Abstract: In this work, two fermentations at different
temperatures (25 and 30ºC), with cell recycling, were accomplished
to produce ethanol, using a mix of commercial substrates, xylose
(70%) and glucose (30%), as organic source for Scheffersomyces
stipitis. Five consecutive fermentations of 80 g L-1 (1º, 2º and 3º
recycles), 96 g L-1 (4º recycle) and 120 g L-1 (5º recycle)reduced
sugars led to a final maximum ethanol concentration of 17.2 and 34.5
g L-1, at 25 and 30ºC, respectively. Glucose was the preferred
substrate; moreover xylose startup degradation was initiated after a
remaining glucose presence in the medium. Results showed that yeast
acid treatment, performed before each cycle, provided improvements
on cell viability, accompanied by ethanol productivity of 2.16 g L-1 h-
1 at 30ºC. A maximum 36% of xylose was retained in the
fermentation medium and after five-cycle fermentation an ethanol
yield of 0.43 g ethanol/g sugars was observed. S. stipitis fermentation
capacity and tolerance showed better results at 30ºC with 83.4% of
theoretical yield referenced on initial biomass.
Abstract: The article represents the results of research of
antitumor activity of different structural types of plant flavonoids
extracted by authors from Polygonum L. plants in commercial
reserves at the territory of the Republic of Kazakhstan. For the first
time ever the results comparative research of antitumor activity of
plant flavonoids of different structural groups and their synthetic
derivatives have been represented. The results of determination of
toxicity of flavonoids in single parenteral infusion conditions have
been represented. Experimental substantiation of possible
mechanisms of antiproliferative and cytotoxic action of flavonoids
has been suggested. The perspectives of usage of plant flavonoids as
medications and creation of effective dosage forms of antitumor
medicines on their basis have been substantiated.
Abstract: An efficient remanufacturing network lead to an
efficient design of sustainable manufacturing enterprise. In
remanufacturing network, products are collected from the customer
zone, disassembled and remanufactured at a suitable remanufacturing
facility. In this respect, another issue to consider is how the returned
product to be remanufactured, in other words, what is the best layout
for such facility. In order to achieve a sustainable manufacturing
system, Cellular Manufacturing System (CMS) designs are highly
recommended, CMSs combine high throughput rates of line layouts
with the flexibility offered by functional layouts (job shop).
Introducing the CMS while designing a remanufacturing network will
benefit the utilization of such a network. This paper presents and
analyzes a comprehensive mathematical model for the design of
Dynamic Cellular Remanufacturing Systems (DCRSs). In this paper,
the proposed model is the first one to date that considers CMS and
remanufacturing system simultaneously. The proposed DCRS model
considers several manufacturing attributes such as multi period
production planning, dynamic system reconfiguration, duplicate
machines, machine capacity, available time for workers, worker
assignments, and machine procurement, where the demand is totally
satisfied from a returned product. A numerical example is presented
to illustrate the proposed model.
Abstract: Structural Equation Modeling (SEM) was used to test
a hypothesized model explaining Malaysian hypermarket customers’
perceptions of brand trust (BT), customer perceived value (CPV) and
perceived service quality (PSQ) on building their brand loyalty
(CBL) and generating positive word-of-mouth communication
(WOM). Self-administered questionnaires were used to collect data
from 374 Malaysian hypermarket customers from Mydin, Tesco,
Aeon Big and Giant in Kuala Lumpur, a metropolitan city of
Malaysia. The data strongly supported the model exhibiting that BT,
CPV and PSQ are prerequisite factors in building customer brand
loyalty, while PSQ has the strongest effect on prediction of customer
brand loyalty compared to other factors. Besides, the present study
suggests the effect of the aforementioned factors via customer brand
loyalty strongly contributes to generate positive word of mouth
communication.
Abstract: Failure of typical seismic frames has been found by
plastic hinge occurring on beams section near column faces. On the
other hand, the seismic capacity of the frames can be enhanced if the
plastic hinges of the beams are shifted away from the column faces.
This paper presents detailing of reinforcements in the interior beam–
column connections aiming to relocate the plastic hinge of reinforced
concrete and precast concrete frames. Four specimens were tested
under quasi-static cyclic load including two monolithic specimens
and two precast specimens. For one monolithic specimen, typical
seismic reinforcement was provided and considered as a reference
specimen named M1. The other reinforced concrete frame M2
contained additional intermediate steel in the connection area
compared with the specimen M1. For the precast specimens,
embedded T-section steels in joint were provided, with and without
diagonal bars in the connection area for specimen P1 and P2,
respectively. The test results indicated the ductile failure with beam
flexural failure in monolithic specimen M1 and the intermediate steel
increased strength and improved joint performance of specimen M2.
For the precast specimens, cracks generated at the end of the steel
inserts. However, slipping of reinforcing steel lapped in top of the
beams was seen before yielding of the main bars leading to the brittle
failure. The diagonal bars in precast specimens P2 improved the
connection stiffness and the energy dissipation capacity.
Abstract: The seismic risk mitigation from the perspective of
the old buildings stock is truly essential in Algerian urban areas,
particularly those located in seismic prone regions, such as Annaba
city, and which the old buildings present high levels of degradation
associated with no seismic strengthening and/or rehabilitation
concerns. In this sense, the present paper approaches the issue of the
seismic vulnerability assessment of old masonry building stocks
through the adaptation of a simplified methodology developed for a
European context area similar to that of Annaba city, Algeria.
Therefore, this method is used for the first level of seismic
vulnerability assessment of the masonry buildings stock of the old
city center of Annaba. This methodology is based on a vulnerability
index that is suitable for the evaluation of damage and for the
creation of large-scale loss scenarios. Over 380 buildings were
evaluated in accordance with the referred methodology and the
results obtained were then integrated into a Geographical Information
System (GIS) tool. Such results can be used by the Annaba city
council for supporting management decisions, based on a global view
of the site under analysis, which led to more accurate and faster
decisions for the risk mitigation strategies and rehabilitation plans.
Abstract: In this research numerical simulations are performed,
using the multi-relaxation-time lattice Boltzmann method, in the
range 3 ≤ β = w[d] ≤ 30 at Re = 100, 200 and 300, where β the
blockage ratio, w is the equispaced distance between centers of
cylinders, d is the diameter of the cylinder and Re is the Reynolds
number, respectively. Special attention is paid to the effect of the
equispaced distance between centers of cylinders. Visualization of
the vorticity contour visualization are presented for some simulation
showing the flow dynamics and patterns for blockage effect. Results
show that the drag and mean drag coefficients, and Strouhal number,
in general, decrease with the increase of β for fixed Re. It is found
that the decreasing rate of drag and mean drag coefficients and
Strouhal number is more distinct in the range 3 ≤ β ≤ 15. We found
that when β > 15, the blockage effect almost diminishes. Our results
further indicate that the drag and mean drag coefficients, peak value
of the lift coefficient, root-mean-square value of the lift and drag
coefficients and the ratio between lift and drag coefficients decrease
with the increase of Re. The results indicate that symmetry boundary
condition have more blockage effect as compared to periodic
boundary condition.
Abstract: The structures obtained with the use of sandwich
technologies combine low weight with high energy absorbing
capacity and load carrying capacity. Hence, there is a growing and
markedly interest in the use of sandwiches with aluminum foam core
because of very good properties such as flexural rigidity and energy
absorption capability. In the current investigation, the static threepoint
bending tests were carried out on the sandwiches with
aluminum foam core and glass fiber reinforced polymer (GFRP)
skins at different values of support span distances aiming the analyses
of their flexural performance. The influence of the core thickness and
the GFRP skin type was reported in terms of peak load and energy
absorption capacity. For this purpose, the skins with two different
types of fabrics which have same thickness value and the aluminum
foam core with two different thicknesses were bonded with a
commercial polyurethane based flexible adhesive in order to combine
the composite sandwich panels. The main results of the bending tests
are: force-displacement curves, peak force values, absorbed energy,
collapse mechanisms and the effect of the support span length and
core thickness. The results of the experimental study showed that the
sandwich with the skins made of S-Glass Woven fabrics and with the
thicker foam core presented higher mechanical values such as load
carrying and energy absorption capacities. The increment of the
support span distance generated the decrease of the mechanical
values for each type of panels, as expected, because of the inverse
proportion between the force and span length. The most common
failure types of the sandwiches are debonding of the lower skin and
the core shear. The obtained results have particular importance for
applications that require lightweight structures with a high capacity
of energy dissipation, such as the transport industry (automotive,
aerospace, shipbuilding and marine industry), where the problems of
collision and crash have increased in the last years.
Abstract: In this paper, an analytical simplified method for
calculating elasto-plastic stresses strains of notched bodies subject to
non-proportional loading paths is discussed. The method was based
on the Neuber notch correction, which relates the incremental elastic
and elastic-plastic strain energy densities at the notch root and the
material constitutive relationship. The validity of the method was
presented by comparing computed results of the proposed model
against finite element numerical data of notched shaft. The
comparison showed that the model estimated notch-root elasto-plastic
stresses strains with good accuracy using linear-elastic stresses. The
prosed model provides more efficient and simple analysis method
preferable to expensive experimental component tests and more
complex and time consuming incremental non-linear FE analysis.
The model is particularly suitable to perform fatigue life and fatigue
damage estimates of notched components subjected to nonproportional
loading paths.
Abstract: The strawberry tree (Arbutus unedo L.) is a small tree
or shrub from botanical Ericaceae family that grows spontaneously
nearby the Mediterranean basin and produce edible red fruits. A
traditional processed fruit application, in Mediterranean countries, is
the production of a spirit (known as aguardente de medronho, in
Portugal) obtained from the fermented fruit. The main objective of
our study was to contribute to the knowledge about the influence of
the degree of maturation of fruits in the volatile composition and
quality of arbutus spirit. The major volatiles in the three distillates
fractions (head, heart and tail) obtained from fermentation of two
different fruit maturation levels were quantified by GC-FID analysis
and ANOVA one-way was performed. Additionally, the total
antioxidant capacity and total phenolic compounds of both arbutus
fruit spirits were determined, by ABTS and Folin-Ciocalteau method,
respectively. The methanol concentration is higher (1022.39 g/hL
a.a.) in the spirit made from fruits with highest total soluble solids,
which is a value above the legal limit (1000 g/hL a.a.). Overall, our
study emphasizes, for the first time, the influence of maturation
degree of arbutus fruits in the spirit volatile composition and quality.
Abstract: During the post-Civil War era, the city of Nashville,
Tennessee, had the highest mortality rate in the United States. The
elevated death and disease rates among former slaves were
attributable to lack of quality healthcare. To address the paucity of
healthcare services, Meharry Medical College, an institution with the
mission of educating minority professionals and serving the
underserved population, was established in 1876.
Purpose: The social ecological framework and partial least squares
(PLS) path modeling were used to quantify the impact of
socioeconomic status and adverse health outcome on primary care
professionals serving the disadvantaged community. Thus, the study
results could demonstrate the accomplishment of the College’s
mission of training primary care professionals to serve in underserved
areas.
Methods: Various statistical methods were used to analyze alumni
data from 1975 – 2013. K-means cluster analysis was utilized to
identify individual medical and dental graduates in the cluster groups
of the practice communities (Disadvantaged or Non-disadvantaged
Communities). Discriminant analysis was implemented to verify the
classification accuracy of cluster analysis. The independent t-test was
performed to detect the significant mean differences of respective
clustering and criterion variables. Chi-square test was used to test if
the proportions of primary care and non-primary care specialists are
consistent with those of medical and dental graduates practicing in
the designated community clusters. Finally, the PLS path model was
constructed to explore the construct validity of analytic model by
providing the magnitude effects of socioeconomic status and adverse
health outcome on primary care professionals serving the
disadvantaged community.
Results: Approximately 83% (3,192/3,864) of Meharry Medical
College’s medical and dental graduates from 1975 to 2013 were
practicing in disadvantaged communities. Independent t-test confirmed the content validity of the cluster analysis model. Also, the
PLS path modeling demonstrated that alumni served as primary care
professionals in communities with significantly lower socioeconomic
status and higher adverse health outcome (p < .001). The PLS path
modeling exhibited the meaningful interrelation between primary
care professionals practicing communities and surrounding
environments (socioeconomic statues and adverse health outcome),
which yielded model reliability, validity, and applicability.
Conclusion: This study applied social ecological theory and
analytic modeling approaches to assess the attainment of Meharry
Medical College’s mission of training primary care professionals to
serve in underserved areas, particularly in communities with low
socioeconomic status and high rates of adverse health outcomes. In
summary, the majority of medical and dental graduates from Meharry
Medical College provided primary care services to disadvantaged
communities with low socioeconomic status and high adverse health
outcome, which demonstrated that Meharry Medical College has
fulfilled its mission. The high reliability, validity, and applicability of
this model imply that it could be replicated for comparable
universities and colleges elsewhere.
Abstract: Present study is carried out on six lane divided urban
arterial road in Patna and Pune city of India. Both the road having
distinct differences in terms of the vehicle composition and the road
side parking. Arterial road in Patan city has 33% of non-motorized
mode, whereas Pune arterial road dominated by 65% of Two wheeler.
Also road side parking is observed in Patna city. The field studies
using videography techniques are carried out for traffic data
collection. Data are extracted for one minute duration for vehicle
composition, speed variation and flow rate on selected arterial road of
the two cities. Speed flow relationship is developed and capacity is
determine. Equivalency factor in terms of dynamic car unit is
determine to represent the vehicle is single unit. The variation in the
capacity due to side friction, presence of non motorized traffic and
effective utilization of lane width is compared at concluding remarks.
Abstract: The model tests were conducted in the laboratory
without and with Plastic recycled polymer in fly ash steep slopes
overlaying soft foundation soils like fly ash and powai soil in order to
check the stability of steep slope. In this experiment, fly ash is used
as a filling material and Plastic Recycled Polymers of diameter =
3mm and length = 4mm were made from waste plastic product (lower
grade plastic product). The properties of fly ash and Plastic recycled
polymers are determined. From the experiments, load and settlement
have measured. From these data, load –settlement curves have
reported. It has been observed from test results that load carrying
capacity of mixture fly ash with Plastic Recycled Polymers slope is
more than that of fly ash slope. The deformation of Plastic Recycled
Polymers slope is slightly more than that of fly ash slope. A Finite
Element Method (F.E.M.) was also evaluated using PLAXIS 3D
version. The failure pattern, deformations and factor of safety are
reported based on analytical programme. The results from
experimental data and analytical programme are compared and
reported.
Abstract: Due to rapid pressured of population growth, city has
started to lose its old tradition. City becomes congested with
uncomfortably living. Urban renewal refers orderly development of
settlements as well as land redevelopment. For this paper Chittagong
city has been selected as study area. It had a great tradition but it has
been losing its concord. Land use pattern of this place is also
haphazard due to lack of planning intervention. Renewal plan is
needed to ascertain suitable redevelopment and to recommend on
preservation of city heritage structure. The goal of this study is to
prepare a renewal plan using local planning approach. Social impact
methods have been used to achieve this goal. Both primary and
secondary data are used to achieve the goal. This study may find out
a complete solution for healthy living in old Part of city. This study
will help to preserve its tradition and makes urban lives more livable.
Abstract: The past two decades, Thailand faced the natural
disasters, for instance, Gay typhoon in 1989, tsunami in 2004, and
huge flood in 2011. The disaster management in Thailand was
improved both structure and mechanism for cope with the natural
disaster since 2007. However, the natural disaster management in
Thailand has various problems, for examples, cooperation between
related an organizations have not unity, inadequate resources, the
natural disaster management of public sectors not proactive, people
has not awareness the risk of the natural disaster, and communities
did not participate in the natural disaster management.
Objective of this study is to find the methods for capacity building
in the natural disaster management of Thailand. The concept and
information about the capacity building and the natural disaster
management of Thailand were reviewed and analyzed by classifying
and organizing data. The result found that the methods for capacity
building in the natural disaster management of Thailand should be
consist of 1) link operation and information in the natural disaster
management between nation, province, local and community levels,
2) enhance competency and resources of public sectors which relate
to the natural disaster management, 3) establish proactive natural
disaster management both planning and implementation, 4)
decentralize the natural disaster management to local government
organizations, 5) construct public awareness in the natural disaster
management to community, 6) support Community Based Disaster
Risk Management (CBDRM) seriously, and 7) emphasis on
participation in the natural disaster management of all stakeholders.
Abstract: Coal is an important non-renewable energy source of
and can be associated with radioactive elements. In Figueira city,
Paraná state, Brazil, it was recorded high uranium activity near the
coal mine that supplies a local thermoelectric power plant. In this
context, the radon activity (Rn-222, produced by the Ra-226 decay in
the U-238 natural series) was evaluated in groundwater, river water
and effluents produced from the acid mine drainage in the coal reject
dumps. The samples were collected in August 2013 and in February
2014 and analyzed at LABIDRO (Laboratory of Isotope and
Hydrochemistry), UNESP, Rio Claro city, Brazil, using an alpha
spectrometer (AlphaGuard) adjusted to evaluate the mean radon
activity concentration in five cycles of 10 minutes. No radon activity
concentration above 100 Bq.L-1, which was a previous critic value
established by the World Health Organization. The average radon
activity concentration in groundwater was higher than in surface
water and in effluent samples, possibly due to the accumulation of
uranium and radium in the aquifer layers that favors the radon
trapping. The lower value in the river waters can indicate dilution and
the intermediate value in the effluents may indicate radon absorption
in the coal particles of the reject dumps. The results also indicate that
the radon activities in the effluents increase with the sample
acidification, possibly due to the higher radium leaching and the
subsequent radon transport to the drainage flow. The water samples
of Laranjinha River and Ribeirão das Pedras stream, which,
respectively, supply Figueira city and receive the mining effluent,
exhibited higher pH values upstream the mine, reflecting the acid
mine drainage discharge. The radionuclides transport indicates the
importance of monitoring their activity concentration in natural
waters due to the risks that the radioactivity can represent to human
health.
Abstract: The Aptima® HIV-1 Quant Dx Assay is a fully
automated assay on the Panther system. It is based on Transcription-
Mediated Amplification and real time detection technologies. This
assay is intended for monitoring HIV-1 viral load in plasma
specimens and for the detection of HIV-1 in plasma and serum
specimens.
Nine-hundred and seventy nine specimens selected at random
from routine testing at St Thomas’ Hospital, London were
anonymised and used to compare the performance of the Aptima
HIV-1 Quant Dx assay and Roche COBAS® AmpliPrep/COBAS®
TaqMan® HIV-1 Test, v2.0. Two-hundred and thirty four specimens
gave quantitative HIV-1 viral load results in both assays. The
quantitative results reported by the Aptima Assay were comparable to
those reported by the Roche COBAS AmpliPrep/COBAS TaqMan
HIV-1 Test, v2.0 with a linear regression slope of 1.04 and an
intercept on -0.097.
The Aptima assay detected HIV-1 in more samples than the
COBAS assay. This was not due to lack of specificity of the Aptima
assay because this assay gave 99.83% specificity on testing plasma
specimens from 600 HIV-1 negative individuals. To understand the
reason for this higher detection rate a side-by-side comparison of low
level panels made from the HIV-1 3rd international standard
(NIBSC10/152) and clinical samples of various subtypes were tested
in both assays. The Aptima assay was more sensitive than the
COBAS assay.
The good sensitivity, specificity and agreement with other
commercial assays make the HIV-1 Quant Dx Assay appropriate for
both viral load monitoring and detection of HIV-1 infections.
Abstract: Reflux condensation occurs in vertical channels and tubes when there is an upward core flow of vapour (or gas-vapour mixture) and a downward flow of the liquid film. The understanding of this condensation configuration is crucial in the design of reflux condensers, distillation columns, and in loss-of-coolant safety analyses in nuclear power plant steam generators. The unique feature of this flow is the upward flow of the vapour-gas mixture (or pure vapour) that retards the liquid flow via shear at the liquid-mixture interface. The present model solves the full, elliptic governing equations in both the film and the gas-vapour core flow. The computational mesh is non-orthogonal and adapts dynamically the phase interface, thus produces a sharp and accurate interface. Shear forces and heat and mass transfer at the interface are accounted for fundamentally. This modeling is a big step ahead of current capabilities by removing the limitations of previous reflux condensation models which inherently cannot account for the detailed local balances of shear, mass, and heat transfer at the interface. Discretisation has been done based on finite volume method and co-located variable storage scheme. An in-house computer code was developed to implement the numerical solution scheme. Detailed results are presented for laminar reflux condensation from steam-air mixtures flowing in vertical parallel plate channels. The results include velocity and gas mass fraction profiles, as well as axial variations of film thickness.
Abstract: Wavelength Division Multiplexing (WDM) is the dominant transport technology used in numerous high capacity backbone networks, based on optical infrastructures. Given the importance of costs (CapEx and OpEx) associated to these networks, resource management is becoming increasingly important, especially how the optical circuits, called “lightpaths”, are routed throughout the network. This requires the use of efficient algorithms which provide routing strategies with the lowest cost. We focus on the lightpath routing and wavelength assignment problem, known as the RWA problem, while optimizing wavelength fragmentation over the network. Wavelength fragmentation poses a serious challenge for network operators since it leads to the misuse of the wavelength spectrum, and then to the refusal of new lightpath requests. In this paper, we first establish a new Integer Linear Program (ILP) for the problem based on a node-link formulation. This formulation is based on a multilayer approach where the original network is decomposed into several network layers, each corresponding to a wavelength. Furthermore, we propose an efficient heuristic for the problem based on a greedy algorithm followed by a post-treatment procedure. The obtained results show that the optimal solution is often reached. We also compare our results with those of other RWA heuristic methods
Abstract: This paper is focused on the CFD simulation of the radiaxial pump (i.e. mixed flow pump) with the aim to detect the reasons of Y-Q characteristic instability. The main reasons of pressure pulsations were detected by means of the analysis of velocity and pressure fields within the pump combined with the theoretical approach. Consequently, the modifications of spiral case and pump suction area were made based on the knowledge of flow conditions and the shape of dissipation function. The primary design of pump geometry was created as the base model serving for the comparison of individual modification influences. The basic experimental data are available for this geometry. This approach replaced the more complicated and with respect to convergence of all computational tasks more difficult calculation for the compressible liquid flow. The modification of primary pump consisted in inserting the three fins types. Subsequently, the evaluation of pressure pulsations, specific energy curves and visualization of velocity fields were chosen as the criterion for successful design.