Abstract: Using the pseudopotential technique the Sagdeev
potential equation has been derived in a plasma consisting of twotemperature
nonisothermal electrons, negatively charged dust grains
and warm positive ions. The study shows that the presence of
nonisothermal two-temperature electrons and charged dust grains
have significant effects on the excitation and structure of the ionacoustic
double layers in the model plasma under consideration. Only
compressive type double layer is obtained in the present plasma
model. The double layer solution has also been obtained by including
higher order nonlinearity and nonisothermality, which is shown to
modify the amplitude and deform the shape of the double layer.
Abstract: The article deals with modelling of the fire
pragmatism in the area of military management and its experimental
verification. Potential approaches are based on the synergy of
mathematical and theoretical ideas, operational and tactical
requirements and the military decision-making process. This issue
has taken on importance in recent times, particularly with the
increasing trend of digitized battlefield, the development of C4ISR
systems and intention to streamline the command and control process
at the lowest levels of command. From fundamental and
philosophical point of view, these new approaches seek to
significantly upgrade and enhance the decision-making process of the
tactical commanders.
Abstract: Enterococci are important inhabitants of the animal
intestine and are widely used in probiotic products. A probiotic strain
is expected to possess several desirable properties in order to exert
beneficial effects. Therefore, the objective of this study was to
isolate, characterize and identify Enterococcus sp. from chicken cecal
and fecal samples to determine potential probiotic properties.
Enterococci were isolated from chicken ceca and feces of thirty three
clinically healthy chickens from a local farm. In vitro studies were
performed to assess antibacterial activity of the isolated LAB (using
agar well diffusion and cell free supernatant broth technique against
Salmonella enterica serotype Enteritidis), survival in acidic
conditions, resistance to bile salts, and their survival during simulated
gastric juice conditions at pH 2.5. Isolates were identified by
biochemical carbohydrate fermentation patterns using an API 50
CHL kit and API ZYM kits and by sequenced 16S rDNA. An isolate
belonging to E. faecium species exhibited inhibitory effect against S.
enteritidis. This isolate producing a clear zone as large as 10.30 mm
or greater and was able to grow in the coculture medium and at the
same time, inhibited the growth S. enteritidis. In addition, E. faecium
exhibited significant resistance under highly acidic conditions at pH
2.5 for 8 h and survived well in bile salt at 0.2% for 24 h and showing
ability to survive in the presence of simulated gastric juice at pH 2.5.
Based on these results, E. faecium isolate fulfills some of the criteria
to be considered as a probiotic strain and therefore, could be used as a
feed additive with good potential for controlling S. Enteritidis in
chickens. However, in vivo studies are needed to determine the safety
of the strain.
Abstract: MSMEs are regarded as the sunrise sector of the
Indian economy in view of its large potential for growth and likely
socio economic impact specifically on employment and income
generation. In today’s competitive business environment, global
competition forces companies to continuously seek ways of
improving their products and services. The pressure on organizations
to adapt to new technologies and external threats requires
resourcefulness, creativity and innovation. Market has become more
open, competitive and customers more demanding. Without
continuous technology innovation, no organization can ever remain
competitive. Innovations reflect a critical way in which organizations
respond to either technological or market challenges. The need of the
market is to deliver high quality products through continuous
changing in features in product, improve existing products, reduce
their cost, and improve employee skills, training, technology
infrastructure and financial policies. Therefore, the key factor of
organization’s ability to change is innovation. The study presents a
detailed review of literature on the role of technology innovation in
improving manufacturing performance of industries.
Abstract: Africa enjoys some of the best solar radiation levels in
the world averaging between 4-6 kWh/m2/day for most of the year
and the global economic and political conditions that tend to make
African countries more dependent on their own energy resources
have caused growing interest in renewable energy based
technologies. However to-date, implementation of modern Energy
Technologies in Africa is still very low especially the use of solar
conversion technologies. This paper presents literature review and
analysis relating to the techno-economic feasibility of solar
photovoltaic power generation in Africa. The literature is basically
classified into the following four main categories. Techno-economic
feasibility of solar photovoltaic power generation, design methods,
performance evaluations of various systems and policy of potential
future of technological development of photovoltaic (PV) in Africa
by exploring the impact of alternative policy instruments and
technology cost reductions on the financial viability of investing solar
photovoltaic in Africa.
Abstract: In this paper, we used data mining to extract
biomedical knowledge. In general, complex biomedical data
collected in studies of populations are treated by statistical methods,
although they are robust, they are not sufficient in themselves to
harness the potential wealth of data. For that you used in step two
learning algorithms: the Decision Trees and Support Vector Machine
(SVM). These supervised classification methods are used to make the
diagnosis of thyroid disease. In this context, we propose to promote
the study and use of symbolic data mining techniques.
Abstract: Emissions of atmospheric pollutants from ships and
harbour activities are a growing concern at international level given
their potential impacts on air quality and climate. These close-to-land
emissions have potential impact on local communities in terms of air
quality and health. Recent studies show that the impact of maritime
traffic to atmospheric particulate matter concentrations in several
coastal urban areas is comparable with the impact of road traffic of a
medium size town. However, several different approaches have been
used for these estimates making difficult a direct comparison of
results. In this work, an integrated approach based on emission
inventories and dedicated measurement campaigns has been applied
to give a comparable estimate of the impact of maritime traffic to
PM2.5 and particle number concentrations in three major harbours of
the Adriatic/Ionian Seas. The influences of local meteorology and of
the logistic layout of the harbours are discussed.
Abstract: In this study, we compare the profiles of transitory
hybrid entrepreneurs and persistent hybrid entrepreneurs to determine
how they differ. Hybrid entrepreneurs (HEs) represent a significant
share of entrepreneurial activity yet little is known about them. We
define HEs as individuals who are active as entrepreneurs but do no
support themselves primarily by their enterprise. Persistent HEs
(PHEs) are not planning to transition to fulltime entrepreneurship
whereas transitory HEs (THEs) consider it probable. Our results
show that THEs and PHEs are quite similar in background. THEs are
more interested in increasing their turnover than PHEs, as expected,
but also emphasize self-fulfillment as a motive for entrepreneurship
more than PHEs. The clearest differences between THEs and PHEs
are found in their views on how well their immediate circle supports
full-time entrepreneurship, and their views of their own
entrepreneurial abilities and the market potential of their firm. Our
results support earlier arguments that hybrids should be considered
separately in research on entrepreneurial entry and self-employment.
Abstract: Over the past few years, the online multimedia
collection has grown at a fast pace. Several companies showed
interest to study the different ways to organise the amount of audio
information without the need of human intervention to generate
metadata. In the past few years, many applications have emerged on
the market which are capable of identifying a piece of music in a
short time. Different audio effects and degradation make it much
harder to identify the unknown piece. In this paper, an audio
fingerprinting system which makes use of a non-parametric based
algorithm is presented. Parametric analysis is also performed using
Gaussian Mixture Models (GMMs). The feature extraction methods
employed are the Mel Spectrum Coefficients and the MPEG-7 basic
descriptors. Bin numbers replaced the extracted feature coefficients
during the non-parametric modelling. The results show that nonparametric
analysis offer potential results as the ones mentioned in
the literature.
Abstract: Natural hydrocarbon seepage has helped petroleum
exploration as a direct indicator of gas and/or oil subsurface
accumulations. Surface macro-seeps are generally an indication of a
fault in an active Petroleum Seepage System belonging to a Total
Petroleum System. This paper describes a case study in which
multiple analytical techniques were used to identify and characterize
trace petroleum-related hydrocarbons and other volatile organic
compounds in groundwater samples collected from Sousse aquifer
(Central Tunisia). The analytical techniques used for analyses of
water samples included gas chromatography-mass spectrometry (GCMS),
capillary GC with flame-ionization detection, Compound
Specific Isotope Analysis, Rock Eval Pyrolysis. The objective of the
study was to confirm the presence of gasoline and other petroleum
products or other volatile organic pollutants in those samples in order
to assess the respective implication of each of the potentially
responsible parties to the contamination of the aquifer. In addition,
the degree of contamination at different depths in the aquifer was also
of interest. The oil and gas seeps have been investigated using
biomarker and stable carbon isotope analyses to perform oil-oil and
oil-source rock correlations. The seepage gases are characterized by
high CH4 content, very low δ13CCH4 values (-71,9 ‰) and high
C1/C1–5 ratios (0.95–1.0), light deuterium–hydrogen isotope ratios (-
198 ‰) and light δ13CC2 and δ13CCO2 values (-23,8‰ and-23,8‰
respectively) indicating a thermogenic origin with the contribution of
the biogenic gas. An organic geochemistry study was carried out on
the more ten oil seep samples. This study includes light hydrocarbon
and biomarkers analyses (hopanes, steranes, n-alkanes, acyclic
isoprenoids, and aromatic steroids) using GC and GC-MS. The
studied samples show at least two distinct families, suggesting two
different types of crude oil origins: the first oil seeps appears to be
highly mature, showing evidence of chemical and/or biological
degradation and was derived from a clay-rich source rock deposited
in suboxic conditions. It has been sourced mainly by the lower
Fahdene (Albian) source rocks. The second oil seeps was derived
from a carbonate-rich source rock deposited in anoxic conditions,
well correlated with the Bahloul (Cenomanian-Turonian) source rock.
Abstract: The paper deals with behaviour of the segment 50+ in
the financial market in the Czech Republic. This segment could be
said as the strong market power and it can be a crucial business
potential for financial business units. The main defined objective of
this paper is analysis of the customers´ behaviour of the segment 50-
60 years in the financial market in the Czech Republic and proposal
making of the suitable marketing approach to satisfy their demands in
the area of product, price, distribution and marketing communication
policy. This paper is based on data from one part of primary
marketing research. Paper determinates the basic problem areas as
well as definition of financial services marketing, defining the
primary research problem, hypothesis and primary research
methodology. Finally suitable marketing approach to selected sub
segment at age of 50-60 years is proposed according to marketing
research findings.
Abstract: Diminished antioxidant defense or increased
production of reactive oxygen species in the biological system can
result in oxidative stress which may lead to various
neurodegenerative diseases including Alzheimer’s disease (AD).
Microglial activation also contributes to the progression of AD by
producing several proinflammatory cytokines, nitric oxide (NO) and
prostaglandin E2 (PGE2). Oxidative stress and inflammation have
been reported to be possible pathophysiological mechanisms
underlying AD. In addition, the cholinergic hypothesis postulates that
memory impairment in patient with AD is also associated with the
deficit of cholinergic function in the brain. Although a number of
drugs have been approved for the treatment of AD, most of these
synthetic drugs have diverse side effects and yield relatively modest
benefits. Marine algae have great potential in pharmaceutical and
biomedical applications as they are valuable sources of bioactive
properties such as anticoagulation, antimicrobial, antioxidative,
anticancer and anti-inflammatory. Hence, this study aimed to provide
an overview of the properties of Malaysian seaweeds (Padina
australis, Sargassum polycystum and Caulerpa racemosa) in
inhibiting oxidative stress, neuroinflammation and cholinesterase
enzymes. These seaweeds significantly exhibited potent DPPH and
moderate superoxide anion radical scavenging ability (P
Abstract: Due to the rapid increase of Internet, web opinion
sources dynamically emerge which is useful for both potential
customers and product manufacturers for prediction and decision
purposes. These are the user generated contents written in natural
languages and are unstructured-free-texts scheme. Therefore, opinion
mining techniques become popular to automatically process customer
reviews for extracting product features and user opinions expressed
over them. Since customer reviews may contain both opinionated and
factual sentences, a supervised machine learning technique applies
for subjectivity classification to improve the mining performance. In
this paper, we dedicate our work is the task of opinion
summarization. Therefore, product feature and opinion extraction is
critical to opinion summarization, because its effectiveness
significantly affects the identification of semantic relationships. The
polarity and numeric score of all the features are determined by
Senti-WordNet Lexicon. The problem of opinion summarization
refers how to relate the opinion words with respect to a certain
feature. Probabilistic based model of supervised learning will
improve the result that is more flexible and effective.
Abstract: With drug resistance becoming widespread in
Plasmodium falciparum infections, the development of the alternative
drugs is the desired strategy for prevention and cure of malaria. Three
drug targets were selected to screen promising drug molecules from
the GSK library of 13469 molecules. Using an in silico structure-based
drug designing approach, the differences in binding energies of
the substrate and inhibitor were exploited between target sites of
parasite and human to design a drug molecule against Plasmodium.
The docking studies have shown several promising molecules from
GSK library with more effective binding as compared to the already
known inhibitors for the drug targets. Though stronger interaction has
been shown by several molecules as compared to the reference, few
molecules have shown the potential as drug candidates though in
vitro studies are required to validate the results. In case of
thymidylate synthase-dihydrofolatereductase (TS-DHFR), three
compounds have shown promise for future studies as potential drugs.
Abstract: Livestock is one of the fastest-growing sectors in
agriculture. If carefully managed, have potential opportunities for
economic growth, food sovereignty and food security. In this study
we mainly analyse and compare long-term i.e. for year 2030 climate
variability impact on predicted productivity of meat i.e. beef, mutton
and poultry for the Kingdom of Saudi Arabia w.r.t three factors i.e. i)
climatic-change vulnerability ii) CO2 fertilization and iii) water
scarcity and compare the results with two countries of the region i.e.
Iraq and Yemen. We do the analysis using data from diverse sources,
which was extracted, transformed and integrated before usage. The
collective impact of the three factors had an overall negative effect on
the production of meat for all the three countries, with adverse impact
on Iraq. High similarity was found between CO2 fertilization
(effecting animal fodder) and water scarcity i.e. higher than that
between production of beef and mutton for the three countries
considered. Overall, the three factors do not seem to be favorable for
the three Middle-East countries considered. This points to possibility
of a vegetarian year 2030 based on dependency on indigenous livestock
population.
Abstract: Risk analysis is considered as a fundamental aspect
relevant for ensuring the level of critical infrastructure protection,
where the critical infrastructure is seen as system, asset or its part
which is important for maintaining the vital societal functions. Article
actually discusses and analyzes the potential application of selected
tools of information support for the implementation and within the
framework of risk analysis and critical infrastructure protection. Use
of the information in relation to their risk analysis can be viewed as a
form of simplifying the analytical process. It is clear that these
instruments (information support) for these purposes are countless, so
they were selected representatives who have already been applied in
the selected area of critical infrastructure, or they can be used. All
presented fact were the basis for critical infrastructure resilience
evaluation methodology development.
Abstract: The Cone Penetration Test (CPT) is a common in-situ
test which generally investigates a much greater volume of soil more
quickly than possible from sampling and laboratory tests. Therefore,
it has the potential to realize both cost savings and assessment of soil
properties rapidly and continuously. The principle objective of this
paper is to demonstrate the feasibility and efficiency of using
artificial neural networks (ANNs) to predict the soil angle of internal
friction (Φ) and the soil modulus of elasticity (E) from CPT results
considering the uncertainties and non-linearities of the soil. In
addition, ANNs are used to study the influence of different
parameters and recommend which parameters should be included as
input parameters to improve the prediction. Neural networks discover
relationships in the input data sets through the iterative presentation
of the data and intrinsic mapping characteristics of neural topologies.
General Regression Neural Network (GRNN) is one of the powerful
neural network architectures which is utilized in this study. A large
amount of field and experimental data including CPT results, plate
load tests, direct shear box, grain size distribution and calculated data
of overburden pressure was obtained from a large project in the
United Arab Emirates. This data was used for the training and the
validation of the neural network. A comparison was made between
the obtained results from the ANN's approach, and some common
traditional correlations that predict Φ and E from CPT results with
respect to the actual results of the collected data. The results show
that the ANN is a very powerful tool. Very good agreement was
obtained between estimated results from ANN and actual measured
results with comparison to other correlations available in the
literature. The study recommends some easily available parameters
that should be included in the estimation of the soil properties to
improve the prediction models. It is shown that the use of friction
ration in the estimation of Φ and the use of fines content in the
estimation of E considerable improve the prediction models.
Abstract: Human leukocyte antigen (HLA) typing from next
generation sequencing (NGS) data has the potential for applications in
clinical laboratories and population genetic studies. Here we introduce
a novel technique for HLA typing from NGS data based on
read-mapping using a comprehensive reference panel containing all
known HLA alleles and de novo assembly of the gene-specific short
reads. An accurate HLA typing at high-digit resolution was achieved
when it was tested on publicly available NGS data, outperforming
other newly-developed tools such as HLAminer and PHLAT.
Abstract: Doxorubicin, also known as Adriamycin, is an
anthracycline class of drug used in cancer chemotherapy. It is used in
the treatment of non-Hodgkin’s lymphoma, multiple myeloma, acute
leukemia, breast cancer, lung cancer, endometrium cancer and ovary
cancers. It functions via intercalating DNA and ultimately killing
cancer cells. The major side effects of doxorubicin are hair loss,
myelosuppression, nausea & vomiting, oesophagitis, diarrhea, heart
damage and liver dysfunction. The minor modifications in the
structure of compound exhibit large variation in the biological
activity, has prompted us to carry out the synthesis of sulfonamide
derivatives. Sulfonamide is an important feature with broad spectrum
of biological activity such as antiviral, antifungal, diuretics, antiinflammatory,
antibacterial and anticancer activities. Structure of the
synthesized compound N-(1-methyl-2-oxo-2-N-methyl anilinoethyl)
benzene sulfonamide confirmed by proton nuclear magnetic
resonance (1H NMR),13C NMR, Mass and FTIR spectroscopic tools
to assure the position of all protons and hence stereochemistry of the
molecule. Further we have reported the binding potential of
synthesized sulfonamide analogues in comparison to doxorubicin
drug using Auto Dock 4.2 software. Computational binding energy
(B.E.) and inhibitory constant (Ki) has been evaluated for the
synthesized compound in comparison of doxorubicin against Poly
(dA-dT).Poly (dA-dT) and Poly (dG-dC).Poly (dG-dC) sequences.
The in vitro cytotoxic study against human breast cancer cell lines
confirms the better anticancer activity of the synthesized compound
over currently in use anticancer drug doxorubicin. The IC50 value of
the synthesized compound is 7.12 μM whereas for doxorubicin is 7.2
μM.
Abstract: Operations, maintenance and reliability of wind
turbines have received much attention over the years due to the rapid
expansion of wind farms. This paper explores early fault diagnosis
technique for a 5MW wind turbine system subjected to multiple
faults, where genetic optimization algorithm is employed to make the
residual sensitive to the faults, but robust against disturbances. The
proposed technique has a potential to reduce the downtime mostly
caused by the breakdown of components and exploit the productivity
consistency by providing timely fault alarms. Simulation results show
the effectiveness of the robust fault detection methods used under
Matlab/Simulink/Gatool environment.