Abstract: Gastric Cancer (GC) has high morbidity and fatality
rate in various countries. It is still one of the most frequent and
deadly diseases. Gastrokine1 (GKN1) and gastrokine2 (GKN2) genes
are highly expressed in the normal stomach epithelium and play
important roles in maintaining the integrity and homeostasis of
stomach mucosal epithelial cells. In this study, 47 paired samples that
were grouped according to the types of gastric cancer and the clinical
characteristics of the patients, including gender and average of age.
They were investigated with gene expression analysis and mutation
screening by monitoring RT-PCR, SSCP and nucleotide sequencing
techniques. Both GKN1 and GKN2 genes were observed significantly
reduced found by (Wilcoxon signed rank test; p
Abstract: Monitoring the conditions of rotating machinery, such
as bearings, is important in order to improve the stability of work.
Acoustic Emission (AE) and vibration analysis are some of the most
accomplished techniques used for this purpose. Acoustic emission
has the ability to detect the initial phase of component degradation.
Moreover, it has been observed that vibration analysis is not as
successful at low rotational speeds (below 100 rpm). This because the
energy generated within this speed region is not detectable using
conventional vibration. From this perspective, this paper has
presented a brief review of using acoustic emission techniques for
monitoring bearing conditions.
Abstract: The Com-Poisson (CMP) model is one of the most
popular discrete generalized linear models (GLMS) that handles
both equi-, over- and under-dispersed data. In longitudinal context,
an integer-valued autoregressive (INAR(1)) process that incorporates
covariate specification has been developed to model longitudinal
CMP counts. However, the joint likelihood CMP function is
difficult to specify and thus restricts the likelihood-based estimating
methodology. The joint generalized quasi-likelihood approach
(GQL-I) was instead considered but is rather computationally
intensive and may not even estimate the regression effects due
to a complex and frequently ill-conditioned covariance structure.
This paper proposes a new GQL approach for estimating the
regression parameters (GQL-III) that is based on a single score vector
representation. The performance of GQL-III is compared with GQL-I
and separate marginal GQLs (GQL-II) through some simulation
experiments and is proved to yield equally efficient estimates as
GQL-I and is far more computationally stable.
Abstract: To maintain a healthy balanced loyalty, whether to art
or society, posits a debatable issue. The artist is always on the look
out for the potential tension between those two realms. Therefore,
one of the most painful dilemmas the artist finds is how to function in
a society without sacrificing the aesthetic values of his/her work. In
other words, the life-long awareness of failure which derives from the
concept of the artist as caught between unflattering social realities
and the need to invent genuine art forms becomes a fertilizing soil for
the artists to be tackled. Thus, within the framework of this dilemma,
the question of the responsibility of the artist and the relationship of
the art to politics will be illuminating. To a larger extent, however, in
drama, this dilemma is represented by the fictional characters of the
play. The present paper tackles the idea of the amorality of the artist in
selected plays by Tom Stoppard. However, Stoppard’s awareness of
his situation as a refugee has led him to keep at a distance from
politics. He tried hard to avoid any intervention into the realms of
political debate, especially in his earliest work. On the one hand, it is
not meant that he did not interest in politics as such, but rather he
preferred to question it than to create a fixed ideological position. On
the other hand, Stoppard’s refusal to intervene in politics is ascribed
to his feeling of gratitude to Britain where he settled. As a result,
Stoppard has frequently been criticized for a lack of political
engagement and also for not leaning too much for the left when he
does engage. His reaction to these public criticisms finds expression
in his self-conscious statements which defensively stressed the
artifice of his work. He, like Oscar Wilde thinks that the
responsibility of the artist is devoted to the realm of his/her art.
Consequently, his consciousness for the role of the artist is truly
reflected in his two plays, Artist Descending a Staircase (1972) and
Travesties (1974).
Abstract: Background: Breast milk may impact early brain
development, with potentially important biological, medical and
social implications. There is an important discussion on which is the
adequate breastfeeding extension to the development consolidation
and how the children breastfeeding affects their psychomotor
development, in the first year of life, and in following periods as
well. Some special fats (LC PUFA) contained in breast milk play a
key role in the brain’s maturation and cognitive development or
social skills. These capacities created during breastfeeding time
would be unfolded throughout all lifespan. Aim of the study: In our research, we have studied the effect of
breastfeeding in preschooler's psychomotor assessment.
Method: This study was conducted in a sample of 158 preschool
children in Vlorë, Albania. We have measured the psychometric
parameters of preschoolers with ASQ-3 (Age&Stage Questionnaires-
3). The studied sample was divided in three groups according to their
breastfeeding duration (3, 6 and 12 months). Results: Children breastfed for only 3 months have definitely
lower psychometric scores compared to the ones with 6 or more
months of breastfeeding (respectively 217 to 239 ASQ-3 scores). Six
and twelvemonth breastfed children have progressively more odds to
have high levels of psychomotor development comparing to those
with only 3 months of breastfeeding. The most affected psychometric
domains by shortness of breastfeeding are Communication and
Global motor. Conclusion: This leads to conclusion that to ensure high
psychomotor parameters during childhood is necessary breastfeeding
for at least 6 months.
Abstract: The floor beams of steel buildings, cold-formed steel
floor joists in particular, often require large web openings, which may
affect their shear capacities. A cost effective way to mitigate the
detrimental effects of such openings is to weld/fasten reinforcements.
A difficulty associated with an experimental investigation to establish
suitable reinforcement schemes for openings in shear zone is that
moment always coexists with the shear, and thus, it is impossible to
create pure shear state in experiments, resulting in moment
influenced results. However, Finite Element Method (FEM) based
analysis can be conveniently used to investigate the pure shear
behaviour of webs including webs with reinforced openings. This
paper presents the details associated with the finite element analysis
of thick/thin-plates (representing the web of hot-rolled steel beam,
and the web of a cold-formed steel member) having a large
reinforced opening. The study considered simply-supported
rectangular plates subjected to in-plane shear loadings until failure
(including post-buckling behaviour). The plate was modelled using
geometrically non-linear quadrilateral shell elements, and non-linear
stress-strain relationship based on experiments. Total Langrangian
with large displacement/small strain formulation was used for such
analyses. The model also considered the initial geometric
imperfections. This study considered three reinforcement schemes,
namely, flat, lip, and angle reinforcements. This paper discusses the
modelling considerations and presents the results associated with the
various reinforcement schemes under consideration.
Abstract: Within this paper, latest results on processing of energetic nanomaterials by means of the Spray Flash Evaporation technique are presented. This technology constitutes a highly effective and continuous way to prepare fascinating materials on the nano- and micro-scale. Within the process, a solution is set under high pressure and sprayed into an evacuated atomization chamber. Subsequent ultrafast evaporation of the solvent leads to an aerosol stream, which is separated by cyclones or filters. No drying gas is required, so the present technique should not be confused with spray dying. Resulting nanothermites, insensitive explosives or propellants and compositions are foreseen to replace toxic (according to REACH) and very sensitive matter in military and civil applications. Diverse examples are given in detail: nano-RDX (n-Cyclotrimethylentrinitramin) and nano-aluminum based systems, mixtures (n-RDX/n-TNT - trinitrotoluene) or even cocrystalline matter like n-CL-20/HMX (Hexanitrohexaazaisowurtzitane/ Cyclotetra-methylentetranitramin). These nanomaterials show reduced sensitivity by trend without losing effectiveness and performance. An analytical study for material characterization was performed by using Atomic Force Microscopy, X-Ray Diffraction, and combined techniques as well as spectroscopic methods. As a matter of course, sensitivity tests regarding electrostatic discharge, impact, and friction are provided.
Abstract: Liver segmentation from medical images poses more
challenges than analogous segmentations of other organs. This
contribution introduces a liver segmentation method from a series of
computer tomography images. Overall, we present a novel method for
segmenting liver by coupling density matching with shape priors.
Density matching signifies a tracking method which operates via
maximizing the Bhattacharyya similarity measure between the
photometric distribution from an estimated image region and a model
photometric distribution. Density matching controls the direction of
the evolution process and slows down the evolving contour in regions
with weak edges. The shape prior improves the robustness of density
matching and discourages the evolving contour from exceeding liver’s
boundaries at regions with weak boundaries. The model is
implemented using a modified distance regularized level set (DRLS)
model. The experimental results show that the method achieves a
satisfactory result. By comparing with the original DRLS model, it is
evident that the proposed model herein is more effective in addressing
the over segmentation problem. Finally, we gauge our performance of
our model against matrices comprising of accuracy, sensitivity, and
specificity.
Abstract: Machine visualization is an area of interest with fast
and progressive development. We present a method of machine
visualization which will be applicable in real industrial conditions
according to current needs and demands. Real factory data were
obtained in a newly built research plant. Methods described in this
paper were validated on a case study. Input data were processed and
the virtual environment was created. The environment contains
information about dimensions, structure, disposition, and function.
Hardware was enhanced by modular machines, prototypes, and
accessories. We added functionalities and machines into the virtual
environment. The user is able to interact with objects such as testing
and cutting machines, he/she can operate and move them. Proposed
design consists of an environment with two degrees of freedom of
movement. Users are in touch with items in the virtual world which
are embedded into the real surroundings. This paper describes development of the virtual environment. We
compared and tested various options of factory layout virtualization
and visualization. We analyzed possibilities of using a 3D scanner in
the layout obtaining process and we also analyzed various virtual
reality hardware visualization methods such as: Stereoscopic (CAVE)
projection, Head Mounted Display (HMD) and augmented reality
(AR) projection provided by see-through glasses.
Abstract: Slash or Yaoi fan art is the artwork that contains a
homosexual relationship between fictional male characters, who were
heterosexual in the original media. Previous belief about Slash or
Yaoi fan art is that the fan fiction writers and the fan artists need to
see the equality in romantic relationship. They do not prefer the
pairing of man and woman, since both genders are not equal. The
objectives of the current study are to confirm this belief, and to
examine the relationship between equality found in Slash fan art,
friendship in original media, and violence contained in fan art. Mean
comparisons show that equality could be found in the pairing of hero
and hero, but rarely found in the pairing of hero and villain.
Regression analysis shows that the level of equality in fan art and
friendship in original media are significant predictors of violence
contained in fan art. Since villain-related pairings yield a high level
of violence in fan art and a low level of equality, researchers of future
studies should find the strategies to prevent fans to include villains in
their Slash or Yaoi fan art.
Abstract: Audio visual communication is a type of collective
expression. Due to inform the masses, give direction to opinions, and
establish public opinion, audio visual communication must be
subjected to special restrictions. This has been stipulated in both the
Constitution and the European Human Rights Agreement. This paper
aims to review freedom of expression and its restriction in audio
visual media. For this purpose, the authorization of the Radio and
Television Supreme Council to impose sanctions as an independent
administrative authority empowered to regulate the field of audio
visual communication has been reviewed with regard to freedom of
expression and its limits.
Abstract: Concurrent planning of project scheduling and
material ordering can provide more flexibility to the project
scheduling problem, as the project execution costs can be enhanced.
Hence, the issue has been taken into account in this paper. To do so, a
mixed-integer mathematical model is developed which considers the
aforementioned flexibility, in addition to the materials quantity
discount and space availability restrictions. Moreover, the activities
duration has been treated as decision variables. Finally, the efficiency
of the proposed model is tested by different instances. Additionally,
the influence of the aforementioned parameters is investigated on the
model performance.
Abstract: This paper concentrates on the sustainable traditional
architecture and urban planning in hot-humid regions of Iran. In a
vast country such as Iran with different climatic zones traditional
builders have presented series of logical solutions for human comfort.
The aim of this paper is to demonstrate traditional architecture in hothumid
climate of Iran as a sample of sustainable architecture. Iranian
traditional architecture has been able to response to environmental
problems for a long period of time. Its features are based on climatic
factors, local construction materials of hot-humid regions and culture.
This paper concludes that Iranian traditional architecture can be
addressed as a sustainable architecture.
Abstract: Numerical study of the static response of
homogeneous clay stratum considering a wide range of cohesion and
subject to foundation loads is presented. The linear elastic–perfectly
plastic constitutive relation with the von Mises yield criterion were
utilised to develop a numerically cost effective finite element model
for the soil while imposing a rigid body constrain to the foundation
footing. From the analyses carried out, estimate of the bearing
capacity factor, Nc as well as the ultimate load-carrying capacities of
these soils, effect of cohesion on foundation settlements, stress fields
and failure propagation were obtained. These are consistent with
other findings in the literature and hence can be a useful guide in
design of safe foundations in clay soils for buildings and other
structure.
Abstract: Cooperative groups through much research have been
recognized to churn remarkable achievements instead of solitary or
individualistic efforts. Based on Johnson and Johnson’s model of
cooperative learning, the five key components of cooperation are
positive interdependence, face-to-face promotive interaction,
individual accountability, social skills, and group processing. In
2011, the Malaysian Ministry of Higher Education (MOHE)
introduced the Holistic Student Development policy with the aim to
develop morally sound individuals equipped with lifelong learning
skills. The Community Service project was included in the
improvement initiative. The purpose of this study is to assess the
relationship of team-based learning in facilitating particularly
students’ positive interdependence and face-to-face promotive
interaction. The research methods involve in-depth interviews with
the team leaders and selected team members, and a content analysis
of the undergraduate students’ reflective journals. A significant
positive relationship was found between students’ progressive
outlook towards teamwork and the highlighted two components. The
key findings show that students have gained in their individual
learning and work results through teamwork and interaction with
other students. The inclusion of Community Service as a MOHE
subject resonates with cooperative learning methods that enhances
supportive relationships and develops students’ social skills together
with their professional skills.
Abstract: The main cause of Alzheimer disease (AD) was
believed to be mainly due to the accumulation of free radicals owing
to oxidative stress (OS) in brain tissue. The mechanism of the
neurotoxicity of Aluminum chloride (AlCl3) induced AD in
hippocampus Albino wister rat brain tissue, the curative & the
protective effects of Lipidium sativum group (LS) water extract were
assessed after 8 weeks by attenuated total reflection spectroscopy
ATR-IR and histologically by light microscope. ATR-IR results
revealed that the membrane phospholipid undergo free radical
attacks, mediated by AlCl3, primary affects the polyunsaturated fatty
acids indicated by the increased of the olefinic -C=CH sub-band area
around 3012 cm-1 from the curve fitting analysis. The narrowing in
the half band width (HBW) of the sνCH2 sub-band around 2852 cm-1
due to Al intoxication indicates the presence of trans form fatty acids
rather than gauch rotomer. The degradation of hydrocarbon chain to
shorter chain length, increasing in membrane fluidity, disorder, and
decreasing in lipid polarity in AlCl3 group indicated by the detected
changes in certain calculated area ratios compared to the control.
Administration of LS was greatly improved these parameters
compared to the AlCl3 group. Al influences the Aβ aggregation and
plaque formation, which in turn interferes to and disrupts the
membrane structure. The results also showed a marked increase in
the β-parallel and antiparallel structure, that characterize the Aβ
formation in Al-induced AD hippocampal brain tissue, indicated by
the detected increase in both amide I sub-bands around 1674, 1692
cm-1. This drastic increase in Aβ formation was greatly reduced in the
curative and protective groups compared to the AlCl3 group and
approached nearly the control values. These results supported too by
the light microscope. AlCl3 group showed significant marked
degenerative changes in hippocampal neurons. Most cells appeared
small, shrieked and deformed. Interestingly, the administration of LS
in curative and protective groups markedly decreases the amount of
degenerated cells compared to the non-treated group. In addition, the
intensity of congo red stained cells was decreased. Hippocampal
neurons looked more/or less similar to those of control. This study showed a promising therapeutic effect of Lipidium
sativum group (LS) on AD rat model that seriously overcome the
signs of oxidative stress on membrane lipid and restore the protein
misfolding.
Abstract: Lagos urban mini bus drivers play a critical role in the
transportation sector. The current major mode of transportation
within Lagos metropolis remains road transportation and this
confirms the relevance of urban mini-bus drivers in transporting the
populace to their various destinations. Other modes of transportation
such as the train and waterways are currently inadequate. Various
threats to the well-being of urban bus drivers include congested
traffic typical of modern day lifestyles, dwindling financial returns
due to long hours in traffic, fewer hours of sleep, inadequate diet,
time pressure, and assaults related to fare disputes. Several healthrelated
problems have been documented to be associated with urban
bus driving. For instance, greater rates of hypertension, obesity and
cholesterol level have been reported. Research studies are yet to
identify the influence of age and marital status on the well-being of
urban mini-bus drivers in Lagos metropolis. A study of this nature is
necessary as it is culturally perceived in Nigeria that older and
married people are especially influenced by family affiliation and
would behave in ways that would project positive outcomes. The
study sample consisted of 150 urban mini-bus drivers who were
conveniently sampled from six (6) different terminuses where their
journey begins and terminates. The well-being questionnaire was
administered to participants. The criteria for inclusion in the study
included the ability to read in English language and the confirmation
that interested participants were on duty and suited to be driving
mini-buses. Due to the nature of the job of bus driving, the researcher
administered the questionnaires on participants who were free and
willing to respond to the survey. All participants were males of
various age groups and of different marital statuses. Results of
analyses conducted revealed no significant influence of age and
marital status on the well-being of urban mini-bus drivers. This
indicates that the well-being of urban mini bus drivers is not
influenced by age or marital status. The findings of this study have
cultural implications. It negates the popularly held belief that older
and married people care more about their well-being than younger
and single people. It brings to fore the need to also identify and
consider other factors when certifying people for the job of urban bus
driving.
Abstract: This study was aimed to measure effective transverse
relaxation rates (R2*) in the liver and muscle of normal New Zealand
White (NZW) rabbits. R2* relaxation rate has been widely used in
various hepatic diseases for iron overload by quantifying iron contents
in liver. R2* relaxation rate is defined as the reciprocal of T2*
relaxation time and mainly depends on the constituents of tissue.
Different tissues would have different R2* relaxation rates. The signal
intensity decay in Magnetic resonance imaging (MRI) may be
characterized by R2* relaxation rates. In this study, a 1.5T GE Signa
HDxt whole body MR scanner equipped with an 8-channel high
resolution knee coil was used to observe R2* values in NZW rabbit’s
liver and muscle. Eight healthy NZW rabbits weighted 2 ~ 2.5 kg were
recruited. After anesthesia using Zoletil 50 and Rompun 2% mixture,
the abdomen of rabbit was landmarked at the center of knee coil to
perform 3-plane localizer scan using fast spoiled gradient echo
(FSPGR) pulse sequence. Afterwards, multi-planar fast gradient echo
(MFGR) scans were performed with 8 various echo times (TEs) to
acquire images for R2* measurements. Regions of interest (ROIs) at
liver and muscle were measured using Advantage workstation.
Finally, the R2* was obtained by a linear regression of ln(sı) on TE.
The results showed that the longer the echo time, the smaller the signal
intensity. The R2* values of liver and muscle were 44.8 ± 10.9 s-1 and
37.4 ± 9.5 s-1, respectively. It implies that the iron concentration of
liver is higher than that of muscle. In conclusion, the more the iron
contents in tissue, the higher the R2*. The correlations between R2*
and iron content in NZW rabbits might be valuable for further
exploration.
Abstract: High Performance Liquid Chromatography (HPLC)
method was developed and validated for simultaneous estimation of
6-Gingerol(6G) and 6-Shogaol(6S) in joint pain relief gel containing
ginger extract. The chromatographic separation was achieved by
using C18 column, 150 x 4.6mm i.d., 5μ Luna, mobile phase
containing acetonitrile and water (gradient elution). The flow rate
was 1.0 ml/min and the absorbance was monitored at 282 nm. The
proposed method was validated in terms of the analytical parameters
such as specificity, accuracy, precision, linearity, range, limit of
detection (LOD), limit of quantification (LOQ), and determined
based on the International Conference on Harmonization (ICH)
guidelines. The linearity ranges of 6G and 6S were obtained over 20-
60 and 6-18 μg/ml respectively. Good linearity was observed over the
above-mentioned range with linear regression equation Y= 11016x-
23778 for 6G and Y = 19276x-19604 for 6S (x is concentration of
analytes in μg/ml and Y is peak area). The value of correlation
coefficient was found to be 0.9994 for both markers. The limit of
detection (LOD) and limit of quantification (LOQ) for 6G were
0.8567 and 2.8555 μg/ml and for 6S were 0.3672 and 1.2238 μg/ml
respectively. The recovery range for 6G and 6S were found to be
91.57 to 102.36 % and 84.73 to 92.85 % for all three spiked levels.
The RSD values from repeated extractions for 6G and 6S were 3.43
and 3.09% respectively. The validation of developed method on
precision, accuracy, specificity, linearity, and range were also
performed with well-accepted results.
Abstract: The effects of the contact ball-lens on the soda lime
glass in laser thermal cleavage with a cw Nd-YAG laser were
investigated in this study. A contact ball-lens was adopted to generate
a bending force on the crack formation of the soda-lime glass in the
laser cutting process. The Nd-YAG laser beam (wavelength of 1064
nm) was focused through the ball-lens and transmitted to the soda-lime
glass, which was coated with a carbon film on the surface with a
bending force from a ball-lens to generate a tensile stress state on the
surface cracking. The fracture was controlled by the contact ball-lens
and a straight cutting was tested to demonstrate the feasibility.
Experimental observations on the crack propagation from the leading
edge, main section and trailing edge of the glass sheet were compared
with various mechanical and thermal loadings. Further analyses on the
stress under various laser powers and contact ball loadings were made
to characterize the innovative technology. The results show that the distributions of the side crack at the
leading and trailing edges are mainly dependent on the boundary
condition, contact force, cutting speed and laser power. With the
increase of the mechanical and thermal loadings, the region of the side
cracks might be dramatically reduced with proper selection of the
geometrical constrains. Therefore the application of the contact
ball-lens is a possible way to control the fracture in laser cleavage with
improved cutting qualities.