Abstract: Five crystal modifications of water insoluble
artesunate were generated by recrystallizing it from various solvents
with improved physicochemical properties. These generated crystal
forms were characterized to select the most potent and soluble form.
SEM of all the forms showed changes in external shape leading them
to be different morphologically. DSC thermograms of Form III and
Form V showed broad endotherm peaks at 83.04oC and 76.96oC prior
to melting fusion of drug respectively. Calculated weight loss in TGA
revealed that Form III and Form V are methanol and acetone solvates
respectively. However, few additional peaks were appeared in XRPD
pattern in these two solvate forms. All forms exhibit exothermic
behavior in buffer and two solvates display maximum ease of
molecular release from the lattice. Methanol and acetone solvates
were found to be most soluble forms and exhibited higher
antimalarial efficacy showing higher survival rate (83.3%) after 30
days.
Abstract: This study was conducted to evaluate factors
regulating groundwater quality in an area with agriculture as main
use. Under this study twelve groundwater samples have been
collected from Padra taluka, Dabhoi taluka and Savli taluka of
Vadodara district. Groundwater samples were chemically analyzed
for major physicochemical parameter in order to understand the
different geochemical processes affecting the groundwater quality.
The analytical results shows higher concentration of total dissolved
solids (16.67%), electrical conductivity (25%) and magnesium
(8.33%) for pre monsoon and total dissolved solids (16.67%),
electrical conductivity (33.3%) and magnesium (8.33%) for post
monsoon which indicates signs of deterioration as per WHO and BIS
standards. On the other hand, 50% groundwater sample is unsuitable
for irrigation purposes based on irrigation quality parameters. The
study revealed that application of fertilizer for agricultural
contributing the higher concentration of ions in aquifer of Vadodara
district.
Abstract: The Beshar River is one aquatic ecosystem, which is
located next to the city of Yasuj in southern Iran. The Beshar river
has been contaminated by industrial factories such as effluent of
sugar factory, agricultural and other activities in this region such as,
Imam Sajjad hospital, drainage from agricultural farms, Yasuj urban
surface runoff and effluent of wastewater treatment plants ,specially
Yasuj waste water treatment plant. In order to evaluate the effects of
these pollutants on the quality of the Beshar river, five monitoring
stations were selected along its course. The first station is located
upstream of Yasuj near the Dehnow village; stations 2 to 4 are
located east, south and west of city; and the 5th station is located
downstream of Yasuj. Several water quality parameters were
sampled. These include pH, dissolved oxygen, biological oxygen
demand (BOD), temperature, conductivity, turbidity, total dissolved
solids and discharge or flow measurements. Water samples from the
five stations were collected and analyzed to determine the following
physicochemical parameters: EC, pH, T.D.S, T.H, No2, DO, BOD5,
COD during 2008 to 2010. The study shows that the BOD5 value of
station 1 is at a minimum (1.7 ppm) and increases downstream from
stations 2 to 4 to a maximum (11.6 ppm), and then decreases at
station 5. The DO values of station 1 is a maximum (8.45 ppm),
decreases downstream to stations 2 - 4 which are at a minimum (3.1
ppm), before increasing at station 5. The amount of BOD and TDS
are highest at the 4th station and the amount of DO is lowest at this
station, marking the 4th station as more highly polluted than the
other stations .This study shows average amount of the water quality
parameters in first year of sampling (2008) have had a better quality
relation to third year in 2010 because of recent drought in this region
and pollutant increasing .As the Beshar river path after 5th station
goes through the mountain area with more slope and flow velocity
,so the physicochemical parameters improve at the 5th station due to
pollutant degradation and dilution. Finally the point and nonpoint
pollutant sources of Beshar river were determined and compared to
the monitoring results.
Abstract: Mining tailings represent a generating source of rich heavy metal material with a potential danger the public health and the environment, since these metals, under certain conditions, can leach and contaminate aqueous systems that serve like supplying potable water sources. The strategy for this work is based on the observation, experimentation and the simulation that can be obtained by binding real answers of the hydrodynamic behavior of metals leached from mining tailings, and the applied mathematics that provides the logical structure to decipher the individual effects of the general physicochemical phenomenon. The case of study presented herein focuses on mining tailings deposits located in Monte San Nicolas, Guanajuato, Mexico, an abandoned mine. This was considered the contamination source that under certain physicochemical conditions can favor the metal leaching, and its transport towards aqueous systems. In addition, the cartography, meteorology, geology and the hydrodynamics and hydrological characteristics of the place, will be helpful in determining the way and the time in which these systems can interact. Preliminary results demonstrated that arsenic presents a great mobility, since this one was identified in several superficial aqueous systems of the micro watershed, as well as in sediments in concentrations that exceed the established maximum limits in the official norms. Also variations in pH and potential oxide-reduction were registered, conditions that favor the presence of different species from this element its solubility and therefore its mobility.
Abstract: This paper present some preliminary work on the
preparation and physicochemical caracterization of nanocomposite
MFI-alumina structures based on alumina hollow fibres. The fibers
are manufactured by a wet spinning process. α-alumina particles were
dispersed in a solution of polysulfone in NMP. The resulting slurry is
pressed through the annular gap of a spinneret into a precipitation
bath. The resulting green fibres are sintered. The mechanical strength
of the alumina hollow fibres is determined by a three-point-bending
test while the pore size is characterized by bubble-point testing. The
bending strength is in the range of 110 MPa while the average pore
size is 450 nm for an internal diameter of 1 mm and external diameter
of 1.7 mm. To characterize the MFI membranes various techniques
were used for physicochemical characterization of MFI–ceramic
hollow fibres membranes: The nitrogen adsorption, X-ray
diffractometry, scanning electron microscopy combined with X
emission microanalysis. Scanning Electron Microscopy (SEM) and
Energy Dispersive Microanalysis by the X-ray were used to observe
the morphology of the hollow fibre membranes (thickness,
infiltration into the carrier, defects, homogeneity). No surface film,
has been obtained, as observed by SEM and EDX analysis and
confirmed by high temperature variation of N2 and CO2 gas
permeances before cation exchange. Local analysis and characterise
(SEM and EDX) and overall (by ICP elemental analysis) were
conducted on two samples exchanged to determine the quantity and
distribution of the cation of cesium on the cross section fibre of the
zeolite between the cavities.
Abstract: New design of a grid for preparation of high density
granules with enhanced mechanical strength by granulation of
dispersed materials is suggested.
A method for hydrodynamic dimensioning of the grid depending
on granulation conditions, hydrodynamic regime of the operation,
dispersity and physicochemical characteristics of the materials to be
granulated was suggested.
The aim of the grid design is to solve the problems arising by the
granulation of disperse materials.
Abstract: Controlled modification of appropriate sharpness for
nanotips is of paramount importance to develop novel materials and
functional devices at a nanometer resolution. Herein, we present a
reliable and unique strategy of laser irradiation enhanced
physicochemical etching to manufacture super sharp tungsten tips
with reproducible shape and dimension as well as high yields
(~80%). The corresponding morphology structure evolution of
tungsten tips and laser-tip interaction mechanisms were
systematically investigated and discussed using field emission
scanning electron microscope (SEM) and physical optics statistics
method with different fluences under 532 nm laser irradiation. This
work paves the way for exploring more accessible metallic tips
applications with tunable apex diameter and aspect ratio, and,
furthermore, facilitates the potential sharpening enhancement
technique for other materials used in a variety of nanoscale devices.
Abstract: The Beshar River is one aquatic ecosystem,which is
affected by pollutants. This study was conducted to evaluate the
effects of human activities on the water quality of the Beshar river.
This river is approximately 190 km in length and situated at the
geographical positions of 51° 20' to 51° 48' E and 30° 18' to 30° 52'
N it is one of the most important aquatic ecosystems of Kohkiloye
and Boyerahmad province next to the city of Yasuj in southern Iran.
The Beshar river has been contaminated by industrial, agricultural
and other activities in this region such as factories, hospitals,
agricultural farms, urban surface runoff and effluent of wastewater
treatment plants. In order to evaluate the effects of these pollutants
on the quality of the Beshar river, five monitoring stations were
selected along its course. The first station is located upstream of
Yasuj near the Dehnow village; stations 2 to 4 are located east, south
and west of city; and the 5th station is located downstream of Yasuj.
Several water quality parameters were sampled. These include pH,
dissolved oxygen, biological oxygen demand (BOD), temperature,
conductivity, turbidity, total dissolved solids and discharge or flow
measurements. Water samples from the five stations were collected
and analysed to determine the following physicochemical
parameters: EC, pH, T.D.S, T.H, No2, DO, BOD5, COD during 2008
to 2009. The study shows that the BOD5 value of station 1 is at a
minimum (1.5 ppm) and increases downstream from stations 2 to 4 to
a maximum (7.2 ppm), and then decreases at station 5. The DO
values of station 1 is a maximum (9.55 ppm), decreases downstream
to stations 2 - 4 which are at a minimum (3.4 ppm), before increasing
at station 5. The amount of BOD and TDS are highest at the 4th
station and the amount of DO is lowest at this station, marking the
4th station as more highly polluted than the other stations. The
physicochemical parameters improve at the 5th station due to
pollutant degradation and dilution. Finally the point and nonpoint
pollutant sources of Beshar river were determined and compared to
the monitoring results.
Abstract: Yam starch obtained from the water yam (munlued)
by the wet milling process was studied for some physicochemical
properties. Yam starch film was prepared by casting using glycerol as
a plasticizer. The effect of different glycerol (1.30, 1.65 and
2.00g/100g of filmogenic solution) and starch concentrations (3.30,
3.65 and 4.00g /100g of filmogenic solution) were evaluated on some
characteristics of the film. The temperature for obtaining the
gelatinized starch solution was 70-80°C and then dried at 45°C for 4
hours. The resulting starch from munlued granular morphology was
triangular and the average size of the granule was 26.68 μm. The
amylose content by colorimetric method was 26 % and the gelatinize
temperature was 70-80°C. The appearance of the film was smooth,
transparent, and glossy with average moisture content of 25.96% and
thickness of 0.01mm. Puncture deformation and flexibility increased
with glycerol content. The starch and glycerol concentration were a
significant factor of the yam starch film characteristics. Yam starch
film can be described as a biofilm providing many applications and
developments with the advantage of biodegradability.
Abstract: The γ-turns play important roles in protein folding and
molecular recognition. The prediction and analysis of γ-turn types are
important for both protein structure predictions and better
understanding the characteristics of different γ-turn types. This study
proposed a physicochemical property-based decision tree (PPDT)
method to interpretably predict γ-turn types. In addition to the good
prediction performance of PPDT, three simple and human
interpretable IF-THEN rules are extracted from the decision tree
constructed by PPDT. The identified informative physicochemical
properties and concise rules provide a simple way for discriminating
and understanding γ-turn types.
Abstract: Solid dispersions (SD) of curcuminpolyvinylpyrrolidone
in the ratio of 1:2, 1:4, 1:5, 1:6, and 1:8 were
prepared in an attempt to increase the solubility and dissolution.
Solubility, dissolution, powder X-ray diffraction (XRD), differential
scanning calorimetry (DSC) and Fourier transform infrared
spectroscopy (FTIR) of solid dispersions, physical mixtures (PM)
and curcumin were evaluated. Both solubility and dissolution of
curcumin solid dispersions were significantly greater than those
observed for physical mixtures and intact curcumin. The powder
X-ray diffractograms indicated that the amorphous curcumin was
obtained from all solid dispersions. It was found that the optimum
weight ratio for curcumin:PVP K-30 is 1:6. The 1:6 solid dispersion
still in the amorphous from after storage at ambient temperature for 2
years and the dissolution profile did not significantly different from
freshly prepared.
Abstract: The present study was designed to demonstrate the seasonal variations in physico-chemical parameters of fish farm at Govt. Nursery Unit, Muzaffargarh, Department of Fisheries Govt. of Punjab, Pakistan for a period of eight months from January to August 2008. Water samples were collected on fifteen days basis and have been analyzed for estimation of Air temperature, Water temperature, Light penetration, pH, Total dissolved oxygen, Clouds, Carbonates, Bicarbonates, Total carbonates, Total dissolved solids, Chlorides, Calcium and Hardness. Seasonal fluctuations were observed in all the physico-chemical parameters of fish farm. The overall physicochemical parameters of fish pond water remained within the tolerable range throughout the study period.
Abstract: Mung bean starches were subjected to heat-moisture treatment (HMT) by different moisture contents (15%, 20%, 25%, 30% and 35%) at 120Ôäâ for 12h. The impact on the yields of resistant starch (RS), microstructure, physicochemical and functional properties was investigated. Compared to native starch, the RS content of heat-moisture treated starches increased significantly. The RS level of HMT-20 was the highest of all the starches. Birefringence was displayed clear at the center of native starch. For HMT starches, pronounced birefringence was exhibited on the periphery of starch granules; however, birefringence disappeared at the centre of some starch granules. The shape of HMT starches hadn-t been changed and the integrity of starch granules was preserved for all the conditions. Concavity could be observed on HMT starches under scanning electronic microscopy. After HMT, apparent amylose contents were increased and starch macromolecule was degraded in comparison with those of native starch. There was a reduction in swelling power on HMT starches, but the solubility of HMT starches was higher than that of native starch. Both of native and HMT starches showed A-type X-ray diffraction pattern. Furthermore, there is a higher intensity at the peak of 15.0 and 22.9 Å than those of native starch.
Abstract: We aimed to investigate how can target and optimize
pulmonary delivery distribution by changing physicochemical
characteristics of instilled liquid.Therefore, we created a new liquids
group:
a. eligible for desired distribution within lung because of
assorted physicochemical characteristics
b. capable of being augmented with a broad range of
chemicals inertly
c. no interference on respiratory function
d. compatible with airway surface liquid
We developed forty types of new liquid,were composed of
Carboxymethylcellulose sodium,Glycerin and different types of
Polysorbates.Viscosity was measured using a Programmable
Rheometer and surface tension by KRUSS Tensiometer.We
subsequently examined the liquids and delivery protocols by simple
and branched glass capillary tube models of airways.Eventually,we
explored pulmonary distribution of liquids being augmented with
technetium-99m in mechanically ventilated rabbits.We used a single
head large field of view gamma camera.Kinematic viscosity between
0.265Stokes and 0.289Stokes,density between 1g/cm3 and 1.5g/cm3
and surface tension between 25dyn/cm and 35dyn/cm were the most
acceptable.
Abstract: Although oil-based drilling fluids are of paramount practical and economical interest, they represent a serious source of pollution, once released into the environment as drill cuttings. The aim of this study is to assess the capability of isolated microorganisms to degrade gasoil fuel. The commonly used physicochemical and biodegradation remediation techniques of petroleum contaminated soil were both investigated. The study revealed that natural biodegradation is favorable. Even though, the presence of heavy metals, the moisture level of (8.55%) and nutrient deficiencies put severe constrains on microorganisms- survival ranges inhibiting the biodegradation process. The selected strains were able to degrade the diesel fuel at significantly high rates (around 98%).
Abstract: This study determines the effect of naked and heparinbased
super-paramagnetic iron oxide nanoparticles on the human
cancer cell lines of A2780. Doxorubicin was used as the anticancer
drug, entrapped in the SPIO-NPs. This study aimed to decorate
nanoparticles with heparin, a molecular ligand for 'active' targeting
of cancerous cells and the application of modified-nanoparticles in
cancer treatment. The nanoparticles containing the anticancer drug
DOX were prepared by a solvent evaporation and emulsification
cross-linking method. The physicochemical properties of the
nanoparticles were characterized by various techniques, and uniform
nanoparticles with an average particle size of 110±15 nm with high
encapsulation efficiencies (EE) were obtained. Additionally, a
sustained release of DOX from the SPIO-NPs was successful.
Cytotoxicity tests showed that the SPIO-DOX-HP had higher cell
toxicity than the individual HP and confocal microscopy analysis
confirmed excellent cellular uptake efficiency. These results indicate
that HP based SPIO-NPs have potential uses as anticancer drug
carriers and also have an enhanced anticancer effect.
Abstract: Characteristics and sonocatalytic activity of zeolite
Y catalysts loaded with TiO2 using impregnation and ion exchange
methods for the degradation of amaranth dye were investigated.
The Ion-exchange method was used to encapsulate the TiO2 into
the internal pores of the zeolite while the incorporation of TiO2
mostly on the external surface of zeolite was carried out using the
impregnation method. Different characterization techniques were
used to elucidate the physicochemical properties of the produced
catalysts. The framework of zeolite Y remained virtually
unchanged after the encapsulation of TiO2 while the crystallinity of
zeolite decreased significantly after the incorporation of 15 wt% of
TiO2. The sonocatalytic activity was enhanced by TiO2
incorporation with maximum degradation efficiencies of 50% and
68% for the encapsulated titanium and titanium loaded onto the
zeolite, respectively after 120min of reaction. Catalysts
characteristics and sonocatalytic behaviors were significantly
affected by the preparation method and the location of TiO2
introduced with zeolite structure. Behaviors in the sonocatalytic
process were successfully correlated with the characteristics of the
catalysts used.
Abstract: The microbiological and physicochemical
characteristics of wetland soils in Eket Local Government Area were
studied between May 2001 and June 2003. Total heterotrophic
bacterial counts (THBC), total fungal counts (TFC), and total
actinomycetes counts (TAC) were determined from soil samples
taken from four locations at two depths in the wet and dry seasons.
Microbial isolates were characterized and identified. Particle size and
chemical parameters were also determined using standard methods.
THBC ranged from 5.2 (+0.17) x106 to 1.7 (+0.18) x107 cfu/g and
from 2.4 (+0.02) x106 to 1.4 (+0.04) x107cfu/g in the wet and dry
seasons, respectively. TFC ranged from 1.8 (+0.03) x106 to 6.6 (+
0.18) x106 cfu/g and from 1.0 (+0.04) x106 to 4.2 (+ 0.01) x106 cfu/g
in the wet and dry seasons, respectively .TAC ranged from 1.2
(+0.53) x106 to 6.0 (+0.05) x106 cfu/g and from 0.6 (+0.01) x106 to
3.2 (+ 0.12) x106 cfu/g in the wet and dry season, respectively.
Acinetobacter, Alcaligenes, Arthrobacter, Bacillus, Beijerinckja,
Enterobacter, Micrococcus, Flavobacterium, Serratia, Enterococcus,
and Pseudomonas species were predominant bacteria while
Aspergillus, Fusarium, Mucor, Penicillium, and Rhizopus were the
dominant fungal genera isolated. Streptomyces and Norcadia were
the actinomycetes genera isolated. The particle size analysis showed
high sand fraction but low silt and clay. The pH and % organic
matter were generally acidic and low, respectively at all locations.
Calcium dominated the exchangeable bases with low electrical
conductivity and micronutrients. These results provide the baseline
data of Eket wetland soils for its management for sustainable
agriculture.