Abstract: The mechanisms underlying the association between
obesity and asthma may be related to a decreased immunological
tolerance induced by a defective function of regulatory T cells
(Tregs). The aim of this study is to establish the potential link
between these diseases and CD4+, CD25+ FoxP3+ Tregs as well as T
helper cells (Ths) in children. This is a prospective case control
study. Obese (n:40), asthmatic (n:40), asthmatic obese (n:40) and
healthy children (n:40), who don't have any acute or chronic diseases,
were included in this study. Obese children were evaluated according
to WHO criteria. Asthmatic patients were chosen based on GINA
criteria. Parents were asked to fill up the questionnaire. Informed
consent forms were taken. Blood samples were marked with CD4+,
CD25+ and FoxP3+ in order to determine Tregs and Ths by flow
cytometric method. Statistical analyses were performed. p≤0.05 was
chosen as meaningful threshold. Tregs exhibiting anti-inflammatory
nature were significantly lower in obese (0,16%; p≤0,001), asthmatic
(0,25%; p≤0,01) and asthmatic obese (0,29%; p≤0,05) groups than
the control group (0,38%). Ths were counted higher in asthma group
than the control (p≤0,01) and obese (p≤0,001) groups. T cell
immunity plays important roles in obesity and asthma pathogeneses.
Decreased numbers of Tregs found in obese, asthmatic and asthmatic
obese children may help to elucidate some questions in
pathophysiology of these diseases. For HOMA-IR levels, any
significant difference was not noted between control and obese
groups, but statistically higher values were found for obese
asthmatics. The values obtained in all groups were found to be below
the critical cut off points. This finding has made the statistically
significant difference observed between Tregs of obese, asthmatic,
obese asthmatic and control groups much more valuable. These
findings will be useful in diagnosis and treatment of these disorders
and future studies are needed. The production and propagation of
Tregs may be promising in alternative asthma and obesity treatments.
Abstract: Many organizations are investing in web applications
and technologies in order to be competitive, some of them could not
achieve its goals. The quality of web-based applications could play
an important role for organizations to be competitive. So the aim of
this study is to investigate the impact of quality of web-based
applications to achieve a competitive advantage. A new model has
been developed. An empirical investigation was performed on a
banking sector in Jordan to test the new model. The results show that
impact of web-based applications on competitive advantage is
significant. Finally, further work is planned to validate and evaluate
the proposed model using several domains.
Abstract: Employer branding is considered as a useful tool for
addressing the global-local problem facing complex organisations
that have operations scattered across the globe and face challenges of
dealing with the local environment alongside. Despite being an
established field of study within the Western developed world, there
is little empirical evidence concerning the relevance of employer
branding to global companies that operate in the under-developed
economies. This paper fills this gap by gaining rich insight into the
implementation of employer branding programs in a foreign
multinational operating in Pakistan dealing with the global-local
problem. The study is qualitative in nature and employs semistructured
and focus group interviews with senior/middle managers
and local frontline employees to deeply examine the phenomenon in
case organisation. Findings suggest that authenticity is required in
employer brands to enable them to respond to the local needs thereby
leading to the resolution of the global-local problem. However, the
role of signaling theory is key to the development of authentic
employer brands as it stresses on the need to establish an efficient and
effective signaling environment where in signals travel in both
directions (from signal designers to receivers and backwards) and
facilitate firms with the global-local problem. The paper also
identifies future avenues of research for the employer branding field.
Abstract: Image segmentation plays an important role in
medical imaging applications. Therefore, accurate methods are
needed for the successful segmentation of medical images for
diagnosis and detection of various diseases. In this paper, we have
used maximum entropy to achieve image segmentation. Maximum
entropy has been calculated using Shannon, Renyi and Tsallis
entropies. This work has novelty based on the detection of skin lesion
caused by the bite of a parasite called Sand Fly causing the disease is
called Cutaneous Leishmaniasis.
Abstract: This paper describes the issues relating to the role of
the flash flood early warning system provided by the Malaysian
Government to the communities in Malaysia, specifically during the
flash flood disaster in the Cameron Highlands, Malaysia. Normally,
flash flood disasters can occur as a result of heavy rainfall in an area,
and that water may possibly cause flooding via streams or narrow
channels. The focus of this study is the flash flood disaster which
occurred on 23 October 2013 in the Cameron Highlands, and as a
result the Sungai Bertam overflowed after the release of water from
the Sultan Abu Bakar Dam. This release of water from the dam
caused flash flooding which led to damage to properties and also the
death of residents and livestock in the area. Therefore, the effort of
this study is to identify the perceptions of the flash flood victims on
the role of the flash flood early warning system. For the purposes of
this study, data were gathered through face-to-face interviews from
those flood victims who were willing to participate in this study. This
approach helped the researcher to glean in-depth information about
their feelings and perceptions of the role of the flash flood early
warning system offered by the government. The data were analysed
descriptively and the findings show that the respondents of 22 flood
victims believe strongly that the flash flood early warning system was
confusing and dysfunctional, and communities had failed to response
positively to it. Therefore, most of the communities were not well
prepared for the releasing of water from the dam which caused
property damage, and 3 people were killed in the Cameron Highland
flash flood disaster.
Abstract: The paper discusses mineral water consumer market
and development policy in Georgia, the tools and measures, which
will contribute to production of mineral waters and increase its
export.
The paper studies and analyses current situation in mineral water
production sector as well as the factors affecting increase and
reduction of its export. It’s noted that in order to gain and maintain
competitive advantage, it’s necessary to provide continuous supply of
high quality goods with modern design, open new distribution
channels to enter new markets, carry out broad promotional activities,
organize e-commerce. Economic policy plays an important role in
protecting markets from counterfeit goods. The state also plays an
important role in attracting foreign direct investments. Stable
business environment and export oriented strategy is the basis for the
country’s economic growth.
Based on the research, the paper suggests the strategy for
improving competitiveness of Georgian mineral waters; relevant
conclusions and recommendations are provided.
Abstract: Experimental study on slicing of sapphire with fixed
abrasive diamond wire saw was conducted in this paper. The process
parameters were optimized through orthogonal experiment of three
factors and four levels. The effects of wire speed, feed speed and
tension pressure on the surface roughness were analyzed. Surface
roughness in cutting direction and feed direction were both detected.
The results show that feed speed plays the most significant role on the
surface roughness of sliced sapphire followed by wire speed and
tension pressure. The optimized process parameters are as follows:
wire speed 1.9 m/s, feed speed 0.187 mm/min and tension pressure
0.18 MPa. In the end, the results were verified by analysis of variance.
Abstract: This exploratory study gives an overview of the
evolution of the main financial and performance indicators of the
Academic Spin-Off’s and High Growth Academic Spin-Off’s in year
3 and year 6 after its creation in the region of Catalonia in Spain. The
study compares and evaluates results of these different measures of
performance and the degree of success of these companies for each
University.
We found that the average Catalonian Academic Spin-Off is small
and have not achieved the sustainability stage at year 6. On the
contrary, a small group of High Growth Academic Spin-Off’s
exhibits robust performance with high profits in year 6. Our results
support the need to increase selectivity and support for these
companies especially near year 3, because are the ones that will bring
wealth and employment. University role as an investor has rigid
norms and habits that impede an efficient economic return from their
ASO investment.
Universities with high performance on sales and employment in
year 3 not always could sustain this growth in year 6 because their
ASO’s are not profitable. On the contrary, profitable ASO exhibit
superior performance in all measurement indicators in year 6. We
advocate the need of a balanced growth (with profits) as a way to
obtain subsequent continuous growth.
Abstract: In the past researchers have questioned the
effectiveness of ethics training in higher education. Also, there are
observations that support the view that ethical behaviour (range of
actions)/ethical decision making models used in the past make use of
vignettes to explain ethical behaviour. The understanding remains in
the perspective that these vignettes play a limited role in determining
individual intentions and not actions. Some authors have also agreed
that there are possibilities of differences in one’s intentions and
actions. This paper makes an attempt to fill those gaps by evaluating
real actions rather than intentions. In a way this study suggests the
use of an experiential methodology to explore Berlo’s model of
communication as an action along with orchestration of various
principles. To this endeavor, an attempt was made to use
conversational analysis in the pursuance of evaluating ethical
decision making behaviour among students and middle level
managers. The process was repeated six times with the set of an
average of 15 participants. Similarities have been observed in the
behaviour of students and middle level managers that calls for
understanding that both the groups of individuals have no cognizance
of their actual actions. The deliberations derived out of conversation
were taken a step forward for meta-ethical evaluations to portray a
clear picture of ethical behaviour among participants. This study
provides insights for understanding demonstrated unconscious human
behaviour which may fortuitously be termed both ethical and
unethical.
Abstract: These days customer satisfaction plays vital role in
any business. When customer searches for a product, significantly a
junk of irrelevant information is what is given, leading to customer
dissatisfaction. To provide exactly relevant information on the
searched product, we are proposing a model of KaaS (Knowledge as
a Service), which pre-processes the information using decision
making paradigm using Multi-agents.
Information obtained from various sources is taken to derive
knowledge and they are linked to Cloud to capture new idea. The
main focus of this work is to acquire relevant information
(knowledge) related to product, then convert this knowledge into a
service for customer satisfaction and deploy on cloud.
For achieving these objectives we are have opted to use multi
agents. They are communicating and interacting with each other,
manipulate information, provide knowledge, to take decisions. The
paper discusses about KaaS as an intelligent approach for Knowledge
acquisition.
Abstract: The main purpose of this paper is to determine the
applicability of the constitutional social rights in the so-called
horizontal relations, i.e. the relations between private entities.
Nowadays the constitutional rights are more and more often violated
by private entities and not only by the state. The private entities
interfere with the privacy of individuals, limit their freedom of
expression or disturb their peaceful gatherings. International
corporations subordinate individuals in a way which may limit their
constitutional rights. These new realities determine the new role of
the constitution in protecting human rights.
The paper will aim at answering two important questions. Firstly,
are the private entities obliged to respect the constitutional social
rights of other private entities and can they be liable for violation of
these rights? Secondly, how the constitutional social rights can
receive horizontal effect? Answers to these questions will have a
significant meaning for the popularisation of the practice of applying
the Constitution among the citizens as well as for the courts which
settle disputes between them.
Abstract: Cloud computing is a new technology in industry and
academia. The technology has grown and matured in last half decade
and proven their significant role in changing environment of IT
infrastructure where cloud services and resources are offered over the
network. Cloud technology enables users to use services and
resources without being concerned about the technical implications of
technology. There are substantial research work has been performed
for the usage of cloud computing in educational institutes and
majority of them provides cloud services over high-end blade servers
or other high-end CPUs. However, this paper proposes a new stack
called “CiCKAStack” which provide cloud services over unutilized
computing resources, named as commodity computers.
“CiCKAStack” provides IaaS and PaaS using underlying commodity
computers. This will not only increasing the utilization of existing
computing resources but also provide organize file system, on
demand computing resource and design and development
environment.
Abstract: Groundwater inflow to the tunnels is one of the most
important problems in tunneling operation. The objective of this
study is the investigation of model dimension effects on tunnel inflow
assessment in discontinuous rock masses using numerical modeling.
In the numerical simulation, the model dimension has an important
role in prediction of water inflow rate. When the model dimension is
very small, due to low distance to the tunnel border, the model
boundary conditions affect the estimated amount of groundwater flow
into the tunnel and results show a very high inflow to tunnel. Hence,
in this study, the two-dimensional universal distinct element code
(UDEC) used and the impact of different model parameters, such as
tunnel radius, joint spacing, horizontal and vertical model domain
extent has been evaluated. Results show that the model domain extent
is a function of the most significant parameters, which are tunnel
radius and joint spacing.
Abstract: This paper presents system level CMOS solid-state
nanopore techniques enhancement for speedup next generation
molecular recording and high throughput channels. This discussion
also considers optimum number of base-pair (bp) measurements
through channel as an important role to enhance potential read
accuracy. Effective power consumption estimation offered suitable
range of multi-channel configuration. Nanopore bp extraction model
in statistical method could contribute higher read accuracy with
longer read-length (200 < read-length). Nanopore ionic current
switching with Time Multiplexing (TM) based multichannel readout
system contributed hardware savings.
Abstract: The aim of this paper is to understand emerging
learning conditions, when a visual analytics is implemented and used
in K 12 (education). To date, little attention has been paid to the role
visual analytics (digital media and technology that highlight visual
data communication in order to support analytical tasks) can play in
education, and to the extent to which these tools can process
actionable data for young students. This study was conducted in three
public K 12 schools, in four social science classes with students aged
10 to 13 years, over a period of two to four weeks at each school.
Empirical data were generated using video observations and analyzed
with help of metaphors within Actor-network theory (ANT). The
learning conditions are found to be distinguished by broad
complexity, characterized by four dimensions. These emerge from
the actors’ deeply intertwined relations in the activities. The paper
argues in relation to the found dimensions that novel approaches to
teaching and learning could benefit students’ knowledge building as
they work with visual analytics, analyzing visualized data.
Abstract: Corrosion of concrete sewer pipes induced by sulfuric
acid is an acknowledged problem and a ticking time-bomb to sewer
operators. Whilst the chemical reaction of the corrosion process is
well-understood, the indirect roles of other parameters in the
corrosion process which are found in sewer environment are not
highly reflected on. This paper reports on a field studies undertaken
in Austria and United Kingdom, where the parameters of
temperature, pH, H2S and CO2 were monitored over a period of time.
The study establishes that (i) effluent temperature and pH have
similar daily pattern and peak times, when examined in minutes
scale; (ii) H2S and CO2 have an identical hourly pattern; (iii) H2S
instant or shifted relation to effluent temperature is governed by the
root mean square value of CO2.
Abstract: In recent years parasitic antenna play major role in
MIMO systems because of their gain and spectral efficiency. In this
paper, single RF chain MIMO transmitter is designed using
reconfigurable parasitic antenna. The Spatial Modulation (SM) is a
recently proposed scheme in MIMO scenario which activates only
one antenna at a time. The SM entirely avoids ICI and IAS, and only
requires a single RF chain at the transmitter. This would switch ON a
single transmit-antenna for data transmission while all the other
antennas are kept silent. The purpose of the parasitic elements is to
change the radiation pattern of the radio waves which is emitted from
the driven element and directing them in one direction and hence
introduces transmit diversity. Diode is connect between the patch and
ground by changing its state (ON and OFF) the parasitic element act
as reflector and director and also capable of steering azimuth and
elevation angle. This can be achieved by changing the input
impedance of each parasitic element through single RF chain. The
switching of diode would select the single parasitic antenna for
spatial modulation. This antenna is expected to achieve maximum
gain with desired efficiency.
Abstract: This paper aims to investigate the influence of quality
of education and quality of research, provided by local educational
institutions, on the adoption of Information and Communication
Technology (ICT) in managing business operations for companies in
Saudi market. A model was developed and tested using data collected
from 138 Chief Executive Officers (CEOs) of foreign companies in
diverse business sectors. The data is analyzed and managed using
multivariate approaches through standard statistical packages. The
results showed that educational quality has little contribution to the
ICT adoption while research quality seems to play a more prominent
role. These results are analyzed in terms of business environment and
market constraints and further extended to the perceived effectiveness
of applied pedagogical approaches in schools and universities.
Abstract: The key role in phenomenological modelling of cyclic
plasticity is good understanding of stress-strain behaviour of given
material. There are many models describing behaviour of materials
using numerous parameters and constants. Combination of individual
parameters in those material models significantly determines whether
observed and predicted results are in compliance. Parameter
identification techniques such as random gradient, genetic algorithm
and sensitivity analysis are used for identification of parameters using
numerical modelling and simulation. In this paper genetic algorithm
and sensitivity analysis are used to study effect of 4 parameters of
modified AbdelKarim-Ohno cyclic plasticity model. Results
predicted by Finite Element (FE) simulation are compared with
experimental data from biaxial ratcheting test with semi-elliptical
loading path.
Abstract: A Smart Building Controller (SBC) is a server
software that offers secured access to a pool of building specific
resources, executes monitoring tasks and performs automatic
administration of a building, thus optimizing the exploitation cost and
maximizing comfort. This paper brings to discussion the issues that
arise with the secure exploitation of the SBC administered resources
and proposes a technical solution to implement a robust secure access
system based on roles, individual rights and privileges (special
rights).