Abstract: Doxorubicin, also known as Adriamycin, is an
anthracycline class of drug used in cancer chemotherapy. It is used in
the treatment of non-Hodgkin’s lymphoma, multiple myeloma, acute
leukemia, breast cancer, lung cancer, endometrium cancer and ovary
cancers. It functions via intercalating DNA and ultimately killing
cancer cells. The major side effects of doxorubicin are hair loss,
myelosuppression, nausea & vomiting, oesophagitis, diarrhea, heart
damage and liver dysfunction. The minor modifications in the
structure of compound exhibit large variation in the biological
activity, has prompted us to carry out the synthesis of sulfonamide
derivatives. Sulfonamide is an important feature with broad spectrum
of biological activity such as antiviral, antifungal, diuretics, antiinflammatory,
antibacterial and anticancer activities. Structure of the
synthesized compound N-(1-methyl-2-oxo-2-N-methyl anilinoethyl)
benzene sulfonamide confirmed by proton nuclear magnetic
resonance (1H NMR),13C NMR, Mass and FTIR spectroscopic tools
to assure the position of all protons and hence stereochemistry of the
molecule. Further we have reported the binding potential of
synthesized sulfonamide analogues in comparison to doxorubicin
drug using Auto Dock 4.2 software. Computational binding energy
(B.E.) and inhibitory constant (Ki) has been evaluated for the
synthesized compound in comparison of doxorubicin against Poly
(dA-dT).Poly (dA-dT) and Poly (dG-dC).Poly (dG-dC) sequences.
The in vitro cytotoxic study against human breast cancer cell lines
confirms the better anticancer activity of the synthesized compound
over currently in use anticancer drug doxorubicin. The IC50 value of
the synthesized compound is 7.12 μM whereas for doxorubicin is 7.2
μM.
Abstract: Formal verification is proposed to ensure the
correctness of the design and make functional verification more
efficient. As cache plays a vital role in the design of System on Chip
(SoC), and cache with Memory Management Unit (MMU) and cache
memory unit makes the state space too large for simulation to verify,
then a formal verification is presented for such system design. In the
paper, a formal model checking verification flow is suggested and a
new cache memory model which is called “exhaustive search model”
is proposed. Instead of using large size ram to denote the whole cache
memory, exhaustive search model employs just two cache blocks. For
cache system contains data cache (Dcache) and instruction cache
(Icache), Dcache memory model and Icache memory model are
established separately using the same mechanism. At last, the novel
model is employed to the verification of a cache which is module of a
custom-built SoC system that has been applied in practical, and the
result shows that the cache system is verified correctly using the
exhaustive search model, and it makes the verification much more
manageable and flexible.
Abstract: As the economies of other countries in the
Mediterranean Basin, the tourism sector in our country has a high
denominator in economics. Tourism businesses, which are building
blocks of tourism, sector faces with a variety of problems during their
activities. These problems faced make business efficiency and
competition conditions of the businesses difficult. Most of the
problems faced by the tourism businesses and the information of
consumers about consumers’ rights were used in this study, which is
conducted to determine the problems of tourism businesses in the
Central Anatolia Region. It is aimed to contribute the awareness of
staff and executives working at tourism sector and to attract attention
of businesses active concurrently with tourism sector and legislators.
Abstract: In this paper, we regard as a coded transmission over a
frequency-selective channel. We plan to study analytically the
convergence of the turbo-detector using a maximum a posteriori
(MAP) equalizer and a MAP decoder. We demonstrate that the
densities of the maximum likelihood (ML) exchanged during the
iterations are e-symmetric and output-symmetric. Under the Gaussian
approximation, this property allows to execute a one-dimensional
scrutiny of the turbo-detector. By deriving the analytical terminology
of the ML distributions under the Gaussian approximation, we confirm
that the bit error rate (BER) performance of the turbo-detector
converges to the BER performance of the coded additive white
Gaussian noise (AWGN) channel at high signal to noise ratio (SNR),
for any frequency selective channel.
Abstract: A quartz crystal microbalance (QCM) nanosensor was developed to detect lysozyme enzyme by functionalizing its gold surface with the attachment of poly(methacroyl-L-phenylalanine) (PMAPA) nanoparticles. PMAPA was chosen as a hydrophobic matrix. The hydrophobic nanoparticles were synthesized by micro-emulsion polymerization method. Hydrophobic QCM nanosensor was tested for real time detection of lysozyme enzyme from aqueous solution. The kinetic and affinity studies were determined by using lysozyme solutions with different concentrations. The responses related with mass (Δm) and frequency (Δf) shifts were used to evaluate adsorption properties.
Abstract: The aim of research was to define the relations
between volatile compounds, some parameters (pH, titratable acidity
(TA), total soluble solid (TSS), lactic acid bacteria count) and
consumer preference of commercial fermented milks. These relations
tend to be used for controlling and developing new fermented milk
product. Three leading commercial brands of fermented milks in
Thailand were evaluated by consumers (n=71) using hedonic scale
for four attributes (sweetness, sourness, flavour, and overall liking),
volatile compounds using headspace-solid phase microextraction
(HS-SPME) GC-MS, pH, TA, TSS and LAB count. Then the
relations were analyzed by principal component analysis (PCA). The
PCA data showed that all of four attributes liking scores were related
to each other. They were also related to TA, TSS and volatile
compounds. The related volatile compounds were mainly on
fermented produced compounds including acetic acid, furanmethanol,
furfural, octanoic acid and the volatiles known as artificial fruit
flavour (beta pinene, limonene, vanillin, and ethyl vanillin). These
compounds were provided the information about flavour addition in
commercial fermented milk in Thailand.
Abstract: Operations, maintenance and reliability of wind
turbines have received much attention over the years due to the rapid
expansion of wind farms. This paper explores early fault diagnosis
technique for a 5MW wind turbine system subjected to multiple
faults, where genetic optimization algorithm is employed to make the
residual sensitive to the faults, but robust against disturbances. The
proposed technique has a potential to reduce the downtime mostly
caused by the breakdown of components and exploit the productivity
consistency by providing timely fault alarms. Simulation results show
the effectiveness of the robust fault detection methods used under
Matlab/Simulink/Gatool environment.
Abstract: The purpose of this presentation is to describe an interdisciplinary teaching program that integrates physical education concepts using a philosophical approach. The presentation includes a review of: a) the philosophy of American education, b) the philosophy of sports and physical education, c) the interdisciplinary physical education program, d) professional development programs, (e) the Success of this physical education program, f) future of physical education. This unique interdisciplinary program has been implemented in an urban school physical education discipline in East Orange, New Jersey for over 10 years.
During the program the students realize that the bodies go through different experiences. The body becomes a place where a child can recognize in an enjoyable way to express and perceive particular feelings or mental states. Children may distinguish themselves to have high abilities in the social or other domains but low abilities in the field of athletics.
The goal of this program for the individuals is to discover new skills, develop and demonstrate age appropriate mastery level at different tasks, therefore the program consists of 9 to 12 sports, including many game. Each successful experience increases the awareness ability. Engaging in sports and physical activities are social movements involving groups of children in situations such as teams, friends, and recreational settings, which serve as a primary socializing agent for teaching interpersonal skills. As a result of this presentation the audience will reflect and explore how to structure a physical education program to integrate interdisciplinary subjects with philosophical concepts.
Abstract: This study presents the moisture variations of
unbound layers from April 2012 to January 2014 in the Interstate 40
(I-40) pavement section in New Mexico. Three moisture probes were
installed at different layers inside the pavement which measure the
continuous moisture variations of the unbound layers. Data show that
the moisture contents of unbound layers are typically constant
throughout the day and month unless there is rainfall. Moisture
contents of all unbound layers change with rainfall. Change in ground
water table may affect the moisture content of unbound layers which
has not been investigated in this study. In addition, the Level 3
predictions of moisture contents using the Pavement Mechanistic-
Empirical (ME) Design software were compared and found quite
reasonable. However, results presented in the current study may not
be applicable for pavement in other regions.
Abstract: In reference to the legal state in the Thai legal system,
most people understand the minor principles of the legal state form,
which are the principles that can be explained and understood easily
and the results can be seen clearly, especially in the legitimacy of
administrative acts. Therefore, there is no awareness of justice, which
is the fundamental value of Thai law. The legitimacy of administrative
acts requires the administration to adhere to the constitution and
legislative laws in enforcement of the laws. If it appears that the
administrative acts are illegitimate, the administrative court, as the
court of justice, will revoke those acts as if they had never been set in
the legal system, this will affect people’s trust as they are unaware as
to whether the administrative acts that appoint their lives are
legitimate or not. Regarding the revocation of administrative orders
by the administrative court as if those orders had never existed, the
common individual surely cannot be expected to comprehend the
security of their juristic position. Therefore, the legal state does not
require a revocation of the government’s acts to terminate its legal
results merely because those acts are illegitimate, but there should be
considerations and realizations regarding the “The Principle of the
Protection of Legitimate Expectation,” which is a minor principle in
the legal state’s content that focuses on supporting and protecting
legitimate expectations of the juristic position of an individual and
maintaining justice, which is the fundamental value of Thai law.
Abstract: Cement concrete is a complex mixture of different
materials. Behaviour of concrete depends on its mix proportions and
constituents when it is subjected to elevated temperatures. Principal
effects due to elevated temperatures are loss in compressive strength,
loss in weight or mass, change in colour and spall of concrete. The
experimental results of normal concrete and high strength concrete
subjected elevated temperatures at 200°C, 400°C, 600°C, and 800°C
and different cooling regimes viz. air cooling, water quenching on
different grade of concrete are reported in this paper.
Abstract: Conservation works in Malaysia that is procured by
public organisation usually follow the traditional approach where the
works are tendered based on Bills of Quantities (BQ). One of the
purposes of tendering is to enable the selection of a competent
contractor that offers a competitive price. While competency of the
contractors are assessed by their technical knowledge, experience and
track records, the assessment of pricing will be dependent on the
tender amount. However, the issue currently faced by the
conservation works sector is the difficulty in assessing the
competitiveness and reasonableness of the tender amount due to the
high variance between the tenders amount. Thus, this paper discusses
the factors that cause difficulty to the tenderers in pricing
competitively in a bidding exercise for conservation tenders. Data on
tendering is collected from interviews with conservation works
contractors to gain in-depth understanding of the barriers faced in
pricing tenders of conservation works. Findings from the study lent
support to the contention that the variance of tender amount is very
high amongst tenderers. The factors identified in the survey are the
format of BQ, hidden works, experience and labour and material
costs.
Abstract: This research aimed to study about motivation for
students of Suan Sunandha Rajabhat University to follow and happily
live according to Sufficiency Economy Philosophy. Having collected
394 questionnaires, the result showed that most students had great
motivation to follow this philosophy at a high level, especially in
terms of righteousness in profession; besides, students’ determination
and intention to apply this philosophy in everyday lives was
impressive though the students’ families were not completely ready.
Each of students, in fact, consulted their families for plans of any
activities without tiredness and discouragement based on the saying,
“Where there’s a will, there’s a way.” On the part of universities life,
students interacted with society and created projects that supported
income to the community including exercises, sports, recreational
activities, and community services.
Abstract: In this paper, we consider the vehicle routing problem
with mixed fleet of conventional and heterogenous electric vehicles
and time dependent charging costs, denoted VRP-HFCC, in which
a set of geographically scattered customers have to be served by a
mixed fleet of vehicles composed of a heterogenous fleet of Electric
Vehicles (EVs), having different battery capacities and operating
costs, and Conventional Vehicles (CVs). We include the possibility
of charging EVs in the available charging stations during the routes
in order to serve all customers. Each charging station offers charging
service with a known technology of chargers and time dependent
charging costs. Charging stations are also subject to operating time
windows constraints. EVs are not necessarily compatible with all
available charging technologies and a partial charging is allowed.
Intermittent charging at the depot is also allowed provided that
constraints related to the electricity grid are satisfied.
The objective is to minimize the number of employed vehicles and
then minimize the total travel and charging costs.
In this study, we present a Mixed Integer Programming Model and
develop a Charging Routing Heuristic and a Local Search Heuristic
based on the Inject-Eject routine with different insertion methods. All
heuristics are tested on real data instances.
Abstract: In order to detect and quantify the phenolic contents
of a wastewater with biosensors, two working electrodes based on
modified Poly(Pyrrole) films were fabricated. Enzyme horseradish
peroxidase was used as biomolecule of the prepared electrodes.
Various phenolics were tested at the biosensor. Phenol detection was
realized by electrochemical reduction of quinones produced by
enzymatic activity. Analytical parameters were calculated and the
results were compared with each other.
Abstract: IEEE 802.16 (WiMAX) aims to present high speed
wireless access to cover wide range coverage. The base station (BS)
and the subscriber station (SS) are the main parts of WiMAX.
WiMAX uses either Point-to-Multipoint (PMP) or mesh topologies.
In the PMP mode, the SSs connect to the BS to gain access to the
network. However, in the mesh mode, the SSs connect to each other
to gain access to the BS.
The main components of QoS management in the 802.16 standard
are the admission control, buffer management and packet scheduling.
In this paper, we use QualNet 5.0.2 to study the performance of
different scheduling schemes, such as WFQ, SCFQ, RR and SP when
the numbers of SSs increase. We find that when the number of SSs
increases, the average jitter and average end-to-end delay is increased
and the throughput is reduced.
Abstract: The work studied the effect of germination on
proximate, phenol and flavonoid content and antioxidant activities
(AOA) of African Yam been (AYB). Germination was done in
controlled dark chamber (100% RH, 28oC). The proximate, phenol
and flavonoid content and antioxidant activities before and after
germination were investigated. The crude protein, moisture, and
crude fiber content of germinated AYB were significantly higher
(P
Abstract: It is likely that robots will cross the boundaries of
industry into households over the next decades. With demographic
challenges worldwide, the future ageing populations will require the
introduction of assistive technologies capable of providing, care,
human dignity and quality of life through the aging process. Robotics
technology has a high potential for being used in the areas of social
and healthcare by promoting a wide range of activities such as
entertainment, companionship, supervision or cognitive and physical
assistance. However such close Human Robotics Interaction (HRI)
encompass a rich set of ethical scenarios that need to be addressed
before Socially Assistive Robots (SARs) reach the global markets.
Such interactions with robots may seem a worthy goal for many
technical/financial reasons but inevitably require close attention to
the ethical dimensions of such interactions. This article investigates
the current HRI benchmark of social success. It revises it according
to the ethical principles of beneficence, non-maleficence and justice
aligned with social care ethos. An extension of such benchmark is
proposed based on an empirical study of HRIs conducted with elderly
groups.
Abstract: In urban area, several landmarks may affect housing
price and rents, and hedonic analysis should employ distance variables
corresponding to each landmarks. Unfortunately, the effects of
distances to landmarks on housing prices are generally not consistent
with the true price. These distance variables may cause magnitude
error in regression, pointing a problem of spatial multicollinearity. In
this paper, we provided some approaches for getting the samples with
less bias and method on locating the specific sampling area to avoid
the multicollinerity problem in two specific landmarks case.
Abstract: Fluid viscous damping systems are well suited for
many air vehicles subjected to shock and vibration. These damping
system work with the principle of viscous fluid throttling through the
orifice to create huge pressure difference between compression and
rebound chamber and obtain the required damping force. One
application of such systems is its use in aircraft door system to
counteract the door’s velocity and safely stop it. In exigency
situations like crash or emergency landing where the door doesn’t
open easily, possibly due to unusually tilting of fuselage or some
obstacles or intrusion of debris obstruction to move the parts of the
door, such system can be combined with other systems to provide
needed force to forcefully open the door and also securely stop it
simultaneously within the required time i.e. less than 8 seconds. In
the present study, a hydraulic system called snubber along with other
systems like actuator, gas bottle assembly which together known as
emergency power assist system (EPAS) is designed, built and
experimentally studied to check the magnitude of angular velocity,
damping force and time required to effectively open the door.
Whenever needed, the gas pressure from the bottle is released to
actuate the actuator and at the same time pull the snubber’s piston to
operate the emergency opening of the door. Such EPAS installed in
the suspension arm of the aircraft door is studied explicitly changing
parameters like orifice size, oil level, oil viscosity and bypass valve
gap and its spring of the snubber at varying temperature to generate
the optimum design case. Comparative analysis of the EPAS at
several cases is done and conclusions are made. It is found that
during emergency condition, the system opening time and angular
velocity, when snubber with 0.3mm piston and shaft orifice and
bypass valve gap of 0.5 mm with its original spring is used, shows
significant improvement over the old ones.