Abstract: Chitosan has been an attractive biopolymer for
decades, but its processability is lowered by its poor solubility,
especially in physiological pH values. Freeze concentrated reactions
of chitosan with several organic acids including acrylic, citraconic,
itaconic, and maleic acid revealed improved solubility and
morphological properties. Solubility traits were assessed with a
modified ninhydrin test. Chitosan derivatives were characterized by
ATR-FTIR and morphological characteristics were determined by
SEM. This study is a unique approach to chemically modify chitosan
to enhance water solubility.
Abstract: Diminished antioxidant defense or increased
production of reactive oxygen species in the biological system can
result in oxidative stress which may lead to various
neurodegenerative diseases including Alzheimer’s disease (AD).
Microglial activation also contributes to the progression of AD by
producing several proinflammatory cytokines, nitric oxide (NO) and
prostaglandin E2 (PGE2). Oxidative stress and inflammation have
been reported to be possible pathophysiological mechanisms
underlying AD. In addition, the cholinergic hypothesis postulates that
memory impairment in patient with AD is also associated with the
deficit of cholinergic function in the brain. Although a number of
drugs have been approved for the treatment of AD, most of these
synthetic drugs have diverse side effects and yield relatively modest
benefits. Marine algae have great potential in pharmaceutical and
biomedical applications as they are valuable sources of bioactive
properties such as anticoagulation, antimicrobial, antioxidative,
anticancer and anti-inflammatory. Hence, this study aimed to provide
an overview of the properties of Malaysian seaweeds (Padina
australis, Sargassum polycystum and Caulerpa racemosa) in
inhibiting oxidative stress, neuroinflammation and cholinesterase
enzymes. These seaweeds significantly exhibited potent DPPH and
moderate superoxide anion radical scavenging ability (P
Abstract: With drug resistance becoming widespread in
Plasmodium falciparum infections, the development of the alternative
drugs is the desired strategy for prevention and cure of malaria. Three
drug targets were selected to screen promising drug molecules from
the GSK library of 13469 molecules. Using an in silico structure-based
drug designing approach, the differences in binding energies of
the substrate and inhibitor were exploited between target sites of
parasite and human to design a drug molecule against Plasmodium.
The docking studies have shown several promising molecules from
GSK library with more effective binding as compared to the already
known inhibitors for the drug targets. Though stronger interaction has
been shown by several molecules as compared to the reference, few
molecules have shown the potential as drug candidates though in
vitro studies are required to validate the results. In case of
thymidylate synthase-dihydrofolatereductase (TS-DHFR), three
compounds have shown promise for future studies as potential drugs.
Abstract: Learning Management System (LMS) is the system
which uses to manage the learning in order to grouping the content
and learning activity between the lecturer and learner including
online examination and evaluation. Nowadays, it is the borderless
learning era so the learning activities can be accessed from
everywhere in the world and also anytime via the information
technology and media. The learner can easily access to the
knowledge so the different in time and distance is not a constraint for
learning anymore.
The learning pattern which was used in this research is the
integration of the in-class learning and online learning via internet
and will be able to monitor the progress by the Learning management
system which will create the fast response and accessible learning
process via the social media. In order to increase the capability and
freedom of the learner, the system can show the current and history
of the learning document, video conference and also has the chat
room for the learner and lecturer to interact to each other.
So the objectives of the “The Design and Applied of Learning
Management System via Social Media on Internet: Case Study of
Operating System for Business Subject” are to expand the
opportunity of learning and to increase the efficiency of learning as
well as increase the communication channel between lecturer and
student. The data of this research was collect from 30 users of the
system which are students who enroll in the subject. And the result of
the research is in the “Very Good” which is conformed to the
hypothesis.
Abstract: The detection of the polymer melt state during
manufacture process is regarded as an efficient way to control the
molded part quality in advance. Online monitoring rheological
property of polymer melt during processing procedure provides an
approach to understand the melt state immediately. Rheological
property reflects the polymer melt state at different processing
parameters and is very important in injection molding process
especially. An approach that demonstrates how to calculate
rheological property of polymer melt through in-process
measurement, using injection molding as an example, is proposed in
this study. The system consists of two sensors and a data acquisition
module can process the measured data, which are used for the
calculation of rheological properties of polymer melt. The rheological
properties of polymer melt discussed in this study include shear rate
and viscosity which are investigated with respect to injection speed
and melt temperature. The results show that the effect of injection
speed on the rheological properties is apparent, especially for high
melt temperature and should be considered for precision molding
process.
Abstract: Although there had been a many studies that shows
the impact of air pollution on physical health, comparatively less was
known of human behavioral responses and annoyance impacts.
Annoyance caused by air pollution is a public health problem because
it can be an ambient stressor causing stress and disease and can affect
quality of life. The objective of this work is to evaluate the
annoyance caused by air pollution in two different industrialized
urban areas, Dunkirk (France) and Vitoria (Brazil). The populations
of these cities often report feeling annoyed by dust. Surveys were
conducted, and the collected data were analyzed using statistical
analyses. The results show that sociodemographic variables,
importance of air quality, perceived industrial risk, perceived air
pollution and occurrence of health problems play important roles in
the perceived annoyance. These results show the existence of a
common problem in geographically distant areas and allow
stakeholders to develop prevention strategies.
Abstract: Doxorubicin, also known as Adriamycin, is an
anthracycline class of drug used in cancer chemotherapy. It is used in
the treatment of non-Hodgkin’s lymphoma, multiple myeloma, acute
leukemia, breast cancer, lung cancer, endometrium cancer and ovary
cancers. It functions via intercalating DNA and ultimately killing
cancer cells. The major side effects of doxorubicin are hair loss,
myelosuppression, nausea & vomiting, oesophagitis, diarrhea, heart
damage and liver dysfunction. The minor modifications in the
structure of compound exhibit large variation in the biological
activity, has prompted us to carry out the synthesis of sulfonamide
derivatives. Sulfonamide is an important feature with broad spectrum
of biological activity such as antiviral, antifungal, diuretics, antiinflammatory,
antibacterial and anticancer activities. Structure of the
synthesized compound N-(1-methyl-2-oxo-2-N-methyl anilinoethyl)
benzene sulfonamide confirmed by proton nuclear magnetic
resonance (1H NMR),13C NMR, Mass and FTIR spectroscopic tools
to assure the position of all protons and hence stereochemistry of the
molecule. Further we have reported the binding potential of
synthesized sulfonamide analogues in comparison to doxorubicin
drug using Auto Dock 4.2 software. Computational binding energy
(B.E.) and inhibitory constant (Ki) has been evaluated for the
synthesized compound in comparison of doxorubicin against Poly
(dA-dT).Poly (dA-dT) and Poly (dG-dC).Poly (dG-dC) sequences.
The in vitro cytotoxic study against human breast cancer cell lines
confirms the better anticancer activity of the synthesized compound
over currently in use anticancer drug doxorubicin. The IC50 value of
the synthesized compound is 7.12 μM whereas for doxorubicin is 7.2
μM.
Abstract: Operations, maintenance and reliability of wind
turbines have received much attention over the years due to the rapid
expansion of wind farms. This paper explores early fault diagnosis
technique for a 5MW wind turbine system subjected to multiple
faults, where genetic optimization algorithm is employed to make the
residual sensitive to the faults, but robust against disturbances. The
proposed technique has a potential to reduce the downtime mostly
caused by the breakdown of components and exploit the productivity
consistency by providing timely fault alarms. Simulation results show
the effectiveness of the robust fault detection methods used under
Matlab/Simulink/Gatool environment.
Abstract: ESPRIT-TLS method appears a good choice for high
resolution fault detection in induction machines. It has a very high
effectiveness in the frequency and amplitude identification.
Contrariwise, it presents a high computation complexity which
affects its implementation in real time fault diagnosis. To avoid this
problem, a Fast-ESPRIT algorithm that combined the IIR band-pass
filtering technique, the decimation technique and the original
ESPRIT-TLS method was employed to enhance extracting accurately
frequencies and their magnitudes from the wind stator current with
less computation cost. The proposed algorithm has been applied to
verify the wind turbine machine need in the implementation of an online,
fast, and proactive condition monitoring. This type of remote
and periodic maintenance provides an acceptable machine lifetime,
minimize its downtimes and maximize its productivity. The
developed technique has evaluated by computer simulations under
many fault scenarios. Study results prove the performance of Fast-
ESPRIT offering rapid and high resolution harmonics recognizing
with minimum computation time and less memory cost.
Abstract: Remote sensing plays a vital role in mapping of
resources and monitoring of environments of the earth. In the present
research study, mapping and monitoring of clay siltations occurred in
the Alkhod Dam of Muscat, Sultanate of Oman are carried out using
low-cost multispectral Landsat and ASTER data. The dam is
constructed across the Wadi Samail catchment for ground water
recharge. The occurrence and spatial distribution of siltations in the
dam are studied with five years of interval from the year 1987 of
construction to 2014. The deposits are mainly due to the clay, sand
and silt occurrences derived from the weathering rocks of ophiolite
sequences occurred in the Wadi Samail catchment. The occurrences
of clays are confirmed by minerals identification using ASTER
VNIR-SWIR spectral bands and Spectral Angle Mapper supervised
image processing method. The presence of clays and their spatial
distribution are verified in the field. The study recommends the
technique and the low-cost satellite data to similar region of the
world.
Abstract: Governments collect and produce large amounts of
data. Increasingly, governments worldwide have started to implement
open data initiatives and also launch open data portals to enable the
release of these data in open and reusable formats. Therefore, a large
number of open data repositories, catalogues and portals have been
emerging in the world. The greater availability of interoperable and
linkable open government data catalyzes secondary use of such data,
so they can be used for building useful applications which leverage
their value, allow insight, provide access to government services, and
support transparency. The efficient development of successful open
data portals makes it necessary to evaluate them systematic, in order
to understand them better and assess the various types of value they
generate, and identify the required improvements for increasing this
value. Thus, the attention of this paper is directed particularly to the
field of open data portals. The main aim of this paper is to compare
the selected open data portals on the national level using content
analysis and propose a new evaluation framework, which further
improves the quality of these portals. It also establishes a set of
considerations for involving businesses and citizens to create eservices
and applications that leverage on the datasets available from
these portals.
Abstract: This paper describes the tradeoffs and the design from
scratch of a self-contained, easy-to-use health dashboard software
system that provides customizable data tracking for patients in smart
homes. The system is made up of different software modules and
comprises a front-end and a back-end component. Built with HTML,
CSS, and JavaScript, the front-end allows adding users, logging into
the system, selecting metrics, and specifying health goals. The backend
consists of a NoSQL Mongo database, a Python script, and a
SimpleHTTPServer written in Python. The database stores user
profiles and health data in JSON format. The Python script makes use
of the PyMongo driver library to query the database and displays
formatted data as a daily snapshot of user health metrics against
target goals. Any number of standard and custom metrics can be
added to the system, and corresponding health data can be fed
automatically, via sensor APIs or manually, as text or picture data
files. A real-time METAR request API permits correlating weather
data with patient health, and an advanced query system is
implemented to allow trend analysis of selected health metrics over
custom time intervals. Available on the GitHub repository system,
the project is free to use for academic purposes of learning and
experimenting, or practical purposes by building on it.
Abstract: The development of Drugs Delivery System (DDS)
has been widely investigated in the last decades. In this paper, first a
general overview of traditional and modern wound dressing is
presented. This is followed by a review of what scientists have done
in the medical environment, focusing on the possibility to develop a
new alternative for DDS through transdermal pathway, aiming to
treat melanoma skin cancer.
Abstract: In this paper, we have compared and analyzed the
electroabsorption properties between with and without excitonic
effect bulk in high purity GaAs spatial light modulator for optical
fiber communication network. The eletroabsorption properties such
as absorption spectra, change in absorption spectra, change in
refractive index and extinction ration has been calculated. We have
also compared the result of absorption spectra and change in
absorption spectra with the experimental results and found close
agreement with experimental results.
Abstract: In this paper, we propose an intelligent system that is
used for monitoring the health conditions of patients. Monitoring the
health condition of patients is a complex problem that involves
different medical units and requires continuous monitoring especially
in rural areas because of inadequate number of available specialized
physicians. The proposed system will improve patient care and drive
costs down comparing to the existing system in Jordan. The proposed
system will be the start point to faster and improve the
communication between different units in the health system in
Jordan. Connecting patients and their physicians beyond hospital
doors regarding their geographical area is an important issue in
developing the health system in Jordan. The ability of making
medical decisions, the quality of medical is expected to be improved.
Abstract: Macro invertebrates have been used to monitor
organic pollution in rivers and streams. Several biotic indices based
on macro invertebrates have been developed over the years including
the Biological Monitoring Working Party (BMWP). A new biotic
index, the Gammarus:Asellus ratio has been recently proposed as an
index of organic pollution. This study tested the validity of the
Gammarus:Asellus ratio as an index of organic pollution, by
examining the relationship between the Gammarus:Asellus ratio and
physical chemical parameters, and other biotic indices such as
BMWP and, Average Score Per Taxon (ASPT) from lakes and
streams at Markeaton Park, Allestree Park and Kedleston Hall,
Derbyshire. Macro invertebrates were sampled using the standard
five minute kick sampling techniques physical and chemical
environmental variables were obtained based on standard sampling
techniques. Eighteen sites were sampled, six sites from Markeaton
Park (three sites across the stream and three sites across the lake). Six
sites each were also sampled from Allestree Park and Kedleston Hall
lakes. The Gammarus:Asellus ratio showed an opposite significant
positive correlations with parameters indicative of organic pollution
such as the level of nitrates, phosphates, and calcium and also
revealed a negatively significant correlations with other biotic indices
(BMWP/ASPT). The BMWP score correlated positively significantly
with some water quality parameters such as dissolved oxygen and
flow rate, but revealed no correlations with other chemical
environmental variables. The BMWP score was significantly higher
in the stream than the lake in Markeaton Park, also The ASPT scores
appear to be significantly higher in the upper Lakes than the middle
and lower lakes. This study has further strengthened the use of
BMWP/ASPT score as an index of organic pollution. But additional
application is required to validate the use of Gammarus:Asellus as a
rapid bio monitoring tool.
Abstract: As the use of geothermal energy grows internationally
more effort is required to monitor and protect areas with rare and
important geothermal surface features. A number of approaches are
presented for developing and calibrating numerical geothermal
reservoir models that are capable of accurately representing
geothermal surface features. The approaches are discussed in the
context of cases studies of the Rotorua geothermal system and the
Orakei-korako geothermal system, both of which contain important
surface features. The results show that models are able to match the
available field data accurately and hence can be used as valuable
tools for predicting the future response of the systems to changes in
use.
Abstract: An experiment was conducted to determine the effect
of pollination on seed quality of rapeseed in Chitwan, Nepal during
2012-2013. The experiment was designed in Randomized Complete
Block with four replications and five treatments. The rapeseed plots
were caged with mosquito nets at 10% flowering except natural
pollination. Two-framed colonies of Apis mellifera L. and Apis
cerana F. were introduced separately for pollination, and control plot
caged without pollinators. The highest germination percent was
observed on Apis cerana F. pollinated plot seeds (90.50%
germination) followed by Apis mellifera L. pollinated plots (87.25 %)
and lowest on control plots (42.00% germination) seeds. Similarly,
seed test weight of Apis cerana F. pollinated plots (3.22 gm/ 1000
seed) and Apis mellifera L. pollinated plots (2.93 gm/1000 seed) were
and lowest on control plots (2.26 gm/ 1000 seed) recorded. Likewise,
oil content was recorded highest on pollinated by Apis cerana F.
(36.1%) followed by pollinated by Apis mellifera L. (35.4%) and
lowest on control plots (32.8%). This study clearly indicated
pollination increases the seed quality of rapeseed and therefore,
management of honeybee is necessary for producing higher quality of
rapeseed under Chitwan condition.
Abstract: The study examined the effect of Bonny Light whole
crude oil (WC) and its water soluble fraction (WSF) on the activities
of antioxidant enzymes (catalase (CAT) and superoxide dismutase
(SOD)) and crude mitochondria ATPases in the radicle of
germinating bean (Vigna unguiculata). The percentage germination,
level of lipid peroxidation, antioxidant enzyme and mitochondria
Ca2+ and Mg2+ ATPase activities were measured in the radicle of
bean after 7, 14 and 21 days post germination. Viable bean seeds
were planted in soils contaminated with 10ml, 25ml and 50ml of
whole crude oil (WC) and its water soluble fraction (WSF) to obtain
2, 5 and 10% v/w crude oil contamination. There was dose dependent
reduction of the number of bean seeds that germinated in the
contaminated soils compared with control (p
Abstract: Urban areas have been expanded throughout the
globe. Monitoring and modelling urban growth have become a
necessity for a sustainable urban planning and decision making.
Urban prediction models are important tools for analyzing the causes
and consequences of urban land use dynamics. The objective of this
research paper is to analyze and model the urban change, which has
been occurred from 1990 to 2000 using CORINE land cover maps.
The model was developed using drivers of urban changes (such as
road distance, slope, etc.) under an Artificial Neural Network
modelling approach. Validation was achieved using a prediction map
for 2006 which was compared with a real map of Urban Atlas of
2006. The accuracy produced a Kappa index of agreement of 0,639
and a value of Cramer's V of 0,648. These encouraging results
indicate the importance of the developed urban growth prediction
model which using a set of available common biophysical drivers
could serve as a management tool for the assessment of urban
change.