Abstract: Optimization of a microwave-assisted extraction of cherry laurel (Prunus laurocerasus) fruit using methanol was studied. The influence of process parameters (microwave power, plant material-to-solvent ratio and the extraction time) on the extraction efficiency were optimized by using response surface methodology. The predicted maximum yield of extractive substances (41.85 g/100 g fresh plant material) was obtained at microwave power of 600 W and plant material to solvent ratio of 0.2 g/cm3 after 26 minutes of extraction, while a mean value of 40.80±0.41 g/100 g fresh plant material was obtained from laboratory experiments. This proves applicability of the model in predicting optimal extraction conditions with minimal laborious and time consuming. The results indicated that all process parameters were effective on the extraction efficiency, while the most important factor was extraction time. In order to rationalize production the optimal economical condition which gave a large total extract yield with minimal energy and solvent consumption was found.
Abstract: In this work, sorption of nickel from aqueous solution on hypnea valentiae, red macro algae, was investigated. Batch experiments have been carried out to find the effect of various parameters such as pH, temperature, sorbent dosage, metal concentration and contact time on the sorption of nickel using hypnea valentiae. Response surface methodology (RSM) is employed to optimize the process parameters. Based on the central composite design, quadratic model was developed to correlate the process variables to the response. The most influential factor on each experimental design response was identified from the analysis of variance (ANOVA). The optimum conditions for the sorption of nickel were found to be: pH – 5.1, temperature – 36.8oC, sorbent dosage – 5.1 g/L, metal concentration – 100 mg/L and contact time – 30 min. At these optimized conditions the maximum removal of nickel was found to be 91.97%. A coefficient of determination R2 value 0.9548 shows the fitness of response surface methodology in this work.
Abstract: A statistical optimization of the saccharification
process of EFB was studied. The statistical analysis was done by
applying faced centered central composite design (FCCCD) under
response surface methodology (RSM). In this investigation, EFB
dose, enzyme dose and saccharification period was examined, and the
maximum 53.45% (w/w) yield of reducing sugar was found with 4%
(w/v) of EFB, 10% (v/v) of enzyme after 120 hours of incubation. It
can be calculated that the conversion rate of cellulose content of the
substrate is more than 75% (w/w) which can be considered as a
remarkable achievement. All the variables, linear, quadratic and
interaction coefficient, were found to be highly significant, other than
two coefficients, one quadratic and another interaction coefficient.
The coefficient of determination (R2) is 0.9898 that confirms a
satisfactory data and indicated that approximately 98.98% of the
variability in the dependent variable, saccharification of EFB, could
be explained by this model.
Abstract: This paper presents a case study that uses processoriented
simulation to identify bottlenecks in the service delivery
system in an emergency department of a hospital in the United Arab
Emirates. Using results of the simulation, response surface models
were developed to explain patient waiting time and the total time
patients spend in the hospital system. Results of the study could be
used as a service improvement tool to help hospital management in
improving patient throughput and service quality in the hospital
system.
Abstract: The objective of this research was to investigate biodegradation of water hyacinth (Eichhornia crassipes) to produce bioethanol using dilute-acid pretreatment (1% sulfuric acid) results in high hemicellulose decomposition and using yeast (Pachysolen tannophilus) as bioethanol producing strain. A maximum ethanol yield of 1.14g/L with coefficient, 0.24g g-1; productivity, 0.015g l-1h-1 was comparable to predicted value 32.05g/L obtained by Central Composite Design (CCD). Maximum ethanol yield coefficient was comparable to those obtained through enzymatic saccharification and fermentation of acid hydrolysate using fully equipped fermentor. Although maximum ethanol concentration was low in lab scale, the improvement of lignocellulosic ethanol yield is necessary for large scale production.
Abstract: An attempt has been made to investigate the
machinability of zirconia toughened alumina (ZTA) inserts while
turning AISI 4340 steel. The insert was prepared by powder
metallurgy process route and the machining experiments were
performed based on Response Surface Methodology (RSM) design
called Central Composite Design (CCD). The mathematical model of
flank wear, cutting force and surface roughness have been developed
using second order regression analysis. The adequacy of model has
been carried out based on Analysis of variance (ANOVA) techniques.
It can be concluded that cutting speed and feed rate are the two most
influential factor for flank wear and cutting force prediction. For
surface roughness determination, the cutting speed & depth of cut
both have significant contribution. Key parameters effect on each
response has also been presented in graphical contours for choosing
the operating parameter preciously. 83% desirability level has been
achieved using this optimized condition.
Abstract: In recent years, response surface methodology (RSM) has
brought many attentions of many quality engineers in different
industries. Most of the published literature on robust design
methodology is basically concerned with optimization of a single
response or quality characteristic which is often most critical to
consumers. For most products, however, quality is multidimensional,
so it is common to observe multiple responses in an experimental
situation. Through this paper interested person will be familiarize
with this methodology via surveying of the most cited technical
papers.
It is believed that the proposed procedure in this study can resolve
a complex parameter design problem with more than two responses.
It can be applied to those areas where there are large data sets and a
number of responses are to be optimized simultaneously. In addition,
the proposed procedure is relatively simple and can be implemented
easily by using ready-made standard statistical packages.
Abstract: With the aim of improving nutritional profile and antioxidant capacity of gluten-free cookies, blueberry pomace, by-product of juice production, was processed into a new food ingredient by drying and grinding and used for a gluten-free cookie formulation. Since the quality of a baked product is highly influenced by the baking conditions, the objective of this work was to optimize the baking time and thickness of dough pieces, by applying Response Surface Methodology (RSM) in order to obtain the best technological quality of the cookies. The experiments were carried out according to a Central Composite Design (CCD) by selecting the dough thickness and baking time as independent variables, while hardness, color parameters (L*, a* and b* values), water activity, diameter and short/long ratio were response variables. According to the results of RSM analysis, the baking time of 13.74min and dough thickness of 4.08mm was found to be the optimal for the baking temperature of 170°C. As similar optimal parameters were obtained by previously conducted experiment based on sensory analysis, response surface methodology (RSM) can be considered as a suitable approach to optimize the baking process.
Abstract: Response Surface Methodology (RSM) is a powerful
and efficient mathematical approach widely applied in the
optimization of cultivation process. Cellulase enzyme production by
Trichoderma reesei RutC30 using agricultural waste rice straw and
banana fiber as carbon source were investigated. In this work,
sequential optimization strategy based statistical design was
employed to enhance the production of cellulase enzyme through
submerged cultivation. A fractional factorial design (26-2) was applied
to elucidate the process parameters that significantly affect cellulase
production. Temperature, Substrate concentration, Inducer
concentration, pH, inoculum age and agitation speed were identified
as important process parameters effecting cellulase enzyme synthesis.
The concentration of lignocelluloses and lactose (inducer) in the
cultivation medium were found to be most significant factors. The
steepest ascent method was used to locate the optimal domain and a
Central Composite Design (CCD) was used to estimate the quadratic
response surface from which the factor levels for maximum
production of cellulase were determined.
Abstract: Pretreatment is an essential step in the conversion of
lignocellulosic biomass to fermentable sugar that used for biobutanol
production. Among pretreatment processes, microwave is considered
to improve pretreatment efficiency due to its high heating efficiency,
easy operation, and easily to combine with chemical reaction. The
main objectives of this work are to investigate the feasibility of
microwave pretreatment to enhance enzymatic hydrolysis of
corncobs and to determine the optimal conditions using response
surface methodology. Corncobs were pretreated via two-stage
pretreatment in dilute sodium hydroxide (2 %) followed by dilute
sulfuric acid 1 %. Pretreated corncobs were subjected to enzymatic
hydrolysis to produce reducing sugar. Statistical experimental design
was used to optimize pretreatment parameters including temperature,
residence time and solid-to-liquid ratio to achieve the highest amount
of glucose. The results revealed that solid-to-liquid ratio and
temperature had a significant effect on the amount of glucose.
Abstract: Implementation of response surface methodology (RSM) was employed to study the effects of two factor (rubber clearance and round per minute) in brown rice peeling machine of The optimal BROKENS yield (19.02, average of three repeats),.The optimized composition derived from RSM regression was analyzed using Regression analysis and Analysis of Variance (ANOVA). At a significant level α = 0.05, the values of Regression coefficient, R 2 (adj)were 97.35 % and standard deviation were 1.09513. The independent variables are initial rubber clearance, and round per minute parameters namely. The investigating responses are final rubber clearance, and round per minute (RPM). The restriction of the optimization is the designated.
Abstract: This study deals with a multi-criteria optimization
problem which has been transformed into a single objective
optimization problem using Response Surface Methodology (RSM),
Artificial Neural Network (ANN) and Grey Relational Analyses
(GRA) approach. Grey-RSM and Grey-ANN are hybrid techniques
which can be used for solving multi-criteria optimization problem.
There have been two main purposes of this research as follows.
1. To determine optimum and robust fiber dyeing process
conditions by using RSM and ANN based on GRA,
2. To obtain the best suitable model by comparing models
developed by different methodologies.
The design variables for fiber dyeing process in textile are
temperature, time, softener, anti-static, material quantity, pH,
retarder, and dispergator. The quality characteristics to be evaluated
are nominal color consistency of fiber, maximum strength of fiber,
minimum color of dyeing solution. GRA-RSM with exact level
value, GRA-RSM with interval level value and GRA-ANN models
were compared based on GRA output value and MSE (Mean Square
Error) performance measurement of outputs with each other. As a
result, GRA-ANN with interval value model seems to be suitable
reducing the variation of dyeing process for GRA output value of the
model.
Abstract: Global approximation using metamodel for complex
mathematical function or computer model over a large variable
domain is often needed in sensibility analysis, computer simulation,
optimal control, and global design optimization of complex, multiphysics
systems. To overcome the limitations of the existing
response surface (RS), surrogate or metamodel modeling methods for
complex models over large variable domain, a new adaptive and
regressive RS modeling method using quadratic functions and local
area model improvement schemes is introduced. The method applies
an iterative and Latin hypercube sampling based RS update process,
divides the entire domain of design variables into multiple cells,
identifies rougher cells with large modeling error, and further divides
these cells along the roughest dimension direction. A small number
of additional sampling points from the original, expensive model are
added over the small and isolated rough cells to improve the RS
model locally until the model accuracy criteria are satisfied. The
method then combines local RS cells to regenerate the global RS
model with satisfactory accuracy. An effective RS cells sorting
algorithm is also introduced to improve the efficiency of model
evaluation. Benchmark tests are presented and use of the new
metamodeling method to replace complex hybrid electrical vehicle
powertrain performance model in vehicle design optimization and
optimal control are discussed.
Abstract: In this research, natural canthaxanthin as one of the
most important carotenoids was extracted from Dietzia
natronolimnaea HS-1. The changes of canthaxanthin enriched in oilin-
water emulsions with vegetable oil (5 mg/ 100 mL), Arabic gum (5
mg/100 mL), and potassium sorbate (0.5 g/100 mL) was investigated.
The effects of different pH (3, 5 and 7), as well as, time treatment (3,
18 and 33 days) in the environmental temperature (24°C) on the
degradation were studied by response surface methodology (RSM).
The Hunter values (L*, a*, and b*) and the concentration of
canthaxanthin (C, mg/L) illustrated more degradation of this pigment
at low pHs (pH≤ 4) by passing the time (days≥10) with R² 97.00%,
91.31%, 97.60%, and 99.54% for C, L*, a*, and b* respectively. The
predicted model were found to be significant (p
Abstract: The objective of the research is to study and compare
response surface designs: Central composite designs (CCD), Box-
Behnken designs (BBD), Small composite designs (SCD), Hybrid
designs, and Uniform shell designs (USD) over sets of reduced models
when the design is in a spherical region for 3 and 4 design variables.
The two optimality criteria ( D and G ) are considered which larger
values imply a better design. The comparison of design optimality
criteria of the response surface designs across the full second order
model and sets of reduced models for 3 and 4 factors based on the
two criteria are presented.
Abstract: This study investigated the removal efficiency of electrokinetic remediation of copper-contaminated soil at different combinations of enhancement reagents used as anolyte and catholyte. Sodium hydroxide (at 0.1, 0.5, and 1.0 M concentrations) and distilled water were used as anolyte, while lactic acid (at 0.01, 0.1, and 0.5 M concentrations), ammonium citrate (also at 0.01, 0.1, and 0.5 M concentrations) and distilled water were used as catholyte. A continuous voltage application (1.0 VDC/cm) was employed for 240 hours for each experiment. The copper content of the catholyte was determined at the end of the 240-hour period. Optimization was carried out with a Response Surface Methodology - Optimal Design, including F test, and multiple comparison method, to determine which pair of anolyte-catholyte was the most significant for the removal efficiency. "1.0 M NaOH" was found to be the most significant anolyte while it was established that lactic acid was the most significant type of catholyte to be used for the most successful electrokinetic experiments. Concentrations of lactic acid should be at the range of 0.1 M to 0.5 M to achieve maximum percent removal values.
Abstract: Various intelligences and inspirations have been
adopted into the iterative searching process called as meta-heuristics.
They intelligently perform the exploration and exploitation in the
solution domain space aiming to efficiently seek near optimal
solutions. In this work, the bee algorithm, inspired by the natural
foraging behaviour of honey bees, was adapted to find the near
optimal solutions of the transportation management system, dynamic
multi-zone dispatching. This problem prepares for an uncertainty and
changing customers- demand. In striving to remain competitive,
transportation system should therefore be flexible in order to cope
with the changes of customers- demand in terms of in-bound and outbound
goods and technological innovations. To remain higher service
level but lower cost management via the minimal imbalance scenario,
the rearrangement penalty of the area, in each zone, including time
periods are also included. However, the performance of the algorithm
depends on the appropriate parameters- setting and need to be
determined and analysed before its implementation. BEE parameters
are determined through the linear constrained response surface
optimisation or LCRSOM and weighted centroid modified simplex
methods or WCMSM. Experimental results were analysed in terms
of best solutions found so far, mean and standard deviation on the
imbalance values including the convergence of the solutions
obtained. It was found that the results obtained from the LCRSOM
were better than those using the WCMSM. However, the average
execution time of experimental run using the LCRSOM was longer
than those using the WCMSM. Finally a recommendation of proper
level settings of BEE parameters for some selected problem sizes is
given as a guideline for future applications.
Abstract: Air infiltration in mass scale industrial applications of
bio char production is inevitable. The presence of oxygen during the
carbonization process is detrimental to the production of biochar yield
and properties. The experiment was carried out on several wood
species in a fixed-bed pyrolyser under various fractions of oxygen
ranging from 0% to 11% by varying nitrogen and oxygen composition
in the pyrolysing gas mixtures at desired compositions. The bed
temperature and holding time were also varied. Process optimization
was carried out by Response Surface Methodology (RSM) by
employing Central Composite Design (CCD) using Design Expert 6.0
Software. The effect of oxygen ratio and holding time on biochar yield
within the range studied were statistically significant. From the
analysis result, optimum condition of 15.2% biochar yield of
mangrove wood was predicted at pyrolysis temperature of 403 oC,
oxygen percentage of 2.3% and holding time of two hours. This
prediction agreed well with the experiment finding of 15.1% biochar
yield.
Abstract: In this study, the effects of machining parameters on
specific energy during surface grinding of 6061Al-SiC35P
composites are investigated. Vol% of SiC, feed and depth of cut were
chosen as process variables. The power needed for the calculation of
the specific energy is measured from the two watt meter method.
Experiments are conducted using standard RSM design called Central
composite design (CCD). A second order response surface model was
developed for specific energy. The results identify the significant
influence factors to minimize the specific energy. The confirmation
results demonstrate the practicability and effectiveness of the
proposed approach.
Abstract: Rambutan is a tropical fruit which peel possesses antioxidant properties. This work was conducted to optimize extraction conditions of phenolic compounds from rambutan peel. Response surface methodology (RSM) was adopted to optimize subcritical water extraction (SWE) on temperature, extraction time and percent solvent mixture. The results demonstrated that the optimum conditions for SWE were as follows: temperature 160°C, extraction time 20min. and concentration of 50% ethanol. Comparison of the phenolic compounds from the rambutan peels in maceration 6h, soxhlet 4h, and SWE 20min., it indicated that total phenolic content (using Folin-Ciocalteu-s phenol reagent) was 26.42, 70.29, and 172.47mg of tannic acid equivalent (TAE) per g dry rambutan peel, respectively. The comparative study concluded that SWE was a promising technique for phenolic compounds extraction from rambutan peel, due to much more two times of conventional techniques and shorter extraction times.