Abstract: The possible therapeutic effect of cannabidiol, the major non-psychotropic Cannabis constituent, was investigated against acute hepatotoxicity induced by a single oral dose of acetaminophen (500mg/kg) in mice. Cannabidiol (two intraperitoneal injections, 5mg/kg, each) was given 1 hour and 12 hours following acetaminophen administration. Acetaminophen administration caused significant elevations of serum alanine aminotransferase, and hepatic malondialdehyde, and nitric oxide levels, and a significant decrease in hepatic reduced glutathione. Cannabidiol significantly attenuated the deterioration in the measured biochemical parameters resulted from acetaminophen administration. Also, histopathological examination showed that cannabidiol markedly attenuated ameliorated acetaminophen-induced liver tissue damage. These results emphasize that cannabidiol represents a potential therapeutic option to protect against acetaminophen hepartotoxicity which is a common clinical problem.
Abstract: In medical therapy, laser has been widely used to conduct cosmetic, tumor and other treatments. During the process of laser irradiation, there may be thermal damage caused by excessive laser exposure. Thus, the establishment of a complete thermal analysis model is clinically helpful to physicians in reference data. In this study, porcine liver in place of tissue was subjected to laser irradiation to set up the experimental data considering the explored impact on surface thermal field and thermal damage region under different conditions of power, laser irradiation time, and distance between laser and porcine liver. In the experimental process, the surface temperature distribution of the porcine lever was measured by the infrared thermal imager. In the part of simulation, the bio heat transfer Pennes-s equation was solved by software SYSWELD applying in welding process. The double ellipsoid function as a laser source term is firstly considered in the prediction for surface thermal field and internal tissue damage. The simulation results are compared with the experimental data to validate the mathematical model established here in.
Abstract: This study include the effect of strain and storage
period and their interaction on some quantitative and qualitative traits
and percentages of the egg components in the eggs collected at the
start of production (at age 24 weeks). Eggs were divided into three
storage periods (1, 7 and 14) days under refrigerator temperature (5-
7)0C. Fifty seven eggs obtained randomly from each strain including
Isa Brown and Lohman White. General Linear Model within
SAS programme was used to analyze the collected data
and correlations between the studied traits were calculated for each
strain.Average egg weight (EW), Haugh Unit (HU), yolk index (YI),
yolk % (HP), albumin % (AP) and yolk to albumin ratio (YAR) was
56.629 gm, 87.968 %, 0.493, 22.13%, 67.74% and 32.76
respectively. Egg produced from ISA Brown surpassed those
produced by Lohman White significantly (P
Abstract: The results show that the bridge equipped with seismic isolation bearing system shows a high amount of energy dissipation. The purpose of the present study is to analyze the overall performance of continuous curved highway viaducts with different bearing supports, with an emphasis on the effectiveness of seismic isolation based on lead rubber bearing and hedge reaction force bearing system consisted of friction sliding bearing and rubber bearing. The bridge seismic performance has been evaluated on six different cases with six bearing models. The effects of the different arrangement of bearing on the deck superstructure displacements, the seismic damage at the bottom of the piers, movement track at the pier-s top and the total and strain energies absorbed by the structure are evaluated. In conclusion, the results provide sufficient evidence of the effectiveness on the use of seismic isolation on steel curved highway bridges.
Abstract: Oxidative stress is considered to be the cause for onset
and the progression of type 2 diabetes mellitus (T2DM) and
complications including neuropathy. It is a deleterious process that
can be an important mediator of damage to cell structures: protein,
lipids and DNA. Data suggest that in patients with diabetes and
diabetic neuropathy DNA repair is impaired, which prevents effective
removal of lesions. Objective: The aim of our study was to evaluate
the association of the hOGG1 (326 Ser/Cys) and XRCC1 (194
Arg/Trp, 399 Arg/Gln) gene polymorphisms whose protein is
involved in the BER pathway with DNA repair efficiency in patients
with diabetes type 2 and diabetic neuropathy compared to the healthy
subjects. Genotypes were determined by PCR-RFLP analysis in 385
subjects, including 117 with type 2 diabetes, 56 with diabetic
neuropathy and 212 with normal glucose metabolism. The
polymorphisms studied include codon 326 of hOGG1 and 194, 399
of XRCC1 in the base excision repair (BER) genes. Comet assay was
carried out using peripheral blood lymphocytes from the patients and
controls. This test enabled the evaluation of DNA damage in cells
exposed to hydrogen peroxide alone and in the combination with the
endonuclease III (Nth). The results of the analysis of polymorphism
were statistically examination by calculating the odds ratio (OR) and
their 95% confidence intervals (95% CI) using the ¤ç2-tests. Our data
indicate that patients with diabetes mellitus type 2 (including those
with neuropathy) had higher frequencies of the XRCC1 399Arg/Gln
polymorphism in homozygote (GG) (OR: 1.85 [95% CI: 1.07-3.22],
P=0.3) and also increased frequency of 399Gln (G) allele (OR: 1.38
[95% CI: 1.03-1.83], P=0.3). No relation to other polymorphisms
with increased risk of diabetes or diabetic neuropathy. In T2DM
patients complicated by neuropathy, there was less efficient repair of
oxidative DNA damage induced by hydrogen peroxide in both the
presence and absence of the Nth enzyme. The results of our study
suggest that the XRCC1 399 Arg/Gln polymorphism is a significant
risk factor of T2DM in Polish population. Obtained data suggest a
decreased efficiency of DNA repair in cells from patients with
diabetes and neuropathy may be associated with oxidative stress.
Additionally, patients with neuropathy are characterized by even
greater sensitivity to oxidative damage than patients with diabetes,
which suggests participation of free radicals in the pathogenesis of
neuropathy.
Abstract: –In this paper the damage in clamped-free, clampedclamped and free-free beam are analyzed considering samples
without and with structural modifications. The damage location is
investigated by the use of the bispectrum and wavelet analysis. The
mathematical models are obtained using 2D elasticity theory and the
Finite Element Method (FEM). The numerical and experimental data
are approximated using the Particle Swarm Optimizer (PSO) method
and this way is possible to adjust the localization and the severity of
the damage. The experimental data are obtained through
accelerometers placed along the sample. The system is excited using
impact hammer.
Abstract: A method is presented for using thermo-mechanical fatigue analysis as a tool in the design of automotive heat exchangers. Use of infra-red thermography to measure the real thermal history in the heat exchanger reduces the time necessary for calculating design parameters and improves prediction accuracy. Thermal shocks are the primary cause of heat exchanger damage. Thermo-mechanical simulation is based on the mean behavior of the aluminum tubes used in the heat exchanger. An energetic fatigue criterion is used to detect critical zones.
Abstract: To determine the length of engagement threads of a bolt installed in a tapped part in order to avoid the threads stripping remains a very current problem in the design of the thread assemblies. It does not exist a calculation method formalized for the cases where the bolt is screwed directly in a ductile material. In this article, we study the behavior of the threads stripping of a loaded assembly by using a modelling by finite elements and a rupture criterion by damage. This modelling enables us to study the different parameters likely to influence the behavior of this bolted connection. We study in particular, the influence of couple of materials constituting the connection, of the bolt-s diameter and the geometrical characteristics of the tapped part, like the external diameter and the length of engagement threads. We established an experiments design to know the most significant parameters. That enables us to propose a simple expression making possible to calculate the resistance of the threads whatever the metallic materials of the bolt and the tapped part. We carried out stripping tests in order to validate our model. The estimated results are very close to those obtained by the tests.
Abstract: Increasing energy absorption is a significant parameter
in vehicle design. Absorbing more energy results in decreasing
occupant damage. Limitation of the deflection in a side impact results
in decreased energy absorption (SEA) and increased peak load (PL).
Hence a high crash force jeopardizes passenger safety and vehicle
integrity. The aims of this paper are to determine suitable dimensions
and material of a square beam subjected to side impact, in order to
maximize SEA and minimize PL. To achieve this novel goal, the
geometric parameters of a square beam are optimized using the
response surface method (RSM).multi-objective optimization is
performed, and the optimum design for different response features is
obtained.
Abstract: Single-pole switching scheme is widely used in the
Extra High Voltage system. However, the substantial negativesequence
current injected to the turbine-generators imposes the
electromagnetic (E/M) torque of double system- frequency
components during the dead time (between single-pole clearing and
line reclosing). This would induce supersynchronous resonance
(SPSR) torque amplifications on low pressure turbine generator
blades and even lead to fatigue damage. This paper proposes the
design of a mechanical filter (MF) with natural frequency close to
double-system frequency. From the simulation results, it is found that
such a filter not only successfully damps the resonant effect, but also
has the characteristics of feasibility and compact.
Abstract: We investigated oxidative DNA damage caused by
radio frequency radiation using 8-oxo-7, 8-dihydro-2'-
deoxyguanosine (8-oxodG) generated in mice tissues after exposure
to 900 MHz mobile phone radio frequency in three independent
experiments. The RF was generated by a Global System for Mobile
Communication (GSM) signal generator. The radio frequency field
was adjusted to 25 V/m. The whole body specific absorption rate
(SAR) was 1.0 W/kg. Animals were exposed to this field for 30 min
daily for 30 days. 24 h post-exposure, blood serum, brain and spleen
were removed and DNA was isolated. Enzyme-linked
immunosorbent assay (ELISA) was used to measure 8-oxodG
concentration. All animals survived the whole experimental period.
The body weight of animals did not change significantly at the end of
the experiment. No statistically significant differences observed in
the levels of oxidative stress. Our results are not in favor of the
hypothesis that 900 MHz RF induces oxidative damage.
Abstract: Concrete strength evaluated from compression tests
on cores is affected by several factors causing differences from the
in-situ strength at the location from which the core specimen was
extracted. Among the factors, there is the damage possibly occurring
during the drilling phase that generally leads to underestimate the
actual in-situ strength. In order to quantify this effect, in this study
two wide datasets have been examined, including: (i) about 500 core
specimens extracted from Reinforced Concrete existing structures,
and (ii) about 600 cube specimens taken during the construction of
new structures in the framework of routine acceptance control. The
two experimental datasets have been compared in terms of
compression strength and specific weight values, accounting for the
main factors affecting a concrete property, that is type and amount of
cement, aggregates' grading, type and maximum size of aggregates,
water/cement ratio, placing and curing modality, concrete age. The
results show that the magnitude of the strength reduction due to
drilling damage is strongly affected by the actual properties of
concrete, being inversely proportional to its strength. Therefore, the
application of a single value of the correction coefficient, as generally
suggested in the technical literature and in structural codes, appears
inappropriate. A set of values of the drilling damage coefficient is
suggested as a function of the strength obtained from compressive
tests on cores.
Abstract: This work is focused on the numerical prediction of the fracture resistance of a flat stiffened panel made of the aluminium alloy 2024 T3 under a monotonic traction condition. The performed numerical simulations have been based on the micromechanical Gurson-Tvergaard (GT) model for ductile damage. The applicability of the GT model to this kind of structural problems has been studied and assessed by comparing numerical results, obtained by using the WARP 3D finite element code, with experimental data available in literature. In the sequel a home-made procedure is presented, which aims to increase the residual strength of a cracked stiffened aluminum panel and which is based on the stochastic design improvement (SDI) technique; a whole application example is then given to illustrate the said technique.
Abstract: In this paper, quantitative evaluation of ultrasonic Cscan
images through estimation of their Fractal Dimension (FD) is
discussed. Necessary algorithm for evaluation of FD of any 2-D
digitized image is implemented by developing a computer code. For
the evaluation purpose several C-scan images of the Kevlar
composite impacted by high speed bullet and glass fibre composite
having flaw in the form of inclusion is used. This analysis
automatically differentiates a C-scan image showing distinct damage
zone, from an image that contains no such damage.
Abstract: A good green building design project, designers should consider not only energy consumption, but also healthy and comfortable needs of inhabitants. In recent years, the Taiwan government paid attentions on both carbon reduction and indoor air quality issues, which be presented in the legislation of Building Codes and other regulations. Taiwan located in hot and humid climates, dampness in buildings leads to significant microbial pollution and building damage. This means that the high temperature and humidity present a serious indoor air quality issue. The interactions between vapor transfers and energy fluxes are essential for the whole building Heat Air and Moisture (HAM) response. However, a simulation tool with short calculation time, property accuracy and interface is needed for practical building design processes. In this research, we consider the vapor transfer phenomenon of building materials as well as temperature and humidity and energy consumption in a building space. The simulation bases on the EMPD method, which was performed by EnergyPlus, a simulation tool developed by DOE, to simulate the indoor moisture variation in a one-zone residential unit based on the Effective Moisture Penetration Depth Method, which is more suitable for practical building design processes.
Abstract: This paper investigates the effectiveness of the use of
seismic isolation devices on the overall 3D seismic response of
curved highway viaducts with an emphasis on expansion joints.
Furthermore, an evaluation of the effectiveness of the use of cable
restrainers is presented. For this purpose, the bridge seismic
performance has been evaluated on four different radii of curvature,
considering two cases: restrained and unrestrained curved viaducts.
Depending on the radius of curvature, three-dimensional non-linear
dynamic analysis shows the vulnerability of curved viaducts to
pounding and deck unseating damage. In this study, the efficiency of
using LRB supports combined with cable restrainers on curved
viaducts is demonstrated, not only by reducing in all cases the
possible damage, but also by providing a similar behavior in the
viaducts despite of curvature radius.
Abstract: One of the difficulties of the vibration-based damage identification methods is the nonuniqueness of the results of damage identification. The different damage locations and severity may cause the identical response signal, which is even more severe for detection of the multiple damage. This paper proposes a new strategy for damage detection to avoid this nonuniqueness. This strategy firstly determines the approximates damage area based on the statistical pattern recognition method using the dynamic strain signal measured by the distributed fiber Bragg grating, and then accurately evaluates the damage information based on the Bayesian model updating method using the experimental modal data. The stochastic simulation method is then used to compute the high-dimensional integral in the Bayesian problem. Finally, an experiment of the plate structure, simulating one part of mechanical structure, is used to verify the effectiveness of this approach.
Abstract: This paper proposes a novel system for monitoring the
health of underground pipelines. Some of these pipelines transport
dangerous contents and any damage incurred might have catastrophic
consequences. However, most of these damage are unintentional and
usually a result of surrounding construction activities. In order to
prevent these potential damages, monitoring systems are
indispensable. This paper focuses on acoustically recognizing road
cutters since they prelude most construction activities in modern
cities. Acoustic recognition can be easily achieved by installing a
distributed computing sensor network along the pipelines and using
smart sensors to “listen" for potential threat; if there is a real threat,
raise some form of alarm. For efficient pipeline monitoring, a novel
monitoring approach is proposed. Principal Component Analysis
(PCA) was studied and applied. Eigenvalues were regarded as the
special signature that could characterize a sound sample, and were
thus used for the feature vector for sound recognition. The denoising
ability of PCA could make it robust to noise interference. One class
SVM was used for classifier. On-site experiment results show that the
proposed PCA and SVM based acoustic recognition system will be
very effective with a low tendency for raising false alarms.
Abstract: It is believed that DNA damaging toxic metabolites contributes to the development of different pathological conditions. To prevent harmful influence of toxic agents, cells developed number of protecting mechanisms, such as enzymatic reaction of detoxification of reactive metabolites and repair of DNA damage. The aim of the study was to examine the association between polymorphism of GSTT1/GSTM1 and XRCC1/3 genes and coronary artery disease (CAD) incidence. To examine a polymorphism of these genes in CAD susceptibility in patients and controls, PCR based genotyping assay was performed. For GST genes, frequency of GSTM1 null genotype among CAD affected group was significantly increased than in control group (P0.1). We found that neither XRCC1 Arg399Gln nor XRCC3 Thr241Met were associated with CAD risk. Obtained data suggests that GSTM1 null genotype carriers are more susceptible to CAD development.
Abstract: Environmental impact assessment (EIA) is a procedure tool of environmental management for identifying, predicting, evaluating and mitigating the adverse effects of development proposals. EIA reports usually analyze how the amounts or concentrations of pollutants obey the relevant standards. Actually, many analytical tools can deepen the analysis of environmental impacts in EIA reports, such as life cycle assessment (LCA) and environmental risk assessment (ERA). Life cycle impact assessment (LCIA) is one of steps in LCA to introduce the causal relationships among environmental hazards and damage. Incorporating the LCIA concept into ERA as an integrated tool for EIA can extend the focus of the regulatory compliance of environmental impacts to determine of the significance of environmental impacts. Sometimes, when using integrated tools, it is necessary to consider fuzzy situations due to insufficient information; therefore, ERA should be generalized to fuzzy risk assessment (FRA). Finally, the use of the proposed methodology is demonstrated through the study case of the expansion plan of the world-s largest plastics processing factory.