Abstract: The passive electrical properties of a tissue depends
on the intrinsic constituents and its structure, therefore by measuring
the complex electrical impedance of the tissue it might be possible to
obtain indicators of the tissue state or physiological activity [1].
Complete bio-impedance information relative to physiology and
pathology of a human body and functional states of the body tissue or
organs can be extracted by using a technique containing a fourelectrode
measurement setup. This work presents the estimation
measurement setup based on the four-electrode technique. First, the
complex impedance is estimated by three different estimation
techniques: Fourier, Sine Correlation and Digital De-convolution and
then estimation errors for the magnitude, phase, reactance and
resistance are calculated and analyzed for different levels of
disturbances in the observations. The absolute values of relative
errors are plotted and the graphical performance of each technique is
compared.
Abstract: Non-stationary trend in R-R interval series is
considered as a main factor that could highly influence the evaluation
of spectral analysis. It is suggested to remove trends in order to obtain
reliable results. In this study, three detrending methods, the
smoothness prior approach, the wavelet and the empirical mode
decomposition, were compared on artificial R-R interval series with
four types of simulated trends. The Lomb-Scargle periodogram was
used for spectral analysis of R-R interval series. Results indicated that
the wavelet method showed a better overall performance than the other
two methods, and more time-saving, too. Therefore it was selected for
spectral analysis of real R-R interval series of thirty-seven healthy
subjects. Significant decreases (19.94±5.87% in the low frequency
band and 18.97±5.78% in the ratio (p
Abstract: Interactive web-based computer simulations are
needed by the medical community to replicate the experience of
surgical procedures as closely and realistically as possible without
the need to practice on corpses, animals and/or plastic models. In this
paper, we offer a review on current state of the research on
simulations of surgical threads, identify future needs and present our
proposed plans to meet them. Our goal is to create a physics-based
simulator, which will predict the behavior of surgical thread when
subjected to conditions commonly encountered during surgery. To
that end, we will i) develop three dimensional finite element models
based on the Cosserat theory of elasticity ii) test and feedback results
with the medical community and iii) develop a web-based user
interface to run/command our simulator and visualize the results. The
impacts of our research are that i) it will contribute to the
development of a new generation of training for medical school
students and ii) the simulator will be useful to expert surgeons in
developing new, better and less risky procedures.
Abstract: Electroencephalogram (EEG) recordings are often
contaminated with ocular and muscle artifacts. In this paper, the
canonical correlation analysis (CCA) is used as blind source
separation (BSS) technique (BSS-CCA) to decompose the artifact
contaminated EEG into component signals. We combine the BSSCCA
technique with wavelet filtering approach for minimizing both
ocular and muscle artifacts simultaneously, and refer the proposed
method as wavelet enhanced BSS-CCA. In this approach, after
careful visual inspection, the muscle artifact components are
discarded and ocular artifact components are subjected to wavelet
filtering to retain high frequency cerebral information, and then clean
EEG is reconstructed. The performance of the proposed wavelet
enhanced BSS-CCA method is tested on real EEG recordings
contaminated with ocular and muscle artifacts, for which power
spectral density is used as a quantitative measure. Our results suggest
that the proposed hybrid approach minimizes ocular and muscle
artifacts effectively, minimally affecting underlying cerebral activity
in EEG recordings.
Abstract: The purpose of this study was to determine the
influence of physical activity and dietary fat intake on Body Mass
Index (BMI) of lecturers within a higher learning institutionalized
setting. The study adopted a Cross-sectional Correlational Design
and included 120 lecturers selected proportionately by simple
random sampling techniques from a population of 600 lecturers. Data
was collected using questionnaires, which had sections including
physical activity checklist adopted from the international physical
activity questionnaire (IPAQ), 24-hour food recall, anthropometric
measurements mainly weight and height. Analysis involved the use
of bivariate correlations and linear regression. A significant inverse
association was registered between BMI and duration (in minutes)
spent doing moderate intense physical activity per day (r=-0.322,
p
Abstract: Glomerular filtration rate (GFR) is a measure of
kidney function. It is usually estimated from serum concentrations of
cystatin C or creatinine although there has been considerable debate
in the literature about (i) the best equation to use and (ii) the
variability in the correlation between the concentrations of creatinine
and cystatin C. The equations for GFR can be written in a general
form and from these I calculate the error of the GFR estimates
associated with analyte measurement error. These show that the
error of the GFR estimates is such that it is not possible to distinguish
between the equations over much of the concentration range of either
analyte. The general forms of the equations are also used to derive
an expression for the concentration of cystatin C as a function of the
concentration of creatinine. This equation shows that these analyte
concentrations are not linearly related. Clinical reports of cystatin C
and creatinine concentration are consistent with the expression
derived.
Abstract: The sanitary sewerage connection rate becomes an
important indicator of advanced cities. Following the construction of
sanitary sewerages, the maintenance and management systems are
required for keeping pipelines and facilities functioning well. These
maintenance tasks often require sewer workers to enter the manholes
and the pipelines, which are confined spaces short of natural
ventilation and full of hazardous substances. Working in sewers could
be easily exposed to a risk of adverse health effects. This paper
proposes the use of Bayesian belief networks (BBN) as a higher level
of noncarcinogenic health risk assessment of sewer workers. On the
basis of the epidemiological studies, the actual hospital attendance
records and expert experiences, the BBN is capable of capturing the
probabilistic relationships between the hazardous substances in sewers
and their adverse health effects, and accordingly inferring the
morbidity and mortality of the adverse health effects. The provision of
the morbidity and mortality rates of the related diseases is more
informative and can alleviate the drawbacks of conventional methods.
Abstract: Fungal infections are becoming more common and the
range of susceptible individuals has expanded. While Candida
albicans remains the most common infective species, other Candida
spp. are becoming increasingly significant. In a range of large-scale
studies of candidaemia between 1999 and 2006, about 52% of 9717
cases involved C. albicans, about 30% involved either C. glabrata or
C. parapsilosis and less than 15% involved C. tropicalis, C. krusei or
C. guilliermondii. However, the probability of mortality within 30
days of infection with a particular species was at least 40% for C.
tropicalis, C. albicans, C. glabrata and C. krusei and only 22% for
C. parapsilopsis. Clinical isolates of Candida spp. grew at rates
ranging from 1.65 h-1 to 4.9 h-1. Three species (C. krusei, C. albicans
and C. glabrata) had relatively high growth rates (μm > 4 h-1), C.
tropicalis and C. dubliniensis grew moderately quickly (Ôëê 3 h-1) and
C. parapsilosis and C. guilliermondii grew slowly (< 2 h-1). Based
on these data, the log of the odds of mortality within 30 days of
diagnosis was linearly related to μm. From this the underlying
probability of mortality is 0.13 (95% CI: 0.10-0.17) and it increases
by about 0.09 ± 0.02 for each unit increase in μm. Given that the
overall crude mortality is about 0.36, the growth of Candida spp.
approximately doubles the rate, consistent with the results of larger
case-matched studies of candidaemia.
Abstract: The analysis to detect arrhythmias and life-threatening
conditions are highly essential in today world and this analysis
can be accomplished by advanced non-linear processing methods
for accurate analysis of the complex signals of heartbeat dynamics.
In this perspective, recent developments in the field of multiscale
information content have lead to the Microcanonical Multiscale
Formalism (MMF). We show that such framework provides several
signal analysis techniques that are especially adapted to the
study of heartbeat dynamics. In this paper, we just show first hand
results of whether the considered heartbeat dynamics signals have
the multiscale properties by computing local preticability exponents
(LPEs) and the Unpredictable Points Manifold (UPM), and thereby
computing the singularity spectrum.
Abstract: Many recent electrophysiological studies have
revealed the importance of investigating meditation state in order to
achieve an increased understanding of autonomous control of
cardiovascular functions. In this paper, we characterize heart rate
variability (HRV) time series acquired during meditation using
nonlinear dynamical parameters. We have computed minimum
embedding dimension (MED), correlation dimension (CD), largest
Lyapunov exponent (LLE), and nonlinearity scores (NLS) from HRV
time series of eight Chi and four Kundalini meditation practitioners.
The pre-meditation state has been used as a baseline (control) state to
compare the estimated parameters. The chaotic nature of HRV during
both pre-meditation and meditation is confirmed by MED. The
meditation state showed a significant decrease in the value of CD and
increase in the value of LLE of HRV, in comparison with premeditation
state, indicating a less complex and less predictable nature
of HRV. In addition, it was shown that the HRV of meditation state
is having highest NLS than pre-meditation state. The study indicated
highly nonlinear dynamic nature of cardiac states as revealed by
HRV during meditation state, rather considering it as a quiescent
state.
Abstract: Automatic detection of bleeding is of practical
importance since capsule endoscopy produces an extremely large
number of images. Algorithm development of bleeding detection in
the digestive tract is difficult due to different contrasts among the
images, food dregs, secretion and others. In this study, were assigned
weighting factors derived from the independent features of the
contrast and brightness between bleeding and normality. Spectral
analysis based on weighting factors was fast and accurate. Results
were a sensitivity of 87% and a specificity of 90% when the accuracy
was determined for each pixel out of 42 endoscope images.
Abstract: The present research was designed to investigate the
anti-microbial activity of aristolochic acid from the root of
Aristolochia bracteata. From the methanolic & ethyl extract extracts
of Aristolochia bracteata aristolochic acid I was isolated and
conformed through IR, NMR & MS. The percentage purity of
aristolochic acid I was determined by UV & HPLC method. Antibacterial
activity of extracts of Aristolochia bracteata and the
isolated compound was determined by disc diffusion method. The
results reveled that the isolated aristolochic acid from methanolic
extract was more pure than the compound from ethyl acetate extract.
The various extracts (500μg/disc) of Aristolochia bracteata showed
moderate antibacterial activity with the average zone of inhibition of
7-18 mm by disc diffusion method. Among the extracts, ethyl acetate
& methanol extracts were shown good anti-microbial activity and the
growth of E.coli (18 mm) was strongly inhibited. Microbial assay of
isolated compound (Aristolochic acid I) from ethyl acetate &
methanol extracts were shown good antimicrobial activity and the
zone of inhibition of both at higher concentration 50 μg/ml was
similar with the standard aristolochic acid. It may be concluded that
the isolated compound of aristolochic acid I has good anti-bacterial
activity.
Abstract: A five-class density histogram with an index named cumulative density was proposed to analyze the short-term HRV. 150 subjects participated in the test, falling into three groups with equal numbers -- the healthy young group (Young), the healthy old group (Old), and the group of patients with congestive heart failure (CHF). Results of multiple comparisons showed a significant differences of the cumulative density in the three groups, with values 0.0238 for Young, 0.0406 for Old and 0.0732 for CHF (p