Abstract: The p53 tumor suppressor gene plays two important
roles in genomic stability: blocking cell proliferation after DNA
damage until it has been repaired, and starting apoptosis if the
damage is too critical. Codon 72 exon4 polymorphism (Arg72Pro) of
the P53 gene has been implicated in cancer risk. Various studies have
been done to investigate the status of p53 at codon 72 for arginine
(Arg) and proline (Pro) alleles in different populations and also the
association of this codon 72 polymorphism with various tumors. Our
objective was to investigate the possible association between P53
Arg72Pro polymorphism and susceptibility to colorectal cancer
among Isfahan and Chaharmahal Va Bakhtiari (a part of south west
of Iran) population. We investigated the status of p53 at codon 72 for
Arg/Arg, Arg/Pro and Pro/Pro allele polymorphisms in blood
samples from 145 colorectal cancer patients and 140 controls by
Nested-PCR of p53 exon 4 and digestion with BstUI restriction
enzyme and the DNA fragments were then resolved by
electrophoresis in 2% agarose gel. The Pro allele was 279 bp, while
the Arg allele was restricted into two fragments of 160 and 119 bp.
Among the 145 colorectal cancer cases 49 cases (33.79%) were
homozygous for the Arg72 allele (Arg/Arg), 18 cases (12.41%) were
homozygous for the Pro72 allele (Pro/Pro) and 78 cases (53.8%)
found in heterozygous (Arg/Pro).
In conclusion, it can be said that p53Arg/Arg genotype may be
correlated with possible increased risk of this kind of cancers in south
west of Iran.
Abstract: Levan, an exopolysaccharide, was produced by
Microbacterium laevaniformans and its yield was characterized as a
function of concentrations of date syrup, sucrose and the fermentation
time. The optimum condition for levan production from sucrose was
at concentration of 20% sucrose for 48 h and for date syrup was 25%
for 48 h. The results show that an increase in fermentation time
caused a decrease in the levan production at all concentrations of date
syrup tested. Under these conditions after 48 h in sucrose medium,
levan production reached 48.9 g/L and for date syrup reached 10.48
g/L . The effect of pH on the yield of the purified levan was examined
and the optimum pH for levan production was determined to be 6.0.
Levan was composed mainly of fructose residues when analyzed by
TLC and FT-IR spectroscopy. Date syrup is a cheap substrate widely
available in Iran and has potential for levan production. The thermal
stability of levan was assessed by Thermo Gravimetric Analysis
(TGA) that revealed the onset of decomposition near to 49°C for the
levan produced from sucrose and 51°C for the levan from date syrup.
DSC results showed a single Tg at 98°C for levan produced from
sucrose and 206 °C for levan from date syrup.
Abstract: This paper provides an in-depth study of Wireless
Sensor Network (WSN) application to monitor and control the
swiftlet habitat. A set of system design is designed and developed
that includes the hardware design of the nodes, Graphical User
Interface (GUI) software, sensor network, and interconnectivity for
remote data access and management. System architecture is proposed
to address the requirements for habitat monitoring. Such applicationdriven
design provides and identify important areas of further work
in data sampling, communications and networking. For this
monitoring system, a sensor node (MTS400), IRIS and Micaz radio
transceivers, and a USB interfaced gateway base station of Crossbow
(Xbow) Technology WSN are employed. The GUI of this monitoring
system is written using a Laboratory Virtual Instrumentation
Engineering Workbench (LabVIEW) along with Xbow Technology
drivers provided by National Instrument. As a result, this monitoring
system is capable of collecting data and presents it in both tables and
waveform charts for further analysis. This system is also able to send
notification message by email provided Internet connectivity is
available whenever changes on habitat at remote sites (swiftlet farms)
occur. Other functions that have been implemented in this system
are the database system for record and management purposes; remote
access through the internet using LogMeIn software. Finally, this
research draws a conclusion that a WSN for monitoring swiftlet
habitat can be effectively used to monitor and manage swiftlet
farming industry in Sarawak.
Abstract: Chaos and fractals are novel fields of physics and mathematics showing up a new way of universe viewpoint and creating many ideas to solve several present problems. In this paper, a novel algorithm based on the chaotic sequence generator with the highest ability to adapt and reach the global optima is proposed. The adaptive ability of proposal algorithm is flexible in 2 steps. The first one is a breadth-first search and the second one is a depth-first search. The proposal algorithm is examined by 2 functions, the Camel function and the Schaffer function. Furthermore, the proposal algorithm is applied to optimize training Multilayer Neural Networks.
Abstract: In the recent past Learning Classifier Systems have
been successfully used for data mining. Learning Classifier System
(LCS) is basically a machine learning technique which combines
evolutionary computing, reinforcement learning, supervised or
unsupervised learning and heuristics to produce adaptive systems. A
LCS learns by interacting with an environment from which it
receives feedback in the form of numerical reward. Learning is
achieved by trying to maximize the amount of reward received. All
LCSs models more or less, comprise four main components; a finite
population of condition–action rules, called classifiers; the
performance component, which governs the interaction with the
environment; the credit assignment component, which distributes the
reward received from the environment to the classifiers accountable
for the rewards obtained; the discovery component, which is
responsible for discovering better rules and improving existing ones
through a genetic algorithm. The concatenate of the production rules
in the LCS form the genotype, and therefore the GA should operate
on a population of classifier systems. This approach is known as the
'Pittsburgh' Classifier Systems. Other LCS that perform their GA at
the rule level within a population are known as 'Mitchigan' Classifier
Systems. The most predominant representation of the discovered
knowledge is the standard production rules (PRs) in the form of IF P
THEN D. The PRs, however, are unable to handle exceptions and do
not exhibit variable precision. The Censored Production Rules
(CPRs), an extension of PRs, were proposed by Michalski and
Winston that exhibit variable precision and supports an efficient
mechanism for handling exceptions. A CPR is an augmented
production rule of the form: IF P THEN D UNLESS C, where
Censor C is an exception to the rule. Such rules are employed in
situations, in which conditional statement IF P THEN D holds
frequently and the assertion C holds rarely. By using a rule of this
type we are free to ignore the exception conditions, when the
resources needed to establish its presence are tight or there is simply
no information available as to whether it holds or not. Thus, the IF P
THEN D part of CPR expresses important information, while the
UNLESS C part acts only as a switch and changes the polarity of D
to ~D. In this paper Pittsburgh style LCSs approach is used for
automated discovery of CPRs. An appropriate encoding scheme is
suggested to represent a chromosome consisting of fixed size set of
CPRs. Suitable genetic operators are designed for the set of CPRs
and individual CPRs and also appropriate fitness function is proposed
that incorporates basic constraints on CPR. Experimental results are
presented to demonstrate the performance of the proposed learning
classifier system.
Abstract: Link reliability and transmitted power are two important design constraints in wireless network design. Error control coding (ECC) is a classic approach used to increase link reliability and to lower the required transmitted power. It provides coding gain, resulting in transmitter energy savings at the cost of added decoder power consumption. But the choice of ECC is very critical in the case of wireless sensor network (WSN). Since the WSNs are energy constraint in nature, both the BER and power consumption has to be taken into count. This paper develops a step by step approach in finding suitable error control codes for WSNs. Several simulations are taken considering different error control codes and the result shows that the RS(31,21) fits both in BER and power consumption criteria.
Abstract: In this paper, the effect of atmospheric turbulence on
bit error probability in free-space optical CDMA scheme with
Sequence Inverse Keyed (SIK) optical correlator receiver is analyzed.
Here Intensity Modulation scheme is considered for transmission.
The turbulence induced fading is described by the newly introduced
gamma-gamma pdf[1] as a tractable mathematical model for
atmospheric turbulence. Results are evaluated with Gold and Kasami
code & it is shown that Gold sequence can be used for more
efficient transmission than Kasami sequence in an atmospheric
turbulence channel.
Abstract: Human identification at a distance has recently gained
growing interest from computer vision researchers. Gait recognition
aims essentially to address this problem by identifying people based
on the way they walk [1]. Gait recognition has 3 steps. The first step
is preprocessing, the second step is feature extraction and the third
one is classification. This paper focuses on the classification step that
is essential to increase the CCR (Correct Classification Rate).
Multilayer Perceptron (MLP) is used in this work. Neural Networks
imitate the human brain to perform intelligent tasks [3].They can
represent complicated relationships between input and output and
acquire knowledge about these relationships directly from the data
[2]. In this paper we apply MLP NN for 11 views in our database and
compare the CCR values for these views. Experiments are performed
with the NLPR databases, and the effectiveness of the proposed
method for gait recognition is demonstrated.
Abstract: We aimed to investigate how can target and optimize
pulmonary delivery distribution by changing physicochemical
characteristics of instilled liquid.Therefore, we created a new liquids
group:
a. eligible for desired distribution within lung because of
assorted physicochemical characteristics
b. capable of being augmented with a broad range of
chemicals inertly
c. no interference on respiratory function
d. compatible with airway surface liquid
We developed forty types of new liquid,were composed of
Carboxymethylcellulose sodium,Glycerin and different types of
Polysorbates.Viscosity was measured using a Programmable
Rheometer and surface tension by KRUSS Tensiometer.We
subsequently examined the liquids and delivery protocols by simple
and branched glass capillary tube models of airways.Eventually,we
explored pulmonary distribution of liquids being augmented with
technetium-99m in mechanically ventilated rabbits.We used a single
head large field of view gamma camera.Kinematic viscosity between
0.265Stokes and 0.289Stokes,density between 1g/cm3 and 1.5g/cm3
and surface tension between 25dyn/cm and 35dyn/cm were the most
acceptable.
Abstract: The temporal nature of negative selection is an under exploited area. In a negative selection system, newly generated antibodies go through a maturing phase, and the survivors of the phase then wait to be activated by the incoming antigens after certain number of matches. These without having enough matches will age and die, while these with enough matches (i.e., being activated) will become active detectors. A currently active detector may also age and die if it cannot find any match in a pre-defined (lengthy) period of time. Therefore, what matters in a negative selection system is the dynamics of the involved parties in the current time window, not the whole time duration, which may be up to eternity. This property has the potential to define the uniqueness of negative selection in comparison with the other approaches. On the other hand, a negative selection system is only trained with “normal" data samples. It has to learn and discover unknown “abnormal" data patterns on the fly by itself. Consequently, it is more appreciate to utilize negation selection as a system for pattern discovery and recognition rather than just pattern recognition. In this paper, we study the potential of using negative selection in discovering unknown temporal patterns.
Abstract: Dredged sediment (DS) was utilized as source of
silt-clay and organic matter in artificially prepared eelgrass substrates with mountain sand (MS) as the sand media. Addition of DS showed
improved growth of eelgrass in the mixed substrates. Increase in added
DS up to 15% silt-clay showed increased shoot growth but additional
DS in 20% silt-clay mixture didn-t result to further increase in eelgrass
growth. Improved root establishment were also found for plants in pots
with added DS as shown by the increased resistance to uprooting, increased number of rhizome nodes and longer roots. Results demonstrated that addition of DS may be beneficial to eelgrass up to a
certain extent only and too much of it might be harmful to eelgrass plants.
Abstract: Three alumina-supported Pt-Sn catalysts have been
prepared by means of co-impregnation and characterized by XRD and
N2 adsorption. The influence of catalyst composition and reaction
conditions on the conversion and selectivity were investigated in the
hydrogenation of acetic acid in an isothermal integral fixed bed
reactor. The experiments were performed on the temperature interval
468-548 K, liquid hourly space velocity (LHSV) of 0.3-0.7h-1,
pressures between 1.0 and 5.0Mpa. A good compromise of
0.75%Pt-1.5%Sn can act as an optimized acetic acid hydrogenation
catalyst, and the conversion and selectivity can be tuned through the
variation of reaction conditions.
Abstract: In recent years, scanning probe atomic force
microscopy SPM AFM has gained acceptance over a wide spectrum
of research and science applications. Most fields focuses on physical,
chemical, biological while less attention is devoted to manufacturing
and machining aspects. The purpose of the current study is to assess
the possible implementation of the SPM AFM features and its
NanoScope software in general machining applications with special
attention to the tribological aspects of cutting tool. The surface
morphology of coated and uncoated as-received carbide inserts is
examined, analyzed, and characterized through the determination of
the appropriate scanning setting, the suitable data type imaging
techniques and the most representative data analysis parameters
using the MultiMode SPM AFM in contact mode. The NanoScope
operating software is used to capture realtime three data types
images: “Height", “Deflection" and “Friction". Three scan sizes are
independently performed: 2, 6, and 12 μm with a 2.5 μm vertical
range (Z). Offline mode analysis includes the determination of three
functional topographical parameters: surface “Roughness", power
spectral density “PSD" and “Section". The 12 μm scan size in
association with “Height" imaging is found efficient to capture every
tiny features and tribological aspects of the examined surface. Also,
“Friction" analysis is found to produce a comprehensive explanation
about the lateral characteristics of the scanned surface. Configuration
of many surface defects and drawbacks has been precisely detected
and analyzed.
Abstract: Trust management and Reputation models are
becoming integral part of Internet based applications such as CSCW,
E-commerce and Grid Computing. Also the trust dimension is a
significant social structure and key to social relations within a
collaborative community. Collaborative Decision Making (CDM) is
a difficult task in the context of distributed environment (information
across different geographical locations) and multidisciplinary
decisions are involved such as Virtual Organization (VO). To aid
team decision making in VO, Decision Support System and social
network analysis approaches are integrated. In such situations social
learning helps an organization in terms of relationship, team
formation, partner selection etc. In this paper we focus on trust
learning. Trust learning is an important activity in terms of
information exchange, negotiation, collaboration and trust
assessment for cooperation among virtual team members. In this
paper we have proposed a reinforcement learning which enhances the
trust decision making capability of interacting agents during
collaboration in problem solving activity. Trust computational model
with learning that we present is adapted for best alternate selection of
new project in the organization. We verify our model in a multi-agent
simulation where the agents in the community learn to identify
trustworthy members, inconsistent behavior and conflicting behavior
of agents.
Abstract: We have previously introduced an ultrasonic imaging
approach that combines harmonic-sensitive pulse sequences with a
post-beamforming quadratic kernel derived from a second-order
Volterra filter (SOVF). This approach is designed to produce images
with high sensitivity to nonlinear oscillations from microbubble
ultrasound contrast agents (UCA) while maintaining high levels of
noise rejection. In this paper, a two-step algorithm for computing the
coefficients of the quadratic kernel leading to reduction of tissue
component introduced by motion, maximizing the noise rejection and
increases the specificity while optimizing the sensitivity to the UCA
is presented. In the first step, quadratic kernels from individual
singular modes of the PI data matrix are compared in terms of their
ability of maximize the contrast to tissue ratio (CTR). In the second
step, quadratic kernels resulting in the highest CTR values are
convolved. The imaging results indicate that a signal processing
approach to this clinical challenge is feasible.
Abstract: This paper describes the Multilingual Virtual Simulated Patient framework. It has been created to train the social skills and testing the knowledge of primary health care medical students. The framework generates conversational agents which perform in serveral languages as virtual simulated patients that help to improve the communication and diagnosis skills of the students complementing their training process.
Abstract: Fungal infections are becoming more common and the
range of susceptible individuals has expanded. While Candida
albicans remains the most common infective species, other Candida
spp. are becoming increasingly significant. In a range of large-scale
studies of candidaemia between 1999 and 2006, about 52% of 9717
cases involved C. albicans, about 30% involved either C. glabrata or
C. parapsilosis and less than 15% involved C. tropicalis, C. krusei or
C. guilliermondii. However, the probability of mortality within 30
days of infection with a particular species was at least 40% for C.
tropicalis, C. albicans, C. glabrata and C. krusei and only 22% for
C. parapsilopsis. Clinical isolates of Candida spp. grew at rates
ranging from 1.65 h-1 to 4.9 h-1. Three species (C. krusei, C. albicans
and C. glabrata) had relatively high growth rates (μm > 4 h-1), C.
tropicalis and C. dubliniensis grew moderately quickly (Ôëê 3 h-1) and
C. parapsilosis and C. guilliermondii grew slowly (< 2 h-1). Based
on these data, the log of the odds of mortality within 30 days of
diagnosis was linearly related to μm. From this the underlying
probability of mortality is 0.13 (95% CI: 0.10-0.17) and it increases
by about 0.09 ± 0.02 for each unit increase in μm. Given that the
overall crude mortality is about 0.36, the growth of Candida spp.
approximately doubles the rate, consistent with the results of larger
case-matched studies of candidaemia.
Abstract: The main objective of this paper is to analyse the influence of preparation and control of orders on performance. The focused activities explored in this research are: procurement, production and distribution. These changes in performance were obtained through improvement of the supply chain. It is proved using all the company activities that it is possible to increase de efficiency and do services in an adequate way, placing the products in the market efficiently. For that, it was explored the importance of the supply chain, with privilege to the practical environment and the quantification of the obtained results.
Abstract: There are several approaches for handling multiclass classification. Aside from one-against-one (OAO) and one-against-all (OAA), hierarchical classification technique is also commonly used. A binary classification tree is a hierarchical classification structure that breaks down a k-class problem into binary sub-problems, each solved by a binary classifier. In each node, a set of classes is divided into two subsets. A good class partition should be able to group similar classes together. Many algorithms measure similarity in term of distance between class centroids. Classes are grouped together by a clustering algorithm when distances between their centroids are small. In this paper, we present a binary classification tree with tuned observation-based clustering (BCT-TOB) that finds a class partition by performing clustering on observations instead of class centroids. A merging step is introduced to merge any insignificant class split. The experiment shows that performance of BCT-TOB is comparable to other algorithms.
Abstract: Car accident is one of the major causes of death in many countries. Many researchers have attempted to design and develop techniques to increase car safety in the past recent years. In spite of all the efforts, it is still challenging to design a system adaptive to the driver rather than the automotive characteristics. In this paper, the adaptive car safety system is explained which attempts to find a balance.