Abstract: The literature reports a large number of approaches for
measuring the similarity between protein sequences. Most of these
approaches estimate this similarity using alignment-based techniques
that do not necessarily yield biologically plausible results, for two
reasons.
First, for the case of non-alignable (i.e., not yet definitively aligned
and biologically approved) sequences such as multi-domain, circular
permutation and tandem repeat protein sequences, alignment-based
approaches do not succeed in producing biologically plausible results.
This is due to the nature of the alignment, which is based on the
matching of subsequences in equivalent positions, while non-alignable
proteins often have similar and conserved domains in non-equivalent
positions.
Second, the alignment-based approaches lead to similarity measures
that depend heavily on the parameters set by the user for the alignment
(e.g., gap penalties and substitution matrices). For easily alignable
protein sequences, it's possible to supply a suitable combination of
input parameters that allows such an approach to yield biologically
plausible results. However, for difficult-to-align protein sequences,
supplying different combinations of input parameters yields different
results. Such variable results create ambiguities and complicate the
similarity measurement task.
To overcome these drawbacks, this paper describes a novel and
effective approach for measuring the similarity between protein
sequences, called SAF for Substitution and Alignment Free. Without
resorting either to the alignment of protein sequences or to substitution
relations between amino acids, SAF is able to efficiently detect the
significant subsequences that best represent the intrinsic properties of
protein sequences, those underlying the chronological dependencies of
structural features and biochemical activities of protein sequences.
Moreover, by using a new efficient subsequence matching scheme,
SAF more efficiently handles protein sequences that contain similar
structural features with significant meaning in chronologically
non-equivalent positions. To show the effectiveness of SAF, extensive
experiments were performed on protein datasets from different
databases, and the results were compared with those obtained by
several mainstream algorithms.
Abstract: This paper reports the tensile fracture location
characterizations of dissimilar friction stir welds between 5754
aluminium alloy and C11000 copper. The welds were produced using
three shoulder diameter tools; namely, 15, 18 and 25 mm by varying
the process parameters. The rotational speeds considered were 600,
950 and 1200 rpm while the feed rates employed were 50, 150 and
300 mm/min to represent the low, medium and high settings
respectively. The tensile fracture locations were evaluated using the
optical microscope to identify the fracture locations and were
characterized. It was observed that 70% of the tensile samples failed
in the Thermo Mechanically Affected Zone (TMAZ) of copper at the
weld joints. Further evaluation of the fracture surfaces of the pulled
tensile samples revealed that welds with low Ultimate Tensile
Strength either have defects or intermetallics present at their joint
interfaces.
Abstract: The ITE Project is a project that has 1800 km length
and across the Turkey's land through east to west. The project of
pipeline enters geographically from Iran to Doğubayazit (Turkey) in
the east, exits to Greece from Ipsala province of Turkey in the west.
This project is the one of the international projects in such scale that
provides the natural gas of Iran and Caspian Sea through the
European continent. In this investigation, some information will be
given about the methods used to verify the direction of the pipeline
and the technical properties of the results obtained. The cost of
project itself entirely depends on the direction of the pipeline which
would be as short as possible and the specifications of the land cover.
Production standards of 1/2000 scaled digital orthophoto and vectoral
maps as a results of the use of map production materials and methods
(such as high resolution satellite images, and digital aerial images
captured from digital aerial cameras), will also be given in this report.
According to Turkish national map production standards, TM
((Transversal Mercator, 3 degree) projection is used for large scale
map and UTM (Universal Transversal Mercator, 6 degree) is used for
small scale map production standards. Some information is also given
about the projection used in the ITE natural gas pipeline project.
Abstract: Data mining uses a variety of techniques each of which is useful for some particular task. It is important to have a deep understanding of each technique and be able to perform sophisticated analysis. In this article we describe a tool built to simulate a variation of the Kohonen network to perform unsupervised clustering and support the entire data mining process up to results visualization. A graphical representation helps the user to find out a strategy to optmize classification by adding, moving or delete a neuron in order to change the number of classes. The tool is also able to automatically suggest a strategy for number of classes optimization.The tool is used to classify macroeconomic data that report the most developed countries? import and export. It is possible to classify the countries based on their economic behaviour and use an ad hoc tool to characterize the commercial behaviour of a country in a selected class from the analysis of positive and negative features that contribute to classes formation.
Abstract: This study presents a new approach based on Tanaka's
fuzzy linear regression (FLP) algorithm to solve well-known power
system economic load dispatch problem (ELD). Tanaka's fuzzy linear
regression (FLP) formulation will be employed to compute the
optimal solution of optimization problem after linearization. The
unknowns are expressed as fuzzy numbers with a triangular
membership function that has middle and spread value reflected on
the unknowns. The proposed fuzzy model is formulated as a linear
optimization problem, where the objective is to minimize the sum of
the spread of the unknowns, subject to double inequality constraints.
Linear programming technique is employed to obtain the middle and
the symmetric spread for every unknown (power generation level).
Simulation results of the proposed approach will be compared with
those reported in literature.
Abstract: Heat-inducible gene expression vectors are useful for hyperthermia-induced cancer gene therapy, because the combination
of hyperthermia and gene therapy can considerably improve the therapeutic effects. In the present study, we developed an enhanced
heat-inducible transgene expression system in which a heat-shock
protein (HSP) promoter and tetracycline-responsive transactivator
were combined. When the transactivator plasmid containing the
tetracycline-responsive transactivator gene was co-transfected with
the reporter gene expression plasmid, a high level of heat-induced gene expression was observed compared with that using the HSP
promoter without the transactivator. In vitro evaluation of the
therapeutic effect using HeLa cells showed that heat-induced therapeutic gene expression caused cell death in a high percentage of
these cells, indicating that this strategy is promising for cancer gene therapy.
Abstract: Several studies have shown the association between
ambient particulate matter (PM) and adverse health effects and
climate change, thus highlighting the need to limit the anthropogenic
sources of PM. PM Exposure is commonly monitored as mass
concentration of PM10 (particle aerodynamic diameter < 10μm) or
PM2.5 (particle aerodynamic diameter < 2.5μm), although increasing
toxicity with decreasing aerodynamic diameter has been reported due
to increased surface area and enhanced chemical reactivity with other
species. Additionally, the light scattering properties of PM increases
with decreasing size. Hence, it is important to study the chemical
characterization of finer fraction of the particulate matter and to
identify their sources so that they can be controlled appropriately to a
large extent at the sources before reaching to the receptors.
Abstract: Chronic diseases prevailed along with economic
growth as well as life style changed in recent years in Taiwan.
According to the governmental statistics, hypertension related disease
is the tenth of death causes with 1,816 died directly from hypertension
in 2010. There were more death causes amongst the top ten had been
proofed that having strong association with the hypertension, such as
heart diseases, cardiovascular diseases, and diabetes. Hypertension or
High blood pressure is one of the major indicators for chronic diseases,
and was generally perceived as the major causes of mortality. The
literature generally suggested that regular physical exercise was
helpful to prevent the occurrence or to ease the progress of a
hypertension. This paper reported the process and outcomes in
detailed of an improvement project of physical exercise intervention
specific for hypertension patients. Physical information were
measured before and after the project to obtain information such as
weight, waistline, cholesterol (HD & LD), blood examination, as well
as self-perceived health status. The intervention project involved a
six-week exercise program, of which contained three times a week, 30
minutes of tutored physical exercise intervention. The project had
achieved several gains in changing the subjects- behavior in terms of
many important biophysical indexes. Around 20% of the participants
had significantly improved their cholesterols, BMI, and changed
unhealthy behaviors. Results from the project were encouraging, and
would be good reference for other samples.
Abstract: In this paper, the issue of pth moment exponential stability of stochastic recurrent neural network with distributed time delays is investigated. By using the method of variation parameters, inequality techniques, and stochastic analysis, some sufficient conditions ensuring pth moment exponential stability are obtained. The method used in this paper does not resort to any Lyapunov function, and the results derived in this paper generalize some earlier criteria reported in the literature. One numerical example is given to illustrate the main results.
Abstract: Many environment specific methods and systems for Robot Navigation exist. However vast strides in the evolution of navigation technologies and system techniques create the need for a general unified framework that is scalable, modular and dynamic. In this paper a Unified Framework for a Robust Conflict-free Robot Navigation System that can be used for either a structured or unstructured and indoor or outdoor environments has been proposed. The fundamental design aspects and implementation issues encountered during the development of the module are discussed. The results of the deployment of three major peripheral modules of the framework namely the GSM based communication module, GIS Module and GPS module are reported in this paper.
Abstract: A phorbol-12-myristate-13-acetate (TPA) is a synthetic analogue of phorbol ester (PE), a natural toxic compound of Euphorbiaceae plant. The oil extracted from plants of this family is useful source for primarily biofuel. However this oil might also be used as a foodstuff due to its significant nutrition content. The limitations for utilizing the oil as a foodstuff are mainly due to a toxicity of PE. Currently, a majority of PE detoxification processes are expensive as include multi steps alcohol extraction sequence.
Ozone is considered as a strong oxidative agent. It reacts with PE by attacking the carbon-carbon double bond of PE. This modification of PE molecular structure yields a non toxic ester with high lipid content.
This report presents data on development of simple and cheap PE detoxification process with water application as a buffer and ozone as reactive component. The core of this new technique is an application for a new microscale plasma unit to ozone production and the technology permits ozone injection to the water-TPA mixture in form of microbubbles.
The efficacy of a heterogeneous process depends on the diffusion coefficient which can be controlled by contact time and interfacial area. The low velocity of rising microbubbles and high surface to volume ratio allow efficient mass transfer to be achieved during the process. Direct injection of ozone is the most efficient way to process with such highly reactive and short lived chemical.
Data on the plasma unit behavior are presented and the influence of gas oscillation technology on the microbubble production mechanism has been discussed. Data on overall process efficacy for TPA degradation is shown.
Abstract: The study will search the level of existence of the
sweethearting in Saudi Arabia's Supermarkets in Riyadh.
Sweethearting occurs when frontline workers give unauthorized free
or uncounted goods and services to customer-s conspirators. The
store managers and /or security managers were asked about the
sweethearting that occurs in the supermarkets. The characteristics of
sweethearting in Riyadh stores were investigated. Two independent
variables were related to the report of sweethearting. These
independent variables are: The effect of store environment on
sweethearting and the security techniques and loss prevention
electronics techniques used. This study expected to shed the light
about the level of sweethearting in Saudi Arabia and the factors
behind it. This study will serve as an exploratory study for such
phenomenon in Saudi Arabia as well as both descriptive for the
characteristics of sweethearting and explanatory study to link
between the environmental and security systems factors to
sweethearting.
Abstract: This paper presents initiatives of Knowledge
Management (KM) applied to Forensic Sciences field, especially
developed at the Forensic Science Institute of the Brazilian Federal
Police. Successful projects, related to knowledge sharing, drugs
analysis and environmental crimes, are reported in the KM
perspective. The described results are related to: a) the importance of
having an information repository, like a digital library, in such a
multidisciplinary organization; b) the fight against drug dealing and
environmental crimes, enabling the possibility to map the evolution
of crimes, drug trafficking flows, and the advance of deforestation in
Amazon rain forest. Perspectives of new KM projects under
development and studies are also presented, tracing an evolution line
of the KM view at the Forensic Science Institute.
Abstract: Flood zoning studies have become more efficient in
recent years because of the availability of advanced computational
facilities and use of Geographic Information Systems (GIS). In the
present study, flood inundated areas were mapped using GIS for the
Dikrong river basin of Arunachal Pradesh, India, corresponding to
different return periods (2, 5, 25, 50, and 100 years). Further, the developed inundation maps corresponding to 25, 50, and 100 year return period floods were compared to corresponding maps
developed by conventional methods as reported in the Brahmaputra Board Master Plan for Dikrong basin. It was found that, the average
deviation of modelled flood inundation areas from reported map
inundation areas is below 5% (4.52%). Therefore, it can be said that
the modelled flood inundation areas matched satisfactorily with
reported map inundation areas. Hence, GIS techniques were proved to be successful in extracting the flood inundation extent in a time and cost effective manner for the remotely located hilly basin of Dikrong, where conducting conventional surveys is very difficult.
Abstract: Air bending is one of the important metal forming
processes, because of its simplicity and large field application.
Accuracy of analytical and empirical models reported for the analysis
of bending processes is governed by simplifying assumption and do
not consider the effect of dynamic parameters. Number of researches
is reported on the finite element analysis (FEA) of V-bending, Ubending,
and air V-bending processes. FEA of bending is found to be
very sensitive to many physical and numerical parameters. FE
models must be computationally efficient for practical use. Reported
work shows the 3D FEA of air bending process using Hyperform LSDYNA
and its comparison with, published 3D FEA results of air
bending in Ansys LS-DYNA and experimental results. Observing the
planer symmetry and based on the assumption of plane strain
condition, air bending problem was modeled in 2D with symmetric
boundary condition in width. Stress-strain results of 2D FEA were
compared with 3D FEA results and experiments. Simplification of
air bending problem from 3D to 2D resulted into tremendous
reduction in the solution time with only marginal effect on stressstrain
results. FE model simplification by studying the problem
symmetry is more efficient and practical approach for solution of
more complex large dimensions slow forming processes.
Abstract: Empirical insights into the implementation of logistics competencies at the top management level are scarce. This paper addresses this issue with an explorative approach which is based on a dataset of 872 observations in the years 2000, 2004 and 2008 using quantitative content analysis from annual reports of the 500 publicly listed firms with the highest global research and development expenditures according to the British Department for Business Innovation and Skills. We find that logistics competencies are more pronounced in Asian companies than in their European or American counterparts. On an industrial level the results are quite mixed. Using partial point-biserial correlations we show that logistics competencies are positively related to financial performance.
Abstract: Teaching and learning about sustainability is a pedagogical endeavour with various innate difficulties and increased demands. Higher education has a dual role to play in addressing this challenge: to identify and explore innovative approaches and tools for addressing the complex and value-laden nature of sustainability in more meaningful ways, and to help teachers to integrate these approaches into their practice through appropriate professional development programs. The study reported here was designed and carried out within the context of a Masters course in Environmental Education. Eight teachers were collaboratively engaged in reconstructing a digital game microworld which was deliberately designed by the researchers to be questioned and evoke critical discussion on the idea of ‘sustainable city’. The study was based on the design-based research method. The findings indicate that the teachers’ involvement in processes of co-constructing the microworld initiated discussion and reflection upon the concepts of sustainability and sustainable lifestyles.
Abstract: In the present paper, a set of parametric FE stress
analyses is carried out for two-planar welded tubular DKT-joints
under two different axial load cases. Analysis results are used to
present general remarks on the effect of geometrical parameters on
the stress concentration factors (SCFs) at the inner saddle, outer
saddle, toe, and heel positions on the main (outer) brace. Then a new
set of SCF parametric equations is developed through nonlinear
regression analysis for the fatigue design of two-planar DKT-joints.
An assessment study of these equations is conducted against the
experimental data; and the satisfaction of the criteria regarding the
acceptance of parametric equations is checked. Significant effort has
been devoted by researchers to the study of SCFs in various uniplanar
tubular connections. Nevertheless, for multi-planar joints
covering the majority of practical applications, very few
investigations have been reported due to the complexity and high
cost involved.
Abstract: This study analyses store layout among the many
factors that underlie supermarket store design, this; in terms of what to
display in a shop and where to place the items. This report examines
newly-opened stores and evaluates their interior shop floor layouts,
which we then attempt to categorize by various styles. We then
consider the interaction between shop floor layout and customer
behavior from the perspective of the supermarket as the seller. At this
point, we focus on the “store magnets"–the main sections within the
shop likely to attract customers into the store.
Abstract: The selective wet-etching of amorphous and
crystalline region of Sb20Se80 thin films was carried out using organic
based solution e.g. amines. We report the development of an in situ
real-time method to study the wet chemical etching process of thin
films. Characterization of the structure and surface of films studied
by X-ray diffraction, SEM and EBSD methods has been done and
potential application suggested.