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Carvacrol Attenuates Lung Injury in Rats with Severe Acute Pancreatitis

Year: 2016 Volume: 10 Issue: 5 294 - 301 Pages

• Authors:
• Salim Cerig
• Fatime Geyikoglu
• Pınar Akpulat
• Suat Colak
• Hasan Turkez
• Murat Bakir
• Mirkhalil Hosseinigouzdagani
• Kubra Koc

Abstract: This study was designed to evaluate whether carvacrol (CAR) could provide protection against lung injury by acute pancreatitis development. The rats were randomized into groups to receive (I) no therapy; (II) 50 μg/kg cerulein at 1h intervals by four intraperitoneal injections (i.p.); (III) 50, 100 and 200 mg/kg CAR by one i.p.; and (IV) cerulein+CAR after 2h of cerulein injection. 12h later, serum samples were obtained to assess pancreatic function the lipase and amylase values. The animals were euthanized and lung samples were excised. The specimens were stained with hematoxylin-eosin (H&E), periodic acid–Schif (PAS), Mallory's trichrome and amyloid. Additionally, oxidative DNA damage was determined by measuring as increases in 8-hydroxy-deoxyguanosine (8-OH-dG) adducts. The results showed that the serum activity of lipase and amylase in AP rats were significantly reduced after the therapy (p

• Keywords:
• Antioxidant activity
• carvacrol
• experimental acute pancreatitis
• lung injury
• oxidative DNA damage.

Essential Oil Blend Containing Capsaicin, Carvacrol and Cinnamaldehyde in Broiler Production Performance and Intestinal Morphometrics

Year: 2015 Volume: 9 Issue: 12 1223 - 1226 Pages

• Authors:
• Marianne D. M. Rendon
• Sonia P. Acda
• Veneranda A. Magpantay
• Norma N. Fajardo
• Amado A. Angeles

Abstract: The aim of this study is to evaluate the effect of supplementing broiler starter diet with different levels of an essential oil blend (EOB) containing capsaicin, carvacrol and cinnamaldehyde on the performance of broilers. A total of 300 day-old straight-run Cobb broiler chicks were randomly assigned to three treatments after 7-day group brooding following a completely randomized design (CRD). Birds assigned in treatment 1 were given starter basal diet while those in treatments 2 and 3 were given starter basal diet with 400 mg/kg antibiotic growth promoter (AGP) and 150 mg/kg EOB, respectively, until the 28th day. Basal finisher feed were given for all the treatments until harvest. Following 37 d feeding, body weight gain, feed consumption, feed efficiency, dressing percentage, livability and jejunal villi height were determined. Results showed no significant differences (P>0.05) in growth performance. However, villi height and crypt depth was significantly lower for birds fed EOB.

• Keywords:
• Broiler
• capsaicin
• carvacrol
• cinnamaldehyde
• essential oil.