Abstract: Bones are dynamic and responsive organs, they
regulate their strength and mass according to the loads which they are subjected. Because, the Wnt/β-catenin pathway has profound
effects on the regulation of bone mass, we hypothesized that mechanical loading of bone cells stimulates Wnt/β-catenin signaling, which results in the generation of new bone mass.
Mechanical loading triggers the secretion of the Wnt molecule, which after binding to transmembrane proteins, causes GSK-3β (Glycogen synthase kinase 3 beta) to cease the phosphorylation of β-catenin. β-catenin accumulation in the cytoplasm, followed by its
transport into the nucleus, binding to transcription factors (TCF/LEF)
that initiate transcription of genes related to bone formation. To test this hypothesis, we used TOPGAL (Tcf Optimal Promoter
β-galactosidase) mice in an experiment in which cyclic loads were
applied to the forearm. TOPGAL mice are reporters for cells effected
by the Wnt/β-catenin signaling pathway. TOPGAL mice are genetically engineered mice in which transcriptional activation of β-
catenin, results in the production of an enzyme, β-galactosidase. The
presence of this enzyme allows us to localize transcriptional
activation of β-catenin to individual cells, thereby, allowing us to quantify the effects that mechanical loading has on the Wnt/β-catenin pathway and new bone formation. The ulnae of loaded TOPGAL
mice were excised and transverse slices along different parts of the
ulnar shaft were assayed for the presence of β-galactosidase.
Our results indicate that loading increases β-catenin transcriptional
activity in regions where this pathway is already primed (i.e. where basal activity is already higher) in a load magnitude dependent
manner. Further experiments are needed to determine the temporal and spatial activation of this signaling in relation to bone formation.
Abstract: We introduce an adaptive technique for the joint mitigation of transients and continuous-wave radio-frequency co-channel interference (CW RFI) in high-frequency (HF) over-the-horizon radars (OTHRs). The performance of this technique is illustrated using data from an operational surface-wave radar (SECAR) and from recent experimental trials with sky-wave (SW) and sky-wave–line-of-sight (SKYLOS) HF OTHRs.
Abstract: The aim of this paper is to express the input-output
matrix as a linear ordering problem which is classified as an NP-hard
problem. We then use a Tabu search algorithm to find the best
permutation among sectors in the input-output matrix that will give
an optimal solution. This optimal permutation can be useful in
designing policies and strategies for economists and government in
their goal of maximizing the gross domestic product.
Abstract: This article presents the simulation, parameterization and optimization of an electromagnet with the C–shaped configuration, intended for the study of magnetic properties of materials. The electromagnet studied consists of a C-shaped yoke, which provides self–shielding for minimizing losses of magnetic flux density, two poles of high magnetic permeability and power coils wound on the poles. The main physical variable studied was the static magnetic flux density in a column within the gap between the poles, with 4cm2 of square cross section and a length of 5cm, seeking a suitable set of parameters that allow us to achieve a uniform magnetic flux density of 1x104 Gaussor values above this in the column, when the system operates at room temperature and with a current consumption not exceeding 5A. By means of a magnetostatic analysis by the finite element method, the magnetic flux density and the distribution of the magnetic field lines were visualized and quantified. From the results obtained by simulating an initial configuration of electromagnet, a structural optimization of the geometry of the adjustable caps for the ends of the poles was performed. The magnetic permeability effect of the soft magnetic materials used in the poles system, such as low– carbon steel (0.08% C), Permalloy (45% Ni, 54.7% Fe) and Mumetal (21.2% Fe, 78.5% Ni), was also evaluated. The intensity and uniformity of the magnetic field in the gap showed a high dependence with the factors described above. The magnetic field achieved in the column was uniform and its magnitude ranged between 1.5x104 Gauss and 1.9x104 Gauss according to the material of the pole used, with the possibility of increasing the magnetic field by choosing a suitable geometry of the cap, introducing a cooling system for the coils and adjusting the spacing between the poles. This makes the device a versatile and scalable tool to generate the magnetic field necessary to perform magnetic characterization of materials by techniques such as vibrating sample magnetometry (VSM), Hall-effect, Kerr-effect magnetometry, among others. Additionally, a CAD design of the modules of the electromagnet is presented in order to facilitate the construction and scaling of the physical device.
Abstract: The Comparison analysis of the Wald-s and Bayestype sequential methods for testing hypotheses is offered. The merits of the new sequential test are: universality which consists in optimality (with given criteria) and uniformity of decision-making regions for any number of hypotheses; simplicity, convenience and uniformity of the algorithms of their realization; reliability of the obtained results and an opportunity of providing the errors probabilities of desirable values. There are given the Computation results of concrete examples which confirm the above-stated characteristics of the new method and characterize the considered methods in regard to each other.
Abstract: This paper presents the comparison ageing deterioration of silicone rubber housing material for outdoor polymer insulators by using salt fog ageing test based on IEC 61109 and outdoor exposure test.Four types of high temperature silicone vulcanized silicone rubber sheet with different amount of ATH were used as testing specimen. For salt fog ageing test, the specimens were tested continuously 1000 hours with energized in test chamber. For outdoor exposure test, the specimens were hung continuously 18 months without energized. Physical and chemical analyses were conducted to evaluate degree of ageing deterioration of tested specimens. Slightly surface erosion was observed on specimen surface after salt fog ageing test and no erosion was observed on surface of outdoor exposure specimen. However, comparable degree of ageing deterioration can be seen from surface analysis results.
Abstract: Brand name plays a vital role for in-shop buying
behavior of consumers and mutated brand name may affect the
selling of leading branded products. In Indian market, there are many
products with mutated brand names which are either orthographically
or phonologically similar. Due to presence of such products, Indian
consumers very often fall under confusion when buying some
regularly used stuff. Authors of the present paper have attempted to
demonstrate relationship between less attention and false recognition
of mutated brand names during a product selection process. To
achieve this goal, visual attention study was conducted on 15 male
college students using eye-tracker against a mutated brand name and
errors in recognition were noted using questionnaire. Statistical
analysis of the acquired data revealed that there was more false
recognition of mutated brand name when less attention was paid
during selection of favorite product. Moreover, it was perceived that
eye tracking is an effective tool for analyzing false recognition of
brand name mutation.
Abstract: This paper has been investigated a technique that predicts the performance of a bar-type unimorph piezoelectric vibration actuator depending on the frequency. This paper has been proposed an equivalent circuit that can be easily analyzed for the bar-type unimorph piezoelectric vibration actuator. In the dynamic analysis, rigidity and resonance frequency, which are important mechanical elements, were derived using the basic beam theory. In the equivalent circuit analysis, the displacement and bandwidth of the piezoelectric vibration actuator depending on the frequency were predicted. Also, for the reliability of the derived equations, the predicted performance depending on the shape change was compared with the result of a finite element analysis program.
Abstract: Lately, significant work in the area of Intelligent
Manufacturing has become public and mainly applied within the
frame of industrial purposes. Special efforts have been made in the
implementation of new technologies, management and control
systems, among many others which have all evolved the field. Aware
of all this and due to the scope of new projects and the need of
turning the existing flexible ideas into more autonomous and
intelligent ones, i.e.: Intelligent Manufacturing, the present paper
emerges with the main aim of contributing to the design and analysis
of the material flow in either systems, cells or work stations under
this new “intelligent" denomination. For this, besides offering a
conceptual basis in some of the key points to be taken into account
and some general principles to consider in the design and analysis of
the material flow, also some tips on how to define other possible
alternative material flow scenarios and a classification of the states a
system, cell or workstation are offered as well. All this is done with
the intentions of relating it with the use of simulation tools, for which
these have been briefly addressed with a special focus on the Witness
simulation package. For a better comprehension, the previous
elements are supported by a detailed layout, other figures and a few
expressions which could help obtaining necessary data. Such data and
others will be used in the future, when simulating the scenarios in the
search of the best material flow configurations.
Abstract: For more than 120 years, gold mining formed the
backbone the South Africa-s economy. The consequence of mine
closure was observed in large-scale land degradation and widespread
pollution of surface water and groundwater. This paper investigates
the feasibility of using natural zeolite in removing heavy metals
contaminating the Wonderfonteinspruit Catchment Area (WCA), a
water stream with high levels of heavy metals and radionuclide
pollution. Batch experiments were conducted to study the adsorption
behavior of natural zeolite with respect to Fe2+, Mn2+, Ni2+, and Zn2+.
The data was analysed using the Langmuir and Freudlich isotherms.
Langmuir was found to correlate the adsorption of Fe2+, Mn2+, Ni2+,
and Zn2+ better, with the adsorption capacity of 11.9 mg/g, 1.2 mg/g,
1.3 mg/g, and 14.7 mg/g, respectively. Two kinetic models namely,
pseudo-first order and pseudo second order were also tested to fit the
data. Pseudo-second order equation was found to be the best fit for
the adsorption of heavy metals by natural zeolite. Zeolite
functionalization with humic acid increased its uptake ability.
Abstract: Based on Rayleigh beam theory, the sub-impacts of a
free-free beam struck horizontally by a round-nosed rigid mass is
simulated by the finite difference method and the impact-separation
conditions. In order to obtain the sub-impact force, a uniaxial
compression elastic-plastic contact model is employed to analyze the
local deformation field on contact zone. It is found that the horizontal
impact is a complicated process including the elastic plastic
sub-impacts in sequence. There are two sub-zones of sub-impact. In
addition, it found that the elastic energy of the free-free beam is more
suitable for the Poisson collision hypothesis to explain compression
and recovery processes.
Abstract: Pretreatment of oil palm empty fruit bunch (OPEFB) with N-Methylmorpholine-N-oxide (NMMO) to enhance biogas production was investigated. The pretreatments were performed at 90 and 120ºC for 1, 3, and 5 h using three different concentrations of NMMO of 73%, 79%, and 85%. The pretreated OPEFB was subsequently anaerobically digested to produce biogas. After pretreatment, there were no significant changes of the main composition of OPEFB and the maximum total solid recovery was 92%. The amorphous phase was increased up to 78% at pretreatment condition using 85% NMMO solution for 3 h at 120oC. In general, higher concentration of NMMO and higher temperature resulted in increased amorphous form and higher biogas production. The best results of biogas production reached enhancement of methane yield of 148% compared to the untreated OPEFB and increased in digestion of 94% compared to starch as reference.
Abstract: The ever increasing use of World Wide Web in the
existing network, results in poor performance. Several techniques
have been developed for reducing web traffic by compressing the size
of the file, saving the web pages at the client side, changing the burst
nature of traffic into constant rate etc. No single method was
adequate enough to access the document instantly through the
Internet. In this paper, adaptive hybrid algorithms are developed for
reducing web traffic. Intelligent agents are used for monitoring the
web traffic. Depending upon the bandwidth usage, user-s preferences,
server and browser capabilities, intelligent agents use the best
techniques to achieve maximum traffic reduction. Web caching,
compression, filtering, optimization of HTML tags, and traffic
dispersion are incorporated into this adaptive selection. Using this
new hybrid technique, latency is reduced to 20 – 60 % and cache hit
ratio is increased 40 – 82 %.
Abstract: Many computational techniques were applied to
solution of heat conduction problem. Those techniques were the
finite difference (FD), finite element (FE) and recently meshless
methods. FE is commonly used in solution of equation of heat
conduction problem based on the summation of stiffness matrix of
elements and the solution of the final system of equations. Because
of summation process of finite element, convergence rate was
decreased. Hence in the present paper Cellular Automata (CA)
approach is presented for the solution of heat conduction problem.
Each cell considered as a fixed point in a regular grid lead to the
solution of a system of equations is substituted by discrete systems of
equations with small dimensions. Results show that CA can be used
for solution of heat conduction problem.
Abstract: Many footbridges have natural frequencies that
coincide with the dominant frequencies of the pedestrian-induced
load and therefore they have a potential to suffer excessive vibrations
under dynamic loads induced by pedestrians. Some of the design
standards introduce load models for pedestrian loads applicable for
simple structures. Load modeling for more complex structures, on the
other hand, is most often left to the designer. The main focus of this
paper is on the human induced forces transmitted to a footbridge and
on the ways these loads can be modeled to be used in the dynamic
design of footbridges. Also design criteria and load models proposed
by widely used standards were introduced and a comparison was
made. The dynamic analysis of the suspension bridge in Kolin in the
Czech Republic was performed on detailed FEM model using the
ANSYS program system. An attempt to model the load imposed by a
single person and a crowd of pedestrians resulted in displacements
and accelerations that are compared with serviceability criteria.
Abstract: This conference paper discusses a risk allocation problem for subprime investing banks involving investment in subprime structured mortgage products (SMPs) and Treasuries. In order to solve this problem, we develop a L'evy process-based model of jump diffusion-type for investment choice in subprime SMPs and Treasuries. This model incorporates subprime SMP losses for which credit default insurance in the form of credit default swaps (CDSs) can be purchased. In essence, we solve a mean swap-at-risk (SaR) optimization problem for investment which determines optimal allocation between SMPs and Treasuries subject to credit risk protection via CDSs. In this regard, SaR is indicative of how much protection investors must purchase from swap protection sellers in order to cover possible losses from SMP default. Here, SaR is defined in terms of value-at-risk (VaR). Finally, we provide an analysis of the aforementioned optimization problem and its connections with the subprime mortgage crisis (SMC).
Abstract: This paper deals with the conceptual design of the
new aeroelastic demonstrator for the whirl flutter simulation. The
paper gives a theoretical background of the whirl flutter phenomenon
and describes the events of the whirl flutter occurrence in the
aerospace practice. The second part is focused on the experimental
research of the whirl flutter on aeroelastic similar models. Finally the
concept of the new aeroelastic demonstrator is described. The
demonstrator represents the wing and engine of the twin turboprop
commuter aircraft including a driven propeller. It allows the changes
of the main structural parameters influencing the whirl flutter
stability characteristics. It is intended for the experimental
investigation of the whirl flutter in the wind tunnel. The results will
be utilized for validation of analytical methods and software tools.
Abstract: Today we tend to go back to the past to our root
relation to nature. Therefore in search of friendly spaces there are
elements of natural environment introduced as elements of spatial
composition. Though reinvented through the use of the new
substance such as greenery, water etc. made possible by state of the
art technologies, still, in principal, they remain the same. As a result,
sustainable design, based upon the recognized means of composition
in addition to the relation of architecture and urbanism vs. nature
introduces a new aesthetical values into architectural and urban
space.
Abstract: In this work, we improve a previously developed
segmentation scheme aimed at extracting edge information from
speckled images using a maximum likelihood edge detector. The
scheme was based on finding a threshold for the probability density
function of a new kernel defined as the arithmetic mean-to-geometric
mean ratio field over a circular neighborhood set and, in a general
context, is founded on a likelihood random field model (LRFM). The
segmentation algorithm was applied to discriminated speckle areas
obtained using simple elliptic discriminant functions based on
measures of the signal-to-noise ratio with fractional order moments.
A rigorous stochastic analysis was used to derive an exact expression
for the cumulative density function of the probability density
function of the random field. Based on this, an accurate probability
of error was derived and the performance of the scheme was
analysed. The improved segmentation scheme performed well for
both simulated and real images and showed superior results to those
previously obtained using the original LRFM scheme and standard
edge detection methods. In particular, the false alarm probability was
markedly lower than that of the original LRFM method with
oversegmentation artifacts virtually eliminated. The importance of
this work lies in the development of a stochastic-based segmentation,
allowing an accurate quantification of the probability of false
detection. Non visual quantification and misclassification in medical
ultrasound speckled images is relatively new and is of interest to
clinicians.
Abstract: Decentralized eco-sanitation system is a promising and sustainable mode comparing to the century-old centralized conventional sanitation system. The decentralized concept relies on an environmentally and economically sound management of water, nutrient and energy fluxes. Source-separation systems for urban waste management collect different solid waste and wastewater streams separately to facilitate the recovery of valuable resources from wastewater (energy, nutrients). A resource recovery centre constituted for 20,000 people will act as the functional unit for the treatment of urban waste of a high-density population community, like Singapore. The decentralized system includes urine treatment, faeces and food waste co-digestion, and horticultural waste and organic fraction of municipal solid waste treatment in composting plants. A design model is developed to estimate the input and output in terms of materials and energy. The inputs of urine (yellow water, YW) and faeces (brown water, BW) are calculated by considering the daily mean production of urine and faeces by humans and the water consumption of no-mix vacuum toilet (0.2 and 1 L flushing water for urine and faeces, respectively). The food waste (FW) production is estimated to be 150 g wet weight/person/day. The YW is collected and discharged by gravity into tank. It was found that two days are required for urine hydrolysis and struvite precipitation. The maximum nitrogen (N) and phosphorus (P) recovery are 150-266 kg/day and 20-70 kg/day, respectively. In contrast, BW and FW are mixed for co-digestion in a thermophilic acidification tank and later a decentralized/centralized methanogenic reactor is used for biogas production. It is determined that 6.16-15.67 m3/h methane is produced which is equivalent to 0.07-0.19 kWh/ca/day. The digestion residues are treated with horticultural waste and organic fraction of municipal waste in co-composting plants.