Abstract: The aim of this study was to determine the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), total antioxidant status (TAS) and accumulation of Hsp70 in porcine ovarian granulosa cells after deoxynivalenol (DON) and zearalenone (ZEA) exposure in vitro. Porcine ovarian granulosa cells were incubated with DON/ZEA administrations as follows: group A (10/10 ng/mL), group B (100/100 ng/mL), group C (1000/1000 ng/mL), and the control group without any additions for 24h. In this study mycotoxins developed stress reaction of porcine ovarian granulosa cells and increased accumulation of Hsp70 what resulted in increasing activities of SOD and GPx in groups with lower doses of mycotoxins. High dose of DON and ZEA had opposite effect on GPx activity than the lower doses. Slight increase in TAS of porcine granulosa cells was observed after mycotoxins exposure. These results contribute towards the understanding of cellular stress and its response.
Abstract: In clinical practice, the selection of an antidepressant often degrades to lengthy trial-and-error. In this work we employ a normalized wavelet power of alpha waves as a biomarker of antidepressant treatment response. This novel EEG metric takes into account both non-stationarity and intersubject variability of alpha waves. We recorded resting, 19-channel EEG (closed eyes) in 22 inpatients suffering from unipolar (UD, n=10) or bipolar (BD, n=12) depression. The EEG measurement was done at the end of the short washout period which followed previously unsuccessful pharmacotherapy. The normalized alpha wavelet power of 11 responders was markedly different than that of 11 nonresponders at several, mostly temporoparietal sites. Using the prediction of treatment response based on the normalized alpha wavelet power, we achieved 81.8% sensitivity and 81.8% specificity for channel T4.
Abstract: Large rotating systems, especially gear drives and gearboxes, occur as parts of many mechanical devices transmitting the torque with relatively small loss of power. With the increased demand for high speed machinery, mathematical modeling and
dynamic analysis of gear drives gained importance. Mathematical description of such mechanical systems is a complex task evolving for several decades. In gear drive dynamic models, which include flexible shafts, bearings and gearing and use the finite elements, nonlinear effects due to gear mesh and bearings are usually ignored, for such models have large number of degrees of freedom (DOF) and it is computationally expensive to analyze nonlinear systems with large number of DOF. Therefore, these models are not suitable for simulation of nonlinear behavior with amplitude jumps in frequency response. The contribution uses a methodology of nonlinear large rotating system modeling which is based on degrees of freedom (DOF) number reduction using modal synthesis method (MSM).
The MSM enables significant DOF number reduction while keeping
the nonlinear behavior of the system in a specific frequency range.
Further, the MSM with DOF number reduction is suitable for
including detail models of nonlinear couplings (mainly gear and
bearing couplings) into the complete gear drive models. Since each
subsystem is modeled separately using different FEM systems, it
is advantageous to parameterize models of subsystems and to use
the parameterization for optimization of chosen design parameters.
Final complex model of gear drive is assembled in MATLAB and
MATLAB tools are used for dynamical analysis of the nonlinear
system. The contribution is further focused on developing of a
methodology for investigation of behavior of the system by Nonlinear
Normal Modes with combination of the MSM using numerical
continuation method. The proposed methodology will be tested using
a two-stage gearbox including its housing.
Abstract: This paper interested in the mechanical deformation behavior of shear deformable functionally graded ceramic-metal (FGM) plates. Theoretical formulations are based on power law theory when build up functional graded material. The mechanical properties of the plate are graded in the thickness direction according to a power-law Displacement and stress is obtained using finite element method (FEM). The load is supposed to be a uniform distribution over the plate surface (XY plane) and varied in the thickness direction only. An FGM’s gradation in material properties allows the designer to tailor material response to meet design criteria. An FGM made of ceramic and metal can provide the thermal protection and load carrying capability in one material thus eliminating the problem of thermo-mechanical deformation behavior. This thesis will explore analysis of FGM flat plates and shell panels, and their applications to r structural problems. FGMs are first characterized as flat plates under pressure in order to understand the effect variation of material properties has on structural response. In addition, results are compared to published results in order to show the accuracy of modeling FGMs using ABAQUS software.
Abstract: Widespread use of response spectra in seismic design and evaluation of different types of structures makes them one of the most important seismic inputs. This importance urges the local design codes to adapt precise data based on updated information about the recent major earthquakes happened and also localized geotechnical data. In this regard, this paper derives the response spectra with a geotechnical approach for various scenarios coming from the recent major earthquakes happened in Iran for different types of hard soils, and compares the results to the corresponding spectra from the current seismic code. This comparison implies the need for adapting new design spectra for seismic design, because of major differences in the frequency domains and amplifications.
Abstract: The paper analyzes the response of buildings and industrially structures on seismic waves (low frequency mechanical vibration) generated by blasting operations. The principles of seismic analysis can be applied for different kinds of excitation such as: earthquakes, wind, explosions, random excitation from local transportation, periodic excitation from large rotating and/or machines with reciprocating motion, metal forming processes such as forging, shearing and stamping, chemical reactions, construction and earth moving work, and other strong deterministic and random energy sources caused by human activities. The article deals with the response of seismic, low frequency, mechanical vibrations generated by nearby blasting operations on a residential home. The goal was to determine the fundamental natural frequencies of the measured structure; therefore it is important to determine the resonant frequencies to design a suitable modal damping. The article also analyzes the package of seismic waves generated by blasting (Primary waves – P-waves and Secondary waves S-waves) and investigated the transfer regions. For the detection of seismic waves resulting from an explosion, the Fast Fourier Transform (FFT) and modal analysis, in the frequency domain, is used and the signal was acquired and analyzed also in the time domain. In the conclusions the measured results of seismic waves caused by blasting in a nearby quarry and its effect on a nearby structure (house) is analyzed. The response on the house, including the fundamental natural frequency and possible fatigue damage is also assessed.
Abstract: A multi-panel PMC infilled system, using polymer matrix composite (PMC) material, was introduced as new conceptual design for seismic retrofitting. A proposed multi panel PMC infilled system was composed of two basic structural components: inner PMC sandwich infills and outer FRP damping panels. The PMC material had high stiffness-to-weight and strength-to-weight ratios. Therefore, the addition of PMC infill panels into existing structures would not significantly alter the weight of the structure, while providing substantial structural enhancement.
In this study, an equivalent linearized dynamic analysis for a proposed multi-panel PMC infilled frame was performed, in order to assess their effectiveness and their responses under the simulated earthquake loading. Upon comparing undamped (without PMC panel) and damped (with PMC panel) structures, numerical results showed that structural damping with passive interface damping layer could significantly enhance the seismic response.
Abstract: This paper presents a generalized d-q model of n- phase induction motor drive. Multi -phase (n-phase) induction motor (more than three phases) drives possess several advantages over conventional three-phase drives, such as reduced current/phase without increasing voltage/phase, lower torque pulsation, higher torque density, fault tolerance, stability, high efficiency and lower current ripple. When the number of phases increases, it is also possible to increase the power in the same frame. In this paper, a generalized dq-axis model is developed in Matlab/Simulink for an n-phase induction motor. The simulation results are presented for 5, 6, 7, 9 and 12 phase induction motor under varying load conditions. Transient response of the multi-phase induction motors are given for different number of phases. Fault tolerant feature is also analyzed for 5-phase induction motor drive.
Abstract: In this letter, we considers a delayed predatory-prey system with Holling type II functional response. Under some sufficient conditions, the existence of multiple positive periodic solutions is obtained by using Mawhin’s continuation theorem of coincidence degree theory. An example is given to illustrate the effectiveness of our results.
Abstract: Introduction: Pegylated Interferon and Ribavirin combination is standard of care in the management of chronic HCV infected patients. Efficacy of the therapy is judged by the ability to achieve biochemical and virological response as judged by RVR, EVR, ETR and SVR.Objective: To evaluate the efficacy of newly marketed biosimilar Pegylated Interferon Alpha 40KD (Peg INF) in chronic HCV patients. Materials and methods: This was observational, prospective multicentre study to evaluate the ability of biosimilar pegylated interferon alfa 2a (40KD) along with Ribavirin (weight based) to achieve SVR. The enrolled patients were separated into Naïve (A), Relapsers (B) and Non Responders(C) based on the previous history of interferon exposure and its response. The RGT was followed on ALT and RVR, EVR, ETR and SVR.Results:As per protocol analysis estimated SVR for three groups is 86.6% for naïve, 89.4% for relapsers and 52.4% for non-responders to standard interferon. Conclusion: It is concluded that Bio-similar pegylated interferon alfa-2a (40kD) along with Ribavirin has good anti-viral efficacy in Naïve, Relapsers and Non-responders to standard IFN of chronic HCV infected patients requiring treatment.
Abstract: An adaptive dynamic cerebellar model articulation
controller (DCMAC) neural network used for solving the prediction
and identification problem is proposed in this paper. The proposed
DCMAC has superior capability to the conventional cerebellar model
articulation controller (CMAC) neural network in efficient learning
mechanism, guaranteed system stability and dynamic response. The
recurrent network is embedded in the DCMAC by adding feedback
connections in the association memory space so that the DCMAC
captures the dynamic response, where the feedback units act as
memory elements. The dynamic gradient descent method is adopted to
adjust DCMAC parameters on-line. Moreover, the analytical method
based on a Lyapunov function is proposed to determine the
learning-rates of DCMAC so that the variable optimal learning-rates
are derived to achieve most rapid convergence of identifying error.
Finally, the adaptive DCMAC is applied in two computer simulations.
Simulation results show that accurate identifying response and
superior dynamic performance can be obtained because of the
powerful on-line learning capability of the proposed DCMAC.
Abstract: In this work, sorption of nickel from aqueous solution on hypnea valentiae, red macro algae, was investigated. Batch experiments have been carried out to find the effect of various parameters such as pH, temperature, sorbent dosage, metal concentration and contact time on the sorption of nickel using hypnea valentiae. Response surface methodology (RSM) is employed to optimize the process parameters. Based on the central composite design, quadratic model was developed to correlate the process variables to the response. The most influential factor on each experimental design response was identified from the analysis of variance (ANOVA). The optimum conditions for the sorption of nickel were found to be: pH – 5.1, temperature – 36.8oC, sorbent dosage – 5.1 g/L, metal concentration – 100 mg/L and contact time – 30 min. At these optimized conditions the maximum removal of nickel was found to be 91.97%. A coefficient of determination R2 value 0.9548 shows the fitness of response surface methodology in this work.
Abstract: An optimal control strategy based on simple model, a
single phase unity power factor boost converter is presented with an
evaluation of first order differential equations. This paper presents an
evaluation of single phase boost converter having power factor
correction. The simple discrete model of boost converter is formed
and optimal control is obtained, digital PI is adopted to adjust control
error. The method of instantaneous current control is proposed in this
paper for its good tracking performance of dynamic response. The
simulation and experimental results verified our design.
Abstract: Behavior of dams against the seismic loads has been
studied by many researchers. Most of them proposed new numerical
methods to investigate the dam safety. In this paper, to study the
effect of nonlinear parameters of concrete in gravity dams, a twodimensional
approach was used including the finite element method,
staggered method and smeared crack approach. Effective parameters
in the models are physical properties of concrete such as modulus of
elasticity, tensile strength and specific fracture energy. Two different
models were used in foundation (mass-less and massed) in order to
determine the seismic response of concrete gravity dams. Results
show that when the nonlinear analysis includes the dam- foundation
interaction, the foundation-s mass, flexibility and radiation damping
are important in gravity dam-s response.
Abstract: Photo-BJMOSFET (Bipolar Junction Metal-Oxide-
Semiconductor Field Effect Transistor) fabricated on SOI film was proposed. ITO film is adopted in the device as gate electrode to reduce
light absorption. Depletion region but not inversion region is formed
in film by applying gate voltage (but low reverse voltage) to achieve
high photo-to-dark-current ratio. Comparisons of photoelectriccharacteristics
executed among VGK=0V, 0.3V, 0.6V, 0.9V and 1.0V
(reverse voltage VAK is equal to 1.0V for total area of 10×10μm2). The
results indicate that the greatest improvement in photo-to-dark-current
ratio is achieved up to 2.38 at VGK=0.6V. In addition,
photo-BJMOSFET is compatible with CMOS integration due to big
input resistance
Abstract: The aim of the current work is to present a comparison among three popular optimization methods in the inverse elastostatics problem (IESP) of flaw detection within a solid. In more details, the performance of a simulated annealing, a Hooke & Jeeves and a sequential quadratic programming algorithm was studied in the test case of one circular flaw in a plate solved by both the boundary element (BEM) and the finite element method (FEM). The proposed optimization methods use a cost function that utilizes the displacements of the static response. The methods were ranked according to the required number of iterations to converge and to their ability to locate the global optimum. Hence, a clear impression regarding the performance of the aforementioned algorithms in flaw identification problems was obtained. Furthermore, the coupling of BEM or FEM with these optimization methods was investigated in order to track differences in their performance.
Abstract: In this paper static and dynamic response of a
varactor of a micro-phase shifter to DC, step DC and AC
voltages have been studied. By presenting a mathematical
modeling Galerkin-based step by step linearization method
(SSLM) and Galerkin-based reduced order model have been
used to solve the governing static and dynamic equations,
respectively. The calculated static and dynamic pull-in
voltages have been validated by previous experimental and
theoretical results and a good agreement has been achieved.
Then the frequency response and phase diagram of the system
has been studied. It has been shown that applying the DC
voltage shifts down the phase diagram and frequency
response. Also increasing the damping ratio shifts up the
phase diagram.
Abstract: The ideal sinc filter, ignoring the noise statistics, is often
applied for generating an arbitrary sample of a bandlimited signal by
using the uniformly sampled data. In this article, an optimal interpolator is proposed; it reaches a minimum mean square error (MMSE)
at its output in the presence of noise. The resulting interpolator is
thus a Wiener filter, and both the optimal infinite impulse response
(IIR) and finite impulse response (FIR) filters are presented. The
mean square errors (MSE-s) for the interpolator of different length
impulse responses are obtained by computer simulations; it shows that
the MSE-s of the proposed interpolators with a reasonable length are
improved about 0.4 dB under flat power spectra in noisy environment with signal-to-noise power ratio (SNR) equal 10 dB. As expected,
the results also demonstrate the improvements for the MSE-s with various fractional delays of the optimal interpolator against the ideal
sinc filter under a fixed length impulse response.
Abstract: Active vibration control is an important problem in
structures. The objective of active vibration control is to reduce the vibrations of a system by automatic modification of the system-s
structural response. In this paper, the modeling and design of a fast
output sampling feedback controller for a smart flexible beam system embedded with shear sensors and actuators for SISO system using
Timoshenko beam theory is proposed. FEM theory, Timoshenko beam theory and the state space techniques are used to model the
aluminum cantilever beam. For the SISO case, the beam is divided into 5 finite elements and the control actuator is placed at finite
element position 1, whereas the sensor is varied from position 2 to 5, i.e., from the nearby fixed end to the free end. Controllers are
designed using FOS method and the performance of the designed FOS controller is evaluated for vibration control for 4 SISO models
of the same plant. The effect of placing the sensor at different locations on the beam is observed and the performance of the
controller is evaluated for vibration control. Some of the limitations of the Euler-Bernoulli theory such as the neglection of shear and
axial displacement are being considered here, thus giving rise to an accurate beam model. Embedded shear sensors and actuators have
been considered in this paper instead of the surface mounted sensors
and actuators for vibration suppression because of lot of advantages. In controlling the vibration modes, the first three dominant modes of
vibration of the system are considered.
Abstract: It has been shown that a load discontinuity at the end of
an impulse will result in an extra impulse and hence an extra amplitude
distortion if a step-by-step integration method is employed to yield the
shock response. In order to overcome this difficulty, three remedies
are proposed to reduce the extra amplitude distortion. The first remedy
is to solve the momentum equation of motion instead of the force
equation of motion in the step-by-step solution of the shock response,
where an external momentum is used in the solution of the momentum
equation of motion. Since the external momentum is a resultant of the
time integration of external force, the problem of load discontinuity
will automatically disappear. The second remedy is to perform a single
small time step immediately upon termination of the applied impulse
while the other time steps can still be conducted by using the time step
determined from general considerations. This is because that the extra
impulse caused by a load discontinuity at the end of an impulse is
almost linearly proportional to the step size. Finally, the third remedy
is to use the average value of the two different values at the integration
point of the load discontinuity to replace the use of one of them for
loading input. The basic motivation of this remedy originates from the
concept of no loading input error associated with the integration point
of load discontinuity. The feasibility of the three remedies are
analytically explained and numerically illustrated.