplicity with linear phase property.
Abstract: This paper presents an application of power line
carrier (PLC) for electrical power telemetering. This system has a
special capability of transmitting the measured values to a centralized
computer via power lines. The PLC modem as a passive high-pass
filter is designed for transmitting and receiving information. Its
function is to send the information carrier together with transmitted
data by superimposing it on the 50 Hz power frequency signal. A
microcontroller is employed to function as the main processing of the
modem. It is programmed for PLC control and interfacing with other
devices. Each power meter, connected via a PLC modem, is assigned
with a unique identification number (address) for distinguishing each
device from one another.
Abstract: This paper uses the radial basis function neural
network (RBFNN) for system identification of nonlinear systems.
Five nonlinear systems are used to examine the activity of RBFNN in
system modeling of nonlinear systems; the five nonlinear systems are
dual tank system, single tank system, DC motor system, and two
academic models. The feed forward method is considered in this
work for modelling the non-linear dynamic models, where the KMeans
clustering algorithm used in this paper to select the centers of
radial basis function network, because it is reliable, offers fast
convergence and can handle large data sets. The least mean square
method is used to adjust the weights to the output layer, and
Euclidean distance method used to measure the width of the Gaussian
function.
Abstract: Unlike general-purpose processors, digital signal
processors (DSP processors) are strongly application-dependent. To
meet the needs for diverse applications, a wide variety of DSP
processors based on different architectures ranging from the
traditional to VLIW have been introduced to the market over the
years. The functionality, performance, and cost of these processors
vary over a wide range. In order to select a processor that meets the
design criteria for an application, processor performance is usually
the major concern for digital signal processing (DSP) application
developers. Performance data are also essential for the designers of
DSP processors to improve their design. Consequently, several DSP
performance benchmarks have been proposed over the past decade or
so. However, none of these benchmarks seem to have included recent
new DSP applications.
In this paper, we use a new benchmark that we recently developed
to compare the performance of popular DSP processors from Texas
Instruments and StarCore. The new benchmark is based on the
Selectable Mode Vocoder (SMV), a speech-coding program from the
recent third generation (3G) wireless voice applications. All
benchmark kernels are compiled by the compilers of the respective
DSP processors and run on their simulators. Weighted arithmetic
mean of clock cycles and arithmetic mean of code size are used to
compare the performance of five DSP processors.
In addition, we studied how the performance of a processor is
affected by code structure, features of processor architecture and
optimization of compiler. The extensive experimental data gathered,
analyzed, and presented in this paper should be helpful for DSP
processor and compiler designers to meet their specific design goals.
Abstract: Attempts to add fibre and polyphenols (PPs) into
popular beverages present challenges related to the properties of
finished products such as smoothies. Consumer acceptability,
viscosity and phenolic composition of smoothies containing high
levels of fruit fibre (2.5-7.5 g per 300 mL serve) and PPs (250-750
mg per 300 mL serve) were examined. The changes in total
extractable PP, vitamin C content, and colour of selected smoothies
over a storage stability trial (4°C, 14 days) were compared. A set of
acidic aqueous model beverages were prepared to further examine
the effect of two different heat treatments on the stability and
extractability of PPs. Results show that overall consumer
acceptability of high fibre and PP smoothies was low, with average
hedonic scores ranging from 3.9 to 6.4 (on a 1-9 scale). Flavour,
texture and overall acceptability decreased as fibre and polyphenol
contents increased, with fibre content exerting a stronger effect.
Higher fibre content resulted in greater viscosity, with an elevated PP
content increasing viscosity only slightly. The presence of fibre also
aided the stability and extractability of PPs after heating. A reduction
of extractable PPs, vitamin C content and colour intensity of
smoothies was observed after a 14-day storage period at 4°C. Two
heat treatments (75°C for 45 min or 85°C for 1 min) that are
normally used for beverage production, did not cause significant
reduction of total extracted PPs. It is clear that high levels of added
fibre and PPs greatly influence the consumer appeal of smoothies,
suggesting the need to develop novel formulation and processing
methods if a satisfactory functional beverage is to be developed
incorporating these ingredients.
Abstract: The purpose of this research is to develop a security model for voice eavesdropping protection over digital networks. The proposed model provides an encryption scheme and a personal secret key exchange between communicating parties, a so-called voice data transformation system, resulting in a real-privacy conversation. The operation of this system comprises two main steps as follows: The first one is the personal secret key exchange for using the keys in the data encryption process during conversation. The key owner could freely make his/her choice in key selection, so it is recommended that one should exchange a different key for a different conversational party, and record the key for each case into the memory provided in the client device. The next step is to set and record another personal option of encryption, either taking all frames or just partial frames, so-called the figure of 1:M. Using different personal secret keys and different sets of 1:M to different parties without the intervention of the service operator, would result in posing quite a big problem for any eavesdroppers who attempt to discover the key used during the conversation, especially in a short period of time. Thus, it is quite safe and effective to protect the case of voice eavesdropping. The results of the implementation indicate that the system can perform its function accurately as designed. In this regard, the proposed system is suitable for effective use in voice eavesdropping protection over digital networks, without any requirements to change presently existing network systems, mobile phone network and VoIP, for instance.
Abstract: Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.
Abstract: In this paper, a delayed predator-prey system with Hassell-Varley-Holling type functional response is studied. A sufficient criterion for the permanence of the system is presented, and further some sufficient conditions for the global attractivity and exponential stability of the system are established. And an example is to show the feasibility of the results by simulation.
Abstract: Turbulence modeling of large-scale flow over a vegetated surface is complex. Such problems involve large scale computational domains, while the characteristics of flow near the surface are also involved. In modeling large scale flow, surface roughness including vegetation is generally taken into account by mean of roughness parameters in the modified law of the wall. However, the turbulence structure within the canopy region cannot be captured with this method, another method which applies source/sink terms to model plant drag can be used. These models have been developed and tested intensively but with a simple surface geometry. This paper aims to compare the use of roughness parameter, and additional source/sink terms in modeling the effect of plant drag on wind flow over a complex vegetated surface. The RNG k-ε turbulence model with the non-equilibrium wall function was tested with both cases. In addition, the k-ω turbulence model, which is claimed to be computationally stable, was also investigated with the source/sink terms. All numerical results were compared to the experimental results obtained at the study site Mason Bay, Stewart Island, New Zealand. In the near-surface region, it is found that the results obtained by using the source/sink term are more accurate than those using roughness parameters. The k-ω turbulence model with source/sink term is more appropriate as it is more accurate and more computationally stable than the RNG k-ε turbulence model. At higher region, there is no significant difference amongst the results obtained from all simulations.
Abstract: Even it has been recognized that Shape Memory
Alloys (SMA) have a significant potential for deployment actuators,
the number of applications of SMA-based actuators to the present
day is still quite small, due to the need of deep understanding of the
thermo-mechanical behavior of SMA, causing an important need for
a mathematical model able to describe all thermo-mechanical
properties of SMA by relatively simple final set of constitutive
equations. SMAs offer attractive potentials such as: reversible strains
of several percent, generation of high recovery stresses and high
power / weight ratios. The paper tries to provide an overview of the
shape memory functions and a presentation of the designed and
developed temperature control system used for a gripper actuated by
two pairs of differential SMA active springs. An experimental setup
was established, using electrical energy for actuator-s springs heating
process. As for holding the temperature of the SMA springs at certain
level for a long time was developed a control system in order to
avoid the active elements overheating.
Abstract: A climate dependent model is proposed to simulate
the population of Aedes aegypti mosquito. In developing the model,
average temperature of Shah Alam, Malaysia was used to determine
the development rate of each stage of the life cycle of mosquito.
Rainfall dependent function was proposed to simulate the hatching
rate of the eggs under several assumptions. The proposed transition
matrix was obtained and used to simulate the population of eggs,
larvae, pupae and adults mosquito. It was found that the peak of
mosquito abundance comes during a relatively dry period following a
heavy rainfall. In addition, lag time between the peaks of mosquito
abundance and dengue fever cases in Shah Alam was estimated.
Abstract: Warranty is a powerful marketing tool for the
manufacturer and a good protection for both the manufacturer and the
customer. However, warranty always involves additional costs to the
manufacturer, which depend on product reliability characteristics and
warranty parameters. This paper presents an approach to optimisation
of warranty parameters for known product failure distribution to
reduce the warranty costs to the manufacturer while retaining the
promotional function of the warranty. Combination free replacement
and pro-rata warranty policy is chosen as a model and the length of
free replacement period and pro-rata policy period are varied, as well
as the coefficients that define the pro-rata cost function. Multiparametric
warranty optimisation is done by using genetic algorithm.
Obtained results are guideline for the manufacturer to choose the
warranty policy that minimises the costs and maximises the profit.