Abstract: A New features are extracted and compared to
improve the prediction of protein-protein interactions. The basic idea
is to select and use the best set of features from the Tensor matrices
that are produced by the frequency vectors of the protein sequences.
Three set of features are compared, the first set is based on the
indices that are the most common in the interacting proteins, the
second set is based on the indices that tend to be common in the
interacting and non-interacting proteins, and the third set is
constructed by using random indices. Moreover, three encoding
strategies are compared; that are based on the amino asides polarity,
structure, and chemical properties. The experimental results indicate
that the highest accuracy can be obtained by using random indices
with chemical properties encoding strategy and support vector
machine.
Abstract: Understanding proteins functions is a major goal in
the post-genomic era. Proteins usually work in context of other
proteins and rarely function alone. Therefore, it is highly relevant to
study the interaction partners of a protein in order to understand its
function. Machine learning techniques have been widely applied to
predict protein-protein interactions. Kernel functions play an
important role for a successful machine learning technique. Choosing
the appropriate kernel function can lead to a better accuracy in a
binary classifier such as the support vector machines. In this paper,
we describe a Bayesian kernel for the support vector machine to
predict protein-protein interactions. The use of Bayesian kernel can
improve the classifier performance by incorporating the probability
characteristic of the available experimental protein-protein
interactions data that were compiled from different sources. In
addition, the probabilistic output from the Bayesian kernel can assist
biologists to conduct more research on the highly predicted
interactions. The results show that the accuracy of the classifier has
been improved using the Bayesian kernel compared to the standard
SVM kernels. These results imply that protein-protein interaction can
be predicted using Bayesian kernel with better accuracy compared to
the standard SVM kernels.
Abstract: Regulatory relationships of 686 intronic miRNA and 784 intergenic miRNAs with mRNAs of 51 intronic miRNA coding genes were established. Interaction features of studied miRNAs with 5'UTR, CDS and 3'UTR of mRNA of each gene were revealed. Functional regions of mRNA were shown to be significantly heterogenous according to the number of binding sites of miRNA and to the location density of these sites.
Abstract: The aim of this paper is to provide an empirical
evidence about the effects that the management of continuous
training have on employability (or employment stability) in the
Spanish labour market. With this purpose a binary logit model with
interaction effect is been used. The dependent variable includes two
situations of the active workers: continuous and discontinuous
employability. To distinguish between them an Employability Index
Stability (ESI) was calculated taking into account two factors: time
worked and job security. Various aspects of the continuous training
and personal workers data are used as independent variables. The
data obtained from a survey of a sample of 918 employed have
revealed a relationship between the likelihood of continuous
employability and continuous training received. The empirical results
support the positive and significant relationship between various
aspects of the training provided by firms and employability
likelihood of the workers, postulate alike from a theoretical point of
view.
Abstract: Ventricular fibrillation is a very important health
problem as is the cause of most of the sudden deaths in the world.
Waves of electrical activity are sent by the SA node, propagate
through the cardiac tissue and activate the mechanisms of cell
contraction, and therefore are responsible to pump blood to the body
harmonically. A spiral wave is an abnormal auto sustainable wave
that is responsible of certain types of arrhythmias. When these waves
break up, give rise to the fibrillation regime, in which there is a
complete loss in the coordination of the contraction of the heart
muscle. Interaction of spiral waves and obstacles is also of great
importance as it is believed that the attachment of a spiral wave to an
obstacle can provide with a transition of two different arrhythmias.
An obstacle can be partially excitable or non excitable. In this talk,
we present a numerical study of the interaction of meandering spiral
waves with partially and non excitable obstacles and focus on the
problem where the obstacle plays a fundamental role in the switch
between different spiral regimes, which represent different
arrhythmic regimes. Particularly, we study the phenomenon of
destabilization of spiral waves due to the presence of obstacles, a
phenomenon not completely understood (This work will appear as a
Chapter in a Book named Cardiac Arrhytmias by INTECH under the
name "Spiral Waves, Obstacles and Cardiac Arrhythmias", ISBN
979-953-307-050-5.).
Abstract: Technology or lack of it will play an important role in Africa-s effort to achieve inclusive development. Although a key determinant of competitiveness, new technology can exacerbate exclusion of the majority from the mainstream economic activities. To minimise potential technology exclusion while leveraging its critical role in African-s development, requires insight into technology diffusion process. Using system dynamics approach, a technology diffusion model is presented. The frequency of interaction of people exposed to and those not exposed to technology, and the technology adoption rate - the fraction of people who embrace new technologies once they are exposed, are identified as the broad factors critical to technology diffusion to wider society enabling more people to be part of the economic growth process. Based on simulation results, it is recommends that these two broad factors should form part of national policy aimed at achieving inclusive and sustainable development in Africa.
Abstract: This paper presents an analytical solution to get a reliable estimation of the hydrodynamic pressure on gravity dams induced by vertical component earthquake when solving the fluid and dam interaction problem. Presented analytical technique is presented for calculation of earthquake-induced hydrodynamic pressure in the reservoir of gravity dams allowing for water compressibility and wave absorption at the reservoir bottom. This new analytical solution can take into account the effect of bottom material on seismic response of gravity dams. It is concluded that because the vertical component of ground motion causes significant hydrodynamic forces in the horizontal direction on a vertical upstream face, responses to the vertical component of ground motion are of special importance in analysis of concrete gravity dams subjected to earthquakes.
Abstract: This study focuses on examining why the range of
experience with respect to HIV infection is so diverse, especially in
regard to the latency period. An agent-based approach in modelling
the infection is used to extract high-level behaviour which cannot be
obtained analytically from the set of interaction rules at the cellular
level. A prototype model encompasses local variation in baseline
properties, contributing to the individual disease experience, and is
included in a network which mimics the chain of lymph nodes. The
model also accounts for stochastic events such as viral mutations.
The size and complexity of the model require major computational
effort and parallelisation methods are used.
Abstract: Social learning network analysis has drawn attention
for most researcher on e-learning research domain. This is due to the
fact that it has the capability to identify the behavior of student
during their social interaction inside e-learning. Normally, the social
network analysis (SNA) is treating the students' interaction merely as
node and edge with less meaning. This paper focuses on providing an
ontology structure of e-learning Moodle that can enrich the
relationships among students, as well as between the students and the
teacher. This ontology structure brings great benefit to the future
development of e-learning system.
Abstract: Designing modern machine tools is a complex task. A
simulation tool to aid the design work, a virtual machine, has
therefore been developed in earlier work. The virtual machine
considers the interaction between the mechanics of the machine
(including structural flexibility) and the control system. This paper
exemplifies the usefulness of the virtual machine as a tool for product
development. An optimisation study is conducted aiming at
improving the existing design of a machine tool regarding weight and
manufacturing accuracy at maintained manufacturing speed. The
problem can be categorised as constrained multidisciplinary multiobjective
multivariable optimisation. Parameters of the control and
geometric quantities of the machine are used as design variables. This
results in a mix of continuous and discrete variables and an
optimisation approach using a genetic algorithm is therefore
deployed. The accuracy objective is evaluated according to
international standards. The complete systems model shows nondeterministic
behaviour. A strategy to handle this based on statistical
analysis is suggested. The weight of the main moving parts is reduced
by more than 30 per cent and the manufacturing accuracy is
improvement by more than 60 per cent compared to the original
design, with no reduction in manufacturing speed. It is also shown
that interaction effects exist between the mechanics and the control,
i.e. this improvement would most likely not been possible with a
conventional sequential design approach within the same time, cost
and general resource frame. This indicates the potential of the virtual
machine concept for contributing to improved efficiency of both
complex products and the development process for such products.
Companies incorporating such advanced simulation tools in their
product development could thus improve its own competitiveness as
well as contribute to improved resource efficiency of society at large.
Abstract: Previous studies have indicated that one of the most
critical failure reasons of enterprise systems is the lack of knowledge
sharing and utilization across organizations. As a consequence, many
information systems researchers have paid attention to examining the
effect of absorptive capacity closely associated with knowledge
sharing and transferring on IS usage performance. A lack of
communications and interactions due to a lack of organizational
citizenship behavior might lead to weak absorptive capacity and thus
negatively influence knowledge sharing across organizations. In this
study, a theoretical model which delves into the relationship between
usage performance of enterprise systems and its determinants was
established.
Abstract: In the globalization context and competitiveness, the role of a university is further enhanced. University is no longer confined to traditional roles. Universities need to interact with others in order to be relevant and progressive. Symbiosis relationships between the university and industry are very significant because the relationship between those two can foster economic development of a nation. In a world of fast changing technology and competition, it is necessary for the university to collaborate with industry to combine efforts fostering the diffusion of knowledge, increasing research and development, patenting innovation and commercializing products. It has become increasingly accepted that the necessity of close university-industry interactions as a mean of national economic prosperity. Therefore, this paper is aim to examine the level of linkages in university-industry interactions to which promotes the regional economic growth and development. This paper will explore the formation of linkages between the Higher Education Institution (University Technology MARA) and industries located in the Klang Valley region of Malaysia. It will present the university-industry linkages with emphasis on the type of linkages existed, the benefits of having such linkages to promote regional economic development and finally the constraints that might impede the linkages and potentials to enhance the linkages towards economic growth and development.
Abstract: The interaction among information and communication technology (ICT) industries is a recently ubiquitous phenomenon through fixed-mobile integration. To monitor the impact of interaction, previous research has mainly focused on measuring spillover effect among ICT industries using various methods. Among others, inter-industry analysis is one of the useful methods for examining spillover effect between industries. However, more complex ICT industries become, more important the impact within an industry is. Inter-industry analysis is limited in mirroring intra-relationships within an industry. Thus, this study applies the analytic network process (ANP) to measure the spillover effect, capturing all of the intra and inter-relationships. Using ANP-based intra and inter-industry analysis, the spillover effect is effectively measured, mirroring the complex structure of ICT industries. A main ICT industry and its linkages are also explored to show the current structure of ICT industries. The proposed approach is expected to allow policy makers to understand interactions of ICT industries and their impact.
Abstract: The paper considers the effect of feed plate location
on the interactions in a seven plate binary distillation column. The
mathematical model of the distillation column is deduced based on
the equations of mass and energy balances for each stage, detailed
model for both reboiler and condenser, and heat transfer equations.
The Dynamic Relative Magnitude Criterion, DRMC is used to assess
the interactions in different feed plate locations for a seven plate
(Benzene-Toluene) binary distillation column ( the feed plate is
originally at stage 4). The results show that whenever we go far from
the optimum feed plate position, the level of interaction augments.
Abstract: This paper examined the influence of matching
students- learning preferences with the teaching methodology
adopted, on their academic performance in an accounting course in
two types of learning environment in one university in Lebanon:
classes with PowerPoint (PPT) vs. conventional classes. Learning
preferences were either for PPT or for Conventional methodology. A
statistically significant increase in academic achievement is found in
the conventionally instructed group as compared to the group taught
with PPT. This low effectiveness of PPT might be attributed to the
learning preferences of Lebanese students. In the PPT group, better
academic performance was found among students with
learning/teaching match as compared with students with
learning/teaching mismatch. Since the majority of students display a
preference for the conventional methodology, the result might
suggest that Lebanese students- performance is not optimized by PPT
in the accounting classrooms, not because of PPT itself, but because
it is not matching the Lebanese students- learning preferences in such
a quantitative course.
Abstract: A filter is used to remove undesirable frequency information from a dynamic signal. This paper shows that the Znotch filter filtering technique can be applied to remove the noise nuisance from a machining signal. In machining, the noise components were identified from the sound produced by the operation of machine components itself such as hydraulic system, motor, machine environment and etc. By correlating the noise components with the measured machining signal, the interested components of the measured machining signal which was less interfered by the noise, can be extracted. Thus, the filtered signal is more reliable to be analysed in terms of noise content compared to the unfiltered signal. Significantly, the I-kaz method i.e. comprises of three dimensional graphical representation and I-kaz coefficient, Z∞ could differentiate between the filtered and the unfiltered signal. The bigger space of scattering and the higher value of Z∞ demonstrated that the signal was highly interrupted by noise. This method can be utilised as a proactive tool in evaluating the noise content in a signal. The evaluation of noise content is very important as well as the elimination especially for machining operation fault diagnosis purpose. The Z-notch filtering technique was reliable in extracting noise component from the measured machining signal with high efficiency. Even though the measured signal was exposed to high noise disruption, the signal generated from the interaction between cutting tool and work piece still can be acquired. Therefore, the interruption of noise that could change the original signal feature and consequently can deteriorate the useful sensory information can be eliminated.
Abstract: The paper is concerned with relationships between
SSME and ICTs and focuses on the role of Web 2.0 tools in
the service development process. The research presented aims at
exploring how collaborative technologies can support and improve
service processes, highlighting customer centrality and value coproduction.
The core idea of the paper is the centrality of user
participation and the collaborative technologies as enabling factors;
Wikipedia is analyzed as an example. The result of such analysis is
the identification and description of a pattern characterising specific
services in which users collaborate by means of web tools with value
co-producers during the service process. The pattern of collaborative
co-production concerning several categories of services including
knowledge based services is then discussed.
Abstract: In this paper we study a system composed by carbon
nanotube (CNT) and bundle of carbon nanotube (BuCNT) interacting
with a specific fatty acid as molecular probe. Full system is
represented by open nanotube (or nanotubes) and the linoleic acid
(LA) relaxing due the interaction with CNT and BuCNT. The LA has
in his form an asymmetric shape with COOH termination provoking
a close BuCNT interaction mainly by van der Waals force field. The
simulations were performed by classical molecular dynamics with
standard parameterizations.
Our results show that these BuCNT and CNT are dynamically
stable and it shows a preferential interaction position with LA
resulting in three features: (i) when the LA is interacting with CNT
and BuCNT (including both termination, CH2 or COOH), the LA is
repelled; (ii) when the LA terminated with CH2 is closer to open
extremity of BuCNT, the LA is also repelled by the interaction
between them; and (iii) when the LA terminated with COOH is
closer to open extremity of BuCNT, the LA is encapsulated by the
BuCNT. These simulations are part of a more extensive work on
searching efficient selective molecular devices and could be useful to
reach this goal.
Abstract: Human Computer Interaction (HCI) has been an
emerging field that draws in the experts from various fields to
enhance the application of computer programs and the ease of
computer users. HCI has much to do with learning and cognition and
an emerging approach to learning and problem-solving is problembased
learning (PBL). The processes of PBL involve important
cognitive functions in the various stages. This paper will illustrate
how closely related fields to HCI, PBL and cognitive psychology can
benefit from informing each other through analysing various
cognitive functions. Several cognitive functions from cognitive
function disc (CFD) would be presented and discussed in relation to
human-computer interface. This paper concludes with the
implications of bridging the gaps amongst these disciplines.
Abstract: Unified Theory of Acceptance and Use of Technology
(UTAUT) model has demonstrated the influencing factors for generic
information systems use such as tablet personal computer (TPC) and
mobile communication. However, in the context of digital library
system, there has been very little effort to determine factors affecting
the intention to use digital library based on the UTAUT model. This
paper investigates factors that are expected to influence the intention
of postgraduate students to use digital library based on modified
UTAUT model. The modified model comprises of constructs
represented by several latent variables, namely performance
expectancy (PE), effort expectancy (EE), information quality (IQ)
and service quality (SQ) and moderated by age, gender and
experience in using digital library. Results show that performance
expectancy, effort expectancy and information quality are positively
related to the intention to use digital library, while service quality is
negatively related to the intention to use digital library. Age and
gender have shown no evidence of any significant interactions, while
experience in using digital library significantly interacts with effort
expectancy and intention to use digital library. This has provided the
evidence of a moderating effect of experience in the intention to use
digital library. It is expected that this research will shed new lights
into research of acceptance and intention to use the library in a digital
environment.