Abstract: Candida spp. are common and aggressive pathogens.
Because of the growing resistance of Candida spp. to current
antifungals, novel targets, found in Candida spp. but not in humans
or other flora, have to be identified. The alternative oxidase (AOX)
is one such possibility. This enzyme is insensitive to cyanide, but is
sensitive to compounds such as salicylhydroxamic acid (SHAM),
disulfiram and n-alkyl gallates. The growth Candida albicans was
inhibited by SHAM (Ki = 9-15 mM) and cyanide (Ki = 2-4 mM),
albeit to differing extents. The rate of O2 uptake was inhibited by
less than 10% by 25 mM SHAM and by about 90% by 250 μM
KCN. Although SHAM substantially inhibited the growth of C.
albicans, it is unlikely that the inhibition of AOX was the cause.
Salicylhydroxamic acid is used therapeutically in the treatment of
urinary tract infections and urolithiasis, but it also has some potential
in the treatment of C. albicans infection.
Abstract: Over the past decade, mobile has experienced a
revolution that will ultimately change the way we communicate.All
these technologies have a common denominator exploitation of
computer information systems, but their operation can be tedious
because of problems with heterogeneous data sources.To overcome
the problems of heterogeneous data sources, we propose to use a
technique of adding an extra layer interfacing applications of
management or supervision at the different data sources.This layer
will be materialized by the implementation of a mediator between
different host applications and information systems frequently used
hierarchical and relational manner such that the heterogeneity is
completely transparent to the VoIP platform.
Abstract: Cooktop burners are widely used nowadays. In
cooktop burner design, nozzle efficiency and greenhouse
gas(GHG) emissions mainly depend on heat transfer from the
premixed flame to the impinging surface. This is a complicated
issue depending on the individual and combined effects of various
input combustion variables. Optimal operating conditions for
sustainable burner design were rarely addressed, especially in the
case of multiple slot-jet burners. Through evaluating the optimal
combination of combustion conditions for a premixed slot-jet
array, this paper develops a practical approach for the sustainable
design of gas cooktop burners. Efficiency, CO and NOx emissions
in respect of an array of slot jets using premixed flames were
analysed. Response surface experimental design were applied to
three controllable factors of the combustion process, viz.
Reynolds number, equivalence ratio and jet-to-vessel distance.
Desirability Function Approach(DFA) is the analytic technique
used for the simultaneous optimization of the efficiency and
emission responses.
Abstract: The present work is concerned with the effect of turning process parameters (cutting speed, feed rate, and depth of cut) and distance from the center of work piece as input variables on the chip micro-hardness as response or output. Three experiments were conducted; they were used to investigate the chip micro-hardness behavior at diameter of work piece for 30[mm], 40[mm], and 50[mm]. Response surface methodology (R.S.M) is used to determine and present the cause and effect of the relationship between true mean response and input control variables influencing the response as a two or three dimensional hyper surface. R.S.M has been used for designing a three factor with five level central composite rotatable factors design in order to construct statistical models capable of accurate prediction of responses. The results obtained showed that the application of R.S.M can predict the effect of machining parameters on chip micro-hardness. The five level factorial designs can be employed easily for developing statistical models to predict chip micro-hardness by controllable machining parameters. Results obtained showed that the combined effect of cutting speed at it?s lower level, feed rate and depth of cut at their higher values, and larger work piece diameter can result increasing chi micro-hardness.
Abstract: Many IT projects come to failure because of having
technical approach, focusing on the final product and lack of proper
attention to strategic alignment. Project management models quite
often have technical management view [4], [8], [13], [14]. These
models focus greatly on the finalization of the project product and the
delivery of the product to the customer. However, many project
problems are due to lack of attention to the needs and capabilities of
the organizations or disregarding how to deploy and use the product
in the organization. In this regard, in the current research we are
trying to present a solution with the purpose of raising the value of
the project in an organization. This way, the project outputs will be
properly deployed in the organization. Therefore, a comprehensive
model is presented which takes into account the whole processes
from initial step of project definition to the deployment of the final
outputs in the organization and then the definition of all roles and
responsibilities to put the model into practice. Taking into account
the opinions of experts and project managers, to prove the
performance of the model, the project problems were recognized and
based on the model, categorized and analyzed. And at the end it is
made clear that ignoring the proper definition of the project and not
having a proper understanding of the expected value on the one hand
and not supervising the emerged value in the process of production
and installment are among the most important factors that bring a
project to failure.
Abstract: This paper describes the shape optimization of impeller
blades for a anti-heeling bidirectional axial flow pump used in ships.
In general, a bidirectional axial pump has an efficiency much lower
than the classical unidirectional pump because of the symmetry of the
blade type. In this paper, by focusing on a pump impeller, the shape of
blades is redesigned to reach a higher efficiency in a bidirectional axial
pump. The commercial code employed in this simulation is CFX v.13.
CFD result of pump torque, head, and hydraulic efficiency was
compared. The orthogonal array (OA) and analysis of variance
(ANOVA) techniques and surrogate model based optimization using
orthogonal polynomial, are employed to determine the main effects
and their optimal design variables. According to the optimal design,
we confirm an effective design variable in impeller blades and explain
the optimal solution, the usefulness for satisfying the constraints of
pump torque and head.
Abstract: The present work faces the problem of automatic enumeration and recognition of an unknown and time-varying number of environmental sound sources while using a single microphone. The assumption that is made is that the sound recorded is a realization of sound sources belonging to a group of audio classes which is known a-priori. We describe two variations of the same principle which is to calculate the distance between the current unknown audio frame and all possible combinations of the classes that are assumed to span the soundscene. We concentrate on categorizing environmental sound sources, such as birds, insects etc. in the task of monitoring the biodiversity of a specific habitat.
Abstract: Chemical detection is still a continuous challenge when
it comes to designing single-walled carbon nanotube (SWCNT)
sensors with high selectivity, especially in complex chemical
environments. A perfect example of such an environment would be in
thermally oxidized soybean oil. At elevated temperatures, oil oxidizes
through a series of chemical reactions which results in the formation of
monoacylglycerols, diacylglycerols, oxidized triacylglycerols, dimers,
trimers, polymers, free fatty acids, ketones, aldehydes, alcohols,
esters, and other minor products. In order to detect the rancidity of
oxidized soybean oil, carbon nanotube chemiresistor sensors have
been coated with polyethylenimine (PEI) to enhance the sensitivity
and selectivity. PEI functionalized SWCNTs are known to have a high
selectivity towards strong electron withdrawing molecules. The
sensors were very responsive to different oil oxidation levels and
furthermore, displayed a rapid recovery in ambient air without the
need of heating or UV exposure.
Abstract: This paper proposed a nonlinear model predictive
control (MPC) method for the control of gantry crane. One of the main
motivations to apply MPC to control gantry crane is based on its
ability to handle control constraints for multivariable systems. A
pre-compensator is constructed to compensate the input nonlinearity
(nonsymmetric dead zone with saturation) by using its inverse
function. By well tuning the weighting function matrices, the control
system can properly compromise the control between crane position
and swing angle. The proposed control algorithm was implemented for
the control of gantry crane system in System Control Lab of University
of Technology, Sydney (UTS), and achieved desired experimental
results.
Abstract: The increase in energy demand has raised concerns
over adverse impacts on the environment from energy generation. It
is important to understand the status of energy consumption for
institutions such as Curtin Sarawak to ensure the sustainability of
energy usage, and also to reduce its costs. In this study, a preliminary
audit framework was developed and was conducted around the
Malaysian campus to obtain information such as the number and
specifications of electrical appliances, built-up area and ambient
temperature to understand the relationship of these factors with
energy consumption. It was found that the number and types of
electrical appliances, population and activities in the campus
impacted the energy consumption of Curtin Sarawak directly.
However, the built-up area and ambient temperature showed no clear
correlation with energy consumption. An investigation of the diurnal
and seasonal energy consumption of the campus was also carried out.
From the data, recommendations were made to improve the energy
efficiency of the campus.
Abstract: Serious games have proven to be a useful instrument
to engage learners and increase motivation. Nevertheless, a broadly
accepted, practical instructional design approach to serious games
does not exist. In this paper, we introduce the use of an instructional
design model that has not been applied to serious games yet, and has
some advantages compared to other design approaches. We present
the case of mechanics mechatronics education to illustrate the close
match with timing and role of knowledge and information that the
instructional design model prescribes and how this has been
translated to a rigidly structured game design. The structured
approach answers the learning needs of applicable knowledge within
the target group. It combines advantages of simulations with
strengths of entertainment games to foster learner-s motivation in the
best possible way. A prototype of the game will be evaluated along a
well-respected evaluation method within an advanced test setting
including test and control group.
Abstract: In this study, inhibition of Microcystis aeruginosa by
antialgal alleochemical gramine, was studied by analyzing algal
metabolic activity (represented by esterase and total dehydrogenase
activities) and cell ultrastructure (showing morphological and
ultrastructure alterations using transmission electron microscopy and
DNA ladder analysis). After gramine exposure, esterase and total
dehydrogenase activities were increased firstly but decreased later. In
contrast with the controls, the cells exposed to gramine showed
apparent ultrastructure alterations with thylakoids in breakage,
phycobilins in decrease, lipid and cyanophycin granules abundant
firstly but dissolved afterwards, DNA in fragementation. The
occurrence of increase of metabolic activity and specific granules
reflected that the resistance of cellular response to gramine was
initiated. DNA fragementation associated with the increase of
metabolic activity and specific granules hinted that gramine caused M.
aeruginosa cells to initiate some morphotype of programmed cell
death.
Abstract: Science and technology of ultrasonic is widely used in
recent years for industrial and medicinal application. The acoustical
properties of 2-mercapto substituted pyrimidines viz.,2- Mercapto-4-
(2’,4’ –dichloro phenyl) – 6-(2’ – hydroxyl -4’ –methyl-5’ –
chlorophenyl) pyrimidine and 2 –Mercapto – 4-(4’ –chloro phenyl) –
6-(2’ – hydroxyl -4’ –methyl-5’ –chlorophenyl) pyrimidine have been
investigated from the ultrasonic velocity and density measurements at
different concentration and different % in dioxane-water mixture at
305K. The adiabatic compressibility (βs), acoustic impedance (Z),
intermolecular free length (Lf), apparent molar volume(ϕv) and
relative association (RA) values have been calculated from the
experimental data of velocity and density measurement at
concentration range of 0.01- 0.000625 mol/lit and 70%,75% and 80%
dioxane water mixture. These above parameters are used to discuss
the structural and molecular interactions.
Abstract: This paper investigates the effectiveness of the use of
seismic isolation devices on the overall 3D seismic response of
curved highway viaducts with an emphasis on expansion joints.
Furthermore, an evaluation of the effectiveness of the use of cable
restrainers is presented. For this purpose, the bridge seismic
performance has been evaluated on four different radii of curvature,
considering two cases: restrained and unrestrained curved viaducts.
Depending on the radius of curvature, three-dimensional non-linear
dynamic analysis shows the vulnerability of curved viaducts to
pounding and deck unseating damage. In this study, the efficiency of
using LRB supports combined with cable restrainers on curved
viaducts is demonstrated, not only by reducing in all cases the
possible damage, but also by providing a similar behavior in the
viaducts despite of curvature radius.
Abstract: Bioprocesses are appreciated as difficult to control because their dynamic behavior is highly nonlinear and time varying, in particular, when they are operating in fed batch mode. The research objective of this study was to develop an appropriate control method for a complex bioprocess and to implement it on a laboratory plant. Hence, an intelligent control structure has been designed in order to produce biomass and to maximize the specific growth rate.
Abstract: The study and development of an innovative material
for building insulation is really important for a sustainable society in order to improve comfort and reducing energy consumption. The aim of this work is the development of insulating panels for
sustainable buildings based on an innovative material made by
cardboard and Phase Change Materials (PCMs).
The research has consisted in laboratory tests whose purpose has been the obtaining of the required properties for insulation panels: lightweight, porous structures and mechanical resistance. PCMs have been used for many years in the building industry as
smart insulation technology because of their properties of storage and release high quantity of latent heat at useful specific temperatures [1]- [2].
The integration of PCMs into cellulose matrix during the waste paper recycling process has been developed in order to obtain a
composite material.
Experiments on the productive process for the realization of insulating panels were done in order to make the new material
suitable for building application. The addition of rising agents
demonstrated the possibility to obtain a lighter structure with better
insulation properties.
Several tests were conducted to verify the new panel properties. The results obtained have shown the possibility to realize an
innovative and sustainable material suitable to replace insulating panels currently used.
Abstract: We propose a formal framework for the specification of
the behavior of a system of agents, as well as those of the constituting
agents. This framework allows us to model each agent-s effectoric
capability including its interactions with the other agents. We also
provide an algorithm based on Milner-s "observation equivalence" to
derive an agent-s perception of its task domain situations from its
effectoric capability, and use "system computations" to model the
coordinated efforts of the agents in the system . Formal definitions
of the concept of "behavior equivalence" of two agents and that of
system computations equivalence for an agent are also provided.
Abstract: Infrared communication in the wavelength band 780-
950 nm is very suitable for short-range point-to-point communications.
It is a good choice for vehicle-to-vehicle communication in several
intelligent-transportation-system (ITS) applications such as cooperative
driving, collision warning, and pileup-crash prevention. In this
paper, with the aid of a physical model established in our previous
works, we explore the communication area of an infrared intervehicle
communication system utilizing a typical low-cost cormmercial lightemitting
diodes (LEDs) as the emitter and planar p-i-n photodiodes
as the receiver. The radiation pattern of the emitter fabricated by
aforementioned LEDs and the receiving pattern of the receiver are
approximated by a linear combination of cosinen functions. This
approximation helps us analyze the system performance easily. Both
multilane straight-road conditions and curved-road conditions with
various radius of curvature are taken into account. The condition of
a small car communicating with a big truck, i.e., there is a vertical
mounting height difference between the emitter and the receiver, is
also considered. Our results show that the performance of the system
meets the requirement of aforementioned ITS applications in terms
of the communication area.
Abstract: In this paper, we study the stability of n-dimensional linear fractional neutral differential equation with time delays. By using the Laplace transform, we introduce a characteristic equation for the above system with multiple time delays. We discover that if all roots of the characteristic equation have negative parts, then the equilibrium of the above linear system with fractional order is Lyapunov globally asymptotical stable if the equilibrium exist that is almost the same as that of classical differential equations. An example is provided to show the effectiveness of the approach presented in this paper.
Abstract: The problem of complex use of water resources in
Central Asia by taking into consideration the sovereignty of the states
and increasing demand on use of water for economic aspects are
considered. Complex program with appropriate mathematical
software intended for calculation of possible variants of using the
Amudarya up-stream water resources according to satisfaction of
incompatible requirements of the national economics in irrigation
and energy generation is proposed.