Abstract: Gene, principal unit of inheritance, is an ordered
sequence of nucleotides. The genes of eukaryotic organisms include
alternating segments of exons and introns. The region of
Deoxyribonucleic acid (DNA) within a gene containing instructions
for coding a protein is called exon. On the other hand, non-coding
regions called introns are another part of DNA that regulates gene
expression by removing from the messenger Ribonucleic acid (RNA)
in a splicing process. This paper proposes to determine splice
junctions that are exon-intron boundaries by analyzing DNA
sequences. A splice junction can be either exon-intron (EI) or intron
exon (IE). Because of the popularity and compatibility of the
artificial neural network (ANN) in genetic fields; various ANN
models are applied in this research. Multi-layer Perceptron (MLP),
Radial Basis Function (RBF) and Generalized Regression Neural
Networks (GRNN) are used to analyze and detect the splice junctions
of gene sequences. 10-fold cross validation is used to demonstrate
the accuracy of networks. The real performances of these networks
are found by applying Receiver Operating Characteristic (ROC)
analysis.
Abstract: The purpose of this paper is to present two different
approaches of financial distress pre-warning models appropriate for
risk supervisors, investors and policy makers. We examine a sample
of the financial institutions and electronic companies of Taiwan
Security Exchange (TSE) market from 2002 through 2008. We
present a binary logistic regression with paned data analysis. With
the pooled binary logistic regression we build a model including
more variables in the regression than with random effects, while the
in-sample and out-sample forecasting performance is higher in
random effects estimation than in pooled regression. On the other
hand we estimate an Adaptive Neuro-Fuzzy Inference System
(ANFIS) with Gaussian and Generalized Bell (Gbell) functions and
we find that ANFIS outperforms significant Logit regressions in both
in-sample and out-of-sample periods, indicating that ANFIS is a
more appropriate tool for financial risk managers and for the
economic policy makers in central banks and national statistical
services.
Abstract: This article experimentally investigates the
thermal performance of thermoelectric air-cooling module
which comprises a thermoelectric cooler (TEC) and an
air-cooling heat sink. The influences of input current and heat
load are determined. And performances under each situation
are quantified by thermal resistance analysis. Since TEC
generates Joule heat, this nature makes construction of thermal
resistance network difficult. To simplify the analysis, this
article emphasizes on the resistance heat load might meet when
passing through the device. Therefore, the thermal resistances
in this paper are to divide temperature differences by heat load.
According to the result, there exists an optimum input current
under every heating power. In this case, the optimum input
current is around 6A or 7A. The performance of the heat sink
would be improved with TEC under certain heating power and
input current, especially at a low heat load. According to the
result, the device can even make the heat source cooler than the
ambient. However, TEC is not always effective at every heat
load and input current. In some situation, the device works
worse than the heat sink without TEC. To determine the
availability of TEC, this study figures out the effective
operating region in which the TEC air-cooling module works
better than the heat sink without TEC. The result shows that
TEC is more effective at a lower heat load. If heat load is too
high, heat sink with TEC will perform worse than without TEC.
The limit of this device is 57W. Besides, TEC is not helpful if
input current is too high or too low. There is an effective range
of input current, and the range becomes narrower when the heat
load grows.
Abstract: This paper proposes a modeling methodology for the
development of data analysis solution. The Author introduce the
approach to address data warehousing issues at the at enterprise level.
The methodology covers the process of the requirements eliciting and
analysis stage as well as initial design of data warehouse. The paper
reviews extended business process model, which satisfy the needs of
data warehouse development. The Author considers that the use of
business process models is necessary, as it reflects both enterprise
information systems and business functions, which are important for
data analysis. The Described approach divides development into
three steps with different detailed elaboration of models. The
Described approach gives possibility to gather requirements and
display them to business users in easy manner.
Abstract: The dynamic behaviour of a four-bar linkage driven by a velocity controlled DC motor is discussed in the paper. In particular the author presents the results obtained by means of a specifically developed software, which implements the mathematical models of all components of the system (linkage, transmission, electric motor, control devices). The use of this software enables a more efficient design approach, since it allows the designer to check, in a simple and immediate way, the dynamic behaviour of the mechanism, arising from different values of the system parameters.
Abstract: Wavelet transform or wavelet analysis is a recently
developed mathematical tool in applied mathematics. In numerical
analysis, wavelets also serve as a Galerkin basis to solve partial
differential equations. Haar transform or Haar wavelet transform has
been used as a simplest and earliest example for orthonormal wavelet
transform. Since its popularity in wavelet analysis, there are several
definitions and various generalizations or algorithms for calculating
Haar transform. Fast Haar transform, FHT, is one of the algorithms
which can reduce the tedious calculation works in Haar transform. In
this paper, we present a modified fast and exact algorithm for FHT,
namely Modified Fast Haar Transform, MFHT. The algorithm or
procedure proposed allows certain calculation in the process
decomposition be ignored without affecting the results.
Abstract: Development of motor car safety devices has reduced
fatality rates in car accidents. Yet despite this increase in car safety,
neck injuries resulting from rear impact collisions, particularly at low
speed, remain a primary concern. In this study, FEA(Finite Element
Analysis) of seat was performed to evaluate neck injuries in rear
impact. And the FEA result was verified by comparison with the actual
test results. The dummy used in FE model and actual test is BioRID II
which is regarded suitable for rear impact collision analysis. A
threshold of the BioRID II neck injury indicators was also proposed to
upgrade seat performance in order to reduce whiplash injury. To
optimize the seat for a low-speed rear impact collision, a method was
proposed, which is multi-objective optimization idea using DOE
(Design of Experiments) results.
Abstract: Ethanol is generally used as a therapeutic reagent against Hepatocellular carcinoma (HCC or hepatoma) worldwide, as it can induce Hepatocellular carcinoma cell apoptosis at low concentration through a multifactorial process regulated by several unknown proteins. This paper provides a simple and available proteomic strategy for exploring differentially expressed proteins in the apoptotic pathway. The appropriate concentrations of ethanol required to induce HepG2 cell apoptosis were first assessed by MTT assay, Gisma and fluorescence staining. Next, the central proteins involved in the apoptosis pathway processs were determined using 2D-PAGE, SDS-PAGE, and bio-software analysis. Finally the downregulation of two proteins, AFP and survivin, were determined by immunocytochemistry and reverse transcriptase PCR (RT-PCR) technology. The simple, useful method demonstrated here provides a new approach to proteomic analysis in key bio-regulating process including proliferation, differentiation, apoptosis, immunity and metastasis.
Abstract: 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) catalyzes the conversion of HMG-CoA to mevalonate using NADPH and the enzyme is involved in rate-controlling step of mevalonate. Inhibition of HMGR is considered as effective way to lower cholesterol levels so it is drug target to treat hypercholesterolemia, major risk factor of cardiovascular disease. To discover novel HMGR inhibitor, we performed structure-based pharmacophore modeling combined with molecular dynamics (MD) simulation. Four HMGR inhibitors were used for MD simulation and representative structure of each simulation were selected by clustering analysis. Four structure-based pharmacophore models were generated using the representative structure. The generated models were validated used in virtual screening to find novel scaffolds for inhibiting HMGR. The screened compounds were filtered by applying drug-like properties and used in molecular docking. Finally, four hit compounds were obtained and these complexes were refined using energy minimization. These compounds might be potential leads to design novel HMGR inhibitor.
Abstract: In this paper, we present a new algorithm for clustering data in large datasets using image processing approaches. First the dataset is mapped into a binary image plane. The synthesized image is then processed utilizing efficient image processing techniques to cluster the data in the dataset. Henceforth, the algorithm avoids exhaustive search to identify clusters. The algorithm considers only a small set of the data that contains critical boundary information sufficient to identify contained clusters. Compared to available data clustering techniques, the proposed algorithm produces similar quality results and outperforms them in execution time and storage requirements.
Abstract: Data envelopment analysis (DEA) has gained great popularity in environmental performance measurement because it can provide a synthetic standardized environmental performance index when pollutants are suitably incorporated into the traditional DEA framework. Since some of the environmental performance indicators cannot be controlled by companies managers, it is necessary to develop the model in a way that it could be applied when discretionary and/or non-discretionary factors were involved. In this paper, we present a semi-radial DEA approach to measuring environmental performance, which consists of non-discretionary factors. The model, then, has been applied on a real case.
Abstract: In the automotive industry test drives are being conducted
during the development of new vehicle models or as a part of
quality assurance of series-production vehicles. The communication
on the in-vehicle network, data from external sensors, or internal
data from the electronic control units is recorded by automotive
data loggers during the test drives. The recordings are used for fault
analysis. Since the resulting data volume is tremendous, manually
analysing each recording in great detail is not feasible.
This paper proposes to use machine learning to support domainexperts
by preventing them from contemplating irrelevant data and
rather pointing them to the relevant parts in the recordings. The
underlying idea is to learn the normal behaviour from available
recordings, i.e. a training set, and then to autonomously detect
unexpected deviations and report them as anomalies.
The one-class support vector machine “support vector data description”
is utilised to calculate distances of feature vectors. SVDDSUBSEQ
is proposed as a novel approach, allowing to classify subsequences
in multivariate time series data. The approach allows to
detect unexpected faults without modelling effort as is shown with
experimental results on recordings from test drives.
Abstract: Nevertheless the widespread application of finite
mixture models in segmentation, finite mixture model selection is
still an important issue. In fact, the selection of an adequate number
of segments is a key issue in deriving latent segments structures and
it is desirable that the selection criteria used for this end are effective.
In order to select among several information criteria, which may
support the selection of the correct number of segments we conduct a
simulation study. In particular, this study is intended to determine
which information criteria are more appropriate for mixture model
selection when considering data sets with only categorical
segmentation base variables. The generation of mixtures of
multinomial data supports the proposed analysis. As a result, we
establish a relationship between the level of measurement of
segmentation variables and some (eleven) information criteria-s
performance. The criterion AIC3 shows better performance (it
indicates the correct number of the simulated segments- structure
more often) when referring to mixtures of multinomial segmentation
base variables.
Abstract: Solid fuel transient burning behavior under oxidizer
gas flow is numerically investigated. It is done using analysis of the
regression rate responses to the imposed sudden and oscillatory
variation at inflow properties. The conjugate problem is considered
by simultaneous solution of flow and solid phase governing
equations to compute the fuel regression rate. The advection
upstream splitting method is used as flow computational scheme in
finite volume method. The ignition phase is completely simulated to
obtain the exact initial condition for response analysis. The results
show that the transient burning effects which lead to the combustion
instabilities and intermittent extinctions could be observed in solid
fuels as the solid propellants.
Abstract: Analysis for the propagation of elastic waves in
arbitrary anisotropic plates is investigated, commencing with a
formal analysis of waves in a layered plate of an arbitrary anisotropic
media, the dispersion relations of elastic waves are obtained by
invoking continuity at the interface and boundary of conditions on
the surfaces of layered plate. The obtained solutions can be used for
material systems of higher symmetry such as monoclinic,
orthotropic, transversely isotropic, cubic, and isotropic as it is
contained implicitly in the analysis. The cases of free layered plate
and layered half space are considered separately. Some special cases
have also been deduced and discussed. Finally numerical solution of
the frequency equations for an aluminum epoxy is carried out, and
the dispersion curves for the few lower modes are presented. The
results obtained theoretically have been verified numerically and
illustrated graphically.
Abstract: This document details the process of developing a
wireless device that captures the basic movements of the foot (plantar
flexion, dorsal flexion, abduction, adduction.), and the knee
movement (flexion). It implements a motion capture system by using
a hardware based on optical fiber sensors, due to the advantages in
terms of scope, noise immunity and speed of data transmission and
reception. The operating principle used by this system is the detection
and transmission of joint movement by mechanical elements and
their respective measurement by optical ones (in this case infrared).
Likewise, Visual Basic software is used for reception, analysis and
signal processing of data acquired by the device, generating a 3D
graphical representation in real time of each movement. The result is
a boot in charge of capturing the movement, a transmission module
(Implementing Xbee Technology) and a receiver module for
receiving information and sending it to the PC for their respective
processing.
The main idea with this device is to help on topics such as
bioengineering and medicine, by helping to improve the quality of
life and movement analysis.
Abstract: This study numerically investigates the effects of Electrohydrodynamic on flow patterns and heat transfer enhancement within a cavity which is on the lower wall of channel. In this simulation, effects of using ground wire and ground plate on the flow patterns are compared. Moreover, the positions of electrode wire respecting with ground are tested in the range of angles θ = 0 - 180o. High electrical voltage exposes to air is 20 kV. Bulk mean velocity and temperature of inlet air are controlled at 0.1 m/s and 60 OC, respectively. The result shows when electric field is applied, swirling flow is appeared in the channel. In addition, swirling flow patterns in the main flow of using ground plate are widely spreader than that of using ground wire. Moreover, direction of swirling flow also affects the flow pattern and heat transfer in a cavity. These cause the using ground wire to give the maximum temperature and heat transfer higher than using ground plate. Furthermore, when the angle is at θ = 60o, high shear flow effect is obtained. This results show high strength of swirling flow and effective heat transfer enhancement.
Abstract: Children with hemiplgic cerebral palsy often walk
with diminished reciprocal arm swing so the purpose of this study
was to describe kinematic characteristics in children with hemiplegic
cerebral palsy (CP) during the gait suphases, and find if there is a
correlation between upper(shoulder and elbow) and lower(hip, knee,
and ankle) limb joints either in involved or uninvolved.48 children
with hemiplegic cerebral palsy (18boys, 30girls) with an average age
of (5.1±0.87) years were selected randomly to evaluate joint angles
during gait by 3D motion analysis system with 6 pro reflex cameras
in a sagittal plane for both sides of the body. The results showed
increased shoulder and elbow flexion, increased hip angular
displacement, decreased knee and ankle arcs during gait cycle, also
there is correlation between shoulder and elbow to hip, knee, and
ankle joints during various subphases of gait.
Abstract: The coverage probability and range of IEEE 802.16
systems depend on different wireless scenarios. Evaluating the
performance of IEEE 802.16 systems over Stanford University
Interim (SUI) channels is suggested by IEEE 802.16 specifications.
In order to derive an effective method for forecasting the coverage
probability and range, this study uses the SUI channel model to
analyze the coverage probability with Rayleigh fading for an IEEE
802.16 system. The BER of the IEEE 802.16 system is shown in the
simulation results. Then, the maximum allowed path loss can be
calculated and substituted into the coverage analysis. Therefore,
simulation results show the coverage range with and without
Rayleigh fading.
Abstract: In this paper a three dimensional thermal model of a
sliding contact system is proposed for both steady-state or transient
conditions. The influence of contact force, electric current and
ambient temperature on the temperature distribution, has been
investigated. A thermal analysis of the different type of the graphite
material of fixed electric contact and its influence on contact system
temperature rise, has been performed. To validate the three
dimensional thermal model, some experimental tests have been done.
There is a good correlation between experimental and simulation
results.