Characteristics of Intronic and Intergenic Human miRNAs and Features of their Interaction with mRNA
Regulatory relationships of 686 intronic miRNA and 784 intergenic miRNAs with mRNAs of 51 intronic miRNA coding genes were established. Interaction features of studied miRNAs with 5'UTR, CDS and 3'UTR of mRNA of each gene were revealed. Functional regions of mRNA were shown to be significantly heterogenous according to the number of binding sites of miRNA and to the location density of these sites.
[1] M. Isik, H. C. Korswagen, E. Berezikov, "Expression pattern of intronic
microRNA in Caenorhabditis elegans," Silence, vol. 1, pp. 5-14, 2010.
[2] B. Zhang, X. Pan, G. P. Cobb, T.A. Anderson, "Plant microRNA: A
small regulatory molecule with big impact," Developmental Biology,
vol. 289, pp. 3-16, 2006.
[3] E. Erson, E.M. Petty, "MicroRNAs in development and disease," Clin.
Genet., vol. 70, pp. 296-306, 2008.
[4] T. Eskildsen, H. Taipaleenmäki, J. Stenvang, B. M. Abdallah, N. Ditzel,
A. Y. Nossent et al., "MicroRNA-138 regulates osteogenic
differentiation of human stromal (mesenchymal) stem cells in vivo,"
PNAS, vol. 108, pp. 6139-6144, 2011.
[5] A. V. Sirotkin, M. Laukova, D. Ovcharenko, P. Brenaut, M. Mlyncek,
"Identification of microRNAs controlling human ovarian cell
proliferation and apoptosis," J. Cell Physiol, vol. 223, pp. 49-56, 2010.
[6] A. Detzer, C. Engel, W. Wunsche, G. Sczakiel, "Cell stress is related to
re-localization of Argonaute 2 and to decreased RNA interference in
human cells," Nucleic Acids Research, vol. 39, pp. 2727-2741, 2011.
[7] Y. Zhao, H. Xu, Y. Yao, L. P. Smith, L. Kgosana, J. Green et al.,
"Critical role of the virus-encoded microRNA-155 ortholog in the
induction of Marek-s disease lymphomas," PLoS Pathog., vol. 7 (2),
e1001305, 2011.
[8] R. K. Jangra, M. Yi, S.M. Lemon, "Regulation of hepatitis C virus
translation and infectious virus production by the microRNA miR-122,"
J. Virol., vol. 84, pp. 6615-6625, 2010.
[9] B. Zhang, X. Pan, T. A. Anderson, "MicroRNA: A new player in stem
cells," J. Cell. Physiol., vol. 209, pp. 266-269, 2006.
[10] E. Moussay, K. Wang, J.-H. Cho, K van Moer, S. Pierson, J. Paggetti et
al., "MicroRNA as biomarkers and regulators in B-cell chronic
lymphocytic leukemia," PNAS, vol. 108, pp. 6573-6578, 2011.
[11] A. Grimson, K. K. Fahr, W. K. Johnston, P. Garrett-Engele, L. P. Lim,
D. P. Bartel, "MicroRNA targeting specificity in mammals:
determinants beyond seed pairing," Mol. Cell., vol. 27, pp. 91-105,
2007.
[12] F. Grey, R. Tirabassi, H. Meyers, G. Wu, S. McWeeney, L. Hook et al.,
"A viral microRNA down-regulates multiple cell cycle genes through
mRNA 5'UTRs," PloS Pathog., vol. 6, e1000967, 2010.
[13] I. Lee, S. S. Ajay, J. I. Yook, H. S. Kim, S. H. Hong, N. H. Kim et al.,
"New class of microRNA targets containing simultaneous 5'-UTR and
3'-UTR interaction sites," Genome Research, vol. 19, pp. 1175-1183,
2009.
[14] A. E. Erson, E. M. Petty, "MicroRNAs in development and disease,"
Clin. Genet, vol. 74, pp. 296-306, 2008.
[1] M. Isik, H. C. Korswagen, E. Berezikov, "Expression pattern of intronic
microRNA in Caenorhabditis elegans," Silence, vol. 1, pp. 5-14, 2010.
[2] B. Zhang, X. Pan, G. P. Cobb, T.A. Anderson, "Plant microRNA: A
small regulatory molecule with big impact," Developmental Biology,
vol. 289, pp. 3-16, 2006.
[3] E. Erson, E.M. Petty, "MicroRNAs in development and disease," Clin.
Genet., vol. 70, pp. 296-306, 2008.
[4] T. Eskildsen, H. Taipaleenmäki, J. Stenvang, B. M. Abdallah, N. Ditzel,
A. Y. Nossent et al., "MicroRNA-138 regulates osteogenic
differentiation of human stromal (mesenchymal) stem cells in vivo,"
PNAS, vol. 108, pp. 6139-6144, 2011.
[5] A. V. Sirotkin, M. Laukova, D. Ovcharenko, P. Brenaut, M. Mlyncek,
"Identification of microRNAs controlling human ovarian cell
proliferation and apoptosis," J. Cell Physiol, vol. 223, pp. 49-56, 2010.
[6] A. Detzer, C. Engel, W. Wunsche, G. Sczakiel, "Cell stress is related to
re-localization of Argonaute 2 and to decreased RNA interference in
human cells," Nucleic Acids Research, vol. 39, pp. 2727-2741, 2011.
[7] Y. Zhao, H. Xu, Y. Yao, L. P. Smith, L. Kgosana, J. Green et al.,
"Critical role of the virus-encoded microRNA-155 ortholog in the
induction of Marek-s disease lymphomas," PLoS Pathog., vol. 7 (2),
e1001305, 2011.
[8] R. K. Jangra, M. Yi, S.M. Lemon, "Regulation of hepatitis C virus
translation and infectious virus production by the microRNA miR-122,"
J. Virol., vol. 84, pp. 6615-6625, 2010.
[9] B. Zhang, X. Pan, T. A. Anderson, "MicroRNA: A new player in stem
cells," J. Cell. Physiol., vol. 209, pp. 266-269, 2006.
[10] E. Moussay, K. Wang, J.-H. Cho, K van Moer, S. Pierson, J. Paggetti et
al., "MicroRNA as biomarkers and regulators in B-cell chronic
lymphocytic leukemia," PNAS, vol. 108, pp. 6573-6578, 2011.
[11] A. Grimson, K. K. Fahr, W. K. Johnston, P. Garrett-Engele, L. P. Lim,
D. P. Bartel, "MicroRNA targeting specificity in mammals:
determinants beyond seed pairing," Mol. Cell., vol. 27, pp. 91-105,
2007.
[12] F. Grey, R. Tirabassi, H. Meyers, G. Wu, S. McWeeney, L. Hook et al.,
"A viral microRNA down-regulates multiple cell cycle genes through
mRNA 5'UTRs," PloS Pathog., vol. 6, e1000967, 2010.
[13] I. Lee, S. S. Ajay, J. I. Yook, H. S. Kim, S. H. Hong, N. H. Kim et al.,
"New class of microRNA targets containing simultaneous 5'-UTR and
3'-UTR interaction sites," Genome Research, vol. 19, pp. 1175-1183,
2009.
[14] A. E. Erson, E. M. Petty, "MicroRNAs in development and disease,"
Clin. Genet, vol. 74, pp. 296-306, 2008.
@article{"International Journal of Biological, Life and Agricultural Sciences:52808", author = "Assel S. Issabekova and Olga A. Berillo and Vladimir A. Khailenko and Shara A. Atambayeva and Mireille Regnier and Anatoly T. Ivachshenko", title = "Characteristics of Intronic and Intergenic Human miRNAs and Features of their Interaction with mRNA", abstract = "Regulatory relationships of 686 intronic miRNA and 784 intergenic miRNAs with mRNAs of 51 intronic miRNA coding genes were established. Interaction features of studied miRNAs with 5'UTR, CDS and 3'UTR of mRNA of each gene were revealed. Functional regions of mRNA were shown to be significantly heterogenous according to the number of binding sites of miRNA and to the location density of these sites.
", keywords = "5'UTR, 3'UTR, CDS, miRNA, target mRNA", volume = "5", number = "11", pages = "664-4", }
