Abstract: MiRNAs participate in gene regulation of translation.
Some studies have investigated the interactions between genes and
intragenic miRNAs. It is important to study the miRNA binding sites
of genes involved in carcinogenesis. RNAHybrid 2.1 and ERNAhybrid
programmes were used to compute the hybridization free
energy of miRNA binding sites. Of these 54 mRNAs, 22.6%, 37.7%,
and 39.7% of miRNA binding sites were present in the 5'UTRs,
CDSs, and 3'UTRs, respectively. The density of the binding sites for
miRNAs in the 5'UTR ranged from 1.6 to 43.2 times and from 1.8 to
8.0 times greater than in the CDS and 3'UTR, respectively. Three
types of miRNA interactions with mRNAs have been revealed: 5'-
dominant canonical, 3'-compensatory, and complementary binding
sites. MiRNAs regulate gene expression, and information on the
interactions between miRNAs and mRNAs could be useful in
molecular medicine. We recommend that newly described sites
undergo validation by experimental investigation.
Abstract: Back-to-back static synchronous compensator (BtBSTATCOM) consists of two back-to-back voltage-source converters (VSC) with a common DC link in a substation. This configuration extends the capabilities of conventional STATCOM that bidirectional active power transfer from one bus to another is possible. In this paper, VSCs are designed in quasi multi-pulse form in which GTOs are triggered only once per cycle in PSCAD/EMTDC. The design details of VSCs as well as gate switching circuits and controllers are fully represented. Regulation modes of BtBSTATCOM are verified and tested on a multi-machine power system through different simulation cases. The results presented in the form of typical time responses show that practical PI controllers are almost robust and stable in case of start-up, set-point change, and line faults.
Abstract: DSTATCOM is one of the equipments for voltage sag mitigation in power systems. In this paper a new control method for balanced and unbalanced voltage sag mitigation using DSTATCOM is proposed. The control system has two loops in order to regulate compensator current and load voltage. Delayed signal cancellation has been used for sequence separation. The compensator should protect sensitive loads against different types of voltage sag. Performance of the proposed method is investigated under different types of voltage sags for linear and nonlinear loads. Simulation results show appropriate operation of the proposed control system.
Abstract: Recently, genetic algorithms (GA) and particle swarm optimization (PSO) technique have attracted considerable attention among various modern heuristic optimization techniques. Since the two approaches are supposed to find a solution to a given objective function but employ different strategies and computational effort, it is appropriate to compare their performance. This paper presents the application and performance comparison of PSO and GA optimization techniques, for Thyristor Controlled Series Compensator (TCSC)-based controller design. The design objective is to enhance the power system stability. The design problem of the FACTS-based controller is formulated as an optimization problem and both the PSO and GA optimization techniques are employed to search for optimal controller parameters. The performance of both optimization techniques in terms of computational time and convergence rate is compared. Further, the optimized controllers are tested on a weakly connected power system subjected to different disturbances, and their performance is compared with the conventional power system stabilizer (CPSS). The eigenvalue analysis and non-linear simulation results are presented and compared to show the effectiveness of both the techniques in designing a TCSC-based controller, to enhance power system stability.
Abstract: Optimization and control of reactive power
distribution in the power systems leads to the better operation of the
reactive power resources. Reactive power control reduces
considerably the power losses and effective loads and improves the
power factor of the power systems. Another important reason of the
reactive power control is improving the voltage profile of the power
system. In this paper, voltage and reactive power control using
Neural Network techniques have been applied to the 33 shines-
Tehran Electric Company. In this suggested ANN, the voltages of PQ
shines have been considered as the input of the ANN. Also, the
generators voltages, tap transformers and shunt compensators have
been considered as the output of ANN. Results of this techniques
have been compared with the Linear Programming. Minimization of
the transmission line power losses has been considered as the
objective function of the linear programming technique. The
comparison of the results of the ANN technique with the LP shows
that the ANN technique improves the precision and reduces the
computation time. ANN technique also has a simple structure and
this causes to use the operator experience.
Abstract: This paper describes an expanded system for a servo
system design by using the Loop Shaping Design Procedure (LSDP).
LSDP is one of the H∞ design procedure. By conducting Loop
Shaping with a compensator and robust stabilization to satisfy the
index function, we get the feedback controller that makes the control
system stable. In this paper, we propose an expanded system for a
servo system design and apply to the DC motor. The proposed method
performs well in the DC motor positioning control. It has no
steady-state error in the disturbance response and it has robust
stability.
Abstract: Human genome is not only the evolutionary
summation of all advantageous events, but also houses lesions of
deleterious foot prints. A single gene mutation sometimes may
express multiple consequences in numerous tissues and a linear
relationship of the genotype and the phenotype may often be obscure.
ß Thalassemia minor, a transfusion independent mild anaemia,
coupled with environment among other factors may articulate into
phenotypic pleotropy with Hypocholesterolemia, Vitamin D
deficiency, Tissue hypoxia, Hyper-parathyroidism and Psychological
alterations. Occurrence of Pancreatic insufficiency, resultant
steatorrhoea, Vitamin-D (25-OH) deficiency (13.86 ngm/ml) with
Hypocholesterolemia (85mg/dl) in a 30 years old male ß Thal-minor
patient (Hemoglobin 11mg/dl with Fetal Hemoglobin 2.10%, Hb A2
4.60% and Hb Adult 84.80% and altered Hemogram) with increased
Para thyroid hormone (62 pg/ml) & moderate Serum Ca+2
(9.5mg/ml) indicate towards a cascade of phenotypic pleotropy
where the ß Thalassemia mutation ,be it in the 5’ cap site of the
mRNA , differential splicing etc in heterozygous state is effecting
several metabolic pathways. Compensatory extramedulary
hematopoiesis may not coped up well with the stressful life style of
the young individual and increased erythropoietic stress with high
demand for cholesterol for RBC membrane synthesis may have
resulted in Hypocholesterolemia.Oxidative stress and tissue hypoxia
may have caused the pancreatic insufficiency, leading to Vitamin D
deficiency. This may in turn have caused the secondary
hyperparathyroidism to sustain serum Calcium level. Irritability and
stress intolerance of the patient was a cumulative effect of the vicious
cycle of metabolic compromises. From these findings we propose
that the metabolic deficiencies in the ß Thalassemia mutations may
be considered as the phenotypic display of the pleotropy to explain
the genetic epidemiology.
According to the recommendations from the NIH Workshop on
Gene-Environment Interplay in Common Complex Diseases: Forging
an Integrative Model, study design of observations should be
informed by gene-environment hypotheses and results of a study
(genetic diseases) should be published to inform future hypotheses.
Variety of approaches is needed to capture data on all possible
aspects, each of which is likely to contribute to the etiology of
disease. Speakers also agreed that there is a need for development of
new statistical methods and measurement tools to appraise
information that may be missed out by conventional method where
large sample size is needed to segregate considerable effect.
A meta analytic cohort study in future may bring about significant
insight on to the title comment.
Abstract: This paper presents a new approach for the protection
of Thyristor-Controlled Series Compensator (TCSC) line using
Support Vector Machine (SVM). One SVM is trained for fault
classification and another for section identification. This method use
three phase current measurement that results in better speed and
accuracy than other SVM based methods which used single phase
current measurement. This makes it suitable for real-time protection.
The method was tested on 10,000 data instances with a very wide
variation in system conditions such as compensation level, source
impedance, location of fault, fault inception angle, load angle at
source bus and fault resistance. The proposed method requires only
local current measurement.
Abstract: To achieve the desired specifications of gain and
phase margins for plants with time-delay that stabilized with FO-PID
controller a lead compensator is designed. At first the range of
controlled system stability based on stability boundary criteria is
determined. Using stability boundary locus method in frequency
domain the fractional order controller parameters are tuned and then
with drawing bode diagram in frequency domain accessing to desired
gain and phase margin are shown. Numerical examples are given to
illustrate the shapes of the stabilizing region and to show the design
procedure.
Abstract: This paper deals with a design method of a discrete
modified Internal Model Control (IMC) for a plant with an integrator
and dead time. If there is a load disturbance in the input or output side
of the plant, the proposed control system can eliminate the steady-state
error caused by it. The disturbance compensator in this method is
simple and its order is low regardless of that of a plant. The simulation
studies show that the proposed method has superior performance for a
load disturbance rejection and robustness.
Abstract: The most common type of controller being used in
the industry is PI(D) controller which has been used since 1945 and
is still being widely used due to its efficiency and simplicity. In
most cases, the PI(D) controller was tuned without taking into
consideration of the effect of actuator saturation. In real processes,
the most common actuator which is valve will act as constraint and
restrict the controller output. Since the controller is not designed to
encounter saturation, the process may windup and consequently
resulted in large oscillation or may become unstable. Usually, an
antiwindup compensator is added to the feedback control loop to
reduce the deterioration effect of integral windup. This research
aims to specifically control processes with constraints. The
proposed method was applied to two different types of food
processes, which are blending and spray drying. Simulations were
done using MATLAB and the performances of the proposed
method were compared with other conventional methods. The
proposed technique was able to control the processes and avoid
saturation such that no anti windup compensator is needed.
Abstract: In this paper, a novel method using Bees Algorithm is proposed to determine the optimal allocation of FACTS devices for maximizing the Available Transfer Capability (ATC) of power transactions between source and sink areas in the deregulated power system. The algorithm simultaneously searches the FACTS location, FACTS parameters and FACTS types. Two types of FACTS are simulated in this study namely Thyristor Controlled Series Compensator (TCSC) and Static Var Compensator (SVC). A Repeated Power Flow with FACTS devices including ATC is used to evaluate the feasible ATC value within real and reactive power generation limits, line thermal limits, voltage limits and FACTS operation limits. An IEEE30 bus system is used to demonstrate the effectiveness of the algorithm as an optimization tool to enhance ATC. A Genetic Algorithm technique is used for validation purposes. The results clearly indicate that the introduction of FACTS devices in a right combination of location and parameters could enhance ATC and Bees Algorithm can be efficiently used for this kind of nonlinear integer optimization.
Abstract: In this paper, based on steady-state models of Flexible
AC Transmission System (FACTS) devices, the sizing of static
synchronous series compensator (SSSC) controllers in transmission
network is formed as an optimization problem. The objective of this
problem is to reduce the transmission losses in the network. The
optimization problem is solved using particle swarm optimization
(PSO) technique. The Newton-Raphson load flow algorithm is
modified to consider the insertion of the SSSC devices in the
network. A numerical example, illustrating the effectiveness of the
proposed algorithm, is introduced. In addition, a novel model of a 3-
phase voltage source converter (VSC) that is suitable for series
connected FACTS a controller is introduced. The model is verified
by simulation using Power System Blockset (PSB) and Simulink
software.
Abstract: Electricity market activities and a growing demand for electricity have led to heavily stressed power systems. This requires operation of the networks closer to their stability limits. Power system operation is affected by stability related problems, leading to unpredictable system behavior. Voltage stability refers to the ability of a power system to sustain appropriate voltage levels through large and small disturbances. Steady-state voltage stability is concerned with limits on the existence of steady-state operating points for the network. FACTS devices can be utilized to increase the transmission capacity, the stability margin and dynamic behavior or serve to ensure improved power quality. Their main capabilities are reactive power compensation, voltage control and power flow control. Among the FACTS controllers, Static Var Compensator (SVC) provides fast acting dynamic reactive compensation for voltage support during contingency events. In this paper, voltage stability assessment with appropriate representations of tap-changer transformers and SVC is investigated. Integrating both of these devices is the main topic of this paper. Effect of the presence of tap-changing transformers on static VAR compensator controller parameters and ratings necessary to stabilize load voltages at certain values are highlighted. The interrelation between transformer off nominal tap ratios and the SVC controller gains and droop slopes and the SVC rating are found. P-V curves are constructed to calculate loadability margins.
Abstract: Many real-world optimization problems involve multiple conflicting objectives and the use of evolutionary algorithms to solve the problems has attracted much attention recently. This paper investigates the application of multi-objective optimization technique for the design of a Thyristor Controlled Series Compensator (TCSC)-based controller to enhance the performance of a power system. The design objective is to improve both rotor angle stability and system voltage profile. A Genetic Algorithm (GA) based solution technique is applied to generate a Pareto set of global optimal solutions to the given multi-objective optimisation problem. Further, a fuzzy-based membership value assignment method is employed to choose the best compromise solution from the obtained Pareto solution set. Simulation results are presented to show the effectiveness and robustness of the proposed approach.
Abstract: In this paper, we propose an advanced ILQ control for the buck-converter via two-degrees of freedom servo-system. Our presented strategy is based on Inverse Linear Quadratic (ILQ) servo-system controller without solving Riccati-s equation directly. The optimal controller of the current and voltage control system is designed. The stability and robust control are analyzed. A conscious and persistent effort has been made to improve ILQ control via two-degrees of freedom guarantees the optimal gains on the basis of polynomial pole assignment, which our results of the proposed strategy shows that the advanced ILQ control can be controlled independently the step response and the disturbance response by appending a feed-forward compensator.
Abstract: This paper aims to select the optimal location and
setting parameters of TCSC (Thyristor Controlled Series
Compensator) controller using Particle Swarm Optimization (PSO)
and Genetic Algorithm (GA) to mitigate small signal oscillations in a
multimachine power system. Though Power System Stabilizers
(PSSs) are prime choice in this issue, installation of FACTS device
has been suggested here in order to achieve appreciable damping of
system oscillations. However, performance of any FACTS devices
highly depends upon its parameters and suitable location in the
power network. In this paper PSO as well as GA based techniques are
used separately and compared their performances to investigate this
problem. The results of small signal stability analysis have been
represented employing eigenvalue as well as time domain response in
face of two common power system disturbances e.g., varying load
and transmission line outage. It has been revealed that the PSO based
TCSC controller is more effective than GA based controller even
during critical loading condition.
Abstract: This paper presents modeling and analysis of 12-phase distribution static compensator (DSTATCOM), which is capable of balancing the source currents in spite of unbalanced loading and phase outages. In addition to balance the supply current, the power factor can be set to a desired value. The theory of instantaneous symmetrical components is used to generate the twelve-phase reference currents. These reference currents are then tracked using current controlled voltage source inverter, operated in a hysteresis band control scheme. An ideal compensator in place of physical realization of the compensator is used. The performance of the proposed DTATCOM is validated through MATLAB simulation and detailed simulation results are given.
Abstract: This paper proposes the application of a hierarchical fuzzy system (HFS) based on multi-input power system stabilizer (MPSS) and also Static Var Compensator (SVC) in multi-machine environment.The number of rules grows exponentially with the number of variables in a conventional fuzzy logic system. The proposed HFS method is developed to solve this problem. To reduce the number of rules the HFS consists of a number of low-dimensional fuzzy systems in a hierarchical structure. In fact, by using HFS the total number of involved rules increases only linearly with the number of input variables. In the MPSS, to have better efficiency an auxiliary signal of reactive power deviation (ΔQ) is added with ΔP+ Δω input type Power system stabilizer (PSS). Phasor model of SVC is described and used in this paper. The performances of MPSS, Conventional power system stabilizer (CPSS), hierarchical Fuzzy Multi-input Power System Stabilizer (HFMPSS) and the proposed method in damping inter-area mode of oscillation are examined in response to disturbances. By using digital simulations the comparative study is illustrated. It can be seen that the proposed PSS is performing satisfactorily within the whole range of disturbances.
Abstract: This paper describes design of a digital feedback loop
for a low switching frequency dc-dc switching converters. Low
switching frequencies were selected in this design. A look up table
for the digital PID (proportional integrator differentiator)
compensator was implemented using Altera Stratix II with built-in
ADC (analog-to-digital converter) to achieve this hardware
realization. Design guidelines are given for the PID compensator,
high frequency DPWM (digital pulse width modulator) and moving
average filter.