Abstract: Single nucleotide polymorphisms (SNPs) hold much promise as a basis for disease-gene association. However, research is limited by the cost of genotyping the tremendous number of SNPs. Therefore, it is important to identify a small subset of informative SNPs, the so-called tag SNPs. This subset consists of selected SNPs of the genotypes, and accurately represents the rest of the SNPs. Furthermore, an effective evaluation method is needed to evaluate prediction accuracy of a set of tag SNPs. In this paper, a genetic algorithm (GA) is applied to tag SNP problems, and the K-nearest neighbor (K-NN) serves as a prediction method of tag SNP selection. The experimental data used was taken from the HapMap project; it consists of genotype data rather than haplotype data. The proposed method consistently identified tag SNPs with considerably better prediction accuracy than methods from the literature. At the same time, the number of tag SNPs identified was smaller than the number of tag SNPs in the other methods. The run time of the proposed method was much shorter than the run time of the SVM/STSA method when the same accuracy was reached.
Abstract: Group contribution based models are widely used in
industrial applications for its convenience and flexibility. Although a
number of group contribution models have been proposed, there were
certain limitations inherent to those models. Models based on group
contribution excess Gibbs free energy are limited to low pressures and
models based on equation of state (EOS) cannot properly describe
highly nonideal mixtures including acids without introducing
additional modification such as chemical theory. In the present study
new a new approach derived from quantum chemistry have been used
to calculate necessary EOS group interaction parameters. The
COSMO-RS method, based on quantum mechanics, provides a
reliable tool for fluid phase thermodynamics. Benefits of the group
contribution EOS are the consistent extension to hydrogen-bonded
mixtures and the capability to predict polymer-solvent equilibria up to
high pressures. The authors are confident that with a sufficient
parameter matrix the performance of the lattice EOS can be improved
significantly.
Abstract: Among all mechanical joining processes, welding has
been employed for its advantage in design flexibility, cost saving,
reduced overall weight and enhanced structural performance.
However, for structures made of relatively thin components, welding
can introduce significant buckling distortion which causes loss of
dimensional control, structural integrity and increased fabrication
costs. Different parameters can affect buckling behavior of welded
thin structures such as, heat input, welding sequence, dimension of
structure. In this work, a 3-D thermo elastic-viscoplastic finite
element analysis technique is applied to evaluate the effect of shell
dimensions on buckling behavior and entropy generation of welded
thin shells. Also, in the present work, the approximated longitudinal
transient stresses which produced in each time step, is applied to the
3D-eigenvalue analysis to ratify predicted buckling time and
corresponding eigenmode. Besides, the possibility of buckling
prediction by entropy generation at each time is investigated and it is
found that one can predict time of buckling with drawing entropy
generation versus out of plane deformation. The results of finite
element analysis show that the length, span and thickness of welded
thin shells affect the number of local buckling, mode shape of global
buckling and post-buckling behavior of welded thin shells.
Abstract: In this paper we study different similarity based approaches for the development of QSAR model devoted to the prediction of activity of antiobesity drugs. Classical similarity approaches are compared regarding to dissimilarity models based on the consideration of the calculation of Euclidean distances between the nonisomorphic fragments extracted in the matching process. Combining the classical similarity and dissimilarity approaches into a new similarity measure, the Approximate Similarity was also studied, and better results were obtained. The application of the proposed method to the development of quantitative structure-activity relationships (QSAR) has provided reliable tools for predicting of inhibitory activity of drugs. Acceptable results were obtained for the models presented here.
Abstract: Pregnancy is considered a special period in a woman’s life. There are myths about pregnancy that describe gender predictions, dietary beliefs, pregnancy signs, and risk of magic or witchcraft. Majority of these myths is in connection with the early childcare. In traditional societies midwives and experienced women practice and teach these myths to young mothers. Mother who feel special and vulnerable, at the same time feel secure in following these socially transmitted myths. Rural Punjab, a province of Pakistan has a culture rich with beliefs and myths. Myths about pregnancy are significant in rural culture and pregnancy care is seen as mother and childcare. This paper presents my research reflections that I did as a part of my Ph.D studies about early childcare beliefs and rituals practiced in rural Punjab, Pakistan.
Abstract: The issue of leadership has been investigated from
several perspectives; however, very less from ethical perspective.
With the growing number of corporate scandals and unethical roles
played by business leaders in several parts of the world, the need to
examine leadership from ethical perspective cannot be over
emphasized. The importance of leadership credibility has been
discussed in the authentic model of leadership. Authentic leaders
display high degree of integrity, have deep sense of purpose, and
committed to their core values. As a result they promote a more
trusting relationship in their work groups that translates into several
positive outcomes. The present study examined how authentic
leadership contribute to subordinates- trust in leadership and how this
trust, in turn, predicts subordinates- work engagement. A sample of
395 employees was randomly selected from several local banks
operating in Malaysia. Standardized tools such as ALQ, OTI, and
EEQ were employed. Results indicated that authentic leadership
promoted subordinates- trust in leader, and contributed to work
engagement. Also, interpersonal trust predicted employees- work
engagement as well as mediated the relationship between this style of
leadership and employees- work engagement.
Abstract: An experimental study is realized in order to verify the
Mini Heat Pipe (MHP) concept for cooling high power dissipation
electronic components and determines the potential advantages of
constructing mini channels as an integrated part of a flat heat pipe. A
Flat Mini Heat Pipe (FMHP) prototype including a capillary structure
composed of parallel rectangular microchannels is manufactured and
a filling apparatus is developed in order to charge the FMHP. The
heat transfer improvement obtained by comparing the heat pipe
thermal resistance to the heat conduction thermal resistance of a
copper plate having the same dimensions as the tested FMHP is
demonstrated for different heat input flux rates. Moreover, the heat
transfer in the evaporator and condenser sections are analyzed, and
heat transfer laws are proposed. In the theoretical part of this work, a
detailed mathematical model of a FMHP with axial microchannels is
developed in which the fluid flow is considered along with the heat
and mass transfer processes during evaporation and condensation.
The model is based on the equations for the mass, momentum and
energy conservation, which are written for the evaporator, adiabatic,
and condenser zones. The model, which permits to simulate several
shapes of microchannels, can predict the maximum heat transfer
capacity of FMHP, the optimal fluid mass, and the flow and thermal
parameters along the FMHP. The comparison between experimental
and model results shows the good ability of the numerical model to
predict the axial temperature distribution along the FMHP.
Abstract: Micro electromechanical sensors (MEMS) play a vital
role along with global positioning devices in navigation of
autonomous vehicles .These sensors are low cost ,easily available but
depict colored noises and unpredictable discontinuities .Conventional
filters like Kalman filters and Sigma point filters are not able to cope
with nonwhite noises. This research has utilized H∞ filter in nonlinear
frame work both with Kalman filter and Unscented filter for
navigation and self alignment of an airborne vehicle. The system is
simulated for colored noises and discontinuities and results are
compared with not robust nonlinear filters. The results are found
40%-70% more robust against colored noises and discontinuities.
Abstract: The mitigation of crop loss due to damaging freezes
requires accurate air temperature prediction models. Previous work
established that the Ward-style artificial neural network (ANN) is a
suitable tool for developing such models. The current research
focused on developing ANN models with reduced average prediction
error by increasing the number of distinct observations used in
training, adding additional input terms that describe the date of an
observation, increasing the duration of prior weather data included in
each observation, and reexamining the number of hidden nodes used
in the network. Models were created to predict air temperature at
hourly intervals from one to 12 hours ahead. Each ANN model,
consisting of a network architecture and set of associated parameters,
was evaluated by instantiating and training 30 networks and
calculating the mean absolute error (MAE) of the resulting networks
for some set of input patterns. The inclusion of seasonal input terms,
up to 24 hours of prior weather information, and a larger number of
processing nodes were some of the improvements that reduced
average prediction error compared to previous research across all
horizons. For example, the four-hour MAE of 1.40°C was 0.20°C, or
12.5%, less than the previous model. Prediction MAEs eight and 12
hours ahead improved by 0.17°C and 0.16°C, respectively,
improvements of 7.4% and 5.9% over the existing model at these
horizons. Networks instantiating the same model but with different
initial random weights often led to different prediction errors. These
results strongly suggest that ANN model developers should consider
instantiating and training multiple networks with different initial
weights to establish preferred model parameters.
Abstract: This study offers a new simple method for assessing
an axial part-through crack in a pipe wall. The method utilizes simple
approximate expressions for determining the fracture parameters K,
J, and employs these parameters to determine critical dimensions of a
crack on the basis of equality between the J-integral and the J-based
fracture toughness of the pipe steel. The crack tip constraint is taken
into account by the so-called plastic constraint factor C, by which the
uniaxial yield stress in the J-integral equation is multiplied. The
results of the prediction of the fracture condition are verified by burst
tests on test pipes.
Abstract: Air infiltration in mass scale industrial applications of
bio char production is inevitable. The presence of oxygen during the
carbonization process is detrimental to the production of biochar yield
and properties. The experiment was carried out on several wood
species in a fixed-bed pyrolyser under various fractions of oxygen
ranging from 0% to 11% by varying nitrogen and oxygen composition
in the pyrolysing gas mixtures at desired compositions. The bed
temperature and holding time were also varied. Process optimization
was carried out by Response Surface Methodology (RSM) by
employing Central Composite Design (CCD) using Design Expert 6.0
Software. The effect of oxygen ratio and holding time on biochar yield
within the range studied were statistically significant. From the
analysis result, optimum condition of 15.2% biochar yield of
mangrove wood was predicted at pyrolysis temperature of 403 oC,
oxygen percentage of 2.3% and holding time of two hours. This
prediction agreed well with the experiment finding of 15.1% biochar
yield.
Abstract: A business case is a proposal for an investment
initiative to satisfy business and functional requirements. The
business case provides the foundation for tactical decision making
and technology risk management. It helps to clarify how the
organization will use its resources in the best way by providing
justification for investment of resources. This paper describes how
simulation was used for business case benefits and return on
investment for the procurement of 8 production machines. With
investment costs of about 4.7 million dollars and annual operating
costs of about 1.3 million, we needed to determine if the machines
would provide enough cost savings and cost avoidance. We
constructed a model of the existing factory environment consisting of
8 machines and subsequently, we conducted average day simulations
with light and heavy volumes to facilitate planning decisions
required to be documented and substantiated in the business case.
Abstract: In this paper we compare the accuracy of data mining
methods to classifying students in order to predicting student-s class
grade. These predictions are more useful for identifying weak
students and assisting management to take remedial measures at early
stages to produce excellent graduate that will graduate at least with
second class upper. Firstly we examine single classifiers accuracy on
our data set and choose the best one and then ensembles it with a
weak classifier to produce simple voting method. We present results
show that combining different classifiers outperformed other single
classifiers for predicting student performance.
Abstract: “Dengue" is an African word meaning “bone
breaking" because it causes severe joint and muscle pain that feels
like bones are breaking. It is an infectious disease mainly transmitted
by female mosquito, Aedes aegypti, and causes four serotypes of
dengue viruses. In recent years, a dramatic increase in the dengue
fever confirmed cases around the equator-s belt has been reported.
Several conventional indices have been designed so far to monitor the
transmitting vector populations known as House Index (HI),
Container Index (CI), Breteau Index (BI). However, none of them
describes the adult mosquito population size which is important to
direct and guide comprehensive control strategy operations since
number of infected people has a direct relationship with the vector
density. Therefore, it is crucial to know the population size of the
transmitting vector in order to design a suitable and effective control
program. In this context, a study is carried out to report a new
statistical index, ABURAS Index, using Poisson distribution based
on the collection of vector population in Jeddah Governorate, Saudi Arabia.
Abstract: Due to heightened concerns over environmental and economic issues the growing important of air pollution, and the importance of conserving fossil fuel resources in the world, the automotive industry is now forced to produce more fuel efficient, low emission vehicles and new drive system technologies. One of the most promising technologies to receive attention is the hybrid electric vehicle (HEV), which consists of two or more energy sources that supply energy to electric traction motors that in turn drive the wheels. This paper presents the various structures of HEV systems, the basic theoretical knowledge for describing their operation and the general behaviour of the HEV in acceleration, cruise and deceleration phases. The conventional design and sizing of a series HEV is studied. A conventional bus and its series configuration are defined and evaluated using the ADVISOR. In this section the simulation of a standard driving cycle and prediction of its fuel consumption and emissions of the HEV are discussed. Finally the bus performance is investigated to establish whether it can satisfy the performance, fuel consumption and emissions requested. The validity of the simulation has been established by the close conformity between the fuel consumption of the conventional bus reported by the manufacturer to what has achieved from the simulation.
Abstract: In literature, there are metrics for identifying the
quality of reusable components but the framework that makes use of
these metrics to precisely predict reusability of software components
is still need to be worked out. These reusability metrics if identified
in the design phase or even in the coding phase can help us to reduce
the rework by improving quality of reuse of the software component
and hence improve the productivity due to probabilistic increase in
the reuse level. As CK metric suit is most widely used metrics for
extraction of structural features of an object oriented (OO) software;
So, in this study, tuned CK metric suit i.e. WMC, DIT, NOC, CBO
and LCOM, is used to obtain the structural analysis of OO-based
software components. An algorithm has been proposed in which the
inputs can be given to K-Means Clustering system in form of
tuned values of the OO software component and decision tree is
formed for the 10-fold cross validation of data to evaluate the in
terms of linguistic reusability value of the component. The developed
reusability model has produced high precision results as desired.
Abstract: this paper aims to provide an approach to predict the
performance of the product produced after multi-stages of
manufacturing processes, as well as the assembly. Such approach
aims to control and subsequently identify the relationship between
the process inputs and outputs so that a process engineer can more
accurately predict how the process output shall perform based on the
system inputs. The approach is guided by a six-sigma methodology to
obtain improved performance.
In this paper a case study of the manufacture of a hermetic
reciprocating compressor is presented. The application of artificial
neural networks (ANNs) technique is introduced to improve
performance prediction within this manufacturing environment. The
results demonstrate that the approach predicts accurately and
effectively.
Abstract: The Emergency Department of a medical center in
Taiwan cooperated to conduct the research. A predictive model of
triage system is contracted from the contract procedure, selection of
parameters to sample screening. 2,000 pieces of data needed for the
patients is chosen randomly by the computer. After three
categorizations of data mining (Multi-group Discriminant Analysis,
Multinomial Logistic Regression, Back-propagation Neural
Networks), it is found that Back-propagation Neural Networks can
best distinguish the patients- extent of emergency, and the accuracy
rate can reach to as high as 95.1%. The Back-propagation Neural
Networks that has the highest accuracy rate is simulated into the triage
acuity expert system in this research. Data mining applied to the
predictive model of the triage acuity expert system can be updated
regularly for both the improvement of the system and for education
training, and will not be affected by subjective factors.
Abstract: In metal cutting industries, mathematical/statistical
models are typically used to predict tool replacement time. These
off-line methods usually result in less than optimum replacement
time thereby either wasting resources or causing quality problems.
The few online real-time methods proposed use indirect measurement
techniques and are prone to similar errors. Our idea is based on
identifying the optimal replacement time using an electronic nose to
detect the airborne compounds released when the tool wear reaches
to a chemical substrate doped into tool material during the
fabrication. The study investigates the feasibility of the idea, possible
doping materials and methods along with data stream mining
techniques for detection and monitoring different phases of tool
wear.
Abstract: UK breweries generate extensive by products in the
form of spent grain, slurry and yeast. Much of the spent grain is
produced by large breweries and processed in bulk for animal feed.
Spent brewery grains contain up to 20% protein dry weight and up to
60% fiber and are useful additions to animal feed. Bulk processing is
economic and allows spent grain to be sold so providing an income
to the brewery. A proportion of spent grain, however, is produced by
small local breweries and is more variably distributed to farms or
other users using intermittent collection methods. Such use is much
less economic and may incur losses if not carefully assessed for
transport costs. This study reports an economic returns of using wet
brewery spent grain (WBSG) in animal feed using the Co-product
Optimizer Decision Evaluator model (Cattle CODE) developed by
the University of Nebraska to predict performance and economic
returns when byproducts are fed to finishing cattle. The results
indicated that distance from brewery to farm had a significantly
greater effect on the economics of use of small brewery spent grain
and that alternative uses than cattle feed may be important to
develop.