Abstract: To ensure targeting of apoferritin nanocarrier with
encapsulated doxorubicin drug, we used a peptide linker based on a
protein G with N-terminus affinity towards Fc region of antibodies.
To connect the peptide to the surface of apoferritin, the C-terminus of
peptide was made of cysteine with affinity to gold. The surface of
apoferritin with encapsulated doxorubicin (APODOX) was coated
either with gold nanoparticles (APODOX-Nano) or gold(III) chloride
hydrate reduced with sodium borohydride (APODOX-HAu). The
reduction with sodium borohydride caused a loss of doxorubicin
fluorescent properties and probably accompanied with the loss of its
biological activity. Fluorescent properties of APODOX-Nano were
similar to the unmodified APODOX; therefore it was more suited for
the intended use. To evaluate the specificity of apoferritin modified
with antibodies, ELISA-like method was used with the surface of
microtitration plate wells coated by the antigen (goat anti-human IgG
antibodies). To these wells, the nanocarrier was applied. APODOX
without the modification showed 5× lower affinity to the antigen than
APODOX-Nano modified gold and targeting antibodies (human IgG
antibodies).
Abstract: WO3/SiO2 catalysts were modified by an ion exchange
method with sodium hydroxide or potassium hydroxide solution. The
performance of the modified catalysts was tested in the metathesis of
ethylene and trans-2-butene to propylene. During ion exchange,
sodium and potassium ions played different roles. Sodium modified
catalysts revealed constant trans-2-butene conversion and propylene
selectivity when the concentrations of sodium in the solution were
varied. In contrast, potassium modified catalysts showed reduction of
the conversion and increase of the selectivity. From these results,
potassium hydroxide may affect the transformation of tungsten oxide
active species, resulting in the decrease in conversion whereas
sodium hydroxide did not. Moreover, the modification of catalysts by
this method improved the catalyst stability by lowering the amount of
coke deposited on the catalyst surface.
Abstract: The objective of this study is to conduct computational
fluid dynamic (CFD) simulations for evaluating the cooling efficacy
from vegetation implanted in a public park in the Taipei, Taiwan. To
probe the impacts of park renewal by means of adding three pavilions
and supplementary green areas on urban microclimates, the simulated
results have revealed that the park having a higher percentage of green
coverage ratio (GCR) tended to experience a better cooling effect.
These findings can be used to explore the effects of different greening
modifications on urban environments for achieving an effective
thermal comfort in urban public spaces.
Abstract: An important problem for the CaSO4/CaSO4･1/2H2O
Chemical heat pump (CHP) is that the material is deactivated through
repetitive reaction between hydration and dehydration in which the
crystal phase of the material is transformed from III-CaSO4 to
II-CaSO4. We investigated suppression on the phase change by adding
a sulfated compound. The most effective material was MgSO4. MgSO4
doping increased the durability of CaSO4 in the actual CHP repetitive
cycle of hydration/dehydration to 3.6 times that of undoped CaSO4.
The MgSO4-doped CaSO4 showed a higher phase transition
temperature and activation energy for crystal transformation from
III-CaSO4 to II-CaSO4. MgSO4 doping decreased the crystal lattice
size of CaSO4･1/2H2O and II-CaSO4 to smaller than that of undoped
CaSO4. Modification of the crystal structure is considered to be related
to the durability change in CaSO4 resulting from MgSO4 doping.
Abstract: Margin-Based Principle has been proposed for a long
time, it has been proved that this principle could reduce the
structural risk and improve the performance in both theoretical
and practical aspects. Meanwhile, feed-forward neural network is
a traditional classifier, which is very hot at present with a deeper
architecture. However, the training algorithm of feed-forward neural
network is developed and generated from Widrow-Hoff Principle that
means to minimize the squared error. In this paper, we propose
a new training algorithm for feed-forward neural networks based
on Margin-Based Principle, which could effectively promote the
accuracy and generalization ability of neural network classifiers
with less labelled samples and flexible network. We have conducted
experiments on four UCI open datasets and achieved good results
as expected. In conclusion, our model could handle more sparse
labelled and more high-dimension dataset in a high accuracy while
modification from old ANN method to our method is easy and almost
free of work.
Abstract: This paper is focused on the CFD simulation of the radiaxial pump (i.e. mixed flow pump) with the aim to detect the reasons of Y-Q characteristic instability. The main reasons of pressure pulsations were detected by means of the analysis of velocity and pressure fields within the pump combined with the theoretical approach. Consequently, the modifications of spiral case and pump suction area were made based on the knowledge of flow conditions and the shape of dissipation function. The primary design of pump geometry was created as the base model serving for the comparison of individual modification influences. The basic experimental data are available for this geometry. This approach replaced the more complicated and with respect to convergence of all computational tasks more difficult calculation for the compressible liquid flow. The modification of primary pump consisted in inserting the three fins types. Subsequently, the evaluation of pressure pulsations, specific energy curves and visualization of velocity fields were chosen as the criterion for successful design.
Abstract: The explosion of the World Wide Web and the
electronic trend of university teaching have transformed the learning
style to become more learner-centered, which has popularized the
digital delivery of mediated lectures as an alternative or an adjunct to
traditional lectures. Despite its potential and popularity, virtual
lectures have not been adopted yet in Jordanian universities. This
research aimed to fill this gap by studying the factors that influence
students’ willingness to accept virtual lectures in one Jordanian
University. A quantitative approach was followed, by obtaining 216
survey responses and statistically applying the UTAUT model with
some modifications. Results revealed that performance expectancy,
effort expectancy, social influences, and self-efficacy could
significantly influence students’ attitudes towards virtual lectures.
Additionally, Facilitating conditions and attitudes towards virtual
lectures were found with significant influence on students’ intention
to take virtual lectures. Research implications and future work were
specified afterwards.
Abstract: Surface modification and functionalization has been
an important tool for scientists in order to open new frontiers in
nanoscience and nanotechnology. Desired surface characteristics for
the intended applications can be achieved with surface
functionalization.
In this work, the effect of water soluble ligands on the adsorption
capabilities of silver nanoparticles onto AC which was synthesized
from German beech wood was investigated. Sodium borohydride
(NaBH4) and polyvinyl alcohol (PVA) were used as the ligands.
Silver nanoparticles with different surface coatings have average
sizes range from 10 to 13 nm. They were synthesized in aqueous
media by reducing Ag (I) ion in the presence of ligands. These
particles displayed adsorption tendencies towards AC when they
were mixed together and shaken in distilled water.
Silver nanoparticles (NaBH4-AgNPs) reduced and stabilized by
NaBH4 adsorbed onto AC with a homogenous dispersion of
aggregates with sizes in the range of 100-400 nm. Beside, silver
nanoparticles, which were prepared in the presence of both NaBH4
and PVA (NaBH4/PVA-Ag NPs), demonstrated that NaBH4/PVA-Ag
NPs adsorbed and dispersed homogenously but, they aggregated with
larger sizes on the AC surface (range from 300 to 600 nm). In
addition, desorption resistance of Ag nanoparticles were investigated
in distilled water. According to the results AgNPs were not desorbed
on the AC surface in distilled water.
Abstract: Today, the pollution due to non-degradable material
such as plastics, has led to studies about the development of
environmental-friendly material. Because of biodegradability
obtained from natural sources, polylactid acid (PLA) and ijuk fiber
are interesting to modify into a composite. This material is also
expected to reduce the impact of environmental pollution. Surface
modification of ijuk fiber through alkalinization with 0.25 M NaOH
solution for 30 minutes was aimed to enhance its compatibility to
PLA, in order to improve properties of the composite such as the
mechanical properties. Alkalinization of the ijuk fibers annihilates
some surface components such as lignin, wax and hemicelloluse, so
the pore on the surface clearly appeared, decreasing of the density
and diameter of the ijuk fibers. The change of the ijuk fiber properties
leads to increase the mechanical properties of PLA composites
reinforced the ijuk fibers through strengthening of the mechanical
interlocking with the PLA matrix. An addition to enhance the
distribution of the fibers in the PLA matrix, the stirring during DCM
solvent evaporation from the mixture of the ijuk fibers and the
dissolved-PLA can reduce amount of the trapped-voids and fibers
pull-out phenomena, which can decrease the mechanical properties of
the composite.
Abstract: This work introduces a simple device designed to
perform in-situ direct shear and sinkage tests on granular materials
as sand, clays, or regolith. It consists of a box nested within a larger
box. Both have open bottoms, allowing them to be lowered into the
material. Afterwards, two rotating plates on opposite sides of the
outer box will rotate outwards in order to clear regolith on either
side, providing room for the inner box to move relative to the plates
and perform a shear test without the resistance of the surrounding
soil. From this test, Coulomb parameters, including cohesion and
internal friction angle, as well as, Bekker parameters can be inferred.
This device has been designed for a laboratory setting, but with few
modifications, could be put on the underside of a rover for use in
a remote location. The goal behind this work is to ultimately create
a compact, but accurate measuring tool to put onto a rover or any
kind of exploratory vehicle to test for regolith properties of celestial
bodies.
Abstract: Doxorubicin, also known as Adriamycin, is an
anthracycline class of drug used in cancer chemotherapy. It is used in
the treatment of non-Hodgkin’s lymphoma, multiple myeloma, acute
leukemia, breast cancer, lung cancer, endometrium cancer and ovary
cancers. It functions via intercalating DNA and ultimately killing
cancer cells. The major side effects of doxorubicin are hair loss,
myelosuppression, nausea & vomiting, oesophagitis, diarrhea, heart
damage and liver dysfunction. The minor modifications in the
structure of compound exhibit large variation in the biological
activity, has prompted us to carry out the synthesis of sulfonamide
derivatives. Sulfonamide is an important feature with broad spectrum
of biological activity such as antiviral, antifungal, diuretics, antiinflammatory,
antibacterial and anticancer activities. Structure of the
synthesized compound N-(1-methyl-2-oxo-2-N-methyl anilinoethyl)
benzene sulfonamide confirmed by proton nuclear magnetic
resonance (1H NMR),13C NMR, Mass and FTIR spectroscopic tools
to assure the position of all protons and hence stereochemistry of the
molecule. Further we have reported the binding potential of
synthesized sulfonamide analogues in comparison to doxorubicin
drug using Auto Dock 4.2 software. Computational binding energy
(B.E.) and inhibitory constant (Ki) has been evaluated for the
synthesized compound in comparison of doxorubicin against Poly
(dA-dT).Poly (dA-dT) and Poly (dG-dC).Poly (dG-dC) sequences.
The in vitro cytotoxic study against human breast cancer cell lines
confirms the better anticancer activity of the synthesized compound
over currently in use anticancer drug doxorubicin. The IC50 value of
the synthesized compound is 7.12 μM whereas for doxorubicin is 7.2
μM.
Abstract: The decision-making process is theoretically clearly
defined. Generally, it includes the problem identification and
analysis, data gathering, goals and criteria setting, alternatives
development and optimal alternative choice and its implementation.
In practice however, various modifications of the theoretical
decision-making process can occur. The managers can consider some
of the phases to be too complicated or unfeasible and thus they do not
carry them out and conversely some of the steps can be
overestimated.
The aim of the paper is to reveal and characterize the perception of
the individual phases of decision-making process by the managers.
The research is concerned with managers in the military environment
– commanders. Quantitative survey is focused cross-sectionally in the
individual levels of management of the Ministry of Defence of the
Czech Republic. On the total number of 135 respondents the analysis
focuses on which of the decision-making process phases are
problematic or not carried out in practice and which are again
perceived to be the easiest. Then it is examined the reasons of the
findings.
Abstract: Organic Rankine Cycle (ORC) is the most commonly used method for recovering energy from small sources of heat. The investigation of the ORC in supercritical condition is a new research area as it has a potential to generate high power and thermal efficiency in a waste heat recovery system. This paper presents a steady state ORC model in supercritical condition and its simulations with a real engine’s exhaust data. The key component of ORC, evaporator, is modelled using finite volume method, modelling of all other components of the waste heat recovery system such as pump, expander and condenser are also presented. The aim of this paper is to investigate the effects of mass flow rate and evaporator outlet temperature on the efficiency of the waste heat recovery process. Additionally, the necessity of maintaining an optimum evaporator outlet temperature is also investigated. Simulation results show that modification of mass flow rate is the key to changing the operating temperature at the evaporator outlet.
Abstract: With increasingly more mobile health applications
appearing due to the popularity of smartphones, the possibility arises
that these data can be used to improve the medical diagnostic process,
as well as the overall quality of healthcare, while at the same time
lowering costs. However, as of yet there have been no reports of a
successful combination of patient-generated data from smartphones
with data from clinical routine. In this paper we describe how these
two types of data can be combined in a secure way without
modification to hospital information systems, and how they can
together be used in a medical expert system for automatic nutritional
classification and triage.
Abstract: Stator elements «Vane diffuser + crossover + return
channel» of stages with different specific speed were investigated by
CFD calculations. The regime parameter was introduced to present
efficiency and loss coefficient performance of all elements together.
Flow structure demonstrated advantages and disadvantages of design.
Flow separation in crossovers was eliminated by its shape
modification. Efficiency increased visibly. Calculated CFD
performances are in acceptable correlation with predicted ones by
engineering design method. The information obtained is useful for
design method better calibration.
Abstract: In this paper, two options of anodic alumina barrier
layer thinning have been demonstrated. The approaches varied with
the duration of the voltage step. It was found that too long step of the
barrier layer thinning process leads to chemical etching of the
nanopores on their top. At the bottoms pores are not fully opened
what is disadvantageous for further applications in nanofabrication.
On the other hand, while the duration of the voltage step is controlled
by the current density (value of the current density cannot exceed
75% of the value recorded during previous voltage step) the pores are
fully opened. However, pores at the bottom obtained with this
procedure have smaller diameter, nevertheless this procedure
provides electric contact between the bare aluminum (substrate) and
electrolyte, what is suitable for template assisted electrodeposition,
one of the most cost-efficient synthesis method in nanotechnology.
Abstract: This work presents synthesis of α,ω-dithienyl
terminated poly(ethylene glycol) (PEGTh) capable for further chain
extension by either chemical or electrochemical polymeriztion.
PEGTh was characterized by FTIR and 1H-NMR. Further
copolymerization of PEGTh and pyrrole (Py) was performed by
chemical oxidative polymerization using ceric (IV) salt as an oxidant
(PPy-PEGTh). PEG without end group modification was used
directly to prepare copolymers with Py by Ce (IV) salt (PPy-PEG).
Block copolymers with mole ratio of pyrrole to PEGTh (PEG) 50:1
and 10:1 were synthesized. The electrical conductivities of
copolymers PPy-PEGTh and PPy-PEG were determined by four
point probe technique. Influence of the synthetic route and content of
the insulating segment on conductivity and yield of the copolymers
were investigated.
Abstract: Water contamination by toxic compound is one of the serious environmental problems today. These toxic compounds mostly originated from industrial effluents, agriculture, natural sources and human waste. These studies focus on modification of multiwalled carbon nanotube (MWCNTs) with nanoparticle of calixarene and explore the possibility of using this modification for the remediation of cadmium in water. The nanocomposites were prepared by dissolving calixarene in chloroform solution as solvent, followed by additional multiwalled carbon nanotube (MWCNTs) then sonication process for 3 hour and fabricated the nanocomposites on substrate by spin coating method. Finally, the nanocomposites were tested on cadmium ion (10 mg/ml). The morphology of nanocomposites was investigated by FESEM showing the formation of calixarene on the outer walls of carbon nanotube and cadmium ion also clearly seen from the micrograph. This formation was supported by using energy dispersive x-ray (EDX). The presence of cadmium ions in the films, leads to some changes in the surface potential and Fourier Transform Infrared spectroscopy (FTIR).The nanocomposites MWCNTs-calixarene have potential for development of sensor for pollutant monitoring and nanoelectronics devices applications.
Abstract: Fracture in hot precision forging of engine valves was
investigated in this paper. The entire valve forging procedure was
described and the possible cause of the fracture was proposed. Finite
Element simulation was conducted for the forging process, with
commercial Finite Element code DEFORMTM. The effects of
material properties, the effect of strain rate and temperature were
considered in the FE simulation. Two fracture criteria were discussed
and compared, based on the accuracy and reliability of the FE
simulation results. The selected criterion predicted the fracture
location and shows the trend of damage increasing with good
accuracy, which matches the experimental observation. Additional
modification of the punch shapes was proposed to further reduce the
tendency of fracture in forging. Finite Element comparison shows a
great potential of such application in the mass production.
Abstract: An existing RC building in Madinah is seismically
evaluated with and without infill wall. Four model systems have been
considered i.e. model I (no infill), model IIA (strut infill-update from
field test), model IIB (strut infill- ASCE/SEI 41) and model IIC (strut
infill-Soft storey- ASCE/SEI 41). Three dimensional pushover
analyses have been carried out using SAP2000 software
incorporating inelastic material behavior for concrete, steel and infill
walls. Infill wall has been modeled as equivalent strut according to
suggested equation matching field test measurements and to the
ASCE/SEI 41 equation. The effect of building modeling on the
performance point as well as capacity and demand spectra due to EQ
design spectrum function in Madinah area has been investigated. The
response modification factor (R) for the 5 story RC building is
evaluated from capacity and demand spectra (ATC-40) for the
studied models. The results are summarized and discussed.