Abstract: Spatial dimension in development planning is becoming more topical in 21st century as a result of changes in population structure. Sustainable spatial development focuses on identifying and using territorial advantages to foster the harmonized development of the entire country, reducing negative effects of population concentration, increasing availability and mobility. EU and national development planning documents state polycentrism as main tool for balance spatial development, including investment concentration in growth centres. If mutual cooperation of growth centres as well as urban–rural cooperation is not fostered, then territorial differences can deepen and create unbalanced development.
The aim of research: to evaluate the urban–rural interaction, elaborating spatial development scenarios in framework of Latvian regional policy. To perform the research monographic, comparison, abstract–logical method, synthesis and analysis will be used when studying the theoretical aspects of research aiming at collecting the ideas of scientists from different countries, concepts, regulations as well as to create meaningful scientific discussion. Hierarchy analysis process (AHP) will be used to state further scenarios of spatial development in Latvia.
Experts from various institutions recognized urban – rural interaction and co-operation as an essential tool for the development. The most important factors for balanced spatial development in Latvia are availability of public transportation and improvement of service availability. Evaluating the three alternative scenarios, it was concluded that the urban – rural partnership will ensure a balanced development in Latvian regions.
Abstract: Soil contamination with radiocesium has a long-term radiological impact due to its long physical half-life (30.1 years for 137Cs and 2 years for 134Cs) and its high biological availability. 137Cs causes the largest concerns because of its deleterious effect on agriculture and stock farming, and, thus, human life for decades. One of the important aspects of the problem of contaminated soils remediation is understand of protective actions aimed at the reduction of biological migration of radionuclides in soil-plant system. The most effective way to bind radionuclides is the use of selective sorbents. The proposed research mainly aims to achieve control on transfer of 137Cs in a system growing media – plant due to counter ions variation in the polymeric sorbents. As research object Japanese basil - Perilla frutescens was chosen. Productivity of plants depending on the presence (control-without presence of polymer) and type of polymer material, as well as content of 137Cs in plant material has been determined. The character of different polymers influences on the 137Cs migration in growing media – plant system as well as accumulation in the plants has been cleared up.
Abstract: The main perspective of the present study aims at overcoming solubility problems by using the technique of solid dispersion. Repaglinide is a BCS Class II drug, having low aqueous solubility and therefore, low bioavailability. Solid dispersions of repaglinide with different carriers Polyvinyl Pyrrolidone (PVP) and Ethyl Cellulose (EC) in different ratios were prepared by suspending method and Dissolving methods. In vitro release studies revealed that the F7 formulation showed extended drug release. So, the dissolution profile of solid dispersion containing EC and PVP K30 (1: 3) was selected as the best formulation because of its extended drug release among all formulations. In conclusion, solid dispersions of Repaglinide in PVP have shown to be a promising approach to improve the bioavailability of Repaglinide.
Abstract: Floating tablets of Marichyadi Vati were developed with an aim to prolong its gastric residence time and increase the bioavailability of drug. Rapid gastrointestinal transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to diminished efficacy of the administered dose. The tablets were prepared by wet granulation technique, using HPMC E50 LV act as Matrixing agent, Carbopol as floating enhancer, microcrystalline cellulose as binder, Sodium bi carbonate as effervescent agent with other excipients. The simplex lattice design was used for selection of variables for tablets formulation. Formulation was optimized on the basis of floating time and in vitro drug release. The results showed that the floating lag time for optimized formulation was found to be 61 second with about 97.32 % of total drug release within 3 hours. The vitro release profiles of drug from the formulation could be best expressed zero order with highest linearity r2 = 0.9943. It was concluded that the gastroretentive drug delivery system can be developed for Marichyadi Vati containing Piperine to increase the residence time of the drug in the stomach and thereby increasing bioavailability.
Abstract: Application of compost in agriculture is very desirable worldwide. In the Czech Republic, compost is the most often used to improve soil structure and increase the content of soil organic matter, but the effects of compost addition on the fate of mineral nitrogen are only scarcely described. This paper deals with possibility of using combined application of compost, mineral and organic fertilizers to reduce the leaching of mineral nitrogen from arable land. To demonstrate the effect of compost addition on leaching of mineral nitrogen, we performed the pot experiment. As a model crop, Lactuca sativa L. was used and cultivated for 35 days in climate chamber in thoroughly homogenized arable soil. Ten variants of the experiment were prepared; two control variants (pure arable soil and arable soil with added compost), four variants with different doses of mineral and organic fertilizers and four variants of the same doses of mineral and organic fertilizers with the addition of compos. The highest decrease of mineral nitrogen leaching was observed by the simultaneous applications of soluble humic substances and compost to soil samples, about 417% in comparison with the control variant. Application of these organic compounds also supported microbial activity and nitrogen immobilization documented by the highest soil respiration and by the highest value of the index of nitrogen availability. The production of plant biomass after this application was not the highest due to microbial competition for the nutrients in soil, but was 24% higher in comparison with the control variant. To support these promising results the experiment should be repeated in field conditions.
Abstract: A computer cluster is a group of tightly coupled
computers that work together closely so that in many respects they
can be viewed as though they are a single computer. The components
of a cluster are commonly, but not always, connected to each other
through fast local area networks. Clusters are usually deployed to
improve performance and/or availability over that provided by a
single computer, while typically being much more cost-effective than
single computers of comparable speed or availability. This paper
proposed the way to implement the Beowulf Cluster in order to
achieve high performance as well as high availability.
Abstract: Optimum communication and performance in
Wireless Sensor Networks, constitute multi-facet challenges due to
the specific networking characteristics as well as the scarce resource
availability. Furthermore, it is becoming increasingly apparent that
isolated layer based approaches often do not meet the demands posed
by WSNs applications due to omission of critical inter-layer
interactions and dependencies. As a counterpart, cross-layer is
receiving high interest aiming to exploit these interactions and
increase network performance. However, in order to clearly identify
existing dependencies, comprehensive performance studies are
required evaluating the effect of different critical network parameters
on system level performance and behavior.This paper-s main
objective is to address the need for multi-parametric performance
evaluations considering critical network parameters using a well
known network simulator, offering useful and practical conclusions
and guidelines. The results reveal strong dependencies among
considered parameters which can be utilized by and drive future
research efforts, towards designing and implementing highly efficient
protocols and architectures.
Abstract: Most of the drugs used for pharmaceutical purposes
are poorly water-soluble drugs. About 40% of all newly discovered
drugs are lipophilic and the numbers of lipophilic drugs seem to
increase more and more. Drug delivery systems such as
nanoparticles, micelles or liposomes are applied to improve their
solubility and thus their bioavailability. Besides various techniques of
solubilization, oil-in-water emulsions are often used to incorporate
lipophilic drugs into the oil phase. To stabilize emulsions surface
active substances (surfactants) are generally used. An alternative
method to avoid the application of surfactants was of great interest.
One possibility is to develop O/W-emulsion without any addition of
surface active agents or the so called “surfactant-free emulsion or
SFE”. The aim of this study was to develop and characterize SFE as a
drug carrier by varying the production conditions. Lidocaine base
was used as a model drug. The injection method was developed.
Effects of ultrasound as well as of temperature on the properties of
the emulsion were studied. Particle sizes and release were
determined. The long-term stability up to 30 days was performed.
The results showed that the surfactant-free O/W emulsions with
pharmaceutical oil as drug carrier can be produced.
Abstract: Wireless LAN technologies have picked up
momentum in the recent years due to their ease of deployment, cost
and availability. The era of wireless LAN has also given rise to
unique applications like VOIP, IPTV and unified messaging.
However, these real-time applications are very sensitive to network
and handoff latencies. To successfully support these applications,
seamless roaming during the movement of mobile station has become
crucial. Nowadays, centralized architecture models support roaming
in WLANs. They have the ability to manage, control and
troubleshoot large scale WLAN deployments. This model is managed
by Control and Provision of Wireless Access Point protocol
(CAPWAP). This paper covers the CAPWAP architectural solution
along with its proposals that have emerged. Based on the literature
survey conducted in this paper, we found that the proposed
algorithms to reduce roaming latency in CAPWAP architecture do
not support seamless roaming. Additionally, they are not sufficient
during the initial period of the network. This paper also suggests
important design consideration for mobility support in future
centralized IEEE 802.11 networks.
Abstract: ''Cocktail party problem'' is well known as one of the human auditory abilities. We can recognize the specific sound that we want to listen by this ability even if a lot of undesirable sounds or noises are mixed. Blind source separation (BSS) based on independent component analysis (ICA) is one of the methods by which we can separate only a special signal from their mixed signals with simple hypothesis. In this paper, we propose an online approach for blind source separation using the sliding DFT and the time domain independent component analysis. The proposed method can reduce calculation complexity in comparison with conventional methods, and can be applied to parallel processing by using digital signal processors (DSPs) and so on. We evaluate this method and show its availability.
Abstract: Authentication plays a vital role in many secure
systems. Most of these systems require user to log in with his or her
secret password or pass phrase before entering it. This is to ensure all
the valuables information is kept confidential guaranteeing also its
integrity and availability. However, to achieve this goal, users are
required to memorize high entropy passwords or pass phrases.
Unfortunately, this sometimes causes difficulty for user to remember
meaningless strings of data. This paper presents a new scheme which
assigns a weight to each personal question given to the user in
revealing the encrypted secrets or password. Concentration of this
scheme is to offer fault tolerance to users by allowing them to forget
the specific password to a subset of questions and still recover the
secret and achieve successful authentication. Comparison on level of
security for weight-based and weightless secret recovery scheme is
also discussed. The paper concludes with the few areas that requires
more investigation in this research.
Abstract: The work presented in this study is related to an
energy system analysis based on passive cooling system for
dwellings. It consists to solar chimney energy performances
determination versus geometrical and environmental considerations
as the size and inlet width conditions of the chimney. Adrar site
located in the southern region of Algeria is chosen for this study
according to ambient temperature and solar irradiance technical data
availability. Obtained results are related to the glazing temperature
distributions, the chimney air flow and internal wall temperatures.
The air room change per hour (ACH) parameter, the outlet air
velocity and mass air flow rate are also determined. It is shown that
the chimney width has a significant effect on energy performances
compared to its entry size. A good agreement is observed between
these results and those obtained by others from the literature.
Abstract: This paper discusses the performance modeling and availability analysis of Yarn Dyeing System of a Textile Industry. The Textile Industry is a complex and repairable engineering system. Yarn Dyeing System of Textile Industry consists of five subsystems arranged in series configuration. For performance modeling and analysis of availability, a performance evaluating model has been developed with the help of mathematical formulation based on Markov-Birth-Death Process. The differential equations have been developed on the basis of Probabilistic Approach using a Transition Diagram. These equations have further been solved using normalizing condition in order to develop the steady state availability, a performance measure of the system concerned. The system performance has been further analyzed with the help of decision matrices. These matrices provide various availability levels for different combinations of failure and repair rates for various subsystems. The findings of this paper are therefore, considered to be useful for the analysis of availability and determination of the best possible maintenance strategies which can be implemented in future to enhance the system performance.
Abstract: The purpose of this article applies the monthly final
energy yield and failure data of 202 PV systems installed in Taiwan to
analyze the PV operational performance and system availability. This
data is collected by Industrial Technology Research Institute through
manual records. Bad data detection and failure data estimation
approaches are proposed to guarantee the quality of the received
information. The performance ratio value and system availability are
then calculated and compared with those of other countries. It is
indicated that the average performance ratio of Taiwan-s PV systems
is 0.74 and the availability is 95.7%. These results are similar with
those of Germany, Switzerland, Italy and Japan.
Abstract: Oxidative stress makes up common incidents in
eukaryotic metabolism. The presence of diverse components
disturbing the equilibrium during oxygen metabolism increases
oxidative damage unspecifically in living cells. Body´s own
ubiquinone (Q10) seems to be a promising drug in defending the
heightened appearance of reactive oxygen species (ROS). Though, its
lipophilic properties require a new strategy in drug formulation to
overcome their low bioavailability. Consequently, the manufacture of
heterogeneous nanodispersions is in focus for medical applications.
The composition of conventional nanodispersions is made up of a
drug-consisting core and a surfactive agent, also named as surfactant.
Long-termed encapsulation of the surfactive components into tissues
might be the consequence of the use during medical therapeutics. The
potential of provoking side-effects is given by their nonbiodegradable
properties. Further improvements during fabrication
process use the incorporation of biodegradable components such as
modified γ-polyglutamic acid which decreases the potential of
prospective side-effects.
Abstract: The market transformation in Kazakhstan during the
last two decades has essentially strengthened a gap between
development of urban and rural areas. Implementation of market
institutes, transition from public financing to paid rendering of social
services, change of forms of financing of social and economic
infrastructure have led to strengthening of an economic inequality of
social groups, including growth of stratification of the city and the
village. Sociological survey of urban and rural households in Almaty
city and villages of Almaty region has been carried out within the
international research project “Livelihoods Strategies of Private
Households in Central Asia: A Rural–Urban Comparison in
Kazakhstan and Kyrgyzstan" (Germany, Kazakhstan, Kyrgyzstan).
The analysis of statistical data and results of sociological research of
urban and rural households allows us to reveal issues of territorial
development, to investigate an availability of medical, educational
and other services in the city and the village, to reveal an evaluation
urban and rural dwellers of living conditions, to compare economic
strategies of households in the city and the village.
Abstract: The present study is aim to prepare and evaluate the selfnanoemulsifying drug delivery (SNEDDS) system of a poorly water soluble drug valsartan in order to achieve a better dissolution rate which would further help in enhancing oral bioavailability. The present research work describes a SNEDDS of valsartan using labrafil M 1944 CS, Tween 80 and Transcutol HP. The pseudoternary phase diagrams with presence and absence of drug were plotted to check for the emulsification range and also to evaluate the effect of valsartan on the emulsification behavior of the phases. The mixtures consisting of oil (labrafil M 1944 CS) with surfactant (tween 80), co-surfactant (Transcutol HP) were found to be optimum formulations. Prepared formulations were evaluated for its particle size distribution, nanoemulsifying properties, robustness to dilution, self emulsication time, turbidity measurement, drug content and invitro dissolution. The optimized formulations are further evaluated for heating cooling cycle, centrifugation studies, freeze thaw cycling, particle size distribution and zeta potential were carried out to confirm the stability of the formed SNEDDS formulations. The prepared formulation revealed t a significant improvement in terms of the drug solubility as compared with marketed tablet and pure drug.
Abstract: Recently, the issue of machine condition monitoring
and fault diagnosis as a part of maintenance system became global
due to the potential advantages to be gained from reduced
maintenance costs, improved productivity and increased machine
availability. The aim of this work is to investigate the effectiveness
of a new fault diagnosis method based on power spectral density
(PSD) of vibration signals in combination with decision trees and
fuzzy inference system (FIS). To this end, a series of studies was
conducted on an external gear hydraulic pump. After a test under
normal condition, a number of different machine defect conditions
were introduced for three working levels of pump speed (1000, 1500,
and 2000 rpm), corresponding to (i) Journal-bearing with inner face
wear (BIFW), (ii) Gear with tooth face wear (GTFW), and (iii)
Journal-bearing with inner face wear plus Gear with tooth face wear
(B&GW). The features of PSD values of vibration signal were
extracted using descriptive statistical parameters. J48 algorithm is
used as a feature selection procedure to select pertinent features from
data set. The output of J48 algorithm was employed to produce the
crisp if-then rule and membership function sets. The structure of FIS
classifier was then defined based on the crisp sets. In order to
evaluate the proposed PSD-J48-FIS model, the data sets obtained
from vibration signals of the pump were used. Results showed that
the total classification accuracy for 1000, 1500, and 2000 rpm
conditions were 96.42%, 100%, and 96.42% respectively. The results
indicate that the combined PSD-J48-FIS model has the potential for
fault diagnosis of hydraulic pumps.
Abstract: Resistance of denial of service attacks is a key security requirement in voting protocols. Acquisti protocol plays an important role in development of internet voting protocols and claims its security without strong physical assumptions. In this study firstly Acquisti protocol is modeled in extended applied pi calculus, and then resistance of denial of service attacks is proved with ProVerif. The result is that it is not resistance of denial of service attacks because two denial of service attacks are found. Finally we give the method against the denial of service attacks.
Abstract: Three reactor types were explored and successfully
used for pigment production by Monascus: shake flasks, and shaken
and stirred miniaturized reactors. Also, the use of dielectric
spectroscopy for the on-line measurement of biomass levels was
explored. Shake flasks gave good pigment yields, but scale up is
difficult, and they cannot be automated. Shaken bioreactors were less
successful with pigment production than stirred reactors.
Experiments with different impeller speeds in different volumes of
liquid in the reactor confirmed that this is most likely due oxygen
availability. The availability of oxygen appeared to affect biomass
levels less than pigment production; red pigment production in
particular needed very high oxygen levels. Dielectric spectroscopy
was effectively used to continuously measure biomass levels during
the submerged fungal fermentation in the shaken and stirred
miniaturized bioreactors, despite the presence of the solid substrate
particles. Also, the capacitance signal gave useful information about
the viability of the cells in the culture.