Abstract: Multipotent mesenchymal stromal cells (MSCs)
possess immunomodulatory properties. The effect of MSCs on the
crucial cellular immunity compartment – T-cells is of a special
interest. It is known that MSC tissue niche and expected milieu of
their interaction with T- cells are characterized by low oxygen
concentration, whereas the in vitro experiments usually are carried
out at a much higher ambient oxygen (20%). We firstly evaluated
immunomodulatory effects of MSCs on T-cells at tissue-related
oxygen (5%) after interaction implied cell-to-cell contacts and
paracrine factors only. It turned out that MSCs under reduced oxygen
can effectively suppress the activation and proliferation of PHAstimulated
T-cells and can provoke decrease in the production of
proinflammatory and increase in anti-inflammatory cytokines. In
hypoxia some effects were amplified (inhibition of proliferation, antiinflammatory
cytokine profile shift). This impact was more evident
after direct cell-to-cell interaction; lack of intercellular contacts could
revoke the potentiating effect of hypoxia.
Abstract: This work studied the ability of adipose tissue-derived
mesenchymal stromal cells (MSCs) to form stroma for expansion of
cord blood hematopoietic cells. We showed that 72-hour interaction
of MSCs with cord blood mononuclear cells (MNCs) in vitro at
atmospheric (20%) and low (5%) O2 conditions increased the
expression of ICAM-1, HCAM (at the beginning of interaction) on
MSCs. Viability of MSCs and MNCs were maintained at high level.
Adhesion of MNCs to MSCs was faster at 20% O2. MSCs promoted
the proliferation of adhered MNCs to form the suspension containing
great number of hematopoietic colony-forming units, and this effect
was more pronounced at 5% O2. Thus, adipose-derived MSCs
supplied sufficient stromal support to cord blood MNCs both at 20%
and 5% О2, providing their adhesion with further expansion of new
generation of different hematopoietic lineages.
Abstract: The acidity (citric acid) is the one of chemical content that can be refer to the internal quality and it’s a maturity index of tomato, The titratable acidity (%TA) can be predicted by a non-destructive method prediction by using the transmittance short wavelength (SW-NIR) spectroscopy in the wavelength range between 665-955 nm. The set of 167 tomato samples divided into groups of 117 tomatoes sample for training set and 50 tomatoes sample for test set were used to establish the calibration model to predict and measure %TA by partial least squares regression (PLSR) technique. The spectra were pretreated with MSC pretreatment and it gave the optimal result for calibration model as (R = 0.92, RMSEC = 0.03%) and this model obtained high accuracy result to use for %TA prediction in test set as (R = 0.81, RMSEP = 0.05%). From the result of prediction in test set shown that the transmittance SW-NIR spectroscopy technique can be used for a non-destructive method for %TA prediction of tomato.
Abstract: The design of an optimised horizontal axis 5-meter-long wind turbine rotor blade in according with IEC 61400-2 standard is a research and development project in order to fulfil the requirements of high efficiency of torque from wind production and to optimise the structural components to the lightest and strongest way possible. For this purpose, a research study is presented here by focusing on the structural characteristics of a composite wind turbine blade via finite element modelling and analysis tools. In this work, first, the required data regarding the general geometrical parts are gathered. Then, the airfoil geometries are created at various sections along the span of the blade by using CATIA software to obtain the two surfaces, namely; the suction and the pressure side of the blade in which there is a hat shaped fibre reinforced plastic spar beam, so-called chassis starting at 0.5m from the root of the blade and extends up to 4 m and filled with a foam core. The root part connecting the blade to the main rotor differential metallic hub having twelve hollow threaded studs is then modelled. The materials are assigned as two different types of glass fabrics, polymeric foam core material and the steel-balsa wood combination for the root connection parts. The glass fabrics are applied using hand wet lay-up lamination with epoxy resin as METYX L600E10C-0, is the unidirectional continuous fibres and METYX XL800E10F having a tri-axial architecture with fibres in the 0,+45,-45 degree orientations in a ratio of 2:1:1. Divinycell H45 is used as the polymeric foam. The finite element modelling of the blade is performed via MSC PATRAN software with various meshes created on each structural part considering shell type for all surface geometries, and lumped mass were added to simulate extra adhesive locations. For the static analysis, the boundary conditions are assigned as fixed at the root through aforementioned bolts, where for dynamic analysis both fixed-free and free-free boundary conditions are made. By also taking the mesh independency into account, MSC NASTRAN is used as a solver for both analyses. The static analysis aims the tip deflection of the blade under its own weight and the dynamic analysis comprises normal mode dynamic analysis performed in order to obtain the natural frequencies and corresponding mode shapes focusing the first five in and out-of-plane bending and the torsional modes of the blade. The analyses results of this study are then used as a benchmark prior to modal testing, where the experiments over the produced wind turbine rotor blade has approved the analytical calculations.
Abstract: The continued rise of e-commerce is the main driver of the rapid growth of global online purchase. Consumers can nearly buy everything they want at one occasion through online shopping. The purchase behavior models which focus on single product category are insufficient to describe online shopping behavior. Therefore, analysis of multi-category purchase gets more and more popular. For example, market basket analysis explores customers’ buying tendency of the association between product categories. The information derived from market basket analysis facilitates to make cross-selling strategies and product recommendation system.
To detect the association between different product categories, we use the market basket analysis with the multidimensional scaling technique to build an associated map which describes how likely multiple product categories are bought at the same time. Besides, we also build an inter-purchase time model for associated products to describe how likely a product will be bought after its associated product is bought. We classify inter-purchase time behaviors of multi-category products into nine types, and use a mixture regression model to integrate those behaviors under our assumptions of purchase sequences. Our sample data is from comScore which provides a panelist-label database that captures detailed browsing and buying behavior of internet users across the United States. Finding the inter-purchase time from books to movie is shorter than the inter-purchase time from movies to books. According to the model analysis and empirical results, this research finally proposes the applications and recommendations in the management.
Abstract: As a node monitoring protocol, which is a part of network management, operates in distributed manner, conformance testing of such protocols is more tedious than testing a peer-to-peer protocol. Various works carried out to give the methodology to do conformance testing of distributed protocol. In this paper, we have presented a formal approach for conformance testing of a Node Monitoring Protocol, which uses both static and mobile agents, for MANETs. First, we use SDL to obtain MSCs, which represent the scenario descriptions by sequence diagrams, which in turn generate test sequences and test cases. Later, Testing and Test Control Notation Version-3 (TTCN-3) is used to execute test cases with respect to generated test sequences to know the conformance of protocol against the given specification. This approach shows, the effective conformance testing of the distributed protocols for the network with varying node density and complex behavior. Experimental results for the protocol scenario represent the effectiveness of the method used.
Abstract: Various cis-regulatory module (CRM) predictors have been proposed in the last decade. Several well-established CRM predictors adopted different categories of prediction strategies, including window clustering, probabilistic modeling and phylogenetic footprinting. Appropriate integration of them has a potential to achieve high quality CRM prediction. This study analyzed four existing CRM predictors (ClusterBuster, MSCAN, CisModule and MultiModule) to seek a predictor combination that delivers a higher accuracy than individual CRM predictors. 465 CRMs across 140 Drosophila melanogaster genes from the RED fly database were used to evaluate the integrated CRM predictor proposed in this study. The results show that four predictor combinations achieved superior performance than the best individual CRM predictor.
Abstract: This study examines the media habits of young people
in Saudi Arabia, in particular their use of the Internet and television
in the domestic sphere, and how use of the Internet impacts upon
other activities. In order to address the research questions, focus
group interviews were conducted with Saudi university students. The
study found that television has become a central part of social life
within the household where television represents a main source for
family time, particularly in Ramadan while the Internet is a solitary
activity where it is used in more private spaces. Furthermore, Saudi
females were also more likely to have their Internet access monitored
and circumscribed by family members, with parents controlling the
location and the amount of time spent using the Internet.
Abstract: A new class of fuzzy closed sets, namely fuzzy weakly closed set in a fuzzy topological space is introduced and it is established that this class of fuzzy closed sets lies between fuzzy closed sets and fuzzy generalized closed sets. Alongwith the study of fundamental results of such closed sets, we define and characterize fuzzy weakly compact space and fuzzy weakly closed space.
Abstract: The purpose of this paper is to guide the effort in
improving the economic added value of Indonesian fisheries product
through post fishing program, which is cold storage program.
Indonesia's fisheries potential has been acknowledged by the world.
FAO (2009) stated that Indonesia is one of the tenth highest
producers of fishery products in the world. Based on BPS (Statistics
Indonesia data), the national fisheries production in 2011 reached
5.714 million tons, which 93.55% came from marine fisheries and
6.45% from open waters. Indonesian territory consist of 2/3 of
Indonesian waters, has given enormous benefits for Indonesia,
especially fishermen. To improve the economic level of fishermen
requires efforts to develop fisheries business unit. On of the efforts is
by improving the quality of products which are marketed in the
regional and international levels. It is certainly need the support of
the existence of various fishery facilities (infrastructure to
superstructure), one of which is cold storage. Given the many
benefits of cold storage as a means of processing of fishery resources,
Indonesia Maritime Security Coordinating Board (IMSCB) as one of
the maritime institutions for maritime security and safety, has a
program to empower the coastal community through encourages the
development of cold storage in the middle and lower fishery business
unit. The development of cold storage facilities which able to run its
maximum role requires synergistic efforts of various parties.
Abstract: This paper presents the design, development and characterization of contractile water jet thruster (CWJT) for mini underwater robot. Instead of electric motor, this CWJT utilizes the Ionic Polymer Metal Composite (IPMC) as the actuator to generate the water jet. The main focus of this paper is to analyze the conceptual design of the proposed CWJT which would determine the thrust force value, jet flow behavior and actuator’s stress. Those thrust force and jet flow studies were carried out using Matlab/Simscape simulation software. The actuator stress had been analyzed using COSMOS simulation software. The results showed that there was no significant change for jet velocity at variable cross sectional nozzle area. However, a significant change was detected for jet velocity at different nozzle cross sectional area ratio which was up to 37%. The generated thrust force has proportional relation to the nozzle cross sectional area.
Abstract: The aim of this study was to compare the
sensitometric properties of commonly used radiographic films
processed with chemical solutions in different workload hospitals.
The effect of different processing conditions on induced densities on
radiologic films was investigated. Two accessible double emulsions
Fuji and Kodak films were exposed with 11-step wedge and
processed with Champion and CPAC processing solutions. The
mentioned films provided in both workloads centers, high and low.
Our findings displays that the speed and contrast of Kodak filmscreen
in both work load (high and low) is higher than Fuji filmscreen
for both processing solutions. However there was significant
differences in films contrast for both workloads when CPAC solution
had been used (p=0.000 and 0.028). The results showed base plus
fog density for Kodak film was lower than Fuji. Generally Champion
processing solution caused more speed and contrast for investigated
films in different conditions and there was significant differences in
95% confidence level between two used processing solutions
(p=0.01). Low base plus fog density for Kodak films provide more
visibility and accuracy and higher contrast results in using lower
exposure factors to obtain better quality in resulting radiographs. In
this study we found an economic advantages since Champion
solution and Kodak film are used while it makes lower patient dose.
Thus, in a radiologic facility any change in film processor/processing
cycle or chemistry should be carefully investigated before
radiological procedures of patients are acquired.
Abstract: A virtualized and virtual approach is presented on
academically preparing students to successfully engage at a strategic
perspective to understand those concerns and measures that are both
structured and not structured in the area of cyber security and
information assurance. The Master of Science in Cyber Security and
Information Assurance (MSCSIA) is a professional degree for those
who endeavor through technical and managerial measures to ensure
the security, confidentiality, integrity, authenticity, control,
availability and utility of the world-s computing and information
systems infrastructure. The National University Cyber Security and
Information Assurance program is offered as a Master-s degree. The
emphasis of the MSCSIA program uniquely includes hands-on
academic instruction using virtual computers. This past year, 2011,
the NU facility has become fully operational using system
architecture to provide a Virtual Education Laboratory (VEL)
accessible to both onsite and online students. The first student cohort
completed their MSCSIA training this past March 2, 2012 after
fulfilling 12 courses, for a total of 54 units of college credits. The
rapid pace scheduling of one course per month is immensely
challenging, perpetually changing, and virtually multifaceted. This
paper analyses these descriptive terms in consideration of those
globalization penetration breaches as present in today-s world of
cyber security. In addition, we present current NU practices to
mitigate risks.
Abstract: Virtual engineering technology has undergone rapid progress in recent years and is being adopted increasingly by manufacturing companies of many engineering disciplines. There is an increasing demand from industry for qualified virtual engineers. The qualified virtual engineers should have the ability of applying engineering principles and mechanical design methods within the commercial software package environment. It is a challenge to the engineering education in universities which traditionally tends to lack the integration of knowledge and skills required for solving real world problems. In this paper, a case study shows some recent development of a MSc Mechanical Engineering course at Department of Engineering and Technology in MMU, and in particular, two units Simulation of Mechanical Systems(SMS) and Computer Aided Fatigue Analysis(CAFA) that emphasize virtual engineering education and promote integration of knowledge acquisition, skill training and industrial application.
Abstract: Recent developments in information and
communication technologies (ICT) have created excellent conditions
for profoundly enhancing the traditional learning and teaching
practices. New modes of teaching in higher education subjects can
profoundly enhance ones ability to proactively constructing his or her
personal learning universe. These developments have contributed to
digital learning environments becoming widely available and
accessible. In addition, there is a trend towards enlargement and
specialization in higher education in Europe. With as a result that
existing Master of Science (MSc) programmes are merged or new
programmes have been established that are offered as joint MSc
programmes to students. In these joint MSc programmes, the need for
(common) digital learning environments capable of surmounting the
barriers of time and location has become evident. This paper
discusses the past and ongoing efforts to establish such common
digital learning environments in two joint MSc programmes in
Europe and discusses the way technology-based learning
environments affect the traditional way of learning.
Abstract: This paper focuses on the Mega-Sub Controlled
Structure Systems (MSCSS) performances and characteristics
regarding the new control principle contained in MSCSS subjected to
strong earthquake excitations. The adopted control scheme consists of
modulated sub-structures where the control action is achieved by
viscous dampers and sub-structure own configuration. The
elastic-plastic time history analysis under severe earthquake excitation
is analyzed base on the Finite Element Analysis Method (FEAM), and
some comparison results are also given in this paper. The result shows
that the MSCSS systems can remarkably reduce vibrations effects
more than the mega-sub structure (MSS). The study illustrates that the
improved MSCSS presents good seismic resistance ability even at 1.2g
and can absorb seismic energy in the structure, thus imply that
structural members cross section can be reduce and achieve to good
economic characteristics. Furthermore, the elasto-plastic analysis
demonstrates that the MSCSS is accurate enough regarding
international building evaluation and design codes. This paper also
shows that the elasto-plastic dynamic analysis method is a reasonable
and reliable analysis method for structures subjected to strong
earthquake excitations and that the computed results are more precise.
Abstract: This paper suggests an algorithm for the evaluation
and selection of suppliers. At the beginning, all the needed materials and services used by the organization were identified and categorized
with regard to their nature by ABC method. Afterwards, in order to reduce risk factors and maximize the organization's profit, purchase strategies were determined. Then, appropriate criteria were identified for primary evaluation of suppliers applying to the organization. The output of this stage was a list of suppliers qualified by the organization to participate in its tenders. Subsequently, considering a material in particular, appropriate criteria on the ordering of the
mentioned material were determined, taking into account the particular materials' specifications as well as the organization's needs. Finally, for the purpose of validation and verification of the
proposed model, it was applied to Mobarakeh Steel Company (MSC), the qualified suppliers of this Company are ranked by the means of a Hierarchical Fuzzy TOPSIS method. The obtained results
show that the proposed algorithm is quite effective, efficient and easy to apply.
Abstract: This paper addresses the development of an intelligent vision system for human-robot interaction. The two novel contributions of this paper are 1) Detection of human faces and 2) Localizing the eye. The method is based on visual attributes of human skin colors and geometrical analysis of face skeleton. This paper introduces a spatial domain filtering method named ?Fuzzily skewed filter' which incorporates Fuzzy rules for deciding the gray level of pixels in the image in their neighborhoods and takes advantages of both the median and averaging filters. The effectiveness of the method has been justified over implementing the eye tracking commands to an entertainment robot, named ''AIBO''.
Abstract: In this work, I present a review on Sparse Distributed
Memory for Small Cues (SDMSCue), a variant of Sparse Distributed
Memory (SDM) that is capable of handling small cues. I then conduct
and show some cognitive experiments on SDMSCue to test its
cognitive soundness compared to SDM. Small cues refer to input
cues that are presented to memory for reading associations; but have
many missing parts or fields from them. The original SDM failed to
handle such a problem. SDMSCue handles and overcomes this
pitfall. The main idea in SDMSCue; is the repeated projection of the
semantic space on smaller subspaces; that are selected based on the
input cue length and pattern. This process allows for Read/Write
operations using an input cue that is missing a large portion.
SDMSCue is augmented with the use of genetic algorithms for
memory allocation and initialization. I claim that SDM functionality
is a subset of SDMSCue functionality.
Abstract: Bone marrow-derived stem cells have been widely
studied as an alternative source of stem cells. Mesenchymal stem
cells (MSCs) were mostly investigated and studies showed MSCs can
promote neurogenesis. Little is known about the non-mesenchymal
mononuclear cell fraction, which contains both hematopoietic and
nonhematopoietic cells, including monocytes and endothelial
progenitor cells. This study focused on unfractionated bone marrow
mononuclear cells (BMMCs), which remained 72 h after MSCs were
adhered to the culture plates. We showed that BMMC-conditioned
medium promoted morphological changes of human SH-SY5Y
neuroblastoma cells from an epithelial-like phenotype towards a
neuron-like phenotype as indicated by an increase in neurite
outgrowth, like those observed in retinoic acid (RA)-treated cells.
The result could be explained by the effects of trophic factors
released from BMMCs, as shown in the RT-PCR results that
BMMCs expressed nerve growth factor (NGF), brain-derived
neurotrophic factor (BDNF), and ciliary neurotrophic factor (CNTF).
Similar results on the cell proliferation rate were also observed
between RA-treated cells and cells cultured in BMMC-conditioned
medium, suggesting that cells creased proliferating and differentiated
into a neuronal phenotype. Using real-time RT-PCR, a significantly
increased expression of tyrosine hydroxylase (TH) mRNA in SHSY5Y
cells indicated that BMMC-conditioned medium induced
catecholaminergic identities in differentiated SH-SY5Y cells.