Abstract: Nowadays scientific data is inevitably digital and
stored in a wide variety of formats in heterogeneous systems.
Scientists need to access an integrated view of remote or local
heterogeneous data sources with advanced data accessing, analyzing,
and visualization tools. This research suggests the use of Service
Oriented Architecture (SOA) to integrate biological data from
different data sources. This work shows SOA will solve the problems
that facing integration process and if the biologist scientists can
access the biological data in easier way. There are several methods to
implement SOA but web service is the most popular method. The
Microsoft .Net Framework used to implement proposed architecture.
Abstract: Over the past decade, mobile has experienced a
revolution that will ultimately change the way we communicate.All
these technologies have a common denominator exploitation of
computer information systems, but their operation can be tedious
because of problems with heterogeneous data sources.To overcome
the problems of heterogeneous data sources, we propose to use a
technique of adding an extra layer interfacing applications of
management or supervision at the different data sources.This layer
will be materialized by the implementation of a mediator between
different host applications and information systems frequently used
hierarchical and relational manner such that the heterogeneity is
completely transparent to the VoIP platform.
Abstract: It has been established that microRNAs (miRNAs) play
an important role in gene expression by post-transcriptional regulation
of messengerRNAs (mRNAs). However, the precise relationships
between microRNAs and their target genes in sense of numbers,
types and biological relevance remain largely unclear. Dissecting the
miRNA-target relationships will render more insights for miRNA
targets identification and validation therefore promote the understanding
of miRNA function. In miRBase, miRanda is the key
algorithm used for target prediction for Zebrafish. This algorithm
is high-throughput but brings lots of false positives (noise). Since
validation of a large scale of targets through laboratory experiments
is very time consuming, several computational methods for miRNA
targets validation should be developed. In this paper, we present an
integrative method to investigate several aspects of the relationships
between miRNAs and their targets with the final purpose of extracting
high confident targets from miRanda predicted targets pool. This is
achieved by using the techniques ranging from statistical tests to
clustering and association rules. Our research focuses on Zebrafish.
It was found that validated targets do not necessarily associate with
the highest sequence matching. Besides, for some miRNA families,
the frequency of their predicted targets is significantly higher in the
genomic region nearby their own physical location. Finally, in a case
study of dre-miR-10 and dre-miR-196, it was found that the predicted
target genes hoxd13a, hoxd11a, hoxd10a and hoxc4a of dre-miR-
10 while hoxa9a, hoxc8a and hoxa13a of dre-miR-196 have similar
characteristics as validated target genes and therefore represent high
confidence target candidates.