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Carvacrol Attenuates Lung Injury in Rats with Severe Acute Pancreatitis

Year: 2016 Volume: 10 Issue: 5 294 - 301 Pages

• Authors:
• Salim Cerig
• Fatime Geyikoglu
• Pınar Akpulat
• Suat Colak
• Hasan Turkez
• Murat Bakir
• Mirkhalil Hosseinigouzdagani
• Kubra Koc

Abstract: This study was designed to evaluate whether carvacrol (CAR) could provide protection against lung injury by acute pancreatitis development. The rats were randomized into groups to receive (I) no therapy; (II) 50 μg/kg cerulein at 1h intervals by four intraperitoneal injections (i.p.); (III) 50, 100 and 200 mg/kg CAR by one i.p.; and (IV) cerulein+CAR after 2h of cerulein injection. 12h later, serum samples were obtained to assess pancreatic function the lipase and amylase values. The animals were euthanized and lung samples were excised. The specimens were stained with hematoxylin-eosin (H&E), periodic acid–Schif (PAS), Mallory's trichrome and amyloid. Additionally, oxidative DNA damage was determined by measuring as increases in 8-hydroxy-deoxyguanosine (8-OH-dG) adducts. The results showed that the serum activity of lipase and amylase in AP rats were significantly reduced after the therapy (p

• Keywords:
• Antioxidant activity
• carvacrol
• experimental acute pancreatitis
• lung injury
• oxidative DNA damage.

Respirator System For Total Liquid Ventilation

Year: 2007 Volume: 1 Issue: 11 572 - 577 Pages

• Authors:
• Miguel A. Gómez
• Enrique Hilario
• Francisco J. Alvarez
• Elena Gastiasoro
• Antonia Alvarez
• Juan L. Larrabe

Abstract: Total liquid ventilation can support gas exchange in animal models of lung injury. Clinical application awaits further technical improvements and performance verification. Our aim was to develop a liquid ventilator, able to deliver accurate tidal volumes, and a computerized system for measuring lung mechanics. The computer-assisted, piston-driven respirator controlled ventilatory parameters that were displayed and modified on a real-time basis. Pressure and temperature transducers along with a lineal displacement controller provided the necessary signals to calculate lung mechanics. Ten newborn lambs (

• Keywords:
• immature lamb
• perfluorocarbon
• pressure-limited
• total liquid ventilation
• ventilator; volume-controlled

Computer-Assisted Piston-Driven Ventilator for Total Liquid Breathing

Year: 2007 Volume: 1 Issue: 3 177 - 188 Pages

• Authors:
• Miguel A. Gómez
• Enrique Hilario
• Francisco J. Alvarez
• Elena Gastiasoro
• Antonia Alvarez
• Jose A. Casla
• Jorge Arguinchona
• Juan L. Larrabe

Abstract: Total liquid ventilation can support gas exchange in animal models of lung injury. Clinical application awaits further technical improvements and performance verification. Our aim was to develop a liquid ventilator, able to deliver accurate tidal volumes, and a computerized system for measuring lung mechanics. The computer-assisted, piston-driven respirator controlled ventilatory parameters that were displayed and modified on a real-time basis. Pressure and temperature transducers along with a lineal displacement controller provided the necessary signals to calculate lung mechanics. Ten newborn lambs (

• Keywords:
• Immature lamb
• perfluorocarbon
• pressure-limited
• total liquid ventilation
• ventilator
• volume-controlled.