Abstract: We have developed an energy based approach for identifying the binding sites and important residues for binding in protein-protein complexes. We found that the residues and residuepairs with charged and aromatic side chains are important for binding. These residues influence to form cation-¤Ç, electrostatic and aromatic interactions. Our observation has been verified with the experimental binding specificity of protein-protein complexes and found good agreement with experiments. The analysis on surrounding hydrophobicity reveals that the binding residues are less hydrophobic than non-binding sites, which suggests that the hydrophobic core are important for folding and stability whereas the surface seeking residues play a critical role in binding. Further, the propensity of residues in the binding sites of receptors and ligands, number of medium and long-range contacts, and influence of neighboring residues will be discussed.
Abstract: In this study, we report the synthesis and
characterization of nanohydroxyapatite (nHAp) in gelatin-starch
matrix via biomimetic method. Characterization of the samples was
performed using X-ray diffraction (XRD) and Fourier Transform
infrared spectroscopy (FT-IR). The Size and morphology of the
nHAp samples were determined using scanning and transmission
electron microscopy (SEM and TEM). The results reveal that the
shape and morphology of nHAp is influenced by presence of
biopolymers as template. Carbonyl and amino groups from gelatin
and hydroxyl from starch play crucial roles in HAp formation on the
surface of gelatin-starch.
Abstract: As the new industrial revolution advances in the
nanotechnology have been followed with interest throughout the
world and also in Turkey. Media has an important role in conveying
these advances to public, rising public awareness and creating
attitudes related to nanotechnology. As well as representing how a
subject is treated, media frames determine how public think about
this subject. In literature definite frames related to nanoscience and
nanotechnology such as process, regulation, conflict and risks were
mentioned in studies focusing different countries. So how
nanotechnology news is treated by which frames and in which news
categories in Turkey as a one of developing countries? In this study
examining different variables about nanotechnology that affect
public attitudes such as category, frame, story tone, source in Turkish
media via framing analysis developed in agenda setting studies was
aimed. In the analysis data between 2005 and 2009 obtained from the
first five national newspapers with wide circulation in Turkey will be
used. In this study the direction of the media about nanotechnology,
in which frames nanotechnologic advances brought to agenda were
reported as news, and sectoral, legal, economic and social scenes
reflected by these frames to public related to nanotechnology in
Turkey were planned.
Abstract: The paper studies implications between knowledge spillovers and technological innovation capability in the following three aspects: firstly, the paper debates on the effect of knowledge spillover on some perspectives of technological innovation ability; secondly, it discusses how different roles of knowledge spillover affect the technological innovation capability; finally, the paper creates the model of the factors of knowledge spillovers influencing to technological innovation capability. It concludes that knowledge spillovers affect all the main aspects of technological innovation ultimately to impact of technological innovation capabilities.
Abstract: The city of Suceava, one of the most important
medieval capital of Moldova, owes its urban genesis to the power
center established in its territory at the turn of the thirteenth and
fourteenth centuries. Freed from the effective control exercised by
the Emir Nogai through Alanians, the local center of power evolved
as the main representative of the interests of indigenous people in
relation to the Hungarian Angevin dinasty and to their
representatives from Maramures. From this perspective, the political
and military role of the settlement of Suceava was archeologically
proved by the discovery of extensive fortifications, unrivaled in the
first half of the XIVth century-s Moldavia. At the end of that century,
voivod Peter I decides to move the capital of the state from Siret to
Suceava. That option stimulated the development of the settlement
on specific urban coordinates.
Abstract: During the last few decades in the academic field, the
debate has increased on the effects of social geography on the
opportunities of socioeconomic integration. On one hand, it has been
discussed how the contents of the urban structure and social
geography affect not only the way people interact, but also their
chances of social and economic integration. On the other hand, it has
also been discussed how the urban structure is also constrained and
transformed by the action of social actors. Without questioning the
powerful influence of structural factors, related to the logic of the
production system, labor markets, education and training, the
research has shown the role played by place of residence in shaping
individual outcomes such as unemployment. In the context of this
debate the importance of territory of residence with respect to the
problem of unemployment has been highlighted.
Although statistics of unemployment have already demonstrated
the unequal incidence of the phenomenon in social groups, the issue
of uneven territorial impact on the phenomenon at intra-urban level
remains relatively unknown.
The purpose of this article is to show and to interpret the spatial
patterns of unemployment in the city of Porto using GIS (Geographic
Information System - GIS) technology. Under this analysis the
overlap of the spatial patterns of unemployment with the spatial
distribution of social housing, allows the discussion of the
relationship that occurs between these patterns and the reasons that
might explain the relative immutability of socioeconomic problems in
some neighborhoods.
Abstract: Purpose: Planning and dosimetry of different VMAT algorithms (SmartArc, Ergo++, Autobeam) is compared with IMRT for Head and Neck Cancer patients. Modelling was performed to rule out the causes of discrepancies between planned and delivered dose. Methods: Five HNC patients previously treated with IMRT were re-planned with SmartArc (SA), Ergo++ and Autobeam. Plans were compared with each other and against IMRT and evaluated using DVHs for PTVs and OARs, delivery time, monitor units (MU) and dosimetric accuracy. Modelling of control point (CP) spacing, Leaf-end Separation and MLC/Aperture shape was performed to rule out causes of discrepancies between planned and delivered doses. Additionally estimated arc delivery times, overall plan generation times and effect of CP spacing and number of arcs on plan generation times were recorded. Results: Single arc SmartArc plans (SA4d) were generally better than IMRT and double arc plans (SA2Arcs) in terms of homogeneity and target coverage. Double arc plans seemed to have a positive role in achieving improved Conformity Index (CI) and better sparing of some Organs at Risk (OARs) compared to Step and Shoot IMRT (ss-IMRT) and SA4d. Overall Ergo++ plans achieved best CI for both PTVs. Dosimetric validation of all VMAT plans without modelling was found to be lower than ss-IMRT. Total MUs required for delivery were on average 19%, 30%, 10.6% and 6.5% lower than ss-IMRT for SA4d, SA2d (Single arc with 20 Gantry Spacing), SA2Arcs and Autobeam plans respectively. Autobeam was most efficient in terms of actual treatment delivery times whereas Ergo++ plans took longest to deliver. Conclusion: Overall SA single arc plans on average achieved best target coverage and homogeneity for both PTVs. SA2Arc plans showed improved CI and some OARs sparing. Very good dosimetric results were achieved with modelling. Ergo++ plans achieved best CI. Autobeam resulted in fastest treatment delivery times.
Abstract: Phase locked loops (PLL) and delay locked loops (DLL) play an important role in establishing coherent references (phase of carrier and symbol timing) in digital communication systems. Fully digital receiver including digital carrier synchronizer and symbol timing synchronizer fulfils the conditions for universal multi-mode communication receiver with option of symbol rate setting over several digit places and long-term stability of requirement parameters. Afterwards it is necessary to realize PLL and DLL in synchronizer in digital form and to approach to these subsystems as a discrete representation of analog template. Analysis of discrete phase locked loop (DPLL) or discrete delay locked loop (DDLL) and technique to determine their characteristics based on analog (continuous-time) template is performed in this posed paper. There are derived transmission response and error function for 1st order discrete locked loop and resulting equations and graphical representations for 2nd order one. It is shown that the spectrum translation due to sampling takes effect at frequency characteristics computing for specific values of loop parameters.
Abstract: The importance of nurturing, accumulating, and efficiently deploying knowledge resources through formal structures and organisational mechanisms is well understood. Recent trends in knowledge management (KM) highlight that the effective creation and transfer of knowledge can also rely upon extra-organisational channels, such as, informal networks. The perception exists that the role of informal networks in knowledge creation and performance has been underestimated in the organisational context. Literature indicates that many managers fail to comprehend and successfully exploit the potential role of informal networks to create value for their organisations. This paper investigates: 1) whether managers share work-specific knowledge with informal contacts within and outside organisational boundaries; and 2) what do they think is the importance of this knowledge collaboration in their learning and work outcomes.
Abstract: Located within the tropical belt region, there are
certain rules which should implemented in creating a passive
sustainable housing design in Malaysia. Traditional Malay house
possess a strong character with certain special spaces to create a
sustainable house which suit to the tropical climate in Malaysia. One
of the special space known as verandah or serambi gantung, create
various advantages in solving various issues. However, this special
space is not extremely being applied currently which produce major
issues in term of social and environmental aspects. Hence, this
phenomena create a negative impact to the occupant while Malaysia
already has a best housing design previously. Therefore, this paper
aims to explore both of the main issues mentioned above and reveal
the advantages of implementing verandah into passive sustainable
housing design in Malaysia. A systematic literature review is the
main methodology in this research to identify the various advantages
about verandah.. The study reveals that verandah is the best solution
in term of social and environmental issues and should be
implemented in current housing design in Malaysia.
Abstract: Fully customized hardware based technology provides high performance and low power consumption by specializing the tasks in hardware but lacks design flexibility since any kind of changes require re-design and re-fabrication. Software based solutions operate with software instructions due to which a great flexibility is achieved from the easy development and maintenance of the software code. But this execution of instructions introduces a high overhead in performance and area consumption. In past few decades the reconfigurable computing domain has been introduced which overcomes the traditional trades-off between flexibility and performance and is able to achieve high performance while maintaining a good flexibility. The dramatic gains in terms of chip performance and design flexibility achieved through the reconfigurable computing systems are greatly dependent on the design of their computational units being integrated with reconfigurable logic resources. The computational unit of any reconfigurable system plays vital role in defining its strength. In this research paper an RFU based computational unit design has been presented using the tightly coupled, multi-threaded reconfigurable cores. The proposed design has been simulated for VLIW based architectures and a high gain in performance has been observed as compared to the conventional computing systems.
Abstract: A comparison between the performance of Latin and
Arabic handwritten digits recognition problems is presented. The
performance of ten different classifiers is tested on two similar
Arabic and Latin handwritten digits databases. The analysis shows
that Arabic handwritten digits recognition problem is easier than that
of Latin digits. This is because the interclass difference in case of
Latin digits is smaller than in Arabic digits and variances in writing
Latin digits are larger. Consequently, weaker yet fast classifiers are
expected to play more prominent role in Arabic handwritten digits
recognition.
Abstract: Support Vector Machine (SVM) is a recent class of statistical classification and regression techniques playing an increasing role in applications to detection problems in various engineering problems, notably in statistical signal processing, pattern recognition, image analysis, and communication systems. In this paper, SVM is applied to an infrared (IR) binary communication system with different types of channel models including Ricean multipath fading and partially developed scattering channel with additive white Gaussian noise (AWGN) at the receiver. The structure and performance of SVM in terms of the bit error rate (BER) metric is derived and simulated for these channel stochastic models and the computational complexity of the implementation, in terms of average computational time per bit, is also presented. The performance of SVM is then compared to classical binary signal maximum likelihood detection using a matched filter driven by On-Off keying (OOK) modulation. We found that the performance of SVM is superior to that of the traditional optimal detection schemes used in statistical communication, especially for very low signal-to-noise ratio (SNR) ranges. For large SNR, the performance of the SVM is similar to that of the classical detectors. The implication of these results is that SVM can prove very beneficial to IR communication systems that notoriously suffer from low SNR at the cost of increased computational complexity.
Abstract: In the context of sensor networks, where every few
dB saving counts, the novel node cooperation schemes are reviewed
where MIMO techniques play a leading role. These methods could be
treated as joint approach for designing physical layer of their
communication scenarios. Then we analyzed the BER performance
of transmission diversity schemes under a general fading channel
model and proposed a power allocation strategy to the transmitting
sensor nodes. This approach is then compared to an equal-power
assignment method and its performance enhancement is verified by
the simulation. Another key point of the contribution lies in the
combination of optimal power allocation and sensor nodes-
cooperation in a transmission diversity regime (MISO). Numerical
results are given through figures to demonstrate the optimality and
efficiency of proposed combined approach.
Abstract: Society has grown to rely on Internet services, and the
number of Internet users increases every day. As more and more
users become connected to the network, the window of opportunity
for malicious users to do their damage becomes very great and
lucrative. The objective of this paper is to incorporate different
techniques into classier system to detect and classify intrusion from
normal network packet. Among several techniques, Steady State
Genetic-based Machine Leaning Algorithm (SSGBML) will be used
to detect intrusions. Where Steady State Genetic Algorithm (SSGA),
Simple Genetic Algorithm (SGA), Modified Genetic Algorithm and
Zeroth Level Classifier system are investigated in this research.
SSGA is used as a discovery mechanism instead of SGA. SGA
replaces all old rules with new produced rule preventing old good
rules from participating in the next rule generation. Zeroth Level
Classifier System is used to play the role of detector by matching
incoming environment message with classifiers to determine whether
the current message is normal or intrusion and receiving feedback
from environment. Finally, in order to attain the best results,
Modified SSGA will enhance our discovery engine by using Fuzzy
Logic to optimize crossover and mutation probability. The
experiments and evaluations of the proposed method were performed
with the KDD 99 intrusion detection dataset.
Abstract: In the present paper, disc loaded interaction structure
for potential application in wideband Gyro-TWT amplifier has been
analyzed, taking all the space and modal harmonics into
consideration, for the eigenwave solutions. The analysis has been
restricted to azimuthally symmetric TE0,n mode. Dispersion
characteristics have been plotted by varying the structure parameters
and have been validated against HFSS simulation results. The
variation of eigenvalue with respect to different structure parameters
has also been presented. It has been observed that disc periodicity
plays very important role for wideband operation of disc-loaded
Gyro-TWT.
Abstract: In this paper, the authors take a look at advantages of
multiphase induction motors comparing them with three phase ones
and present the applications where six-phase induction motors are
used. They elaborate the mathematical model of six-phase induction
motor with two similar stator three phase winding, shifted by 30
degrees in space and three phase winding in rotor, in synchronous
reference frame for soft starting and scalar control. The authors
simulate and discuss results of speed and torque starting transients.
Abstract: While the problem based learning (PBL) approach promotes unsupervised self-directed learning (SDL), many students experience difficulty juggling the role of being an information recipient and information seeker. Logbooks have been used to assess trainee doctors but not in other areas. This study aimed to determine the effectiveness of logbook for assessing SDL during PBL sessions in first year medical students. The log book included a learning checklist and knowledge and skills components. Comparisons with the baseline assessment of student performance in PBL and that at semester end after logbook intervention showed significant improvements in student performance (31.5 ± 8 vs. 17.7 ± 4.4; p
Abstract: An ultrasound-assisted activation method for
electroless silver plating is presented in this study. When the
ultrasound was applied during the activation step, the amount of the Pd
species adsorbed on substrate surfaces was higher than that of sample
pretreated with a conventional activation process without ultrasound
irradiation. With this activation method, it was also shown that the
adsorbed Pd species with a size of about 5 nm were uniformly
distributed on the surfaces, thus a smooth and uniform coating on the
surfaces was obtained by subsequent electroless silver plating. The
samples after each step were characterized by AFM, XPS, FIB, and
SEM.
Abstract: NFκB activation plays a crucial role in anti-apoptotic responses in response to the apoptotic signaling during tumor necrosis factor (TNFa) stimulation in Multiple Myeloma (MM). Although several drugs have been found effective for the treatment of MM by mainly inhibiting NFκB pathway, there are no any quantitative or qualitative results of comparison assessment on inhibition effect between different single drugs or drug combinations. Computational modeling is becoming increasingly indispensable for applied biological research mainly because it can provide strong quantitative predicting power. In this study, a novel computational pathway modeling approach is employed to comparably assess the inhibition effects of specific single drugs and drug combinations on the NFκB pathway in MM, especially the prediction of synergistic drug combinations.