Abstract: The aim of the present study was to evaluate the
mucoadhesion and the release of nicotinamide gel formulations using
in vitro methods. An agar plate technique was used to investigate the
adhesiveness of the gels whereas a diffusion apparatus was employed
to determine the release of nicotinamide from the gels. In this
respect, 10% w/w nicotinamide gels containing bioadhesive
polymers: Carbopol 934P (0.5-2% w/w), hydroxypropylmethyl
cellulose (HPMC) (4-10% w/w), sodium carboxymethyl cellulose
(SCMC) (4-6% w/w) and methylcellulose 4000 (MC) (3-5% w/w)
were prepared. The gel formulations had pH values in the range of
7.14 - 8.17, which were considered appropriate to oral mucosa
application. In general, the rank order of pH values appeared to be
SCMC > MC4000 > HPMC > Carbopol 934P. Types and
concentrations of polymers used somewhat affected the
adhesiveness. It was found that anionic polymers (Carbopol 934 and
SCMC) adhered more firmly to the agar plate than the neutral
polymers (HPMC and MC 4000). The formulation containing 0.5%
Carbopol 934P (F1) showed the highest release rate. With the
exception of the formulation F1, the neutral polymers tended to give
higher relate rates than the anionic polymers. For oral tissue
treatment, the optimum has to be balanced between the residence
time (adhesiveness) of the formulations and the release rate of the
drug. The formulations containing the anionic polymers: Carbopol
934P or SCMC possessed suitable physical properties (appearance,
pH and viscosity). In addition, for anionic polymer formulations,
justifiable mucoadhesive properties and reasonable release rates of
nicotinamide were achieved. Accordingly, these gel formulations
may be applied for the treatment of oral mucosal lesions.
Abstract: Developing a nation geared by the principle of
sustainable development has been one of the piers in moulding a
greater nation for Malaysia since its independence. This is seen by
the act of joining the United Nations in 1957, just a month after
gaining their independence. The United Nations is an international
organization that aims to unite the nations worldwide based on
justice, human dignity and human well-being. Malaysia has
established a local body called the United Nations Malaysia which
collaborates with the government to accomplish the aim of
supporting sustainable development in Malaysia. Agenda 21 is an
international document produced from the Earth Summit providing
guidelines of implementing sustainable development globally,
nationally and locally. Initiatives of applying Agenda 21 in Malaysia
have been taken by the government and non-profit organizations to
expose issues regarding sustainable development and providing
environmental education to the community to increase awareness
towards environmental protection.
Abstract: This research studied recycled waste by the Recyclable Material Bank Project of 4 universities in the central region of Thailand for the evaluation of reducing greenhouse gas emissions compared with landfilling activity during July 2012 to June 2013. The results showed that the projects collected total amount of recyclable wastes of about 911,984.80 kilograms. Office paper had the largest amount among these recycled wastes (50.68% of total recycled waste). Groups of recycled waste can be prioritized from high to low according to their amount as paper, plastic, glass, mixed recyclables, and metal, respectively. The project reduced greenhouse gas emissions equivalent to about 2814.969 metric tons of carbon dioxide. The most significant recycled waste that affects the reduction of greenhouse gas emissions is office paper which is 70.16% of total reduced greenhouse gasses emission. According to amount of reduced greenhouse gasses emission, groups of recycled waste can be prioritized from high to low significances as paper, plastic, metals, mixed recyclables, and glass, respectively.
Abstract: This paper presents a method for the detection of OD in the retina which takes advantage of the powerful preprocessing techniques such as the contrast enhancement, Gabor wavelet transform for vessel segmentation, mathematical morphology and Earth Mover-s distance (EMD) as the matching process. The OD detection algorithm is based on matching the expected directional pattern of the retinal blood vessels. Vessel segmentation method produces segmentations by classifying each image pixel as vessel or nonvessel, based on the pixel-s feature vector. Feature vectors are composed of the pixel-s intensity and 2D Gabor wavelet transform responses taken at multiple scales. A simple matched filter is proposed to roughly match the direction of the vessels at the OD vicinity using the EMD. The minimum distance provides an estimate of the OD center coordinates. The method-s performance is evaluated on publicly available DRIVE and STARE databases. On the DRIVE database the OD center was detected correctly in all of the 40 images (100%) and on the STARE database the OD was detected correctly in 76 out of the 81 images, even in rather difficult pathological situations.
Abstract: Brassinosteroids (BRs) regulate cell elongation,
vascular differentiation, senescence, and stress responses. BRs signal
through the BES1/BZR1 family of transcription factors, which
regulate hundreds of target genes involved in this pathway. In this
research a comprehensive genome-wide analysis was carried out in
BES1/BZR1 gene family in Arabidopsis thaliana, Cucumis sativus,
Vitis vinifera, Glycin max and Brachypodium distachyon.
Specifications of the desired sequences, dot plot and hydropathy plot
were analyzed in the protein and genome sequences of five plant
species. The maximum amino acid length was attributed to protein
sequence Brdic3g with 374aa and the minimum amino acid length
was attributed to protein sequence Gm7g with 163aa. The maximum
Instability index was attributed to protein sequence AT1G19350
equal with 79.99 and the minimum Instability index was attributed to
protein sequence Gm5g equal with 33.22. Aliphatic index of these
protein sequences ranged from 47.82 to 78.79 in Arabidopsis
thaliana, 49.91 to 57.50 in Vitis vinifera, 55.09 to 82.43 in Glycin
max, 54.09 to 54.28 in Brachypodium distachyon 55.36 to 56.83 in
Cucumis sativus. Overall, data obtained from our investigation
contributes a better understanding of the complexity of the
BES1/BZR1 gene family and provides the first step towards directing
future experimental designs to perform systematic analysis of the
functions of the BES1/BZR1 gene family.
Abstract: In this paper, a mathematical model for data object replication in ad hoc networks is formulated. The derived model is general, flexible and adaptable to cater for various applications in ad hoc networks. We propose a game theoretical technique in which players (mobile hosts) continuously compete in a non-cooperative environment to improve data accessibility by replicating data objects. The technique incorporates the access frequency from mobile hosts to each data object, the status of the network connectivity, and communication costs. The proposed technique is extensively evaluated against four well-known ad hoc network replica allocation methods. The experimental results reveal that the proposed approach outperforms the four techniques in both the execution time and solution quality
Abstract: Today Environmental Impact Assessment (EIA) is known as one of the most important tools for decision makers in the construction of civil and industrial projects towards sustainable development. In the past, projects were evaluated based on cost and benefit analysis regardless of the physical and biological environmental effects and its socio-economical impacts. According to the Department of Environment (DOE) of Iran's regulations, the construction of hydroelectric dams is an activity that requires an EIA report. In this paper the environmental impact assessment of the Gotvand hydro-electrical dam has been evaluated in the three environment elements, biological, Physical-chemical and cultural units. This dam is one of the largest dams in Iran with a volume of 4500 MCM and is going to be the last dam on the Karoon River in the south of Iran. In this paper the ICOLD (International Commission on Large Dams) technique was employed for the environmental impact assessment of the dam. The research includes all socio economical and environmental effects of the dam during the construction and operation of the hydro electric dam and Environmental management, monitoring and mitigation of negative impacts were analyzed. In this project the results led to using some techniques to protect the destructive impacts on biological aspects beside the effective long time period impacts on the biological aspects. The impacts on physical aspects are temporary and negative commonly that could be restored and rehabilitated in natural process in the long time in operation period.
Abstract: Studying literature theme in the fields of tourism and
sustainable development and its importance in today world and their
criteria in architecture, here in this article we will also study the area
where the selected site is located; beside the Aab-Ask Village located
in Larijan region in Mazandaran province on the way to Haraz – one
of the tourism routes of Iran. After these studies by analyzing the
site, its strong potentials – such as mineral water springs (hot
springs), geothermal, landscapes and ideal climate - as a tourist
attraction spot in the region, and considering sustainable
development criteria – with regard to limits and available facilities –
a plan was offered that could change the region to provide the needs
of local people and in addition change it to a place where tourism
services is offered to the visitors and make it an acceptable sample of
stable building in Iran. Finally the reason to make design for this
complex is recovery of natural and historical values of Aab-Ask area
regarding development and sustainable architecture criteria in the
form of a functional sample which can be a suitable place to fulfill
this goal for having lots of strong points in attracting cultural and
sustainable tourist.
Abstract: The RK5GL3 method is a numerical method for solving
initial value problems in ordinary differential equations, and is based
on a combination of a fifth-order Runge-Kutta method and 3-point
Gauss-Legendre quadrature. In this paper we describe the propagation
of local errors in this method, and show that the global order of
RK5GL3 is expected to be six, one better than the underlying Runge-
Kutta method.
Abstract: In this paper, we are going to determine the threshold levels of adaptive modulation in a burst by burst CDMA system by a suboptimum method so that the above method attempts to increase the average bit per symbol (BPS) rate of transceiver system by switching between the different modulation modes in variable channel condition. In this method, we choose the minimum values of average bit error rate (BER) and maximum values of average BPS on different values of average channel signal to noise ratio (SNR) and then calculate the relative threshold levels of them, so that when the instantaneous SNR increases, a higher order modulation be employed for increasing throughput and vise-versa when the instantaneous SNR decreases, a lower order modulation be employed for improvement of BER. In transmission step, by this adaptive modulation method, in according to comparison between obtained estimation of pilot symbols and a set of above suboptimum threshold levels, above system chooses one of states no transmission, BPSK, 4QAM and square 16QAM for modulation of data. The expected channel in this paper is a slow Rayleigh fading.
Abstract: The main aim of this study is to describe and introduce a method of numerical analysis in obtaining approximate solutions for the SIR-SI differential equations (susceptible-infectiverecovered for human populations; susceptible-infective for vector populations) that represent a model for dengue disease transmission. Firstly, we describe the ordinary differential equations for the SIR-SI disease transmission models. Then, we introduce the numerical analysis of solutions of this continuous time, discrete space SIR-SI model by simplifying the continuous time scale to a densely populated, discrete time scale. This is followed by the application of this numerical analysis of solutions of the SIR-SI differential equations to the estimation of relative risk using continuous time, discrete space dengue data of Kuala Lumpur, Malaysia. Finally, we present the results of the analysis, comparing and displaying the results in graphs, table and maps. Results of the numerical analysis of solutions that we implemented offers a useful and potentially superior model for estimating relative risks based on continuous time, discrete space data for vector borne infectious diseases specifically for dengue disease.
Abstract: The effect of variable chemical reaction on heat and mass transfer characteristics over unsteady stretching surface embedded in a porus medium is studied. The governing time dependent boundary layer equations are transformed into ordinary differential equations containing chemical reaction parameter, unsteadiness parameter, Prandtl number and Schmidt number. These equations have been transformed into a system of first order differential equations. MATHEMATICA has been used to solve this system after obtaining the missed initial conditions. The velocity gradient, temperature, and concentration profiles are computed and discussed in details for various values of the different parameters.
Abstract: The work presents a development of EN338 strength classes for Strombosia pustulata, Pterygotama crocarpa, Nauclea diderrichii and Entandrophragma cyclindricum Nigerian timber species. The specimens for experimental measurements were obtained from the timber-shed at the famous Panteka market in Kaduna in the northern part of Nigeria. Laboratory experiments were conducted to determine the physical and mechanical properties of the selected timber species in accordance with EN 13183-1 and ASTM D193. The mechanical properties were determined using three point bending test. The generated properties were used to obtain the characteristic values of the material properties in accordance with EN384. The selected timber species were then classified according to EN 338. Strombosia pustulata, Pterygotama crocarpa, Nauclea diderrichii and Entandrophragma cyclindricum were assigned to strength classes D40, C14, D40 and D24 respectively. Other properties such as tensile and compressive strengths parallel and perpendicular to grains, shear strength as well as shear modulus were obtained in accordance with EN 338.
Abstract: The study of morphometric and histologic evolutions
of the Bursa of Fabricus during 27 weeks of post-hashing age,
realized on 88 subjects of broiler chicken they permitted to collect
information about the morpho-histological aspect according to their
post-hashing age; showed the size and the weight of the Bursa of
Fabricius which reach their maximum between the 10th and the 11th
week of age and the physiologic involution phenomena. These
variations are in close relationship to the sexual maturity. These
results can be used in the diagnosis of viral disease such as the
Gumboro disease, Marek disease.
Abstract: This paper describes reactive neural control used to
generate phototaxis and obstacle avoidance behavior of walking
machines. It utilizes discrete-time neurodynamics and consists of
two main neural modules: neural preprocessing and modular neural
control. The neural preprocessing network acts as a sensory fusion
unit. It filters sensory noise and shapes sensory data to drive the
corresponding reactive behavior. On the other hand, modular neural
control based on a central pattern generator is applied for locomotion
of walking machines. It coordinates leg movements and can generate
omnidirectional walking. As a result, through a sensorimotor loop this
reactive neural controller enables the machines to explore a dynamic
environment by avoiding obstacles, turn toward a light source, and
then stop near to it.
Abstract: The evaluation of conversational agents or chatterbots question answering systems is a major research area that needs much attention. Before the rise of domain-oriented conversational agents based on natural language understanding and reasoning, evaluation is never a problem as information retrieval-based metrics are readily available for use. However, when chatterbots began to become more domain specific, evaluation becomes a real issue. This is especially true when understanding and reasoning is required to cater for a wider variety of questions and at the same time to achieve high quality responses. This paper discusses the inappropriateness of the existing measures for response quality evaluation and the call for new standard measures and related considerations are brought forward. As a short-term solution for evaluating response quality of conversational agents, and to demonstrate the challenges in evaluating systems of different nature, this research proposes a blackbox approach using observation, classification scheme and a scoring mechanism to assess and rank three example systems, AnswerBus, START and AINI.
Abstract: Presence of phytosterol compound in Durian seed
(Durio zibethinus) or known as King of fruits has been discovered
from screening work using reagent test. Further analysis work has
been carried out using mass spectrometer in order to support the
priliminary finding. Isolation and purification of the major
phytosterol has been carried out using an open column
chromatography. The separation was monitored using thin layer
chromatography (TLC). Major isolated compounds and purified
phytosterol were identified using mass spectrometer and nuclear
magnetic resonance (NMR). This novel finding could promote
utilization of durian seeds as a functional ingredient in food products
through production of standardized extract based on phytosterol
content.
Abstract: Due to dynamic evolution, the ability of a
manufacturing technology to produce a special product is changing.
Therefore, it is essential to monitor the established techniques and
processes to detect whether a company-s production will fit future
circumstances. Concerning the manufacturing technology planning
process, companies must decide when to change to a new technology
for maintaining and increasing competitive advantages. In this
context, the maturity assessment of the focused technologies is
crucial. This article presents an approach for defining the maturity of
a manufacturing technology from a strategic point of view. The
concept is based on the approach of technology readiness level
(TRL) according to NASA (National Aeronautics and Space
Administration), but also includes dynamic changes. Therefore, the
model takes into account the concept of the technology life cycle.
Furthermore, it enables a company to estimate the ideal date for
implementation of a new manufacturing technology.
Abstract: A modified Genetic Algorithm (GA) based optimal selection of parameters for Automatic Generation Control (AGC) of multi-area electric energy systems is proposed in this paper. Simulations on multi-area reheat thermal system with and without consideration of nonlinearity like governor dead band followed by 1% step load perturbation is performed to exemplify the optimum parameter search. In this proposed method, a modified Genetic Algorithm is proposed where one point crossover with modification is employed. Positional dependency in respect of crossing site helps to maintain diversity of search point as well as exploitation of already known optimum value. This makes a trade-off between exploration and exploitation of search space to find global optimum in less number of generations. The proposed GA along with decomposition technique as developed has been used to obtain the optimum megawatt frequency control of multi-area electric energy systems. Time-domain simulations are conducted with trapezoidal integration along with decomposition technique. The superiority of the proposed method over existing one is verified from simulations and comparisons.
Abstract: In today-s modern world, the number of vehicles is
increasing on the road. This causes more people to choose walking
instead of traveling using vehicles. Thus, proper planning of
pedestrians- paths is important to ensure the safety of pedestrians in a
walking area. Crowd dynamics study the pedestrians- behavior and
modeling pedestrians- movement to ensure safety in their walking paths.
To date, many models have been designed to ease pedestrians-
movement. The Social Force Model is widely used among researchers
as it is simpler and provides better simulation results. We will discuss
the problem regarding the ritual of circumambulating the Ka-aba
(Tawaf) where the entrances to this area are usually congested which
worsens during the Hajj season. We will use the computer simulation
model SimWalk which is based on the Social Force Model to simulate
the movement of pilgrims in the Tawaf area. We will first discuss the
effect of uni and bi-directional flows at the gates. We will then restrict
certain gates to the area as the entrances only and others as exits only.
From the simulations, we will study the effect of the distance of other
entrances from the beginning line and their effects on the duration of
pilgrims circumambulate Ka-aba. We will distribute the pilgrims at the
different entrances evenly so that the congestion at the entrances can be
reduced. We would also discuss the various locations and designs of
barriers at the exits and its effect on the time taken for the pilgrims to
exit the Tawaf area.