Abstract: This study examined the toxicological effects and
safety of polypeptide k isolated from the seeds of Momordica
charantia in laboratory rats. 30 male Sprague Dawley rats (12 weeks
old, bodyweight 180-200 g) were randomly divided into 3 groups
(1000 mg/kg, 500 mg and 0 mg/kg). Rats were acclimatized to
laboratory conditions for 7 days and at day 8 rats were dosed orally
with polypeptide k (in 2% DMSO/normal saline) and the controls
received the dosed vehicle only. Rats were then observed for 72
hours before sacrificed. Rats were anaesthetized by pentobarbital
(50 mg/kg ip) and 2-3.0 mL of blood was taken by cardiac puncture
and rats were scarified by anaesthetic overdose. Immediately, organs
(heart, lungs, liver, kidneys) were weigh and taken for histology.
Organ sections were then evaluated by a histopathologist. Serum
samples were assayed for liver functions (ALT and γ-GT) and kidney
functions (BUN and creatinine). All rats showed normal behavior
after the dosing and no statistical changes were observed in all blood
parameters and organ weight. Histological examinations revealed
normal organ structures. In conclusion, dosing of rats up to 1000
mg/kg did not have any effects on the rat behavior, liver or kidney
functions nor histology of the selected organs.
Abstract: This study examines the mediating effects of male
dyadic adjustment on the relationships between attachment and
attributional styles, and both psychological and physical husband
violence. Based on data from 68 married violent men recruited
through community organizations that work with violent men,
regression analyses showed that husbands- dyadic adjustment
mediates the associations between avoidant attachment and
attributional style, and psychological aggression, but not physical
violence. Scientific and clinical implications are discussed
Abstract: Anxiety is a common disorder that attacks many people in society and often accompanied by physiological sensations such as tachycardia, chest pain, shortness of breath, insensitivity and etc. The purpose of this study is to characterize the putative anxiolytic-like effects of DEV (dichloromethane extracts of valerian) using the elevated plus maze (EPM) in rats. DEV was dissolved in DMSO and orally administered at different doses to adult male wistar rats, 0.5, 1.5 and 3 hours before behavioral evaluation in an EPM respectively. Control rats were treated with an equal volume of DMSO. Single treatment of DEV (at 0.1,0.2. 0.3, and 0.4 g/kg) significantly increased time-spent and arm entries into open arms of EPM versus control groups (p
Abstract: The significance of psychology in studying politics
is embedded in philosophical issues as well as behavioural
pursuits. For the former is often associated with Sigmund Freud
and his followers. The latter is inspired by the writings of Harold
Lasswell. Political psychology or psychopolitics has its own
impression on political thought ever since it deciphers the concept
of human nature and political propaganda. More importantly,
psychoanalysis views political thought as a textual content which
needs to explore the latent from the manifest content. In other
words, it reads the text symptomatically and interprets the hidden
truth. This paper explains the paradigm of dream interpretation
applied by Freud. The dream work is a process which has four
successive activities: condensation, displacement, representation
and secondary revision. The texts dealing with political though can
also be interpreted on these principles. Freud's method of dream
interpretation draws its source after the hermeneutic model of
philological research. It provides theoretical perspective and
technical rules for the interpretation of symbolic structures. The
task of interpretation remains a discovery of equivalence of
symbols and actions through perpetual analogies. Psychoanalysis
can help in studying political thought in two ways: to study the text
distortion, Freud's dream interpretation is used as a paradigm
exploring the latent text from its manifest text; and to apply Freud's
psychoanalytic concepts and theories ranging from individual mind
to civilization, religion, war and politics.
Abstract: The study aimed to identify the logical structure of
data and particularities of developing and testing a website designed
for selling farm products through online auctions.
The research is based on a short literature review in the field and
exploratory trials of some successful models from other industries, in
order to identify the advantages of using such tool, as well as the
optimal structure and functionality of an auction portal. In the last
part, the study focuses on the results of testing the website by the
potential beneficiaries.
Conclusions of the study underlines that the particularities of some
agricultural products could raise difficulties in the process of selling
them through online auctions, but the use of such system it is
perceived to bring significant improvements in the supply chain.
The results of scientific investigations require a more detailed
study regarding the importance of using quality standards for
agricultural products sold via online auction, the impact that
implementation of an online payment system could have on trade
with agricultural products and problems which could arise in using
the website in different countries.
Abstract: This study was conducted using the data collected at the mouth of Jen-Gen River to investigate and analyze chromium (Cr) contained in the sediments, and to evaluate the accumulation of Cr and the degree of its potential risk. The results show that samples collected at all monitoring stations near the mouth of Jen-Gen River contain 92–567 mg/kg of Cr with average of 366±166 mg/kg. The spatial distribution of Cr reveals that the Cr concentration is relatively high in the river mouth region, and gradually diminishes toward the harbor region. This indicates that upstream industrial and municipal wastewater discharges along the river bank are major sources of pollution. The accumulation factor and potential ecological risk index indicate that the sedimentation at Jen-Gen River mouth has the most serious degree of Cr accumulation and the highest ecological potential risk.
Abstract: Higher capacities of power plants together with
increased awareness on environmental considerations have led to
taller height of stacks. It is seen that strong wind can result in falling
of stacks. So, aerodynamic consideration of stacks is very important
in order to save the falling of stacks. One stack is not enough in
industries and power sectors and two or three stacks are required for
proper operation of the unit. It is very important to arrange the stacks
in proper way to resist their downfall. The present experimental
study concentrates on the mutual effect of three nearby stacks on
each other at three different arrangements, viz. linear, side-by-side
and triangular. The experiments find out the directions of resultant
forces acting on the stacks in different configurations so that proper
arrangement of supports can be made with respect to the wind
directionality obtained from local meteorological data. One can also
easily ascertain which stack is more vulnerable to wind in
comparison to the others for a particular configuration. Thus, this
study is important in studying the effect of wind force on three stacks
in different arrangements and is very helpful in placing the supports
in proper places in order to avoid failing of stack-like structures due
to wind.
Abstract: Protein-protein interactions (PPI) play a crucial role in many biological processes such as cell signalling, transcription, translation, replication, signal transduction, and drug targeting, etc. Structural information about protein-protein interaction is essential for understanding the molecular mechanisms of these processes. Structures of protein-protein complexes are still difficult to obtain by biophysical methods such as NMR and X-ray crystallography, and therefore protein-protein docking computation is considered an important approach for understanding protein-protein interactions. However, reliable prediction of the protein-protein complexes is still under way. In the past decades, several grid-based docking algorithms based on the Katchalski-Katzir scoring scheme were developed, e.g., FTDock, ZDOCK, HADDOCK, RosettaDock, HEX, etc. However, the success rate of protein-protein docking prediction is still far from ideal. In this work, we first propose a more practical measure for evaluating the success of protein-protein docking predictions,the rate of first success (RFS), which is similar to the concept of mean first passage time (MFPT). Accordingly, we have assessed the ZDOCK bound and unbound benchmarks 2.0 and 3.0. We also createda new benchmark set for protein-protein docking predictions, in which the complexes have experimentally determined binding affinity data. We performed free energy calculation based on the solution of non-linear Poisson-Boltzmann equation (nlPBE) to improve the binding mode prediction. We used the well-studied thebarnase-barstarsystem to validate the parameters for free energy calculations. Besides,thenlPBE-based free energy calculations were conducted for the badly predicted cases by ZDOCK and ZRANK. We found that direct molecular mechanics energetics cannot be used to discriminate the native binding pose from the decoys.Our results indicate that nlPBE-based calculations appeared to be one of the promising approaches for improving the success rate of binding pose predictions.
Abstract: Two species of Physalis, P.angulataL. and P.
peruviana L. were used as models for comparative study to
understand the values of micro-morphological, -anatomical and
architectural characteristics of leaf for taxonomic purposes and
possibly breeding and commercial applications. Both speciespossess
amphistomaticleaves with 1-layer epidermis, 3-4-layer spongy
mesophyll andbicollateral bundle midrib. Palisade parenchyma cells
of P. angulatawere almost twice longer (65-75 μm) than the other
one. Type of stomata was similar as anomocyticbut stomatal
index(SI) at adaxial surface and abaxial surface of P. angulata were
less than of P. peruvianaas 3.57, 4.00 and6.25, 6.66 respectively.
Some leaf architectural characteristics such as leaf shape, order of
venationalsoprovided information of taxonomic significance
Abstract: Combined therapy using Interferon and Ribavirin is the standard treatment in patients with chronic hepatitis C. However, the number of responders to this treatment is low, whereas its cost and side effects are high. Therefore, there is a clear need to predict patient’s response to the treatment based on clinical information to protect the patients from the bad drawbacks, Intolerable side effects and waste of money. Different machine learning techniques have been developed to fulfill this purpose. From these techniques are Associative Classification (AC) and Decision Tree (DT). The aim of this research is to compare the performance of these two techniques in the prediction of virological response to the standard treatment of HCV from clinical information. 200 patients treated with Interferon and Ribavirin; were analyzed using AC and DT. 150 cases had been used to train the classifiers and 50 cases had been used to test the classifiers. The experiment results showed that the two techniques had given acceptable results however the best accuracy for the AC reached 92% whereas for DT reached 80%.
Abstract: In a 10-week (May – August, 2008) Phase I trial, 840, 1+ rainbow trout, Oncorhynchus mykiss, received a commercial oral immunomodulator, Fin Immune™, at four different dosages (0, 10, 20 and 30 mg g-1) to evaluate immune response and growth. The overall objective of was to determine an optimal dosage of this product for rainbow trout that provides enhanced immunity with maximal growth and health. Biweekly blood samples were taken from 10 randomly selected fish in each tank (30 samples per treatment) to evaluate the duration of enhanced immunity conferred by Fin-Immune™. The immunological assessment included serum white blood cell (lymphocyte, neutrophil) densities and blood hematocrit (packed cell volume %). Of these three variables, only lymphocyte density increased significantly among trout fed Fin- Immune™ at 20 and 30 mg g-1 which peaked at week 6. At week 7, all trout were switched to regular feed (lacking Fin-Immune™) and by week 10, lymphocyte levels decreased among all levels but were still greater than at week 0. There was growth impairment at the highest dose of Fin-Immune™ tested (30 mg g-1) which can be associated with a physiological compensatory mechanism due to a dose-specific threshold level. Thus, our main objective of this Phase I study was achieved, the 20 mg g-1 dose of Fin-Immune™ should be the most efficacious (of those we tested) to use for a Phase II disease challenge trial.
Abstract: Estimates of temperature values at a specific time of day, from daytime and daily profiles, are needed for a number of environmental, ecological, agricultural and technical applications, ranging from natural hazards assessments, crop growth forecasting to design of solar energy systems. The scope of this research is to investigate the efficiency of data mining techniques in estimating minimum, maximum and mean temperature values. For this reason, a number of experiments have been conducted with well-known regression algorithms using temperature data from the city of Patras in Greece. The performance of these algorithms has been evaluated using standard statistical indicators, such as Correlation Coefficient, Root Mean Squared Error, etc.
Abstract: The information on the Web increases tremendously.
A number of search engines have been developed for searching Web
information and retrieving relevant documents that satisfy the
inquirers needs. Search engines provide inquirers irrelevant
documents among search results, since the search is text-based rather
than semantic-based. Information retrieval research area has
presented a number of approaches and methodologies such as
profiling, feedback, query modification, human-computer interaction,
etc for improving search results. Moreover, information retrieval has
employed artificial intelligence techniques and strategies such as
machine learning heuristics, tuning mechanisms, user and system
vocabularies, logical theory, etc for capturing user's preferences and
using them for guiding the search based on the semantic analysis
rather than syntactic analysis. Although a valuable improvement has
been recorded on search results, the survey has shown that still
search engines users are not really satisfied with their search results.
Using ontologies for semantic-based searching is likely the key
solution. Adopting profiling approach and using ontology base
characteristics, this work proposes a strategy for finding the exact
meaning of the query terms in order to retrieve relevant information
according to user needs. The evaluation of conducted experiments
has shown the effectiveness of the suggested methodology and
conclusion is presented.
Abstract: In a representative democracy political parties
promote vital competition on different policy issues and play
essential roles by offering ideological alternatives. They also give
channels for citizens- participation in government decision-making
processes and they are significant conduits and interpreters of
information about government. This paper attempts to examine how
opposition political parties and rebel fronts emerged in Ethiopia, and
examines their present conditions. In this paper, selected case studies
of political parties and rebel fronts are included to highlight the status
and the role of opposition groups in the country in the three
successive administrations: Haile Selassie (1930-1974), Derg (1974-
1991), and EPRDF (1991-Present).
Abstract: In many ways, biomedical analysis is analogous to possibilistic reasoning. In spite of that, there are hardly any applications of possibility theory in biology or medicine. The aim of this work is to demonstrate the use of possibility theory in an epidemiological study. In the paper, we build the possibility distribution for the controlled bloodstream concentrations of any physiologically active substance through few approximate considerations. This possibility distribution is tested later against the empirical histograms obtained from the panel study of the eight different physiologically active substances in 417 individuals.
Abstract: Internet addiction has become a critical problem on
adolescents in Taiwan, and its negative effects on various dimensions
of adolescent development caught the attention of educational and
psychological experts. This study examined the correlation between
cognitive (locus of control) and emotion (emotion venting strategies)
factors on internet addiction of adolescents in Taiwan. Using the
Compulsive Internet Use (CIU) and the Emotion Venting Strategy
scales, a survey was conducted and 215 effective samples (students
ranging from12 to14 years old) returned. Quantitative analysis
methods such as descriptive statistics, t-test, ANOVA, Pearson
correlations and multiple regression were adopted. The results were as
follows: 1. Severity of Internet addiction has significant gender
differences; boys were at a higher risk than girls in becoming addicted
to the Internet. 2. Emotion venting, locus of control and internet
addiction have been shown to be positive correlated with one another.
3. Setting the locus of control as the control variable, emotion venting
strategy has positive and significant contribution to internet addiction.
The results of this study suggest that coaching deconstructive emotion
strategies and cognitive believes are encouraged to integrate with
actual field work.
Abstract: Innovations and innovative activity get the increasing
value for successful financial and economic activity of the countries
and regions. The level of innovative sphere development determines
place of a country or a region in world economy and forms a basis of
steady economic growth. This article is devoted to different aspects
of organization of the national economic safety in the conditions of
innovative development, its problems, risks and threats. Economy
can be considered as aspiring for transition to innovative way only
with finding of economic safety: financial independence, power
stability and technological progress. There are statistical indicators,
defining the level of economic security and factors, threatening
economic safety of the state. The research is based on the analysis of
factors and indicators in conditions of innovative development. The
paper is illustrated by the examples of possible estimated system of
the economic safety level.
Abstract: Inflammatory bowel disease (IBD) is a chronic
relapsing-remitting condition that afflicts millions of people
throughout the world and impairs their daily functions and quality of
life. Treatment of IBD depends largely on 5-aminosalicylic acid (5-
ASA) and corticosteroids. The present study aimed to clarify the
effects of 5-aminosalicylic acid, budesonide and currcumin on 90
male albino rats against trinitrobenzene sulfonic acid (TNB) induced
colitis. TNB was injected intrarectally to 50 rats. The other 40 rats
served as control groups. Both 5-ASA (in a dose of 120 mg/kg) and
budesonide (in a dose of 0.1 mg/kg) were administered daily for one
week whereas currcumin was injected intraperitonially (in a dose of
30 mg/kg daily) for 14 days after injection of either TNB in the
colitis rats (group B) or saline in control groups (group A). The study
included estimation of macroscopic score index, histological
examination of H&E stained sections of the colonic tissue,
biochemical estimation of myeloperoxidase (MPO), nitric oxide
(NO), and caspase-3 levels, in addition to studying the effect of tested
drugs on colonic motility. It was found that budesonide and curcumin
improved mucosal healing, reduced both NO production and caspase-
3 level. They had the best impact on the disturbed colonic motility in
TNBS-model of colitis.
Abstract: Homogeneous composites of alumina and zirconia
with a small amount of MgO (99%) were obtained for ZTA ceramic containing 0.05 wt% MgO in
1500 °C.
Abstract: The sequential morphologic changes of rabbit duodenal mucosa-submucosa were studied from primodial stage to birth in 15 fetuses and during the early days of life in 21 rabbit newborns till maturity using light, scanning and transmission electron microscopy. Fetal rabbit duodenum develops from a simple tube of stratified epithelium to a tube containing villus and intervillus regions of simple columnar epithelium. By day 21 of gestation, the first rudimentary villi were appeared and by day 24 the first true villi were appeared. The Crypts of Lieberkuhn did not appear until birth. By the first day of postnatal life the duodenal glands appeared. The histological maturity of the rabbit small intestine occurred one month after birth. In conclusion, at all stages, the sequential morphologic changes of the rabbit small intestine developed to meet the structural and physiological demands during the fetal stage to be prepared to extra uterine life.