Abstract: The traditional Turkish houses becoming unusable are
a result of the deterioration of the balanced interaction between users
and house (human and house) continuing during the history.
Especially depending upon the change in social structure, the houses
becoming neglected do not meet the desires of the users and do not
have the meaning but the shelter are becoming unusable and are
being destroyed.
A conservation policy should be developed and renovations should
be made in order to pass the traditional houses carrying the quality of
a cultural and historical document presenting the social structure, the
lifestyle and the traditions of its own age to the next generations and
to keep them alive.
Abstract: Epidermal Growth Factor (EGF, Mw=6,045) has been
reported to have high efficiency of wound repair and anti-wrinkle
effect. However, the half-life of EGF in the body is too short to exert
the biological activity effectively when applied in free form. Growth
Factors can be stabilized by immobilization with carbohydrates from
thermal and proteolytic degradation. Low molecular weight chitosan
(LMCS) and its derivate prepared by hydrogen peroxide has high
solubility. LM6A6DC was successfully prepared as a reactive
carbohydrate for the stabilization of EGF by the reactions of LMCS
with alkalization, tosylation, azidation and reduction. The structure of
LM6A6DC was confirmed by FT-IR, 1H NMR and elementary
analysis. For enhancing the stability of free EGF, EGF was attached
with LM6A6DC by using water-soluble carbodiimide.
EGF-LM6A6DC conjugates did not show any cytotoxicity on the
Normal Human Dermal Fibroblast (NHDF) 3T3 proliferation at least
under 100 μg/ml. In the result, it was considered that LM6A6DC is
suitable to immobilize of growth factor.
Abstract: The present work analyses different parameters of end
milling to minimize the surface roughness for AISI D2 steel. D2 Steel
is generally used for stamping or forming dies, punches, forming
rolls, knives, slitters, shear blades, tools, scrap choppers, tyre
shredders etc. Surface roughness is one of the main indices that
determines the quality of machined products and is influenced by
various cutting parameters. In machining operations, achieving
desired surface quality by optimization of machining parameters, is a
challenging job. In case of mating components the surface roughness
become more essential and is influenced by the cutting parameters,
because, these quality structures are highly correlated and are
expected to be influenced directly or indirectly by the direct effect of
process parameters or their interactive effects (i.e. on process
environment). In this work, the effects of selected process parameters
on surface roughness and subsequent setting of parameters with the
levels have been accomplished by Taguchi’s parameter design
approach. The experiments have been performed as per the
combination of levels of different process parameters suggested by
L9 orthogonal array. Experimental investigation of the end milling of
AISI D2 steel with carbide tool by varying feed, speed and depth of
cut and the surface roughness has been measured using surface
roughness tester. Analyses of variance have been performed for mean
and signal-to-noise ratio to estimate the contribution of the different
process parameters on the process.
Abstract: This study estimates the seismic demands of tall
buildings with central symmetric setbacks by using nonlinear time
history analysis. Three setback structures, all 60-story high with
setback in three levels, are used for evaluation. The effects of
irregularities occurred by setback are evaluated by determination of
global-drift, story-displacement and story drift. Story-displacement is
modified by roof displacement and first story displacement and story
drift is modified by global drift. All results are calculated at the
center of mass and in x and y direction. Also the absolute values of
these quantities are determined. The results show that increasing of
vertical irregularities increases the global drift of the structure and
enlarges the deformations in the height of the structure. It is also
observed that the effects of geometry irregularity in the seismic
deformations of setback structures are higher than those of mass
irregularity.
Abstract: Planning of infrastructure and processes in logistic
center within the frame of various kinds of logistic hubs and
technological activities in them represent quite complex problem.
The main goal is to design appropriate layout, which enables to
realize expected operation on the desired levels. The simulation
software represents progressive contemporary experimental
technique, which can support complex processes of infrastructure
planning and all of activities on it. It means that simulation
experiments, reflecting various planned infrastructure variants,
investigate and verify their eligibilities in relation with corresponding
expected operation. The inducted approach enables to make qualified
decisions about infrastructure investments or measures, which derive
benefit from simulation-based verifications. The paper represents
simulation software for simulation infrastructural layout and
technological activities in marshalling yard, intermodal terminal,
warehouse and combination between them as the parts of logistic
center.
Abstract: Due to the rapid increase of Internet, web opinion
sources dynamically emerge which is useful for both potential
customers and product manufacturers for prediction and decision
purposes. These are the user generated contents written in natural
languages and are unstructured-free-texts scheme. Therefore, opinion
mining techniques become popular to automatically process customer
reviews for extracting product features and user opinions expressed
over them. Since customer reviews may contain both opinionated and
factual sentences, a supervised machine learning technique applies
for subjectivity classification to improve the mining performance. In
this paper, we dedicate our work is the task of opinion
summarization. Therefore, product feature and opinion extraction is
critical to opinion summarization, because its effectiveness
significantly affects the identification of semantic relationships. The
polarity and numeric score of all the features are determined by
Senti-WordNet Lexicon. The problem of opinion summarization
refers how to relate the opinion words with respect to a certain
feature. Probabilistic based model of supervised learning will
improve the result that is more flexible and effective.
Abstract: Zinc oxide (ZnO) is one of the light emitting materials in ultraviolet (UV) region. In addition, ZnO nanostructures are also attracting increasing research interest as buildingblocks for UV optoelectronic applications. We have succeeded in synthesizing vertically-aligned ZnO nanostructures by laser interference patterning, which is catalyst-free and non-contact technique. In this study, vertically-aligned ZnO nanowall arrays were synthesized using two-beam interference. The maximum height and average thickness of the ZnO nanowalls were about 4.5µm and 200 nm, respectively.UV lasing from a piece of the ZnO nanowall was obtained under the third harmonic of a Q-switched Nd:YAG laser excitation, and the estimated threshold power density for lasing was about 150 kW/cm2. Furthermore, UV lasing from the vertically-aligned ZnO nanowall was also achieved. The results indicate that ZnO nanowalls can be applied to random laser.
Abstract: With drug resistance becoming widespread in
Plasmodium falciparum infections, the development of the alternative
drugs is the desired strategy for prevention and cure of malaria. Three
drug targets were selected to screen promising drug molecules from
the GSK library of 13469 molecules. Using an in silico structure-based
drug designing approach, the differences in binding energies of
the substrate and inhibitor were exploited between target sites of
parasite and human to design a drug molecule against Plasmodium.
The docking studies have shown several promising molecules from
GSK library with more effective binding as compared to the already
known inhibitors for the drug targets. Though stronger interaction has
been shown by several molecules as compared to the reference, few
molecules have shown the potential as drug candidates though in
vitro studies are required to validate the results. In case of
thymidylate synthase-dihydrofolatereductase (TS-DHFR), three
compounds have shown promise for future studies as potential drugs.
Abstract: The elastic period has a primary role in the seismic
assessment of buildings. Reliable calculations and/or estimates of the
fundamental frequency of a building and its site are essential during
analysis and design process. Various code formulas based on
empirical data are generally used to estimate the fundamental
frequency of a structure. For existing structures, in addition to code
formulas and available analytical tools such as modal analyses,
various methods of testing including ambient and forced vibration
testing procedures may be used to determine dynamic characteristics.
In this study, the dynamic properties of the 32 buildings located in
the Madinah of Saudi Arabia were identified using ambient motions
recorded at several, spatially-distributed locations within each
building. Ambient vibration measurements of buildings have been
analyzed and the fundamental longitudinal and transverse periods for
all tested buildings are presented. The fundamental mode of vibration
has been compared in plots with codes formulae (Saudi Building
Code, EC8, and UBC1997). The results indicate that measured
periods of existing buildings are shorter than that given by most
empirical code formulas. Recommendations are given based on the
common design and construction practice in Madinah city.
Abstract: There has been a significant decline in active travel
and a massive increase in the use of car dependent travel in many
countries during the past two decades. Evidential risks for people’s
physical and mental health problems are correlated with this
increased use of motorized travel. These health related problems
range from overweight and obesity to increased air pollution. In
response to these rising concerns health professionals, traffic planers,
local authorities and others have introduced a variety of initiatives to
counterbalance the dominance of cars for daily journeys.
However, the nature of travel behavior change interventions,
which aim to reduce car use, are very complex and challenging
regarding their interactions with human behavior. To change travel
behavior at least two aspects have to be taken into consideration.
First, how to alter attitudes and perceptions toward the sustainable
and healthy modes of travel, in competition with experiences of
private car use. And second, how to make these behavior change
processes irreversible and sustainable. There are no comprehensive
models available to guide policy interventions to increase the level of
success of travel behavior change interventions across both these
dimensions.
A comprehensive theoretical framework is required in the effort to
optimize how to facilitate and guide the processes of data collection
and analysis to achieve the best possible guidelines for policy
makers. Regarding the gaps in the travel behavior change research
literature, this paper attempted to identify and suggest a
multidimensional framework in order to facilitate planning the
implemented travel behavior change interventions. A structured
mixed-method model is suggested to improve the analytic power of
the results according to the complexity of human behavior.
In order to recognize people’s attitudes towards a specific travel
mode, the Theory of Planned Behavior (TPB) was operationalized.
But in order to capture decision making processes the Transtheoretical
model of Behavior Change (TTM) was also used.
Consequently, the combination of these two theories (TTM and TPB)
has resulted in a synthesis with appropriate concepts to identify and
design an implemented travel behavior change interventions.
Abstract: The goal of this study is to identify success factors
that could influence the ISMS self-implementation in government
sector from qualitative perspective. This study is based on a case
study in one of the Malaysian government agency. Semi-structured
interviews involving five key informants were conducted to examine
factors addressed in the conceptual framework. Subsequently,
thematic analysis was executed to describe the influence of each
factor on the success implementation of ISMS. The result of this
study indicates that management commitment, implementer
commitment and implementer competency are part of the success
factors for ISMS self-implementation in Malaysian Government
Sector.
Abstract: The seismic responses of steel buildings with semirigid
post-tensioned connections (PC) are estimated and compared
with those of steel buildings with typical rigid (welded) connections
(RC). The comparison is made in terms of global and local response
parameters. The results indicate that the seismic responses in terms of
interstory shears, roof displacements, axial load and bending
moments are smaller for the buildings with PC connection. The
difference is larger for global than for local parameters, which in turn
varies from one column location to another. The reason for this
improved behavior is that the buildings with PC dissipate more
hysteretic energy than those with RC. In addition, unlike the case of
buildings with WC, for the PC structures the hysteretic energy is
mostly dissipated at the connections, which implies that structural
damage in beams and columns is not significant. According to these
results, steel buildings with PC are a viable option in high seismicity
areas because of their smaller response and self-centering connection
capacity as well as the fact that brittle failure is avoided.
Abstract: China is currently the world's largest producer and distributor of electric bicycle (e-bike). The increasing number of e-bikes on the road is accompanied by rising injuries and even deaths of e-bike drivers. Therefore, there is a growing need to improve the safety structure of e-bikes. This 3D frictionless contact analysis is a preliminary, but necessary work for further structural design improvement of an e-bike. The contact analysis between e-bike and the ground was carried out as follows: firstly, the Penalty method was illustrated and derived from the simplest spring-mass system. This is one of the most common methods to satisfy the frictionless contact case; secondly, ANSYS static analysis was carried out to verify finite element (FE) models with contact pair (without friction) between e-bike and the ground; finally, ANSYS transient analysis was used to obtain the data of the penetration p(u) of e-bike with respect to the ground. Results obtained from the simulation are as estimated by comparing with that from theoretical method. In the future, protective shell will be designed following the stability criteria and added to the frame of e-bike. Simulation of side falling of the improvedsafety structure of e-bike will be confirmed with experimental data.
Abstract: Risk analysis is considered as a fundamental aspect
relevant for ensuring the level of critical infrastructure protection,
where the critical infrastructure is seen as system, asset or its part
which is important for maintaining the vital societal functions. Article
actually discusses and analyzes the potential application of selected
tools of information support for the implementation and within the
framework of risk analysis and critical infrastructure protection. Use
of the information in relation to their risk analysis can be viewed as a
form of simplifying the analytical process. It is clear that these
instruments (information support) for these purposes are countless, so
they were selected representatives who have already been applied in
the selected area of critical infrastructure, or they can be used. All
presented fact were the basis for critical infrastructure resilience
evaluation methodology development.
Abstract: The wide use of the Internet-based applications bring many challenges to the researchers to guarantee the continuity of the connections needed by the mobile hosts and provide reliable Internet access for them. One of proposed solutions by Internet Engineering Task Force (IETF) is to connect the local, multi-hop, and infrastructure-less Mobile Ad hoc Network (MANET) with Internet structure. This connection is done through multi-interface devices known as Internet Gateways. Many issues are related to this connection like gateway discovery, handoff, address auto-configuration and selecting the optimum gateway when multiple gateways exist. Many studies were done proposing gateway selection schemes with a single selection criterion or weighted multiple criteria. In this research, a review of some of these schemes is done showing the differences, the features, the challenges and the drawbacks of each of them.
Abstract: Micro-alloyed steel components are used in
automotive industry for the necessity to make the manufacturing
process cycles shorter when compared to conventional steel by
eliminating heat treatment cycles, so an important saving of costs and
energy can be reached by reducing the number of operations. Microalloying
elements like vanadium, niobium or titanium have been
added to medium carbon steels to achieve grain refinement with or
without precipitation strengthening along with uniform
microstructure throughout the matrix. Present study reports the
applicability of medium carbon vanadium micro-alloyed steel in hot
forging. Forgeability has been determined with respect to different
cooling rates, after forging in a hydraulic press at 50% diameter
reduction in temperature range of 900-11000C. Final microstructures,
hardness, tensile strength, and impact strength have been evaluated.
The friction coefficients of different lubricating conditions, viz.,
graphite in hydraulic oil, graphite in furnace oil, DF 150 (Graphite,
Water-Based) die lubricant and dry or without any lubrication were
obtained from the ring compression test for the above micro-alloyed
steel. Results of ring compression tests indicate that graphite in
hydraulic oil lubricant is preferred for free forging and dry lubricant
is preferred for die forging operation. Exceptionally good forgeability
and high resistance to fracture, especially for faster cooling rate has
been observed for fine equiaxed ferrite-pearlite grains, some amount
of bainite and fine precipitates of vanadium carbides and
carbonitrides. The results indicated that the cooling rate has a
remarkable effect on the microstructure and mechanical properties at
room temperature.
Abstract: In this research (using induction furnace process)
nodular iron with three different percentages of copper (residual,
0.5% and 1,2%) was obtained. Chemical analysis was performed by
mass spectrometry and microstructures were characterized by Optical
Microscopy (ASTM E3) and Scanning Electron Microscopy (SEM).
The study of mechanical behavior was carried out in a mechanical
test machine (ASTM E8) and a Pin on disk tribometer (ASTM G99)
was used to assess wear resistance. It is observed that the dissolution
of copper in crystal lattice increases the pearlite structure improving
the wear and hardness behavior, but producing a contrary effect on
the energy absorption.
Abstract: The objectives of study are the following: To study
the way of life in terms of one hundred years co-existence of the
Muslim and local community in this area 2) To analyze factors affect
to this community with happy co-existence. The study requires
quantitative research to study a history together with the study of
humanity. The result of this study showed that the area of Petchburi
7 community is an ancient area which has owned by the Muslim for
almost 100 years. There is a sanctuary as & center of unity. Later
Bangkok becomes developed and provides more infrastructures like
motorway and other transportation: however, the owners of lands in
this community still keep their lands and build many buildings to run
business. With this purpose, there are many non-Muslim people come
to live here with co-existence. Not only are they convenient to work
but also easy to transport by sky train. There are factors that make
them live harmonious as following: 1) All Muslims in this area are
strict to follow their rules and allocate their community for business.
2) All people, who come and live here, are middle-aged and working
men and women. They, rent rooms closed to their work. 3) There are
Muslim food and desserts, especially Roti, the popular fried flour,
and local Chachak, tea originated from the south of Thailand. All
these food and desserts are famous for working men and women to
home and join after work 4) All Muslim in this area are independent
to lead their own lives although a society changes rapidly.
Abstract: Doxorubicin, also known as Adriamycin, is an
anthracycline class of drug used in cancer chemotherapy. It is used in
the treatment of non-Hodgkin’s lymphoma, multiple myeloma, acute
leukemia, breast cancer, lung cancer, endometrium cancer and ovary
cancers. It functions via intercalating DNA and ultimately killing
cancer cells. The major side effects of doxorubicin are hair loss,
myelosuppression, nausea & vomiting, oesophagitis, diarrhea, heart
damage and liver dysfunction. The minor modifications in the
structure of compound exhibit large variation in the biological
activity, has prompted us to carry out the synthesis of sulfonamide
derivatives. Sulfonamide is an important feature with broad spectrum
of biological activity such as antiviral, antifungal, diuretics, antiinflammatory,
antibacterial and anticancer activities. Structure of the
synthesized compound N-(1-methyl-2-oxo-2-N-methyl anilinoethyl)
benzene sulfonamide confirmed by proton nuclear magnetic
resonance (1H NMR),13C NMR, Mass and FTIR spectroscopic tools
to assure the position of all protons and hence stereochemistry of the
molecule. Further we have reported the binding potential of
synthesized sulfonamide analogues in comparison to doxorubicin
drug using Auto Dock 4.2 software. Computational binding energy
(B.E.) and inhibitory constant (Ki) has been evaluated for the
synthesized compound in comparison of doxorubicin against Poly
(dA-dT).Poly (dA-dT) and Poly (dG-dC).Poly (dG-dC) sequences.
The in vitro cytotoxic study against human breast cancer cell lines
confirms the better anticancer activity of the synthesized compound
over currently in use anticancer drug doxorubicin. The IC50 value of
the synthesized compound is 7.12 μM whereas for doxorubicin is 7.2
μM.
Abstract: The purpose of this presentation is to describe an interdisciplinary teaching program that integrates physical education concepts using a philosophical approach. The presentation includes a review of: a) the philosophy of American education, b) the philosophy of sports and physical education, c) the interdisciplinary physical education program, d) professional development programs, (e) the Success of this physical education program, f) future of physical education. This unique interdisciplinary program has been implemented in an urban school physical education discipline in East Orange, New Jersey for over 10 years.
During the program the students realize that the bodies go through different experiences. The body becomes a place where a child can recognize in an enjoyable way to express and perceive particular feelings or mental states. Children may distinguish themselves to have high abilities in the social or other domains but low abilities in the field of athletics.
The goal of this program for the individuals is to discover new skills, develop and demonstrate age appropriate mastery level at different tasks, therefore the program consists of 9 to 12 sports, including many game. Each successful experience increases the awareness ability. Engaging in sports and physical activities are social movements involving groups of children in situations such as teams, friends, and recreational settings, which serve as a primary socializing agent for teaching interpersonal skills. As a result of this presentation the audience will reflect and explore how to structure a physical education program to integrate interdisciplinary subjects with philosophical concepts.