Abstract: There is an urgent need to develop novel
Mycobacterium tuberculosis (Mtb) drugs that are active against drug
resistant bacteria but, more importantly, kill persistent bacteria. Our
study structured based on integrated analysis of metabolic pathways,
small molecule screening and similarity Search in PubChem
Database. Metabolic analysis approaches based on Unified weighted
used for potent target selection. Our results suggest that pantothenate
synthetase (panC) and and 3-methyl-2-oxobutanoate hydroxymethyl
transferase (panB) as a appropriate drug targets. In our study, we
used pantothenate synthetase because of existence inhibitors. We
have reported the discovery of new antitubercular compounds
through ligand based approaches using computational tools.
Abstract: This paper presents the effects of migration at the
urban sites with an integrated model under the sustainable local
development policies for the conservation and revitalization of the
site areas as a case at Reyhan heritage site in Bursa. It is known as
the “City of immigrants" because of its richness of cultural plurality.
The city has always regarded the dynamic impact of immigration as a
positive contribution. As a result of this situation, the city created the
earliest urbanization practices: being the first capital city of the
Ottoman Empire. Bursa created the first modern movement practices
and set the first Organized Industrial Zone. The most important aim
of the study is to be offer a model for the similar areas with the
context of conservation and revitalization of the historical areas,
subjected to the local integrated sustainable development policies of
local goverments.
Abstract: In a world worried about water resources with the
shadow of drought and famine looming all around, the quality of
water is as important as its quantity. The source of all concerns is the
constant reduction of per capita quality water for different uses.
Iran With an average annual precipitation of 250 mm compared to
the 800 mm world average, Iran is considered a water scarce country
and the disparity in the rainfall distribution, the limitations of
renewable resources and the population concentration in the margins
of desert and water scarce areas have intensified the problem.
The shortage of per capita renewable freshwater and its poor
quality in large areas of the country, which have saline, brackish or
hard water resources, and the profusion of natural and artificial
pollutant have caused the deterioration of water quality.
Among methods of treatment and use of these waters one can refer
to the application of membrane technologies, which have come into
focus in recent years due to their great advantages. This process is
quite efficient in eliminating multi-capacity ions; and due to the
possibilities of production at different capacities, application as
treatment process in points of use, and the need for less energy in
comparison to Reverse Osmosis processes, it can revolutionize the
water and wastewater sector in years to come. The article studied the
different capacities of water resources in the Persian Gulf and Oman
Sea watershed basins, and processes the possibility of using
nanofiltration process to treat brackish and non-conventional waters
in these basins.
Abstract: This paper attempts to establish the fact that Multi
State Network Classification is essential for performance
enhancement of Transport protocols over Satellite based Networks. A
model to classify Multi State network condition taking into
consideration both congestion and channel error is evolved. In order
to arrive at such a model an analysis of the impact of congestion and
channel error on RTT values has been carried out using ns2. The
analysis results are also reported in the paper. The inference drawn
from this analysis is used to develop a novel statistical RTT based
model for multi state network classification.
An Adaptive Multi State Proactive Transport Protocol consisting
of Proactive Slow Start, State based Error Recovery, Timeout Action
and Proactive Reduction is proposed which uses the multi state
network state classification model. This paper also confirms through
detail simulation and analysis that a prior knowledge about the
overall characteristics of the network helps in enhancing the
performance of the protocol over satellite channel which is
significantly affected due to channel noise and congestion.
The necessary augmentation of ns2 simulator is done for
simulating the multi state network classification logic. This
simulation has been used in detail evaluation of the protocol under
varied levels of congestion and channel noise. The performance
enhancement of this protocol with reference to established protocols
namely TCP SACK and Vegas has been discussed. The results as
discussed in this paper clearly reveal that the proposed protocol
always outperforms its peers and show a significant improvement in
very high error conditions as envisaged in the design of the protocol.
Abstract: This paper illustrates the use of a combined neural
network model for classification of electrocardiogram (ECG) beats.
We present a trainable neural network ensemble approach to develop
customized electrocardiogram beat classifier in an effort to further
improve the performance of ECG processing and to offer
individualized health care.
We process a three stage technique for detection of premature
ventricular contraction (PVC) from normal beats and other heart
diseases. This method includes a denoising, a feature extraction and a
classification. At first we investigate the application of stationary
wavelet transform (SWT) for noise reduction of the
electrocardiogram (ECG) signals. Then feature extraction module
extracts 10 ECG morphological features and one timing interval
feature. Then a number of multilayer perceptrons (MLPs) neural
networks with different topologies are designed.
The performance of the different combination methods as well as
the efficiency of the whole system is presented. Among them,
Stacked Generalization as a proposed trainable combined neural
network model possesses the highest recognition rate of around 95%.
Therefore, this network proves to be a suitable candidate in ECG
signal diagnosis systems. ECG samples attributing to the different
ECG beat types were extracted from the MIT-BIH arrhythmia
database for the study.
Abstract: Urban non-point source (NPS) pollution for a
residential catchment in Miri, Sarawak was investigated for two storm events in 2011. Runoff from two storm events were sampled and tested for water quality parameters including TSS, BOD5, COD,
NH3-N, NO3-N, NO2-N, P and Pb. Concentration of the water quality
parameters was found to vary significantly between storms and the pollutant of concern was found to be NO3-N, TSS, COD and Pb. Results were compared to the Interim National Water Quality
Standards for Malaysia (INWQS),and the stormwater runoff from the
study can be classified as polluted, exceeding class III water quality,
especially in terms of TSS, COD, and NH3-N with maximum EMCs
of 158, 135, and 2.17 mg/L, respectively.
Abstract: Wireless mobile communications have experienced
the phenomenal growth through last decades. The advances in
wireless mobile technologies have brought about a demand for high
quality multimedia applications and services. For such applications
and services to work, signaling protocol is required for establishing,
maintaining and tearing down multimedia sessions. The Session
Initiation Protocol (SIP) is an application layer signaling protocols,
based on request/response transaction model. This paper considers
SIP INVITE transaction over an unreliable medium, since it has been
recently modified in Request for Comments (RFC) 6026. In order to
help in assuring that the functional correctness of this modification is
achieved, the SIP INVITE transaction is modeled and analyzed using
Colored Petri Nets (CPNs). Based on the model analysis, it is
concluded that the SIP INVITE transaction is free of livelocks and
dead codes, and in the same time it has both desirable and
undesirable deadlocks. Therefore, SIP INVITE transaction should be
subjected for additional updates in order to eliminate undesirable
deadlocks. In order to reduce the cost of implementation and
maintenance of SIP, additional remodeling of the SIP INVITE
transaction is recommended.
Abstract: The model-based approach to user interface design relies on developing separate models that are capturing various aspects about users, tasks, application domain, presentation and dialog representations. This paper presents a task modeling approach for user interface design and aims at exploring the mappings between task, domain and presentation models. The basic idea of our approach is to identify typical configurations in task and domain models and to investigate how they relate each other. A special emphasis is put on application-specific functions and mappings between domain objects and operational task structures. In this respect, we will distinguish between three layers in the task decomposition: a functional layer, a planning layer, and an operational layer.
Abstract: A mathematical model of the respiratory system is
introduced in this study. Geometrical dimensions of the respiratory
system were used to compute the acoustic properties of the
respiratory system using the electro-acoustic analogy. The effect of
the geometrical proportions of the respiratory system is observed in
the paper.
Abstract: Image-based Rendering(IBR) techniques recently
reached in broad fields which leads to a critical challenge to build up
IBR-Driven visualization platform where meets requirement of high
performance, large bounds of distributed visualization resource
aggregation and concentration, multiple operators deploying and
CSCW design employing. This paper presents an unique IBR-based
visualization dataflow model refer to specific characters of IBR
techniques and then discusses prominent feature of IBR-Driven
distributed collaborative visualization (DCV) system before finally
proposing an novel prototype. The prototype provides a well-defined
three level modules especially work as Central Visualization Server,
Local Proxy Server and Visualization Aid Environment, by which
data and control for collaboration move through them followed the
previous dataflow model. With aid of this triple hierarchy architecture
of that, IBR oriented application construction turns to be easy. The
employed augmented collaboration strategy not only achieve
convenient multiple users synchronous control and stable processing
management, but also is extendable and scalable.
Abstract: Macrobenthos distribution along the coastal waters of
Penang National Park was studid to estimate the effect of different
environmental parameters at three stations, during six sampling
months, from June 2010 to April 2011. The aim of this survey was to
investigate different environment stress over soft bottom polychaete
community along Teluk Ketapang and Pantai Acheh (Penang
National Park) over a year period. Variations in the polychaete
community were evaluated using univariate and multivariate
methods. A total of 604 individuals were examined which was
grouped into 23 families. Family Nereidae was the most abundant
(22.68%), followed by Spionidae (22.02%), Hesionidae (12.58%),
Nephtylidae (9.27%) and Orbiniidae (8.61%). It is noticeable that
good results can only be obtained on the basis of good taxonomic
resolution. The maximum Shannon-Wiener diversity (H'=2.16) was
recorded at distance 200m and 1200m (August 2010) in Teluk
Ketapang and lowest value of diversity was found at distance 1200m
(December 2010) in Teluk Ketapang.
Abstract: This paper presents the design of a ring-shaped tri-axial fore sensor that can be incorporated into the tip of a guidewire for use in minimally invasive surgery (MIS). The designed sensor comprises a ring-shaped structure located at the center of four cantilever beams. The ringdesign allows surgical tools to be easily passed through which largely simplified the integration process. Silicon nanowires (SiNWs) are used aspiezoresistive sensing elementsembeddedon the four cantilevers of the sensor to detect the resistance change caused by the applied load.An integration scheme with new designed guidewire tip structure having two coils at the distal end is presented. Finite element modeling has been employed in the sensor design to find the maximum stress location in order to put the SiNWs at the high stress regions to obtain maximum output. A maximum applicable force of 5 mN is found from modeling. The interaction mechanism between the designed sensor and a steel wire has been modeled by FEM. A linear relationship between the applied load on the steel wire and the induced stress on the SiNWs were observed.
Abstract: Nowadays, hard disk is one of the most popular storage components. In hard disk industry, the hard disk drive must pass various complex processes and tested systems. In each step, there are some failures. To reduce waste from these failures, we must find the root cause of those failures. Conventionall data analysis method is not effective enough to analyze the large capacity of data. In this paper, we proposed the Hough method for straight line detection that helps to detect straight line defect patterns that occurs in hard disk drive. The proposed method will help to increase more speed and accuracy in failure analysis.
Abstract: In this paper newly reported Cosh window function is
used in the design of prototype filter for M-channel Near Perfect
Reconstruction (NPR) Cosine Modulated Filter Bank (CMFB). Local
search optimization algorithm is used for minimization of distortion
parameters by optimizing the filter coefficients of prototype filter.
Design examples are presented and comparison has been made with
Kaiser window based filterbank design of recently reported work.
The result shows that the proposed design approach provides lower
distortion parameters and improved far-end suppression than the
Kaiser window based design of recent reported work.
Abstract: The clustering ensembles combine multiple partitions
generated by different clustering algorithms into a single clustering
solution. Clustering ensembles have emerged as a prominent method
for improving robustness, stability and accuracy of unsupervised
classification solutions. So far, many contributions have been done to
find consensus clustering. One of the major problems in clustering
ensembles is the consensus function. In this paper, firstly, we
introduce clustering ensembles, representation of multiple partitions,
its challenges and present taxonomy of combination algorithms.
Secondly, we describe consensus functions in clustering ensembles
including Hypergraph partitioning, Voting approach, Mutual
information, Co-association based functions and Finite mixture
model, and next explain their advantages, disadvantages and
computational complexity. Finally, we compare the characteristics of
clustering ensembles algorithms such as computational complexity,
robustness, simplicity and accuracy on different datasets in previous
techniques.
Abstract: In this study, the designed dual stage membrane
bioreactor (MBR) system was conceptualized for the treatment of
cyanide and heavy metals in electroplating wastewater. The design
consisted of a primary treatment stage to reduce the impact of
fluctuations and the secondary treatment stage to remove the residual
cyanide and heavy metal contaminants in the wastewater under
alkaline pH conditions. The primary treatment stage contained
hydrolyzed Citrus sinensis (C. sinensis) pomace and the secondary
treatment stage contained active Aspergillus awamori (A. awamori)
biomass, supplemented solely with C. sinensis pomace extract from
the hydrolysis process. An average of 76.37%, 95.37%, 93.26 and
94.76% and 99.55%, 99.91%, 99.92% and 99.92% degradation
efficiency for total cyanide (T-CN), including the sorption of nickel
(Ni), zinc (Zn) and copper (Cu) were observed after the first and
second treatment stages, respectively. Furthermore, cyanide
conversion by-products degradation was 99.81% and 99.75 for both
formate (CHOO-) and ammonium (NH4
+) after the second treatment
stage. After the first, second and third regeneration cycles of the C.
sinensis pomace in the first treatment stage, Ni, Zn and Cu removal
achieved was 99.13%, 99.12% and 99.04% (first regeneration cycle),
98.94%, 98.92% and 98.41% (second regeneration cycle) and 98.46
%, 98.44% and 97.91% (third regeneration cycle), respectively.
There was relatively insignificant standard deviation detected in all
the measured parameters in the system which indicated
reproducibility of the remediation efficiency in this continuous
system.
Abstract: Orthogonal Frequency Division Multiplexing
(OFDM) is an efficient method of data transmission for high speed
communication systems. However, the main drawback of OFDM
systems is that, it suffers from the problem of high Peak-to-Average
Power Ratio (PAPR) which causes inefficient use of the High Power
Amplifier and could limit transmission efficiency. OFDM consist of
large number of independent subcarriers, as a result of which the
amplitude of such a signal can have high peak values. In this paper,
we propose an effective reduction scheme that combines DCT and
SLM techniques. The scheme is composed of the DCT followed by
the SLM using the Riemann matrix to obtain phase sequences for the
SLM technique. The simulation results show PAPR can be greatly
reduced by applying the proposed scheme. In comparison with
OFDM, while OFDM had high values of PAPR –about 10.4dB our
proposed method achieved about 4.7dB reduction of the PAPR with
low complexities computation. This approach also avoids
randomness in phase sequence selection, which makes it simpler to
decode at the receiver. As an added benefit, the matrices can be
generated at the receiver end to obtain the data signal and hence it is
not required to transmit side information (SI).
Abstract: Steel corrosion in concrete is considered as a main
engineering problems for many countries and lots of expenses has been paid for their repair and maintenance annually. This problem
may occur in all engineering structures whether in coastal and offshore or other areas. Hence, concrete structures should be able to
withstand corrosion factors existing in water or soil. Reinforcing
steel corrosion enhancement can be measured by use of concrete
electrical resistance; and maintaining high electric resistivity in concrete is necessary for steel corrosion prevention. Lots of studies
devoted to different aspects of the subjects worldwide. In this paper, an evaluation of the effects of W/C ratio, cementitious materials, and
percent increase in silica fume were investigated on electric resistivity of high strength concrete. To do that, sixteen mix design
with one aggregate grading was planned. Five of them had varying amount of W/C ratio and other eleven mixes was prepared with
constant W/C ratio but different amount of cementitious materials.
Silica fume and super plasticizer were used with different proportions
in all specimens. Specimens were tested after moist curing for 28 days. A total of 80 cube specimens (50 mm) were tested for concrete
electrical resistance. Results show that concrete electric resistivity can be increased with increasing amount of cementitious materials
and silica fume.
Abstract: A specially designed flat plate was mounted vertically
over the axial line in the wind tunnel of the Aerospace Department of
the Pusan National University. The plate is 2 m long, 0.8 m high and 8
cm thick. The measurements were performed in velocity range from
15 to 60 m/s. A sand paper turbulizer was placed close to the plate nose
to provide fully developed turbulent boundary layer over the most part
of the plate. Strain balances were mounted in the trailing part of the
plate to measure the skin friction drag over removable insertions of
0.55×0.25m2 size. A set of the insertions was designed and
manufactured: 3mm thick polished metal surface and three compliant
surfaces. The compliant surfaces were manufactured of a silicone
rubber Silastic® S2 (Dow Corning company). To modify the
viscoelastic properties of the rubber, its composition was varied: 90%
of the rubber + 10% catalyst (standard), 92.5% + 7.5% (weak), 85% +
15% (strong). Modulus of elasticity and the loss tangent were
measured accurately for these materials in the frequency range from
40 Hz to 3 KHz using the unique proposed technique.
Abstract: Clustering is a very well known technique in data mining. One of the most widely used clustering techniques is the kmeans algorithm. Solutions obtained from this technique depend on the initialization of cluster centers and the final solution converges to local minima. In order to overcome K-means algorithm shortcomings, this paper proposes a hybrid evolutionary algorithm based on the combination of PSO, SA and K-means algorithms, called PSO-SA-K, which can find better cluster partition. The performance is evaluated through several benchmark data sets. The simulation results show that the proposed algorithm outperforms previous approaches, such as PSO, SA and K-means for partitional clustering problem.