Abstract: Kidney cancer is the most lethal urological cancer
accounting for 3% of adult malignancies. VHL, a tumor-suppressor
gene, is best known to be associated with renal cell carcinoma
(RCC). The VHL functions as negative regulator of hypoxia inducible
factors. Recent sequencing efforts have identified several novel
frequent mutations of histone modifying and chromatin remodeling
genes in ccRCC (clear cell RCC) including PBRM1 and SETD2. The
PBRM1 gene encodes the BAF180 protein, which involved in
transcriptional activation and repression of selected genes. SETD2
encodes a histone methyltransferase, which may play a role in
suppressing tumor development. In this study, RNAs of 30 paired
tumor and normal samples that were grouped according to the types
of kidney cancer and clinical characteristics of patients, including
gender and average age were examined by RT-PCR, SSCP and
sequencing techniques. VHL, PBRM1 and SETD2 expressions were
relatively down-regulated. However, statistically no significance was
found (Wilcoxon signed rank test, p>0.05). Interestingly, no mutation
was observed on the contrary of previous studies. Understanding the
molecular mechanisms involved in the pathogenesis of RCC has
aided the development of molecular-targeted drugs for kidney cancer.
Further analysis is required to identify the responsible genes rather
than VHL, PBRM1 and SETD2 in kidney cancer.
Abstract: Corrosion of concrete sewer pipes induced by
sulphuric acid attack is a recognised problem worldwide, which is not
only an attribute of countries with hot climate conditions as thought
before. The significance of this problem is by far only realised when
the pipe collapses causing surface flooding and other severe
consequences. To change the existing post-reactive attitude of
managing companies, easy to use and robust models are required to
be developed which currently lack reliable data to be correctly
calibrated. This paper focuses on laboratory experiments of
establishing concrete pipe corrosion rate by submerging samples in to
0.5pH sulphuric acid solution for 56 days under 10ºC, 20ºC and 30ºC
temperature regimes. The result showed that at very early stage of the
corrosion process the samples gained overall mass, at 30ºC the
corrosion progressed quicker than for other temperature regimes,
however with time the corrosion level for 10ºC and 20ºC regimes
tended towards those at 30ºC. Overall, at these conditions the
corrosion rates of 10 mm/year, 13,5 mm/year and 17 mm/year were
observed.
Abstract: A total of 115 yeast strains isolated from local cassava
processing wastes were measured for crude protein content. Among
these strains, the strain MSY-2 possessed the highest protein
concentration (>3.5 mg protein/mL). By using molecular
identification tools, it was identified to be a strain of Pichia
kudriavzevii based on similarity of D1/D2 domain of 26S rDNA
region. In this study, to optimize the protein production by MSY-2
strain, Response Surface Methodology (RSM) was applied. The
tested parameters were the carbon content, nitrogen content, and
incubation time. Here, the value of regression coefficient (R2) =
0.7194 could be explained by the model which is high to support the
significance of the model. Under the optimal condition, the protein
content was produced up to 3.77 g per L of the culture and MSY-2
strain contains 66.8 g protein per 100 g of cell dry weight. These
results revealed the plausibility of applying the novel strain of yeast
in single-cell protein production.
Abstract: Rice straw is lignocellulosic biomass which can be utilized as substrate for the biogas production. However, due to the property and composition of rice straw, it is difficult to be degraded by hydrolysis enzymes. One of the pretreatment methods that modify such properties of lignocellulosic biomass is the application of lignocellulose-degrading microbial consortia. The aim of this study is to investigate the effect of microbial consortia to enhance biogas production. To select the high efficient consortium, cellulase enzymes were extracted and their activities were analyzed. The results suggested that microbial consortium culture obtained from cattle manure is the best candidate compared to decomposed wood and horse manure. A microbial consortium isolated from cattle manure was then mixed with anaerobic sludge and used as inoculum for biogas production. The optimal conditions for biogas production were investigated using response surface methodology (RSM). The tested parameters were the ratio of amount of microbial consortium isolated and amount of anaerobic sludge (MI:AS), substrate to inoculum ratio (S:I) and temperature. Here, the value of the regression coefficient R2 = 0.7661 could be explained by the model which is high to advocate the significance of the model. The highest cumulative biogas yield was 104.6 ml/g-rice straw at optimum ratio of MI:AS, ratio of S:I, and temperature of 2.5:1, 15:1 and 44°C respectively.
Abstract: This study examined how individuals in their
respective teams contributed to innovation performance besides
defining the term of innovation in their own respective views. This
study also identified factors that motivated University staff to
contribute to the innovation products. In addition, it examined
whether there is a significant relationship between professional
training level and the length of service among university staff
towards innovation and to what extent do the two variables
contributed towards innovative products. The significance of this
study is that it revealed the strengths and weaknesses of the
university staff when contributing to innovation performance.
Stratified-random sampling was employed to determine the samples
representing the population of lecturers in the study, involving 123
lecturers in one of the local universities in Malaysia. The method
employed to analyze the data is through categorizing into themes for
the open-ended questions besides using descriptive and inferential
statistics for the quantitative data. This study revealed that two types
of definition for the term “innovation” exist among the university
staff, namely, creation of new product or new approach to do things
as well as value-added creative way to upgrade or improve existing
process and service to be more efficient. This study found that the
most prominent factor that propels them towards innovation is to
improve the product in order to benefit users, followed by selfsatisfaction
and recognition. This implies that the staff in the
organization viewed the creation of innovative products as a process
of growth to fulfill the needs of others and also to realize their
personal potential. This study also found that there was only a
significant relationship between the professional training level and
the length of service of 4 - 6 years among the university staff. The
rest of the groups based on the length of service showed that there
was no significant relationship with the professional training level
towards innovation. Moreover, results of the study on directional
measures depicted that the relationship for the length of service of 4-
6 years with professional training level among the university staff is
quite weak. This implies that good organization management lies on
the shoulders of the key leaders who enlighten the path to be
followed by the staff.
Abstract: Taking into account the significance of measuring the
daily use of the study space in the libraries in order to develop and
reorganize the space for enhancing the efficiency of the study space,
the current study aimed to apply GIS in analyzing the study halls of
the Central Library and Document Center of Tehran University in
order to determine how study desks and chairs were used by the
students. The study used a combination of survey-descriptive and
system design method. In order to gather the required data, surveydescriptive
method was used. For implementing and entering data
into ArcGIS and analyzing the data and displaying the results on the
maps of the study halls of the library, system design method was
utilized. The design of the spatial database of the use of the study
halls was measured through the extent of occupancy of the space by
the library users and the maps of the study halls of the central library
of Tehran University as the case study. The results showed that
Abooreyhan hall had the highest rate of occupancy of the desks and
chairs compared to the other halls. The Hall of Science and
Technology, with an average occupancy rate of 0.39 for the tables
represented the lowest number of users and Rashid al-Dins hall, and
Science and Technology hall with an average occupancy rate (0.40)
had the lowest number of users for seats. In this study, the
comparison of the space occupied at different periods in the morning,
evenings, afternoons, and several months was performed through
GIS. This system analyzed the space relationships effectively and
efficiently. The output of this study would be used by administrators
and librarians to determine the exact extent of use of the equipment
of the study halls and librarians can use the output map to design the
space more efficiently at the library.
Abstract: Increasing prevalence of childhood obesity has
increased the interest in early and late indicators of gaining weight.
Cell blood counts may be indicators of pro-inflammatory states. The
aim was to evaluate associations of hematological parameters,
including hematocrit (HTC), hemoglobin, blood cell counts and their
indices with the degree of obesity in pediatric population. A total of
249; -139 morbidly obese (MO), 82 healthy normal weight (NW) and
28 overweight (OW) children were included into the scope of the
study. WHO BMI-for age percentiles were used to form age- and sexmatched
groups. Informed consent forms and the Ethics Committee
approval were obtained. Anthropometric measurements were
performed. Hematological parameters were determined. Statistical
analyses were performed using SPSS. The degree for statistical
significance was p≤0.05. Significant differences (p=0.000) between
waist-to-hip ratios and head-to- neck ratios (hnrs) of MO and NW
children were detected. A significant difference between hnrs of OW
and MO children (p=0.000) was observed. Red cell distribution width
(RDW) was higher in OW children than NW group (p=0.030). Such
finding couldn’t be detected between MO and NW groups. Increased
RDW was prominent in OW children. The decrease in mean
corpuscular hemoglobin concentration (MCHC) values in MO
children was sharper than the values in OW children (p=0.006 vs
p=0.042) compared to those in NW group. Statistically higher HTC
levels were observed between MO-NW (p=0.014), but none between
OW-NW. Though the cause-effect relationship between obesity and
erythrocyte indices still needs further investigation, alterations in
RDW, HTC, MCHC during obesity may be of significance in the
early life.
Abstract: The paper presents a practical three-phase PWM
inverter suitable for low voltage, low rating energy efficient systems.
The work in the paper is conducted with the view to establishing the
significance of the loss contribution from the PWM inverter in the
determination of the complete losses of a photovoltaic (PV) arraypowered
induction motor drive water pumping system. Losses
investigated include; conduction and switching loss of the devices
and gate drive losses. It is found that the PWM inverter operates at a
reasonable variable efficiency that does not fall below 92%
depending on the load. The results between the simulated and
experimental results for the system with or without a maximum
power tracker (MPT) compares very well, within an acceptable range
of 2% margin.
Abstract: Effect of biopesticide from wood vinegar and
extracted substances from 3 medicinal plants such as: non taai yak
(Stemona tuberosa Lour), boraphet (Tinospora crispa Mier) and
derris (Derris elliptica Roxb) were tested on the age five years of
pomelo. The selected pomelo was carried out for insects’ pest control
and its quality. The experimental site was located at farmer’s orchard
in Phichit Province, Thailand. This study was undertaken during the
drought season (December to March). The extracted from plants and
wood vinegar were evaluated in 6 treatments: 1) water as control; 2)
wood vinegar; 3) S. tuberosa Lour; 4) T. crispa Mier; 5) D. elliptica
Roxb; 6) mixed (wood vinegar + S. tuberosa Lour + T. crispa Mier +
D. elliptica Roxb). The experiment was RCB with 6 treatments and 3
replications per treatment. The results showed that T. crispa Mier was
the highest effectiveness for reduction population of thrips
(Scirtothrips dorsalis Hood) and citrus leaf miner (Phyllocnistis
citrella Stainton) at 14.10 and 15.37 respectively, followed by
treatment of mixed, D. elliptica Roxb, S. tuberosa Lour and wood
vinegar with significance different. Additionally, T. crispa Mier
promoted the high quality of harvested pomelo in term of thickness
of skin at 12.45 mm and S. tuberosa Lour gave the high quality of the
pomelo in term of firmness (276.5 kg/cm2) and brix (11.0%).
Abstract: Validity, integrity, and impacts of the IT systems of
the US federal courts have been studied as part of the Human Rights
Alert-NGO (HRA) submission for the 2015 Universal Periodic
Review (UPR) of human rights in the United States by the Human
Rights Council (HRC) of the United Nations (UN). The current
report includes overview of IT system analysis, data-mining and case
studies. System analysis and data-mining show: Development and
implementation with no lawful authority, servers of unverified
identity, invalidity in implementation of electronic signatures,
authentication instruments and procedures, authorities and
permissions; discrimination in access against the public and
unrepresented (pro se) parties and in favor of attorneys; widespread
publication of invalid judicial records and dockets, leading to their
false representation and false enforcement. A series of case studies
documents the impacts on individuals' human rights, on banking
regulation, and on international matters. Significance is discussed in
the context of various media and expert reports, which opine
unprecedented corruption of the US justice system today, and which
question, whether the US Constitution was in fact suspended. Similar
findings were previously reported in IT systems of the State of
California and the State of Israel, which were incorporated, subject to
professional HRC staff review, into the UN UPR reports (2010 and
2013). Solutions are proposed, based on the principles of publicity of
the law and the separation of power: Reliance on US IT and legal
experts under accountability to the legislative branch, enhancing
transparency, ongoing vigilance by human rights and internet
activists. IT experts should assume more prominent civic duties in the
safeguard of civil society in our era.
Abstract: In today’s era, it is no news that organizations should
demonstrate honest conduct as well as ethical administration.
Therefore, the concept of corporate social responsibility
(subsequently CSR) has created its tag upon the company’s focal
point as well as marketing communications, and will continue in the
future. The importance of CSR has increased in the last decade, and
this concept has attracted global attention. The notion of CSR has
strategic significance for many organizations. However, businesses
are not adapting the activities of CSR that benefit to all of its
stakeholders (including society). The main reason is the practitioners
are unfortunately unable to comprehend its importance; and
therefore, the activities of the CSR are so detached from the business
activities. Hence, it is required to develop an understanding that the
activities of CSR are not only beneficial for the society but it also
benefit to business. This paper focuses on the concept of strategic
CSR, and develops a theoretical framework that will help
practitioners to filter and chose the activities of CSR that are strategic
in nature.
Abstract: Climate change will affect various aspects of
hydrological cycle such as rainfall. A change in rainfall will affect
flood magnitude and frequency in future which will affect the design
and operation of hydraulic structures. In this paper, trends in subhourly,
sub-daily, and daily extreme rainfall events from 18 rainfall
stations located in Tasmania, Australia are examined. Two nonparametric
tests (Mann-Kendall and Spearman’s Rho) are applied to
detect trends at 10%, 5%, and 1% significance levels. Sub-hourly (6,
12, 18, and 30 minutes) annual maximum rainfall events have been
found to experience statistically significant upward trends at 10%
level of significance. However, sub-daily durations (1 hour, 3 and 12
hours) exhibit decreasing trends and no trends exists for longer
duration rainfall events (e.g. 24 and 72 hours). Some of the durations
(e.g. 6 minutes and 6 hours) show similar results (with upward
trends) for both the tests. For 12, 18, 60 minutes and 3 hours
durations both the tests show similar downward trends. This finding
has important implication for Tasmania in the design of urban
infrastructure where shorter duration rainfall events are more relevant
for smaller urban catchments such as parking lots, roof catchments
and smaller sub-divisions.
Abstract: Stochastic User Equilibrium (SUE) model is a widely
used traffic assignment model in transportation planning, which is
regarded more advanced than Deterministic User Equilibrium (DUE)
model. However, a problem exists that the performance of the SUE
model depends on its error term parameter. The objective of this
paper is to propose a systematic method of determining the
appropriate error term parameter value for the SUE model. First, the
significance of the parameter is explored through a numerical
example. Second, the parameter calibration method is developed
based on the Logit-based route choice model. The calibration process
is realized through multiple nonlinear regression, using sequential
quadratic programming combined with least square method. Finally,
case analysis is conducted to demonstrate the application of the
calibration process and validate the better performance of the SUE
model calibrated by the proposed method compared to the SUE
models under other parameter values and the DUE model.
Abstract: A study was conducted to determine the diversity and
abundance of shorebird species habituating the mudflat area of Jeram
Beach and Remis Beach, Selangor, Peninsular Malaysia. Direct
observation technique (using binoculars and video camera) was
applied to record the presence of bird species in the sampling sites
from August 2013 until July 2014. A total of 32 species of shorebird
were recorded during both migratory and non-migratory seasons. Of
these, eleven species (48%) are migrants, six species (26%) have both
migrant and resident populations, four species (17%) are vagrants and
two species (9%) are residents. The compositions of the birds
differed significantly in all months (χ2 = 84.35, p < 0.001). There is a
significant difference in avian abundance between migratory and
non-migratory seasons (Mann-Whitney, t = 2.39, p = 0.036). The
avian abundance were differed significantly in Jeram and Remis
Beaches during migratory periods (t = 4.39, p = 0.001) but not during
non-migratory periods (t = 0.78, p = 0.456). Shorebird diversity was
also affected by tidal cycle. There is a significance difference
between high tide and low tide (Mann-Whitney, t = 78.0, p < 0.005).
Frequency of disturbance also affected the shorebird distribution
(Mann-Whitney, t = 57.0, p = 0.0134). Therefore, this study
concluded that tides and disturbances are two factors that affecting
temporal distribution of shorebird in mudflats area.
Abstract: In the culture of Thailand, the Yak serve as a mediated
icon representing strength, power, and mystical protection not only
for the Buddha, but for population of worshipers. Originating from
the forests of China, the Yak continues to stand guard at the gates of
Buddhist temples. The Yak represents Thai culture in the hearts of
Thai people. This paper presents a qualitative study regarding the
curious mix of media, culture, and religion that projects the Yak of
Thailand as a larger than life message throughout the political,
cultural, and religious spheres. The gate guardians, or gods as they
are sometimes called, appear throughout the religious temples of
Asian cultures. However, the Asian cultures demonstrate differences
in artistic renditions (or presentations) of such sentinels. Thailand
gate guards (the Yak) stand in front of many Buddhist temples, and
these iconic figures display unique features with varied symbolic
significance. The temple (or wat), plays a vital role in every
community; and, for many people, Thailand’s temples are the
country’s most endearing sights. The authors applied folknography as
a methodology to illustrate the importance of the Thai Yak in serving
as meaningful icons that transcend not only time, but the culture,
religion, and mass media. The Yak represents mythical, religious,
artistic, cultural, and militaristic significance for the Thai people.
Data collection included interviews, focus groups, and natural
observations. This paper summarizes the perceptions of the Thai
people concerning their gate sentries and the relationship,
communication, connection, and the enduring respect that Thai
people hold for their guardians of the gates.
Abstract: This study is an attempt to raise the awareness of the
stakeholders and the authorities on the sensitivity of Algerian
secondary school teachers of English as a Foreign Language about
the students’ loss of English language skills learned during formal
schooling with effort and at expense and the supposed measures to
arrest that loss. Data was collected from secondary school teachers of
EFL and analyzed quantitatively using a questionnaire containing
open-ended and close-ended questions. The results advocate a
consensus about the need for actions to be adopted to make
assessment techniques outcome-oriented. Most of the participants
were in favor of including curricular activities involving
contextualized learning, problem-solving learning critical selfawareness,
self and peer-assisted learning, use of computers and
internet so as to make learners autonomous.
Abstract: Nanotechnology is the new cyber, according to several major leaders in this field. Just as cyber is entrenched across global society now, nano is poised to be major capabilities enabler of the next decades. Expert members from the National Nanotechnology Initiative (in U.S.) representing government and science disciplines say nano has great significance for the military and the general public. It is predicted that after next 15 years nanotechnology will replace information technology as the most economic technology platform. Nanotechnology has even wider applications than information technology.
Abstract: Sustainability, being the urgent issue of our time, is
closely related with the innovations in technology. Nanotechnology
(NT), although not a new science, can be regarded relatively a new
science for buildings with brand new materials and applications. This
paper tends to give a research review of current and near future
applications of nanotechnology (NT) for achieving high-performance
and healthy buildings for a sustainable future. In the introduction, the
driving forces for the sustainability of construction industry are
explained. Then, the term NT is defined, and significance of
innovations in NT for a sustainable construction industry is revealed.
After presenting the application areas of NT and nanomaterials for
buildings with a number of cases, challenges in the adoption of this
technology are put forward, and finally the impacts of nanoparticles
and nanomaterials on human health and environment are discussed.
Abstract: In the past, the most comprehensively adopted light
source was incandescent light bulbs, but with the appearance of LED
light sources, traditional light sources have been gradually replaced by
LEDs because of its numerous superior characteristics. However,
many of the standards do not apply to LEDs as the two light sources
are characterized differently. This also intensifies the significance of
studies on LEDs. As a Kansei design study investigating the visual
glare produced by traffic arrows implemented with LEDs, this study
conducted a semantic analysis on the styles of traffic arrows used in
domestic and international occasions. The results will be able to
reduce drivers’ misrecognition that results in the unsuccessful arrival
at the destination, or in traffic accidents. This study started with a
literature review and surveyed the status quo before conducting
experiments that were divided in two parts. The first part involved a
screening experiment of arrow samples, where cluster analysis was
conducted to choose five representative samples of LED displays. The
second part was a semantic experiment on the display of arrows using
LEDs, where the five representative samples and the selected ten
adjectives were incorporated. Analyzing the results with
Quantification Theory Type I, it was found that among the
composition of arrows, fletching was the most significant factor that
influenced the adjectives. In contrast, a “no fletching” design was
more abstract and vague. It lacked the ability to convey the intended
message and might bear psychological negative connotation including
“dangerous,” “forbidden,” and “unreliable.” The arrow design
consisting of “> shaped fletching” was found to be more concrete and
definite, showing positive connotation including “safe,” “cautious,”
and “reliable.” When a stimulus was placed at a farther distance, the
glare could be significantly reduced; moreover, the visual evaluation
scores would be higher. On the contrary, if the fletching and the shaft
had a similar proportion, looking at the stimuli caused higher
evaluation at a closer distance. The above results will be able to be
applied to the design of traffic arrows by conveying information
definitely and rapidly. In addition, drivers’ safety could be enhanced
by understanding the cause of glare and improving visual
recognizability.
Abstract: Background: The high prevalence of obesity in Egypt has a great impact on the health care system, economic and social situation. Evidence suggests that even a moderate amount of weight loss can be useful. Aim of the study: To analyze the effects of lower body positive pressure supported treadmill training, conducted with hypocaloric diet, on body composition of obese children. Methods: Thirty children aged between 8 and 14 years, were randomly assigned into two groups: intervention group (15 children) and control group (15 children). All of them were evaluated using body composition analysis through bioelectric impedance. The following parameters were measured before and after the intervention: body mass, body fat mass, muscle mass, body mass index (BMI), percentage of body fat and basal metabolic rate (BMR). The study group exercised with antigravity treadmill three times a week during 2 months, and participated in a hypocaloric diet program. The control group participated in a hypocaloric diet program only. Results: Both groups showed significant reduction in body mass, body fat mass and BMI. Only study group showed significant reduction in percentage of body fat (p = 0.0.043). Changes in muscle mass and BMR didn't reach statistical significance in both groups. No significant differences were observed between groups except for muscle mass (p = 0.049) and BMR (p = 0.042) favoring study group. Conclusion: Both programs proved effective in the reduction of obesity indicators, but lower body positive pressure supported treadmill training was more effective in improving muscle mass and BMR.