Abstract: DNA microarray technology is widely used by
geneticists to diagnose or treat diseases through gene expression.
This technology is based on the hybridization of a tissue-s DNA
sequence into a substrate and the further analysis of the image
formed by the thousands of genes in the DNA as green, red or yellow
spots. The process of DNA microarray image analysis involves
finding the location of the spots and the quantification of the
expression level of these. In this paper, a tool to perform DNA
microarray image analysis is presented, including a spot addressing
method based on the image projections, the spot segmentation
through contour based segmentation and the extraction of relevant
information due to gene expression.
Abstract: The nanotechnology based on epitaxial systems
includes single or arranged misfit dislocations. In general, whatever
is the type of dislocation or the geometry of the array formed by the
dislocations; it is important for experimental studies to know exactly
the stress distribution for which there is no analytical expression [1,
2]. This work, using a numerical analysis, deals with relaxation of
epitaxial layers having at their interface a periodic network of edge
misfit dislocations. The stress distribution is estimated by using
isotropic elasticity. The results show that the thickness of the two
sheets is a crucial parameter in the stress distributions and then in the
profile of the two sheets.
A comparative study between the case of single dislocation and
the case of parallel network shows that the layers relaxed better when
the interface is covered by a parallel arrangement of misfit.
Consequently, a single dislocation at the interface produces an
important stress field which can be reduced by inserting a parallel
network of dislocations with suitable periodicity.
Abstract: The flexible follower response of a translating cam with
four different profiles for rise-dwell-fall-dwell (RDFD) motion is
investigated. The cycloidal displacement motion, the modified
sinusoidal acceleration motion, the modified trapezoidal acceleration
motion, and the 3-4-5 polynomial motion are employed to describe the
rise and the fall motions of the follower and the associated four kinds of
cam profiles are studied. Since the follower flexibility is considered,
the contact point of the roller and the cam is an unknown. Two
geometric constraints formulated to restrain the unknown position are
substituted into Hamilton-s principle with Lagrange multipliers.
Applying the assumed mode method, one can obtain the governing
equations of motion as non-linear differential-algebraic equations. The
equations are solved using Runge-Kutta method. Then, the responses of
the flexible follower undergoing the four different motions are
investigated in time domain and in frequency domain.
Abstract: Biclustering is a very useful data mining technique for
identifying patterns where different genes are co-related based on a
subset of conditions in gene expression analysis. Association rules
mining is an efficient approach to achieve biclustering as in
BIMODULE algorithm but it is sensitive to the value given to its
input parameters and the discretization procedure used in the
preprocessing step, also when noise is present, classical association
rules miners discover multiple small fragments of the true bicluster,
but miss the true bicluster itself. This paper formally presents a
generalized noise tolerant bicluster model, termed as μBicluster. An
iterative algorithm termed as BIDENS based on the proposed model
is introduced that can discover a set of k possibly overlapping
biclusters simultaneously. Our model uses a more flexible method to
partition the dimensions to preserve meaningful and significant
biclusters. The proposed algorithm allows discovering biclusters that
hard to be discovered by BIMODULE. Experimental study on yeast,
human gene expression data and several artificial datasets shows that
our algorithm offers substantial improvements over several
previously proposed biclustering algorithms.
Abstract: In this content analysis research note the aim was to explore to how sustainability and especially environmental issues are conveyed into environmental items in annual reports and disclosures. As The Global Reporting Initiative (GRI) is a globally wide multistakeholder process, the enterprises using voluntarily GRI framework are considered to be aware of sustainability and environmental concerns. The findings were that although these enterprises included in an environmentally sensitive industry sector and had special capabilities to consider environmental issues there were few GRIreporting enterprises presented substantially detailed environmental items in audited financial statements. There were only slight differences between publishing years 2008 and 2009 - the beginning years of economic turmoil. The environmental issues seemed not to be considered substantial enough for financial reporting as a basis for concerning investment or voting decisions.
Abstract: We suggest a novel method to incorporate longterm
redundancy (LTR) in signal time domain compression
methods. The proposition is based on block-sorting and curve
simplification. The proposition is illustrated on the ECG
signal as a post-processor for the FAN method. Test
applications on the new so-obtained FAN+ method using the
MIT-BIH database show substantial improvement of the
compression ratio-distortion behavior for a higher quality
reconstructed signal.
Abstract: Free Hemoglobin promotes the accumulation of
hydroxyl radicals by the heme iron, which can react with endogenous
hydrogen peroxide to produce free radicals which may cause severe
oxidative cell damage. Haptoglobin binds to Hemoglobin strongly
and Haptoglobin-Hemoglobin binding is irreversible. Peroxidase
activity of Haptoglobin(2-2)-Hemoglobin complex was assayed by
following increase of absorption of produced tetraguaiacol as the
second substrate of Haptoglobin-Hemoglobin complex at 470 nm and
42°C by UV-Vis spectrophotometer. The results have shown that
peroxidase activity of Haptoglobin(2-2)-Hemoglobin complex is
modulated via homotropic effect of hydrogen peroxide as allostric
substrate. On the other hand antioxidant property of Haptoglobin(2-
2)-Hemoglobin was increased via heterotropic effect of the two drugs
(especially ampicillin) on peroxidase activity of the complex. Both
drugs also have mild effect on quality of homotropic property of
peroxidase activity of Haptoglobin(2-2)-Hemoglobin complex.
Therefore, in vitro studies show that the two drugs may help Hp-Hb
complex to remove hydrogen peroxide from serum at pathologic
temperature ature (42 C).
Abstract: There are various overlay structures that provide
efficient and scalable solutions for point and range query in a peer-topeer
network. Overlay structure based on m-Binary Search Tree
(BST) is one such popular technique. It deals with the division of the
tree into different key intervals and then assigning the key intervals to
a BST. The popularity of the BST makes this overlay structure
vulnerable to different kinds of attacks. Here we present four such
possible attacks namely index poisoning attack, eclipse attack,
pollution attack and syn flooding attack. The functionality of BST is
affected by these attacks. We also provide different security
techniques that can be applied against these attacks.
Abstract: This article is dedicated to development of
mathematical models for determining the dynamics of
concentration of hazardous substances in urban turbulent
atmosphere. Development of the mathematical models implied
taking into account the time-space variability of the fields of
meteorological items and such turbulent atmosphere data as vortex
nature, nonlinear nature, dissipativity and diffusivity. Knowing the
turbulent airflow velocity is not assumed when developing the
model. However, a simplified model implies that the turbulent and
molecular diffusion ratio is a piecewise constant function that
changes depending on vertical distance from the earth surface.
Thereby an important assumption of vertical stratification of urban
air due to atmospheric accumulation of hazardous substances
emitted by motor vehicles is introduced into the mathematical
model. The suggested simplified non-linear mathematical model of
determining the sought exhaust concentration at a priori unknown
turbulent flow velocity through non-degenerate transformation is
reduced to the model which is subsequently solved analytically.
Abstract: In this study, lipase production has been investigated
using submerge fermentation by Aspergillus niger in Kilka fish oil as
main substrate. The Taguchi method with an L9 orthogonal array
design was used to investigate the effect of parameters and their
levels on lipase productivity. The optimum conditions for Kilka fish
oil concentration, incubation temperature and pH were obtained 3
gr./ml 35°C and 7, respectively. The amount of lipase activity in
optimum condition was obtained 4.59IU/ml. By comparing this
amount with the amount of productivity in the olive oil medium
based on the cost of each medium, it was that using Kilka fish oil is
84% economical. Therefore Kilka fish oil can be used as an
economical and suitable substrate in the lipase production and
industrial usages.
Abstract: This paper proposes a solution to the motion planning
and control problem of a point-mass robot which is required to move
safely to a designated target in a priori known workspace cluttered
with fixed elliptical obstacles of arbitrary position and sizes. A
tailored and unique algorithm for target convergence and obstacle
avoidance is proposed that will work for any number of fixed
obstacles. The control laws proposed in this paper also ensures that
the equilibrium point of the given system is asymptotically stable.
Computer simulations with the proposed technique and applications
to a planar (RP) manipulator will be presented.
Abstract: In this paper, the trajectory tracking problem for carlike mobile robots have been studied. The system comprises of a leader and a follower robot. The purpose is to control the follower so that the leader-s trajectory is tracked with arbitrary desired clearance to avoid inter-robot collision while navigating in a terrain with obstacles. A set of artificial potential field functions is proposed using the Direct Method of Lyapunov for the avoidance of obstacles and attraction to their designated targets. Simulation results prove the efficiency of our control technique.
Abstract: The interactions between input/output variables are a very common phenomenon encountered in the design of multi-loop controllers for interacting multivariable processes, which can be a serious obstacle for achieving a good overall performance of multiloop control system. To overcome this impediment, the decomposed dynamic interaction analysis is proposed by decomposing the multiloop control system into a set of n independent SISO systems with the corresponding effective open-loop transfer function (EOTF) within the dynamic interactions embedded explicitly. For each EOTF, the reduced model is independently formulated by using the proposed reduction design strategy, and then the paired multi-loop proportional-integral-derivative (PID) controller is derived quite simply and straightforwardly by using internal model control (IMC) theory. This design method can easily be implemented for various industrial processes because of its effectiveness. Several case studies are considered to demonstrate the superior of the proposed method.
Abstract: This paper deals with condition monitoring of electric switch machine for railway points. Point machine, as a complex electro-mechanical device, switch the track between two alternative routes. There has been an increasing interest in railway safety and the optimal management of railway equipments maintenance, e.g. point machine, in order to enhance railway service quality and reduce system failure. This paper explores the development of Kolmogorov- Smirnov (K-S) test to detect some point failures (external to the machine, slide chairs, fixing, stretchers, etc), while the point machine (inside the machine) is in its proper condition. Time-domain stator Current signatures of normal (healthy) and faulty points are taken by 3 Hall Effect sensors and are analyzed by K-S test. The test is simulated by creating three types of such failures, namely putting a hard stone and a soft stone between stock rail and switch blades as obstacles and also slide chairs- friction. The test has been applied for those three faults which the results show that K-S test can effectively be developed for the aim of other point failures detection, which their current signatures deviate parametrically from the healthy current signature. K-S test as an analysis technique, assuming that any defect has a specific probability distribution. Empirical cumulative distribution functions (ECDF) are used to differentiate these probability distributions. This test works based on the null hypothesis that ECDF of target distribution is statistically similar to ECDF of reference distribution. Therefore by comparing a given current signature (as target signal) from unknown switch state to a number of template signatures (as reference signal) from known switch states, it is possible to identify which is the most likely state of the point machine under analysis.
Abstract: Flow through micro and mini channels requires relatively
high driving pressure due to the large fluid pressure drop
through these channels. Consequently the forces acting on the walls of
the channel due to the fluid pressure are also large. Due to these forces
there are displacement fields set up in the solid substrate containing
the channels. If the movement of the substrate is constrained at some
points, then stress fields are established in the substrate. On the other
hand, if the deformation of the channel shape is sufficiently large
then its effect on the fluid flow is important to be calculated. Such
coupled fluid-solid systems form a class of problems known as fluidstructure
interactions. In the present work a co-located finite volume
discretization procedure on unstructured meshes is described for
solving fluid-structure interaction type of problems. A linear elastic
solid is assumed for which the effect of the channel deformation
on the flow is neglected. Thus the governing equations for the
fluid and the solid are decoupled and are solved separately. The
procedure is validated by solving two benchmark problems, one from
fluid mechanics and another from solid mechanics. A fluid-structure
interaction problem of flow through a U-shaped channel embedded
in a plate is solved.
Abstract: Phytases are acid phosphatase enzymes, which
efficiently cleave phosphate moieties from phytic acid, thereby
generating myo-inositol and inorganic phosphate. Thirty four
isolates of endophytic fungi to produce of phytases were isolated
from leaf, stem and root fragments of soybean. Screening of 34
isolates of endophytic fungi identified the phytases produced by
Rhizoctonia sp. and Fusarium verticillioides . The phytase
production were the best induced by phytic acid and rice bran
compared the others inducer in submerged fermentation medium
used. The phytase produced by both Rhizoctonia sp. and F.
verticillioides have pH optimum at 4.0 and 5.0 respectively. The
characterization of phytase from Fusarium verticillioides showed that
temperature optimum was 500C and stability until 600C, the pH
optimum 5.0 and pH stability was 2.5 – 6.0, and substrate specificity
were rice bran>soybean meal>corn> coconut cake, respectively.
Abstract: Classifying biomedical literature is a difficult and
challenging task, especially when a large number of biomedical
articles should be organized into a hierarchical structure. In this paper,
we present an approach for classifying a collection of biomedical text
abstracts downloaded from Medline database with the help of
ontology alignment. To accomplish our goal, we construct two types
of hierarchies, the OHSUMED disease hierarchy and the Medline
abstract disease hierarchies from the OHSUMED dataset and the
Medline abstracts, respectively. Then, we enrich the OHSUMED
disease hierarchy before adapting it to ontology alignment process for
finding probable concepts or categories. Subsequently, we compute
the cosine similarity between the vector in probable concepts (in the
“enriched" OHSUMED disease hierarchy) and the vector in Medline
abstract disease hierarchies. Finally, we assign category to the new
Medline abstracts based on the similarity score. The results obtained
from the experiments show the performance of our proposed approach
for hierarchical classification is slightly better than the performance of
the multi-class flat classification.
Abstract: One major difficulty that faces developers of
concurrent and distributed software is analysis for concurrency based
faults like deadlocks. Petri nets are used extensively in the
verification of correctness of concurrent programs. ECATNets [2] are
a category of algebraic Petri nets based on a sound combination of
algebraic abstract types and high-level Petri nets. ECATNets have
'sound' and 'complete' semantics because of their integration in
rewriting logic [12] and its programming language Maude [13].
Rewriting logic is considered as one of very powerful logics in terms
of description, verification and programming of concurrent systems.
We proposed in [4] a method for translating Ada-95 tasking
programs to ECATNets formalism (Ada-ECATNet). In this paper,
we show that ECATNets formalism provides a more compact
translation for Ada programs compared to the other approaches based
on simple Petri nets or Colored Petri nets (CPNs). Such translation
doesn-t reduce only the size of program, but reduces also the number
of program states. We show also, how this compact Ada-ECATNet
may be reduced again by applying reduction rules on it. This double
reduction of Ada-ECATNet permits a considerable minimization of
the memory space and run time of corresponding Maude program.
Abstract: As application of re-activation of backside on power
device Insulated Gate Bipolar Transistor (IGBT), laser annealing was
employed to irradiate amorphous silicon substrate, and resistivities
were measured using four point probe measurement. For annealing
the amorphous silicon two lasers were used at wavelength of visible
green (532 nm) together with Infrared (793 nm). While the green
laser efficiently increased temperature at top surface the Infrared
laser reached more deep inside and was effective for melting the
top surface. A finite element method was employed to evaluate time
dependent thermal distribution in silicon substrate.
Abstract: In recent years, Radio Frequency Identification (RFID)
is followed with interest by many researches, especially for the
purpose of indoor positioning as the innate properties of RFID are
profitable for achieving it. A lot of algorithms or schemes are proposed
to be used in the RFID-based positioning system, but most of them are
lack of environmental consideration and it induces inaccuracy of
application. In this research, a lot of algorithms and schemes of RFID
indoor positioning are discussed to see whether effective or not on
application, and some rules are summarized for achieving accurate
positioning. On the other hand, a new term “Noise Factor" is involved
to describe the signal loss between the target and the obstacle. As a
result, experimental data can be obtained but not only simulation; and
the performance of the positioning system can be expressed
substantially.