Biomimetic Preparation of Nano Hydroxyapatite in Gelatin-Starch Matrix
In this study, we report the synthesis and
characterization of nanohydroxyapatite (nHAp) in gelatin-starch
matrix via biomimetic method. Characterization of the samples was
performed using X-ray diffraction (XRD) and Fourier Transform
infrared spectroscopy (FT-IR). The Size and morphology of the
nHAp samples were determined using scanning and transmission
electron microscopy (SEM and TEM). The results reveal that the
shape and morphology of nHAp is influenced by presence of
biopolymers as template. Carbonyl and amino groups from gelatin
and hydroxyl from starch play crucial roles in HAp formation on the
surface of gelatin-starch.
[1] J. Sundaram, T.D. Durance, R. Wang, , "Porous scaffold of gelatin-
starch with nanohydroxyapatite composite processed via novel
microwave vacuum drying", Acta Biomaterialia , vol.4, 2008, pp. 932-
942.
[2] Sh. Teng, L. Chen, Y. Guo, J. Shi, , "Formation of nano-hydroxyapatite
in gelatin droplets and the resulting porous composite micro spheres" ,
Journal of Inorganic Biochemistry, vol. 101, 2007, pp. 686-691.
[3] J. Pe˜na, I. Izquierdo-Barba, M.A. Garc'Ûa, M. Vallet-Reg, "Room
temperature synthesis of chitosan/apatite powders and coatings", Journal
of the European Ceramic Society, vol. 26, 2006, pp. 3631-3638.
[4] H. W. Kim, H. E. Kim, V. Salih , "Stimulation of osteoblast responses to
biomimetic nanocomposites of gelatin-hydroxyapatite for tissue
engineering scaffolds", Biomaterials, vol. 26, 2005, pp. 5221-5230.
[5] H.-W. Kim, J.C. Knowles, H.-E. Kim, "Gelatin/hydroxyapatite
nanocomposite scaffolds for bone repair", J. Biomed. Mater. Res. Vol.
72A, 2005, pp. 136-145.
[6] H. Ishikawa, T. Koshino, R. Takeuchi, T. Saito, "Hydroxyapatite and
gelatin composite foams processed via novel freeze-drying and
crosslinking for use as temporary hard tissue scaffolds", Biomaterials ,
vol. 22, 2001, pp. 1689-1694.
[7] J. F.Mano, Rui A.Sousa, Luciano F.Boesel, Nuno M.Neves, Rui L.Reis,
"Bioinert, biodegradable and injectable polymeric matrix composites for
hard tissue replacement: state of the art and recent developments",
Composites Science and Technology, vol. 64, 2004 , pp. 789-817.
[8] D.C. Dragunski, A. Pawlicka," Preparation and Characterization of
Starch Grafted with Toluene Poly(propylene oxide) Diisocyanate",
Materials Research, vol.4, 2001, pp. 77-81
[9] R. Shi, T. Ding, Q. Liu, Y. Han, L. Zhang, , D. Chen, , W. Tian , "In
vitro degradation and swelling behavior of rubbery thermoplastic starch
in simulated body and simulated saliva fluid and effects of the
degradation products on cells", Polymer Degradation and Stability, vol.
91, 2006, pp. 3289-3300.
[10] Kunal Pal, Ajit K. Banthia, Dipak K. Majumdar, "Preparation and
characterization of polyvinyl alcohol-gelatin hydrogel membranes for
biomedical applications", AAPS Pharm.Sci.Tech. vol. 8, 2007 pp. 142-
146.
[11] Y. W, JingDi Chen., K.Wei, S.Hua Zhang, X. Wang, "Surfactantassisted
synthesis of hydroxyapatite particles", Materials Letters, vol. 60
, 2006, pp. 3227-3231.
[12] A. Sinha and A. Guha , "Biomimetic patterning of polymer hydrogels
with hydroxyapatite nanoparticles", Materials Science & Engineering C,
vol. 29, 2008, pp. 1330 - 1333.
[13] Li Wang, Chunzhong Li, "Preparation and physicochemical properties
of a novel hydroxyapatite/chitosan-silk fibroin composite",
Carbohydrate Polymers, vol. 68, 2007, pp. 740-745.
[1] J. Sundaram, T.D. Durance, R. Wang, , "Porous scaffold of gelatin-
starch with nanohydroxyapatite composite processed via novel
microwave vacuum drying", Acta Biomaterialia , vol.4, 2008, pp. 932-
942.
[2] Sh. Teng, L. Chen, Y. Guo, J. Shi, , "Formation of nano-hydroxyapatite
in gelatin droplets and the resulting porous composite micro spheres" ,
Journal of Inorganic Biochemistry, vol. 101, 2007, pp. 686-691.
[3] J. Pe˜na, I. Izquierdo-Barba, M.A. Garc'Ûa, M. Vallet-Reg, "Room
temperature synthesis of chitosan/apatite powders and coatings", Journal
of the European Ceramic Society, vol. 26, 2006, pp. 3631-3638.
[4] H. W. Kim, H. E. Kim, V. Salih , "Stimulation of osteoblast responses to
biomimetic nanocomposites of gelatin-hydroxyapatite for tissue
engineering scaffolds", Biomaterials, vol. 26, 2005, pp. 5221-5230.
[5] H.-W. Kim, J.C. Knowles, H.-E. Kim, "Gelatin/hydroxyapatite
nanocomposite scaffolds for bone repair", J. Biomed. Mater. Res. Vol.
72A, 2005, pp. 136-145.
[6] H. Ishikawa, T. Koshino, R. Takeuchi, T. Saito, "Hydroxyapatite and
gelatin composite foams processed via novel freeze-drying and
crosslinking for use as temporary hard tissue scaffolds", Biomaterials ,
vol. 22, 2001, pp. 1689-1694.
[7] J. F.Mano, Rui A.Sousa, Luciano F.Boesel, Nuno M.Neves, Rui L.Reis,
"Bioinert, biodegradable and injectable polymeric matrix composites for
hard tissue replacement: state of the art and recent developments",
Composites Science and Technology, vol. 64, 2004 , pp. 789-817.
[8] D.C. Dragunski, A. Pawlicka," Preparation and Characterization of
Starch Grafted with Toluene Poly(propylene oxide) Diisocyanate",
Materials Research, vol.4, 2001, pp. 77-81
[9] R. Shi, T. Ding, Q. Liu, Y. Han, L. Zhang, , D. Chen, , W. Tian , "In
vitro degradation and swelling behavior of rubbery thermoplastic starch
in simulated body and simulated saliva fluid and effects of the
degradation products on cells", Polymer Degradation and Stability, vol.
91, 2006, pp. 3289-3300.
[10] Kunal Pal, Ajit K. Banthia, Dipak K. Majumdar, "Preparation and
characterization of polyvinyl alcohol-gelatin hydrogel membranes for
biomedical applications", AAPS Pharm.Sci.Tech. vol. 8, 2007 pp. 142-
146.
[11] Y. W, JingDi Chen., K.Wei, S.Hua Zhang, X. Wang, "Surfactantassisted
synthesis of hydroxyapatite particles", Materials Letters, vol. 60
, 2006, pp. 3227-3231.
[12] A. Sinha and A. Guha , "Biomimetic patterning of polymer hydrogels
with hydroxyapatite nanoparticles", Materials Science & Engineering C,
vol. 29, 2008, pp. 1330 - 1333.
[13] Li Wang, Chunzhong Li, "Preparation and physicochemical properties
of a novel hydroxyapatite/chitosan-silk fibroin composite",
Carbohydrate Polymers, vol. 68, 2007, pp. 740-745.
@article{"International Journal of Chemical, Materials and Biomolecular Sciences:54293", author = "M.Meskinfam and M. S. Sadjadi and H.Jazdarreh", title = "Biomimetic Preparation of Nano Hydroxyapatite in Gelatin-Starch Matrix", abstract = "In this study, we report the synthesis and
characterization of nanohydroxyapatite (nHAp) in gelatin-starch
matrix via biomimetic method. Characterization of the samples was
performed using X-ray diffraction (XRD) and Fourier Transform
infrared spectroscopy (FT-IR). The Size and morphology of the
nHAp samples were determined using scanning and transmission
electron microscopy (SEM and TEM). The results reveal that the
shape and morphology of nHAp is influenced by presence of
biopolymers as template. Carbonyl and amino groups from gelatin
and hydroxyl from starch play crucial roles in HAp formation on the
surface of gelatin-starch.", keywords = "Biocomposite, Biomimetic , Nano Hydroxyapatite ,Template.", volume = "5", number = "4", pages = "306-4", }
